Archives of Osteoporosis最新文献

{"title":"Correction: Osteosarcopenia in Finland: prevalence and associated factors","authors":"Matias Blomqvist, Maria Nuotio, Katri Sääksjärvi, Seppo Koskinen, Sari Stenholm","doi":"10.1007/s11657-026-01714-9","DOIUrl":"10.1007/s11657-026-01714-9","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-026-01714-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions, beliefs, and experiences of living with osteoporosis among UK South Asian older women","authors":"Shabana Shafiq,&nbsp;Nicky Kime,&nbsp;Jessica Faye Johansson,&nbsp;Elizabeth Teale,&nbsp;Janine Connor,&nbsp;Christine Sharp,&nbsp;Anne Heaven","doi":"10.1007/s11657-026-01726-5","DOIUrl":"10.1007/s11657-026-01726-5","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Older women of a South Asian heritage are at higher risk of osteoporosis yet remain less likely to access healthcare services for support with osteoporosis. Our study found sociocultural and religious factors shape their decisions. Designing culturally tailored services can help South Asian older women access timely osteoporosis support.</p><h3>Purpose</h3><p>To explore South Asian older women’s beliefs and experiences of living with osteoporosis, with the aim of informing health service delivery.</p><h3>Methods</h3><p>Eleven older women with a self-reported diagnosis of osteoporosis were conveniently selected from community organizations in West Yorkshire, UK. Data were collected between September 2024 and March 2025. In-depth semi-structured interviews were audio recorded, transcribed, and analyzed using constructivist grounded theory.</p><h3>Results</h3><p>Four themes were identified; a perceived natural physical deterioration, beliefs about causes of osteoporosis, impact of osteoporosis, and adapting to living with osteoporosis. Osteoporosis was perceived as natural physical deterioration which occurred as an inevitable part of the ageing process. It was also perceived to be associated with existing health conditions and viewed as ordained by God. Osteoporosis impacted lives of South Asian older women by causing loss of familiar routine, loneliness and social isolation, and negative emotions. However, South Asian older women adapted to living with osteoporosis through family-based support, traditional remedies and practices, and using religion as a coping strategy.</p><h3>Conclusion</h3><p>South Asian older women’s sociocultural perspectives and emotional and coping strategies for managing osteoporosis influenced decisions to access healthcare services. It is imperative for health providers to consider the individual meaning of osteoporosis for this population in relation to their specific needs, to improve engagement with osteoporosis healthcare and support services.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-026-01726-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk stratification improves outcomes in an osteoporosis fracture liaison service","authors":"Shejil Kumar,&nbsp;Lillias Nairn,&nbsp;Angela Bowman,&nbsp;Sally Dwyer,&nbsp;Ayanthi Wijewardene,&nbsp;Dahlia F. Davidoff,&nbsp;Matti L. Gild,&nbsp;Christian M. Girgis,&nbsp;Lyn March,&nbsp;Roderick J. Clifton-Bligh","doi":"10.1007/s11657-026-01718-5","DOIUrl":"10.1007/s11657-026-01718-5","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Selecting patients at higher baseline risk of fragility fracture may optimise clinical outcomes and cost-effectiveness of hospital fracture liaison services (FLS). In this cohort study, we found a risk-stratified approach led to a higher rate of treatment initiation and estimated number of fractures prevented compared to the traditional FLS strategy.</p><h3>Purpose</h3><p>Hospital-based fracture liaison services (FLS) are cost-effective and reduce refracture risk. However, optimal FLS characteristics to maximise clinical and cost-effectiveness are uncertain.</p><h3>Methods</h3><p>We reviewed data for FLS patients at Royal North Shore Hospital, Sydney (2015–2023). In 2018, the patient selection strategy was adjusted from a traditional approach (any fragility fracture, ≥ 50 years) to preferentially invite those either ≥ 60 years with any fragility fracture, or any presenting with hip and/or vertebral fractures. Cohorts entering the service pre-(FLS1) and post-this timepoint (FLS2) were compared regarding clinical characteristics, estimated fracture risk and pharmacotherapy initiation. Modelling was performed to estimate fractures averted.</p><h3>Results</h3><p>The total cohort (<i>n</i> = 1903) was median 68-years-old and predominantly female (77%). Both cohorts were similar in sex distribution and prevalence of various fracture risk factors. The FLS2 cohort was older (median 69 vs 65 years, <i>p</i> &lt; 0.001), more frequently presented with hip/vertebral fracture (21.4% vs 13.8%, <i>p</i> &lt; 0.001), had higher Garvan-estimated 10-year fracture-risk (median 36.0% vs 27.4%, <i>p</i> &lt; 0.001) and more frequently initiated pharmacotherapy (79.0% vs 64.6%, <i>p</i> &lt; 0.001). In the overall cohort, strongest predictors of treatment initiation were older age, osteoporotic bone density, hip/vertebral fracture and female sex. Over 5 years, risk-stratified FLS was estimated to avert more osteoporotic (72 vs 44, <i>p</i> &lt; 0.001) and hip fractures (20 vs 10, <i>p</i> &lt; 0.001) per 1000 patients compared with traditional FLS.</p><h3>Conclusion</h3><p>In this large hospital-based FLS study, a risk-stratified selection strategy was associated with more frequent pharmacotherapy initiation and estimated to avert more fractures; however, longitudinal assessment of treatment adherence and refracture rates is required to confirm utility.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-026-01718-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REMS versus DXA in older adults: diagnostic concordance for osteoporosis in a geriatric outpatient population","authors":"Chiara Ceolin,&nbsp;Marianna Noale,&nbsp;Cristina Simonato,&nbsp;Franz Villanova,&nbsp;Silvia Sturani,&nbsp;Anna Bertocco,&nbsp;Sandro Giannini,&nbsp;Gaetano Paride Arcidiacono,&nbsp;Luca Busetto,&nbsp;Angelo Antonini,&nbsp;Alessandra Coin,&nbsp;Giuseppe Sergi,&nbsp;Marina De Rui,&nbsp;on behalf of the O. P. A. working group","doi":"10.1007/s11657-026-01723-8","DOIUrl":"10.1007/s11657-026-01723-8","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>REMS showed moderate concordance with DXA but limited interchangeability in geriatric outpatients. Its high negative predictive value supports its use as a practical first-line screening method, especially in adults ≥ 75 years. Findings highlight REMS’ potential in settings where DXA is limited and the need for further validation.</p><h3>Purpose</h3><p>Concordance between dual-energy X-ray absorptiometry (DXA) and radiofrequency echographic multispectrometry (REMS) in older adults is heterogeneous, and their interchangeability at the patient level is uncertain. The objective of this study is to examine correlations, diagnostic agreement, and performance of REMS versus DXA in geriatric outpatients, focusing on individuals aged ≥ 75 years and BMI.</p><h3>Methods</h3><p>Cross-sectional study of 148 outpatients (median age 75 [70–79] years, 55.4% women). DXA and REMS were performed at the lumbar spine, total hip, and femoral neck. We calculated Spearman correlations, diagnostic performance of REMS using DXA as reference, categorical agreement (Cohen’s kappa), linear regressions, and Bland–Altman plots, stratified by age (&lt; 75/ ≥ 75 years) and BMI.</p><h3>Results</h3><p>DXA–REMS correlations were moderate overall (<i>ρ</i> 0.52–0.64 for BMD and <i>T</i>-scores) but stronger in participants ≥ 75 years (up to <i>ρ</i> 0.75–0.78 at the total hip, <i>p</i> &lt; 0.001). REMS sensitivity was 46–62%, specificity 72–79%, PPV 0.23–0.40, and NPV 0.82–0.93 for osteoporosis (kappa 0.15–0.27). Bland–Altman analyses showed wide limits of agreement, indicating poor interchangeability at the individual level. In adults ≥ 75 years, REMS yielded lower BMD and more negative <i>T</i>-scores at all sites, whereas DXA did not differ by age group. Low BMI was consistently associated with lower BMD and more negative <i>T</i>-scores.</p><h3>Conclusions</h3><p>REMS shows moderate concordance with DXA and limited interchangeability, but its high NPV supports a pragmatic role as a first-line screening tool in geriatric practice, especially in adults ≥ 75 years and when DXA is unavailable.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-026-01723-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Romosozumab for cancer treatment-induced bone loss in postmenopausal women with hormone receptor-positive breast cancer: a case series","authors":"Shohei Tsujino,&nbsp;Hirotaka Koyanagi,&nbsp;Chigusa Sawamura,&nbsp;Katsunori Tozuka,&nbsp;Tabu Gokita","doi":"10.1007/s11657-026-01724-7","DOIUrl":"10.1007/s11657-026-01724-7","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;\u0000 &lt;i&gt;Summary&lt;/i&gt;\u0000 &lt;/h3&gt;&lt;p&gt;Romosozumab was associated with increases in bone mineral density in postmenopausal women with hormone receptor-positive breast cancer and cancer treatment-induced bone loss (CTIBL). No clinical signals of fracture occurrence or cancer recurrence were observed; however, these findings are based on a small retrospective case series and require confirmation in larger prospective studies.&lt;/p&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Cancer treatment-induced bone loss (CTIBL) is a major complication in postmenopausal women with hormone receptor-positive breast cancer receiving aromatase inhibitor therapy. Although antiresorptive agents are commonly used, some patients continue to experience progressive bone loss or fragility fractures. Romosozumab, a monoclonal antibody against sclerostin, has demonstrated efficacy in postmenopausal osteoporosis; however, clinical data in patients with cancer remain limited.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;We retrospectively analyzed 22 postmenopausal women with clinically non-metastatic (Stage I–III) hormone receptor-positive breast cancer who received romosozumab for CTIBL at a single institution. Romosozumab was administered for 12 months in patients with progressive bone loss, new fragility fractures, or high fracture risk. All patients received concomitant calcium and/or active vitamin D supplementation. Changes in bone mineral density (BMD), bone turnover markers, and tumor markers (CA15-3, CEA) were evaluated. Differences in skeletal response were also evaluated between treatment-naïve patients and those with prior exposure to bone-modifying agents. Clinical outcomes, including new fragility fractures and cancer recurrence, were assessed during follow-up.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;The mean age of the patients was 66.8 years, and the mean duration of aromatase inhibitor therapy prior to treatment was 35.3 months to 36.9 months. After 12 months of romosozumab treatment, lumbar spine BMD increased by 11.5% (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), and total hip BMD increased by 4.1% (&lt;i&gt;P&lt;/i&gt; = 0.002). Changes in bone turnover markers were observed, consistent with the known mechanism of action of romosozumab. No new fragility fractures were observed during the treatment period. During a mean follow-up period of 38.3 months (including the 12-month treatment period), tumor markers remained stable, and no clinical evidence of cancer recurrence was observed.&lt;/p&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;p&gt;In this small retrospective case series, romosozumab was associated with increases in BMD in postmenopausal women with hormone receptor-positive breast cancer and CTIBL. No clinical signals suggestive of short-term oncological deterioration were observed; however, given the limited sample size, retrospective design, and lack of a control group, these findings should be interpreted with caution. Further prospective studies with larger cohorts and longer follow-up are required to better define the efficacy a","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underreporting of osteoporosis: an analysis of clinical coding and the effects of a quality improvement trial","authors":"Marjy Grealish,&nbsp;Joel Olney,&nbsp;Markus J. Seibel","doi":"10.1007/s11657-026-01721-w","DOIUrl":"10.1007/s11657-026-01721-w","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Osteoporotic fractures are underrepresented in administrative data. In the present study, only 1 of 94 admissions for osteoporotic fracture was coded correctly, mostly due to inadequate clinical documentation. Following education of junior doctors, 36% of osteoporotic fractures were coded correctly, with coding of femur fractures particularly amenable to improvement.</p><h3>Purpose</h3><p>Osteoporotic fractures are underrepresented in hospital administrative data. This study analysed the accuracy of clinical coding of osteoporotic fractures and prospectively evaluated the effectiveness of an educational intervention for junior medical officers (JMO) to improve documentation and coding accuracy.</p><h3>Methods</h3><p>Coding accuracy was measured in 279 consecutive inpatients deemed to have suffered an osteoporotic fracture based on predetermined criteria. Subsequently, an education programme for JMO was delivered, focusing on osteoporotic fracture criteria and clinical coding requirements. A 10-week post-intervention analysis was conducted to determine improvement in coding accuracy using baseline data as a historical control.</p><h3>Results</h3><p>At baseline, 1 of 94 (1.1%) admissions meeting the criteria for osteoporotic fracture received the correct ICD-10 M80 primary diagnosis code. Post-intervention, coding accuracy improved markedly, with 14 out of 39 (36%) osteoporotic fracture admissions coded correctly. However, this improvement varied by site, with 77% of femur fractures, but only 10% of radius and 13% of humerus fractures receiving the correct primary clinical code. Coding accuracy decreased with time, from 42% in the first 5 weeks post-education to 27% in the subsequent 5 weeks.</p><h3>Conclusion</h3><p>Osteoporotic fractures are severely underrepresented in hospital administrative data due to inadequate documentation leading to inaccurate coding. Whilst education programmes can improve coding accuracy, long-term efficacy is limited by multiple factors. Since clinical coding forms an important part of public health resource allocation, automated system-based solutions are required to ensure accurate statistical capture of the true burden of osteoporosis and associated fractures.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spine–hip bone mineral density discordance in postmenopausal Asian women: fracture burden and incremental risk stratification beyond hip BMD","authors":"Yi-Chieh Huang,&nbsp;Kai-Hsiang Chang,&nbsp;Sheng-Wen Kao,&nbsp;Yi-Chou Chen,&nbsp;Ming-Te Cheng","doi":"10.1007/s11657-026-01720-x","DOIUrl":"10.1007/s11657-026-01720-x","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;\u0000 &lt;i&gt;Summary&lt;/i&gt;\u0000 &lt;/h3&gt;&lt;p&gt;In 4059 postmenopausal women, spine–hip discordance was common (41.3%) and associated with heterogeneous fracture risk. Hip-only screening missed 680 vertebral fractures. Major hip-lower discordance showed the highest fracture burden. Each 1-SD increase in &lt;i&gt;T&lt;/i&gt;-score offset independently increased hip fracture odds by 28%.&lt;/p&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;p&gt;To evaluate the prevalence and clinical significance of spine–hip &lt;i&gt;T&lt;/i&gt;-score discordance in a large cohort of postmenopausal Asian women and to determine whether a standardized discordance metric provides incremental fracture risk information beyond hip bone mineral density (BMD) alone.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;We conducted a retrospective cross-sectional study of 4059 postmenopausal women who underwent dual-energy X-ray absorptiometry (DXA) at a tertiary referral hospital. Participants were classified according to spine–hip diagnostic concordance as concordant, minor discordance (a one-category difference, spine lower or hip lower), or major discordance (a two-category difference, spine lower or hip lower). Three osteoporosis classification strategies (hip-only, spine-only, and combined dual-site DXA) were compared for detection of prevalent fractures. Multivariable logistic regression models were used to evaluate whether the &lt;i&gt;T&lt;/i&gt;-score offset (lumbar spine &lt;i&gt;T&lt;/i&gt;-score minus hip &lt;i&gt;T&lt;/i&gt;-score) provided incremental predictive information beyond hip BMD.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Diagnostic discordance was present in 41.3% of participants, including 39.1% with minor discordance and 2.2% with major discordance. The spine-lower pattern was approximately twice as common as the hip-lower pattern (25.7% vs. 13.4%). Women with major discordance (hip lower) demonstrated the highest prevalence of vertebral fracture (60.0%) and hip fracture (28.6%), exceeding rates observed in the concordant osteoporosis group (53.0% and 16.6%, respectively). Hip-only classification missed 680 prevalent vertebral fractures and showed a sensitivity of 45.1%. For hip fracture detection, hip-only screening demonstrated the highest overall discrimination (AUC 0.701), whereas combined dual-site classification provided the greatest sensitivity (73.0%). Consistent with recent evidence that hip BMD is the dominant densitometric predictor of hip fracture, hip BMD remained the strongest single predictor in our cohort. Importantly, after adjustment for age, body mass index, and hip BMD, each 1-standard deviation increase in &lt;i&gt;T&lt;/i&gt;-score offset was independently associated with a 28% higher odds of hip fracture (adjusted OR 1.28; 95% CI 1.09–1.51; &lt;i&gt;P&lt;/i&gt; = 0.003), indicating statistically significant incremental predictive information beyond absolute hip BMD alone.&lt;/p&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Spine–hip &lt;i&gt;T&lt;/i&gt;-score discordance was common in this clinical DXA cohort and was associated with clinically meaningful heterogeneity in fracture burden. Major ","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and lactation-associated osteoporosis: insights from an online self-reported patient survey","authors":"Sansin Tuzun,&nbsp;Eren Aygun","doi":"10.1007/s11657-026-01666-0","DOIUrl":"10.1007/s11657-026-01666-0","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Pregnancy and lactation-associated osteoporosis (PLO) is a rare yet debilitating cause of vertebral fractures in young women. Despite its significant clinical impact, PLO remains underdiagnosed, and data on its risk factors and management are limited. In our cohort, vitamin D deficiency, heparin exposure and a family history of osteoporosis emerged as key risk factors. Among anti-osteoporotic medications, teriparatide was the most commonly prescribed, followed by denosumab, alendronate and others.</p><h3>Purpose</h3><p>This study aimed to characterize the clinical features of women with PLO and to identify key risk factors using self-reported data from an online patient support group.</p><h3>Methods</h3><p>A cross-sectional study was conducted among 52 women diagnosed with PLO, identified via a patient support group on WhatsApp. Data were collected through an online survey assessing demographics, fracture characteristics, bone mineral density (BMD), treatment approaches, and potential risk factors. Participants were stratified into two groups (with vs. without fractures) for comparative analysis.</p><h3>Results</h3><p>The mean age of participants was 33.8 ± 4.7 years. Fractures occurred in 78.8% of participants, predominantly involving the spine (90.2%). The mean T-scores were -2.9 ± 0.8 at the spine and -1.8 ± 1.3 at the femoral neck. Key reported risk factors were vitamin D deficiency, heparin use during pregnancy, and a family history of osteoporosis. Women with fractures reported significantly higher levels of physical activity during pregnancy (<i>p</i> = 0.026). Anti-osteoporotic medications were used by 58% of participants, and teriparatide was the most frequently prescribed agent (44.8%).</p><h3>Conclusion</h3><p>PLO is an underrecognized and disabling complication of pregnancy, most often resulting in vertebral fractures. Greater clinical awareness, targeted screening, and individualized management are crucial to reduce preventable maternal morbidity in high-risk women.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weak bones, strong obsessions: a controlled study on Orthorexia nervosa, body image, and mood in postmenopausal osteoporosis","authors":"Büşra Şi̇ri̇n Ahısha,&nbsp;Eser Kalaoğlu,&nbsp;Tuba Uyanık Kesmez,&nbsp;Ahmet Yılmaz,&nbsp;Nurdan Paker,&nbsp;Nur Kesiktaş,&nbsp;Yiğit Can Ahısha,&nbsp;Nazlı Derya Buğdaycı","doi":"10.1007/s11657-026-01719-4","DOIUrl":"10.1007/s11657-026-01719-4","url":null,"abstract":"<div><h3>Summary</h3><p>Postmenopausal women with osteoporosis may show higher levels of orthorexic tendencies than healthy peers. These tendencies were associated with lower lumbar spine bone density but not with mood or body image measures. The findings suggest that maladaptive health-focused behaviors may be present in this population.</p><h3>Objective</h3><p>This study aimed to evaluate orthorexic tendencies in postmenopausal women with osteoporosis compared to healthy controls and to investigate the associations between orthorexic tendencies, body appreciation, and mood-related symptoms.</p><h3>Methods</h3><p>This cross-sectional study included 128 participants (64 postmenopausal women with osteoporosis and 64 healthy controls). Femoral neck and L1–L4 T-scores and bone mineral density (BMD) values were obtained from dual-energy X-ray absorptiometry (DXA) measurements performed within the previous six months. Orthorexic tendencies were assessed using the Orthorexia Nervosa Scale–11 (ORTO-11), symptoms related to depression and anxiety were evaluated using the Hospital Anxiety and Depression Scale (HADS), and body satisfaction was assessed using the Body Appreciation Scale (BAS).</p><h3>Results</h3><p>ORTO-11 scores were significantly lower in the osteoporotic group compared to healthy controls (<i>p</i> = 0.041), indicating more pronounced orthorexic tendencies. Although the prevalence of clinically significant orthorexic tendencies (ORTO-11 ≤ 27) was higher in the osteoporotic group (68.8%) than in controls (54.7%), this difference did not reach statistical significance. ORTO-11 scores showed positive correlations with lumbar spine T-scores (r = 0.202, <i>p</i> = 0.022) and BMD values (r = 0.210, <i>p</i> = 0.017), whereas no association was observed with femoral neck measurements. Orthorexic tendencies were not correlated with anxiety, depression, or body appreciation scores. In contrast, depressive and anxiety symptoms were negatively correlated with body appreciation.</p><h3>Conclusion</h3><p>Orthorexic tendencies may be more common in postmenopausal women with osteoporosis. These findings suggest that maladaptive healthy eating behaviors may be present in this population.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148009739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis risk in alpha and beta thalassemia: An age- and sex-specific retrospective cohort study","authors":"Yuan-Sheng Hsu,&nbsp;Sheng-Chieh Tseng,&nbsp;Tze-Fan Chao,&nbsp;Kun-Hui Chen","doi":"10.1007/s11657-026-01711-y","DOIUrl":"10.1007/s11657-026-01711-y","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p><i>Rationale:</i> Differential skeletal risks between alpha- and beta-thalassemia subtypes remain unclear. <i>Main result:</i> Beta-thalassemia correlates with higher fracture risk than alpha-thalassemia. Notably, males aged 18–50 with beta-thalassemia show a 14-fold increase in osteoporosis. <i>Significance:</i> Identifies a notably elevated osteoporosis risk in young males, supporting consideration of earlier skeletal surveillance.</p><h3>Purpose</h3><p>The differences in osteoporosis and fracture risk between alpha- and beta-thalassemia subtypes, and how these differences vary by age and sex, remain poorly understood. We conducted a large-scale analysis to characterize these risks and guide risk-stratified protocols.</p><h3>Methods</h3><p>This retrospective cohort study used the TriNetX health research network. Patients with alpha- and beta-thalassemia (identified by ICD-10 codes) were matched 1:1 with non-anemic controls by age, sex, race, and comorbidities (chronic kidney disease, diabetes mellitus, rheumatoid arthritis, malnutrition, and endocrine dysfunction) using propensity scores. We assessed the risk of osteoporosis, fractures, and mortality from Kaplan–Meier analyses.</p><h3>Results</h3><p>Beta-thalassemia patients have a significantly greater risk of osteoporosis (HR = 1.26, 95% CI: 1.11–1.43) than alpha-thalassemia patients. Within the beta-thalassemia group, males demonstrated a risk of osteoporosis that was more than three times higher than that of controls (HR = 3.28, 95% CI: 2.51–4.28), which was notably higher than that observed in females (HR = 1.42, 95% CI: 1.26–1.60). Young males (aged 18–50) demonstrated a markedly elevated risk of osteoporosis (HR = 13.97, 95% CI: 7.30–26.73) and mortality (HR = 6.31, 95% CI: 3.62–11.01) compared to matched controls.</p><h3>Conclusion</h3><p>Beta-thalassemia is associated with worse skeletal outcomes than alpha-thalassemia. Young male patients demonstrate substantially elevated risk of osteoporosis and mortality. These findings highlight the need for age- and sex-specific risk assessment in thalassemia patients.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-026-01711-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}