Archives of Osteoporosis最新文献

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Patient perceptions of osteoporosis management: a qualitative pilot study by a patient advisory group 患者对骨质疏松管理的看法:一项由患者咨询小组进行的定性初步研究。
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2025-01-15 DOI: 10.1007/s11657-024-01486-0
R. M. Javier, F. Debiais, F. Alliot-Launois, D. Poivret, P. Bosgiraud, F. Barbe, M. Bouyssié, M. Devert, F. Roux, M. P. Sacchi, S. Sirot, P. Halbout, T. Chevalley, J. Y. Reginster, B. Cortet
{"title":"Patient perceptions of osteoporosis management: a qualitative pilot study by a patient advisory group","authors":"R. M. Javier,&nbsp;F. Debiais,&nbsp;F. Alliot-Launois,&nbsp;D. Poivret,&nbsp;P. Bosgiraud,&nbsp;F. Barbe,&nbsp;M. Bouyssié,&nbsp;M. Devert,&nbsp;F. Roux,&nbsp;M. P. Sacchi,&nbsp;S. Sirot,&nbsp;P. Halbout,&nbsp;T. Chevalley,&nbsp;J. Y. Reginster,&nbsp;B. Cortet","doi":"10.1007/s11657-024-01486-0","DOIUrl":"10.1007/s11657-024-01486-0","url":null,"abstract":"<div><h3>Summary</h3><p>The management of osteoporosis even after a fracture is declining. Our pilot study in patients with osteoporosis confirms a large ignorance of the disease and major fears and uncertainties about the treatments. Complete and sustained medical information seems essential to counteract the contradictory information, which are exclusively negative.</p><h3>Purpose</h3><p>The management of osteoporosis (OP) even after a fracture has declined over recent years despite the actions of the medical societies concerned with this disease. The objective of this pilot study was to investigate patients’ perceptions of OP, their treatment pathways, and how information is obtained.</p><h3>Methods</h3><p>The Association Française de Lutte Anti-Rhumatismale (AFLAR) constituted an advisory group of 7 French patients (mean age 63.7 years [54–74 years]), with various stages of OP and duration of disease. A qualitative, anonymized study was conducted with an open-ended semi-structured questionnaire, with a contribution of the International Osteoporosis Foundation (IOF) and the “Groupe de Recherche et Informations sur les Ostéoporoses” (GRIO).</p><h3>Results</h3><p>The onset of OP was often sudden, with the fracture occurring in a context of deep misunderstanding of OP by both the public and physicians. The patients have confidence in the physician, mostly a rheumatologist, who informs about OP and initiates the treatment. The main cause of non-adherence being major fears and uncertainties about efficacy and safety of treatments. Medical information is considered as insufficient, or poorly understood. Negative information has the highest impact, even if the sources seem unreliable, such as media. There is no trust in pharmaceutical companies and the ethics of physicians are in question.</p><h3>Conclusion</h3><p>This IOF/GRIO/AFLAR Patient Advisory Group pilot study illustrates the numerous barriers to effective OP management. Complete and sustained medical information, especially at the time of diagnosis and initiation of treatment, seems essential to counteract the contradictory information, which are exclusively negative.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01486-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The development and implementation of a digital platform in a fracture liaison service 裂缝联络服务中数字平台的开发与实现
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2025-01-08 DOI: 10.1007/s11657-024-01491-3
Bernadette Conlon, Helen O’Brien, Vanessa Clarke
{"title":"The development and implementation of a digital platform in a fracture liaison service","authors":"Bernadette Conlon,&nbsp;Helen O’Brien,&nbsp;Vanessa Clarke","doi":"10.1007/s11657-024-01491-3","DOIUrl":"10.1007/s11657-024-01491-3","url":null,"abstract":"<div><h3>Summary</h3><p>The fracture liaison service in the study hospital developed and successfully implemented a digital platform to support the identification of patients while concurrently optimizing participation in the National Fracture Liaison Database. This initiative provides additional evidence of the capacity of digital health to support fracture liaison services.</p><h3>Purpose</h3><p>Resourced fracture liaison services (FLSs) are accepted internationally as the preeminent means of reducing the risk of future fragility fractures. The FLS in the study hospital sought to develop and implement a digital platform to support the identification of patients and concurrently effectively participate in the National Fracture Liaison Service Database (FLS-DB) established to monitor key performance indicators (KPIs).</p><h3>Method</h3><p>Through linkage with the already established hospital’s eTrauma digital system and Inpatient Management System, a bespoke fracture liaison digital platform was developed and introduced. Platform functionality supports automated patient identification and interoperability with the National Fracture Liaison Service Database enabling the anonymized safe transfer of key performance indicator data.</p><h3>Results</h3><p>Through automated identification of patients who require fracture liaison services, rates of identification have improved from 10% in 2021 to 87%. Time previously spent manually identifying patients is now available for clinical care. Key performance indicator data are recorded as part of the assessment and treatment process and successfully anonymized and transferred to the national database.</p><h3>Conclusion</h3><p>This initiative provides additional evidence of the capacity of digital health to support fracture liaison services. In comparable settings nationally and internationally where there are coexisting digital systems to support patient management and a national digital database for FLS key performance indicators, there is potential for the successful introduction of similar FLS digital platforms.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in osteoporosis assessment, diagnosis after fragility fractures, and treatment for hospitalized patients with osteoporosis or fragility fractures between 2012 and 2021 2012年至2021年间骨质疏松评估、脆性骨折后诊断和住院骨质疏松或脆性骨折患者治疗的趋势
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2025-01-08 DOI: 10.1007/s11657-024-01492-2
Wenhui Zeng, Wei Liu, Lulu Zhang, Yiping Zhang, Yuxiang He, Weijuan Su, Peiying Huang, Caoxin Huang, Mingzhu Lin, Xuejun Li, Xiulin Shi
{"title":"Trends in osteoporosis assessment, diagnosis after fragility fractures, and treatment for hospitalized patients with osteoporosis or fragility fractures between 2012 and 2021","authors":"Wenhui Zeng,&nbsp;Wei Liu,&nbsp;Lulu Zhang,&nbsp;Yiping Zhang,&nbsp;Yuxiang He,&nbsp;Weijuan Su,&nbsp;Peiying Huang,&nbsp;Caoxin Huang,&nbsp;Mingzhu Lin,&nbsp;Xuejun Li,&nbsp;Xiulin Shi","doi":"10.1007/s11657-024-01492-2","DOIUrl":"10.1007/s11657-024-01492-2","url":null,"abstract":"<div><h3>Summary</h3><p>Our study investigated trends in osteoporosis management in Xiamen from 2012 to 2021, revealing improvements in screening and treatment, although medication use remained low. Additionally, we identified factors that may influence medication use and emphasized the importance of effective osteoporosis management strategies.</p><h3>Purpose</h3><p>The goal of the current study is to explore trends in assessment, diagnosis after fragility fractures, and osteoporosis treatment among hospitalized patients in Xiamen, China, between 2012 and 2021.</p><h3>Methods</h3><p>We conducted a retrospective cross-sectional study, using the Cochran-Armitage trend test to describe trends. Logistic regression was performed to identify the influencing factors of anti-osteoporosis medication (AOM) treatment. We performed a sensitivity analysis to verify the robustness of our findings.</p><h3>Results</h3><p>From 2012 to 2021, the rates of dual-energy X-ray absorptiometry (DXA) scans and bone turnover marker (BTM) examinations increased from 0 to 37% and 36.5%, respectively. 29.3% of patients with fragility fractures were diagnosed with osteoporosis. The use rate of AOM was only 22.7%. There was an upward trend in the prescription of bisphosphonates, increasing from 1% in 2012 to 16.8% in 2021. The use of calcitonin ranged from 4.1% (2014) to 32.7% (2021). Calcium and vitamin D supplementation prescribing increased significantly from 5.6% in 2012 to 78.7% in 2021. Logistic regression analysis showed that old age, female sex, history of fractures, DXA scans, and osteoporosis diagnosis were significantly associated with increased AOM use. Tobacco use, hypertension, diabetes, congestive heart failure, cerebral vascular accidents, and severe liver diseases were associated with a reduced likelihood of AOM treatment.</p><h3>Conclusions</h3><p>Although assessment, diagnosis after fragility fractures, and osteoporosis treatment have increased over the past decade, there are still deficiencies in the management of osteoporosis. In the future, it will be necessary to further strengthen management of osteoporosis.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of the FRAX® tool and its adjustments in women living with diabetes: a cohort study in primary care in Brazil FRAX®工具在女性糖尿病患者中的使用及其调整:巴西初级保健队列研究
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2024-12-31 DOI: 10.1007/s11657-024-01489-x
Fernando Meireles de Oliveira, Rafaela Martinez Copês Leal, Fabio Vasconcellos Comim, Melissa Orlandin Premaor
{"title":"The use of the FRAX® tool and its adjustments in women living with diabetes: a cohort study in primary care in Brazil","authors":"Fernando Meireles de Oliveira,&nbsp;Rafaela Martinez Copês Leal,&nbsp;Fabio Vasconcellos Comim,&nbsp;Melissa Orlandin Premaor","doi":"10.1007/s11657-024-01489-x","DOIUrl":"10.1007/s11657-024-01489-x","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>The FRAX® algorithm showed good accuracy in women living with DM followed in primary care. There were no differences between the ROC curve with and without adjustments for major and hip fractures. The FRAX® 10-year and FRAX® AR were better calibrated in this population.</p><h3>Purpose</h3><p>An increased risk of fractures in people living with diabetes has been described. Screening instruments to calculate this risk have been proposed, including the FRAX® algorithm. Some studies suggest that minor modifications to this instrument can improve its performance. These modifications work well in other countries, but we do not know if they work in Brazil. The objective of our study was to evaluate the performance of the FRAX® algorithm with and without adjustments for women living with DM (WLDM) in primary care in Brazil.</p><h3>Methods</h3><p>A cohort study that included post-menopausal women attending primary care in Santa Maria, Brazil, was conducted from 2013 to 2018. The risk for major and hip fractures was calculated using the FRAX® tool. The FRAX® risk was calculated: (1) without adjustments (unadjusted FRAX®); (2) increasing the entered age by 10 years in individuals with DM (FRAX® 10 years); and (3) inserting the diagnosis of DM as rheumatoid arthritis (FRAX® AR).</p><h3>Results</h3><p>The accuracy for major fracture was 0.948 (unadjusted FRAX®), 0.947 (FRAX® 10 years), and 0.946 (FRAX® AR). For hip fractures, the accuracies were 0.989 (unadjusted FRAX®), 0.988 (FRAX® 10 years), and 0.988 (FRAX® AR). Furthermore, there were no differences between the area under the ROC curve with and without adjustments for major and hip fractures. Conversely, the FRAX® 10 years and the FRAX® AR were better calibrated, presenting a lower Chi-square.</p><h3>Conclusion</h3><p>The FRAX® algorithm showed good accuracy in WLDM followed in primary care. The FRAX® 10 years and FRAX® AR were better calibrated in this population.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare association between ankylosing spondylitis and paget’s disease: A case of pagetic vertebral ankylosis 强直性脊柱炎与paget病的罕见关联:1例pagetic椎体强直
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2024-12-27 DOI: 10.1007/s11657-024-01490-4
Celil Barlas Cengiz, Melih Kızıltepe, Hüseyin Kaplan, Emel Oğuz Kökoğlu, Tuğba Kahraman Denizhan, Abdurrahman Soner Şenel
{"title":"Rare association between ankylosing spondylitis and paget’s disease: A case of pagetic vertebral ankylosis","authors":"Celil Barlas Cengiz,&nbsp;Melih Kızıltepe,&nbsp;Hüseyin Kaplan,&nbsp;Emel Oğuz Kökoğlu,&nbsp;Tuğba Kahraman Denizhan,&nbsp;Abdurrahman Soner Şenel","doi":"10.1007/s11657-024-01490-4","DOIUrl":"10.1007/s11657-024-01490-4","url":null,"abstract":"<div><p>Paget’s disease is a condition marked by abnormal bone remodeling, involving both excessive bone formation and destruction, predominantly in the elderly. Pagetic vertebral ankylosis is a rare manifestation, often associated with Paget’s disease, ankylosing spondylitis, or diffuse idiopathic skeletal hyperostosis. This form of acquired vertebral ankylosis is uncommon and occurs in cases with bone-bridging syndesmophytes or osteophytes. Here, we present a case of delayed diagnosis of Paget’s disease in the lower vertebral column, progressing to cervicothoracic vertebral ankylosis secondary to ankylosing spondylitis.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of excluding fractured or abnormal vertebrae on the trabecular bone score measurement 排除骨折或异常椎体对小梁骨评分测量的影响
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2024-12-27 DOI: 10.1007/s11657-024-01485-1
Yen-Huai Lin, Michael Mu Huo Teng
{"title":"Effect of excluding fractured or abnormal vertebrae on the trabecular bone score measurement","authors":"Yen-Huai Lin,&nbsp;Michael Mu Huo Teng","doi":"10.1007/s11657-024-01485-1","DOIUrl":"10.1007/s11657-024-01485-1","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Brief rationale: The use of L1–L4 vertebrae, without exclusions, has been recommended for trabecular bone score (TBS) measurements.</p><p>Main result: Excluding abnormal and fractured vertebrae affected the TBS.</p><p>Significance of the paper: Fracture or degenerative abnormality may not affect TBS. The preferred action may involve including all levels without exclusions.</p><h3>Purpose</h3><p>The use of L1–L4 vertebrae, without exclusions, has been recommended for trabecular bone score (TBS) measurements. We aimed to investigate the effect of excluding fractured or abnormal vertebrae from TBS.</p><h3>Methods</h3><p>Dual-energy X-ray absorptiometry images of 2767 participants, including 1080 without excluded vertebrae, 556 with fractured vertebrae, and 1131 with abnormal vertebrae showing a 1.0 T-score difference compared to the adjacent vertebrae, were retrospectively reviewed. Differences between TBS measurements with and without fractured or abnormal vertebrae were evaluated.</p><h3>Results</h3><p>Among 1080 participants without excluded vertebrae, TBS was 1.234 at L1, 1.296 at L2, 1.308 at L3, and 1.301 at L4. A significantly higher mean TBS was seen after excluding L1, whereas a significantly lower mean TBS was seen after excluding L2–L4. In the 556 participants with fractured vertebrae, excluding the involved level from the TBS calculation led to a significant difference in the total sample, women, ≥ 70 years old, and overweight subgroups. A significantly higher mean TBS was seen after excluding the fractured L1, whereas a significantly lower mean TBS was seen after excluding fractures at L2–L4. Among the 1131 participants with abnormal vertebrae, excluding the involved level from the TBS led to a significant difference in age, sex, and body mass index subgroups. Excluding abnormal L1 and L4 vertebrae led to a significantly higher and lower mean TBS, respectively.</p><h3>Conclusion</h3><p>Excluding fractured or abnormal vertebrae led to differences in TBS across various subgroups. Regarding the effect of vertebral level exclusion, the observed differences may be attributed to the systematic intervertebral variation, which is unrelated to any effect from fractures or degenerative abnormalities.\u0000</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-024-01485-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of 12-week power training on bone in mobility-limited older adults: randomised controlled trial 12周力量训练对活动受限老年人骨骼的影响:随机对照试验
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2024-12-27 DOI: 10.1007/s11657-024-01487-z
Valentina Muollo, Lars G. Hvid, Vikram V. Shanbhogue, Viktoria Steinhauser, Daniela Caporossi, Ivan Dimauro, Marianne Skovsager Andersen, Cristina Fantini, Elisa Grazioli, Elsa S. Strotmeyer, Paolo Caserotti
{"title":"Effects of 12-week power training on bone in mobility-limited older adults: randomised controlled trial","authors":"Valentina Muollo,&nbsp;Lars G. Hvid,&nbsp;Vikram V. Shanbhogue,&nbsp;Viktoria Steinhauser,&nbsp;Daniela Caporossi,&nbsp;Ivan Dimauro,&nbsp;Marianne Skovsager Andersen,&nbsp;Cristina Fantini,&nbsp;Elisa Grazioli,&nbsp;Elsa S. Strotmeyer,&nbsp;Paolo Caserotti","doi":"10.1007/s11657-024-01487-z","DOIUrl":"10.1007/s11657-024-01487-z","url":null,"abstract":"<div><h3>Summary</h3><p>This study examines how power training affects estimated bone strength, revealing that females benefit more than males, especially in the upper limbs (radius). These findings highlight the importance of designing sex-specific exercise programs to enhance bone health. Further research is needed to optimize training duration and address site-specific differences.</p><h3>Purpose</h3><p>This study aimed to compare the effects of 12-week of power training (PWT), an explosive form of strength training, on bone microarchitecture, estimated bone strength, and markers in mobility-limited (gait speed &lt; 0.9 m/s) older adults.</p><h3>Methods</h3><p>Fifty-seven older adults (83 ± 5 years) were randomly assigned to either a training group (TRAIN, <i>n</i> = 28, 15 females, 13 males) performing high-intensity PWT or a control group (CTRL, <i>n</i> = 29, 22 females, 7 males) maintaining their usual lifestyle. High-resolution peripheral quantitative computed tomography (HR-pQCT) assessed bone geometry, densities, microarchitecture (e.g. trabecular number (Tb.N) and thickness (Tb.Th)), and estimated bone strength (stiffness and failure load) at the tibia and radius. Blood markers for bone metabolism (PINP and CTX-1) and muscle strength (handgrip and leg press) were also measured.</p><h3>Results</h3><p>Baseline sex differences showed females having lower stiffness (− 37.5%) and failure load (− 38%) at the radius compared with males. After PWT, females in the TRAIN group exhibited declines in Tb.N (− 4.4%) and improvements in Tb.Th (+ 6.0%), stiffness (+ 2.7%), and failure load (+ 2.4%) at the radius (<i>p</i> &lt; 0.05). A time x group interaction indicated increases in leg press strength for the whole TRAIN group (+ 23%), and within females (+ 29%) and males (+ 19%) (<i>p</i> &lt; 0.001). Baseline handgrip strength correlated with stiffness (<i>r</i> = 0.577) and failure load (<i>r</i> = 0.612) at the radius (<i>p</i> &lt; 0.001). Females in the TRAIN group showed a reduction in PINP (− 25%), while males showed an increase in CTX-1 (+ 18%).</p><h3>Conclusion</h3><p>A 12-week PWT may enhance estimated bone strength in mobility-limited older adults, especially at sites less accustomed to daily loading (i.e. radius).</p><h3>Clinical trial registration</h3><p>NCT02051725.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of isoflavone interventions on bone turnover markers and factors regulating bone metabolism in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials 异黄酮干预措施对绝经后妇女骨转换标志物和骨代谢调节因子的影响:随机对照试验的系统回顾和荟萃分析
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2024-12-21 DOI: 10.1007/s11657-024-01467-3
Ratchanon Inpan, Nahathai Dukaew, Mingkwan Na Takuathung, Supanimit Teekachunhatean, Nut Koonrungsesomboon
{"title":"Effects of isoflavone interventions on bone turnover markers and factors regulating bone metabolism in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials","authors":"Ratchanon Inpan,&nbsp;Nahathai Dukaew,&nbsp;Mingkwan Na Takuathung,&nbsp;Supanimit Teekachunhatean,&nbsp;Nut Koonrungsesomboon","doi":"10.1007/s11657-024-01467-3","DOIUrl":"10.1007/s11657-024-01467-3","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This study examined how isoflavone interventions impact bone health in postmenopausal women. Analyzing 73 trials found that isoflavones reduce bone resorption markers, enhance bone minerals, and increase hormones regulating bone metabolism. This suggests that isoflavones could help address bone health issues in postmenopausal women.</p><h3>Purpose</h3><p>This study aimed to assess the impact of isoflavone interventions on bone turnover markers and various biochemical markers of bone metabolism through systematic review and meta-analysis.</p><h3>Methods</h3><p>Four electronic databases, including PubMed, Embase, Scopus, and Cochrane Library, were searched in September 2023 for investigating the effects of isoflavones on bone turnover markers as well as signaling molecules regulating osteoclast differentiation, bone minerals, and hormones regulating bone metabolism in postmenopausal women. The main effect estimates, obtained using a random-effects model, were summarized using the mean difference (MD) or standardized mean difference (SMD), as appropriate.</p><h3>Results</h3><p>A total of 73 randomized controlled trials were included, comparing an isoflavone intervention to a placebo. Our findings demonstrated that isoflavone interventions significantly reduced bone resorption markers, that is, β cross-linked C-telopeptide of type 1 collagen (β-CrossLaps) (MD = − 0.0943 ng/mL; <i>P</i> = 0.0071) and pyridinoline (PYD) (SMD = − 0.9111; <i>P</i> = 0.0247). Moreover, isoflavone interventions positively affected bone mineral parameters by increasing serum calcium levels (MD = 0.3430 mg/dL; <i>P</i> = 0.0267) and decreasing serum phosphorus levels (MD = − 0.0648 mg/dL; <i>P</i> = 0.0435). Hormones involved in regulating bone metabolism, particularly insulin-like growth factor type 1 (IGF-1), exhibited significant increases following isoflavone interventions (MD = 9.8163 ng/mL; <i>P</i> &lt; 0.0001). Subgroup analysis suggested that the effects of isoflavones on bone turnover markers are influenced by factors such as the duration since menopause and the intervention duration.</p><h3>Conclusion</h3><p>This systematic review and meta-analysis highlight the potential of isoflavone interventions to rectify imbalances in bone remodeling, enhance bone mineral homeostasis, and optimize hormones regulating bone metabolism in postmenopausal women.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Acquired hypophosphatemic osteomalacia: case series from a Peruvian referral center (1999–2023) 更正:获得性低磷性骨软化症:秘鲁转诊中心的病例系列(1999-2023)
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2024-12-06 DOI: 10.1007/s11657-024-01481-5
José Paz-Ibarra, Sofía Sáenz-Bustamante, Manuel Inostroza-Fernández, Paola Sifuentes Hermenegildo, Liliana Ancajima Lescano, Marcio Concepción-Zavaleta, Alejandro Román-González, Alfredo Adolfo Reza-Albarrán
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引用次数: 0
Correction: Bilateral lumbar pedicle fracture in a patient receiving long-term bisphosphonate therapy: a case report with pathological evaluation 更正:长期接受双膦酸盐治疗的患者双侧腰椎椎弓根骨折:病例报告与病理评估
IF 3.1 3区 医学
Archives of Osteoporosis Pub Date : 2024-11-29 DOI: 10.1007/s11657-024-01477-1
Ryo Fujita, Kota Suda, Zen-Ichi Tanei, Satoko Matsumoto Harmon, Miki Komatsu, Keiichi Nakai, Kento Inomata, Shin Matsushima, Tsutomu Endo, Katsuhisa Yamada, Masahiko Takahata, Norimasa Iwasaki
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引用次数: 0
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