B Raffin, G Lacher, F Devars, C Benassayag, P Boudard, L Traissac
{"title":"Anatomical and surgical particularities of cholesteatomas in children.","authors":"B Raffin, G Lacher, F Devars, C Benassayag, P Boudard, L Traissac","doi":"10.1007/BF00463572","DOIUrl":"https://doi.org/10.1007/BF00463572","url":null,"abstract":"<p><p>In children, cholesteatoma is closely related to dysfunction of the eustachian tube and evolves inside a malleable temporal bone. The importance of auditory and speech functions in such patients has caused us to use a very particular clinical philosophy. At the present time we have studied 154 cases of cholesteatomas in children under 15 years old. The following three points have been shown: the pathogenesis of a cholesteatoma can be of the primary type, secondary (due to an unfavorable extension of retraction pocket or to squamous cell migration) or even be iatrogenic; anatomical and clinical findings (with X-ray studies) predicate the treatment used; surgical treatment frequently requires a \"second-look\" operation.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 5","pages":"271-3"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00463572","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13731504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Remacle, E Marbaix, M Hamoir, X Declaye, J van den Eeckhaut
{"title":"Initial long-term results of collagen injection for vocal and laryngeal rehabilitation.","authors":"M Remacle, E Marbaix, M Hamoir, X Declaye, J van den Eeckhaut","doi":"10.1007/BF00463606","DOIUrl":"https://doi.org/10.1007/BF00463606","url":null,"abstract":"<p><p>The records of 14 patients who have benefited from intralaryngeal injections of ZCI collagen for at least 3-4 years were reviewed. All patients still living were evaluated. Qualitative phonatory measurements included laryngostroboscopy and frequency voice analysis, while quantitative studies included maximum phonation times and phonatory quotients. The absence of both local and general inflammatory reactions was observed in these patients, confirming the excellent host tolerance of ZCI collagen and the stability of the functional results achieved.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 5","pages":"403-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00463606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13734065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A subpopulation of outer hair cells possessing GABA receptors with tonotopic organization.","authors":"P K Plinkert, H Möhler, H P Zenner","doi":"10.1007/BF00464301","DOIUrl":"https://doi.org/10.1007/BF00464301","url":null,"abstract":"<p><p>The olivocochlear innervation has been postulated to regulate active mechanical processes in the mammalian cochlea. Histochemical studies led to the suggestion that a subpopulation of these efferent nerves, which predominantly terminate on outer hair cells (OHCs), are gamma-aminobutyric acid (GABA)-ergic. By means of two monoclonal antibodies, we were able to visualize GABAA-receptor immunoreactivity at the basal pole of isolated sensory cells. Both subunits of the GABAA receptor, the alpha- and beta-subunit, are known to form the transmembranous GABA/benzodiazepine-receptor complex and were present on OHCs. In addition, these inhibitory receptors were more numerous in the apical turns of the cochlea, indicating another criterion for distinguishing the apical from basal turns of the cochlea. These results support the concept that a subpopulation of axosomatic synapses at the basal pole of OHCs liberate the inhibitory neurotransmitter GABA into the synaptic cleft. Binding of the transmitter to these newly observed subsynaptic receptors is possibly followed by a change in OHC motility and a subsequent modulation of the movement of the basilar membrane.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 6","pages":"417-22"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00464301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13702925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensorineural high-frequency hearing loss after drill-generated acoustic trauma in tympanoplasty.","authors":"J Doménech, M Carulla, J Traserra","doi":"10.1007/BF00463575","DOIUrl":"https://doi.org/10.1007/BF00463575","url":null,"abstract":"<p><p>Tympanoplasty can cause a sensorineural hearing loss by a mechanism of acoustic trauma. Although this lesion appears to be relatively infrequent in clinical practice, we believe that its low apparent incidence is caused when clinicians fail to assess the auditory frequencies above 8000 Hz. Twenty-four patients with normal bone-conduction audiometric thresholds scheduled for tympanoplasty were assessed with an electro-stimulation, bone-conduction high-frequency audiometer which can measure hearing frequencies up to 20 kHz before and after surgery. A measurable hearing loss was found in the upper limits of the audible frequencies in 9 patients (37.5%), and was considered important in 4 of them (16.7%). This hearing loss was recorded above the upper frequency limit of conventional audiometers. The findings in this study indicate that drilling of the temporal bone can impair the hearing level in the high frequencies in a significant number of patients. High-frequency audiometry is a very sensitive tool to assess any damage caused to the inner ear by surgical procedures carried out in the middle ear and temporal bone.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 5","pages":"280-2"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00463575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13731507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopy of the eustachian tube: use of the fiberscope and the telescope.","authors":"S Conticello, V Saita, I La Mantia, S Ferlito","doi":"10.1007/BF00463567","DOIUrl":"https://doi.org/10.1007/BF00463567","url":null,"abstract":"<p><p>The necessity for direct observation of the pharyngeal outlet of the normal or pathological eustachian tube has always stimulated research for suitable diagnostic instruments. As the result of various investigation procedures currently available, we performed a series of endoscopic screenings using both the Hopkins telescope and the fiberoptic rhinopharyngolaryngoscope. The present study aimed at evaluating and demonstrating the morphological and dynamic functional condition of the pharyngeal outlet of the tube. The present investigation was carried out on 60 males and females, ranging in age from 4 to 70 years. Inspection of the pharyngeal outlet of the tube and its adjoining region enabled us to document some of the various causes for tubal dysfunction. By visualizing tubal movements, endoscopy also made it possible to perform a dynamic study of tubal functions. However, the investigation procedure utilized did not allow us to record any significant differences between the two diagnostic instruments used, except that the fiberscope can be more easily handled, whereas the photographs taken with the telescope are of better quality.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 5","pages":"256-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00463567","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13733713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hematoporphyrin uptake by experimentally induced cholesteatomas in an animal model.","authors":"G P Teatini, C Perria, G Iori, F Meloni, F Tanda","doi":"10.1007/BF00454135","DOIUrl":"https://doi.org/10.1007/BF00454135","url":null,"abstract":"<p><p>Photodynamic therapy is based on the production of a cytotoxic factor by porphyrins, particularly hematoporphyrin (HP), when exposed to light of a suitable wavelength and intensity. The uptake of HP is notably large in tissues with a high mitotic index. Although cholesteatomas are not malignant tumors, our working hypothesis was that their high lipid content might result in their exhibiting a remarkable affinity to HP, which is normally carried in the blood by lipoproteins. Cholesteatomas were induced in rabbits using the Tübingen procedure (closure of the auditory canal by sutures). Animals were killed 30-40 days later at intervals of 1, 3, 6, 12, and 24 h following intravenous HP administration (5 mg/kg). Specimens were divided into two portions, one for histological examination and the other for biochemical study. The latter revealed that HP accumulates in experimental cholesteatomas, with a maximum uptake after 3 h. The level then gradually decreases, although at a lower rate than in the liver, but remains considerably high even after 24 h. These results suggest that the photodynamic treatment of cholesteatomas should be feasible in our animal model, although such treatment is still speculative in man.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 1","pages":"53-5"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00454135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13875375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Our experiences at Semmelweis University with different techniques and materials in the surgery of chronic otitis media.","authors":"A Hirschberg, O Ribàri","doi":"10.1007/BF00463574","DOIUrl":"https://doi.org/10.1007/BF00463574","url":null,"abstract":"<p><p>Different techniques and materials used in the surgery of chronic otitis media have been evaluated in a large clinical experience at Semmelweis University, Budapest. Data from 1572 operations performed during the last 5 years (1983-1988) are summarized. In the 870 non-cholesteatomatous processes (55.3%), mastoidectomies and tympanoplasties were performed, with the latter primarily using temporalis fascia and cortical bone. Out of the 250 cholesteatoma cases (15.9%), one-fourth was solved by a primary wall-up technique followed by a second stage revision and tympanoplasty within 1.5 years later.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 5","pages":"277-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00463574","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13731506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Jorissen, B Van der Schueren, H Van den Berghe, J J Cassiman
{"title":"The preservation and regeneration of cilia on human nasal epithelial cells cultured in vitro.","authors":"M Jorissen, B Van der Schueren, H Van den Berghe, J J Cassiman","doi":"10.1007/BF00463582","DOIUrl":"https://doi.org/10.1007/BF00463582","url":null,"abstract":"<p><p>Dissociated human nasal epithelial cells from nasal polyps were cultured in Ham's F12-DME 1/1 supplemented with NU-serum 10%, choleratoxin (10 ng/ml), retinoic acid (10(-7) M) and antibiotics. In monolayer cultures, the epithelial cells grew to confluency on collagen gels, became squamous, and lost their cilia within 2-6 weeks. In suspension cultures, epithelial cell sheaths formed stable vesicles and aggregates. These maintained a respiratory-type morphology and normal ciliary activity for over 6 months. When deciliated, squamous cells from monolayer cultures were brought in suspension, a respiratory-type morphology with cilia reappeared. This in vitro ciliogenesis resulted in normal and coordinated ciliary activity observed for more than 5 months.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 5","pages":"308-14"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00463582","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13732837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B Guerrier, G Balmigere, J P Daures, J G Lallemant, Y Guerrier
{"title":"Cancer of the laryngeal vestibule. A retrospective study of 161 cases.","authors":"B Guerrier, G Balmigere, J P Daures, J G Lallemant, Y Guerrier","doi":"10.1007/BF00463599","DOIUrl":"https://doi.org/10.1007/BF00463599","url":null,"abstract":"<p><p>We report a retrospective study of 161 cases of vestibular or epilaryngeal cancer treated by horizontal laryngectomy. The different factors affecting prognosis were analyzed statistically. Three groups were distinguished according to the size and primary site of the tumor: (1) a group with a very poor prognosis, which included patients with large tumors of the epilarynx; (2) a group with an average prognosis, which included small tumors of the epilarynx and large tumors with their primary site in the vestibule; (3) a group with a favorable prognosis which included tumors classified as T1 or T2 that were initially located in the vestibule.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 5","pages":"378-81"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00463599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13733493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R A Tange, H L Kieviet, J von Marle, D Bagger-Sjöbäck, W Ring
{"title":"An experimental study of vancomycin-induced cochlear damage.","authors":"R A Tange, H L Kieviet, J von Marle, D Bagger-Sjöbäck, W Ring","doi":"10.1007/BF00457456","DOIUrl":"https://doi.org/10.1007/BF00457456","url":null,"abstract":"<p><p>Vancomycin has been successfully used clinically for many years. Although early reports found ototoxicity to be a side effect of this antibiotic, later studies could not confirm this. For this reason we have started an experimental study in an animal model on the ototoxic effects of vancomycin. We now report the results of this study. Fourteen healthy Mongolian gerbils were treated with intraperitoneal injections of vancomycin (80 mg/kg per day) for a 2-week period. Before and after treatment each animal's hearing was evaluated by evoked response audiometry. Post mortem the cochleae were investigated by scanning electron microscopy in Amsterdam and by microdissection with surface preparations (hair cell counting) in Stockholm. The results of this study show that there is no clear evidence for the existence of ototoxicity due to vancomycin in this dosage.</p>","PeriodicalId":8300,"journal":{"name":"Archives of oto-rhino-laryngology","volume":"246 2","pages":"67-70"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00457456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13870818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}