Carmen Gómez-Vaquero, Marta Domínguez-Álvaro, Daniel Seoane-Mato, Pilar Peris Bernal, Santos Castañeda, Eduardo Kanterewicz Binstock, Ramón Mazzucchelli Esteban, Luis Arboleya Rodríguez, Miguel Bernard, Antonio Álvarez-Cienfuegos, Blanca Correa, Luis María Jiménez Liñán, Carmen Mateo Pascual, Ma Mercedes Molina del Rio, Mercedes Retamal Ortiz, Aida Fátima López Laguna, Ruth Molera Valero, Sara Alvar Pariente, Antonio Pascual-Vergara, Adolfo Arias Senso, Nuria Pérez Gutiérrez, Soledad García Frías, David Bouza Alvárez, Susana Sostrés, Daniel Suárez Hernandez, Ana Zamora Casal, Cristina García Ramírez, Enrique González-Dávila, on behalf of the OsteoSER Project Collaborative Group
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The OsteoSER study updated Spanish BMD reference data, showing similarities with MRPO and NHANES III. Peak bone mass occurred at 20–39 years, positively associated with physical activity and negatively with smoking. Osteopenia affected 54.4%, and osteoporosis 10.7% of adults ≥ 50 years, with higher prevalence in women and increasing with age.</p><h3>Purpose</h3><p>This study aimed to estimate the distribution of BMD in lumbar spine, femoral neck, and total hip in the Spanish population aged ≥ 20 years and compare it with MRPO and NHANES III data.</p><h3>Methods</h3><p>A multicenter cross-sectional observational study was conducted in a White Spanish population aged 20–80 years across 12 urban and rural municipalities. Participants were selected by primary care physicians based on inclusion criteria (stratified by sex, age, and BMI) and exclusion criteria (artifacts in BMD imaging in participants of all ages and conditions affecting bone density in younger participants). A vehicle with a Hologic® Horizon W densitometer traveled to each municipality.</p><h3>Results</h3><p>A total of 1522 participants underwent densitometry (51.8% men). Peak bone mass is reached at ages 20–39 years in both sexes at all sites. BMD was positively associated with height, BMI, and physical activity and negatively with smoking (<i>p</i> < 0.05). The distribution of BMD by age and sex was comparable to MRPO and NHANES III. We found that 54.4% of postmenopausal women and men ≥ 50 years had osteopenia, while osteoporosis was observed in 10.7%, with higher prevalence in women (18.6% vs. 2.6%) and increasing with age. Using MRPO criteria, osteoporosis prevalence rose to 14.8%.</p><h3>Conclusion</h3><p>The BMD of the OsteoSER study population is similar to that of MRPO and NHANES III. Physical activity positively influences peak bone mass, while smoking has detrimental effects.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An update in bone mineral density status in Spain: the OsteoSER study\",\"authors\":\"Carmen Gómez-Vaquero, Marta Domínguez-Álvaro, Daniel Seoane-Mato, Pilar Peris Bernal, Santos Castañeda, Eduardo Kanterewicz Binstock, Ramón Mazzucchelli Esteban, Luis Arboleya Rodríguez, Miguel Bernard, Antonio Álvarez-Cienfuegos, Blanca Correa, Luis María Jiménez Liñán, Carmen Mateo Pascual, Ma Mercedes Molina del Rio, Mercedes Retamal Ortiz, Aida Fátima López Laguna, Ruth Molera Valero, Sara Alvar Pariente, Antonio Pascual-Vergara, Adolfo Arias Senso, Nuria Pérez Gutiérrez, Soledad García Frías, David Bouza Alvárez, Susana Sostrés, Daniel Suárez Hernandez, Ana Zamora Casal, Cristina García Ramírez, Enrique González-Dávila, on behalf of the OsteoSER Project Collaborative Group\",\"doi\":\"10.1007/s11657-025-01520-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Summary</h3><p>Bone mineral density (BMD) reference data for the Spanish population come from the Multicenter Research Project on Osteoporosis (MRPO) in 1989. The OsteoSER study updated Spanish BMD reference data, showing similarities with MRPO and NHANES III. Peak bone mass occurred at 20–39 years, positively associated with physical activity and negatively with smoking. Osteopenia affected 54.4%, and osteoporosis 10.7% of adults ≥ 50 years, with higher prevalence in women and increasing with age.</p><h3>Purpose</h3><p>This study aimed to estimate the distribution of BMD in lumbar spine, femoral neck, and total hip in the Spanish population aged ≥ 20 years and compare it with MRPO and NHANES III data.</p><h3>Methods</h3><p>A multicenter cross-sectional observational study was conducted in a White Spanish population aged 20–80 years across 12 urban and rural municipalities. Participants were selected by primary care physicians based on inclusion criteria (stratified by sex, age, and BMI) and exclusion criteria (artifacts in BMD imaging in participants of all ages and conditions affecting bone density in younger participants). A vehicle with a Hologic® Horizon W densitometer traveled to each municipality.</p><h3>Results</h3><p>A total of 1522 participants underwent densitometry (51.8% men). Peak bone mass is reached at ages 20–39 years in both sexes at all sites. BMD was positively associated with height, BMI, and physical activity and negatively with smoking (<i>p</i> < 0.05). The distribution of BMD by age and sex was comparable to MRPO and NHANES III. We found that 54.4% of postmenopausal women and men ≥ 50 years had osteopenia, while osteoporosis was observed in 10.7%, with higher prevalence in women (18.6% vs. 2.6%) and increasing with age. Using MRPO criteria, osteoporosis prevalence rose to 14.8%.</p><h3>Conclusion</h3><p>The BMD of the OsteoSER study population is similar to that of MRPO and NHANES III. 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An update in bone mineral density status in Spain: the OsteoSER study
Summary
Bone mineral density (BMD) reference data for the Spanish population come from the Multicenter Research Project on Osteoporosis (MRPO) in 1989. The OsteoSER study updated Spanish BMD reference data, showing similarities with MRPO and NHANES III. Peak bone mass occurred at 20–39 years, positively associated with physical activity and negatively with smoking. Osteopenia affected 54.4%, and osteoporosis 10.7% of adults ≥ 50 years, with higher prevalence in women and increasing with age.
Purpose
This study aimed to estimate the distribution of BMD in lumbar spine, femoral neck, and total hip in the Spanish population aged ≥ 20 years and compare it with MRPO and NHANES III data.
Methods
A multicenter cross-sectional observational study was conducted in a White Spanish population aged 20–80 years across 12 urban and rural municipalities. Participants were selected by primary care physicians based on inclusion criteria (stratified by sex, age, and BMI) and exclusion criteria (artifacts in BMD imaging in participants of all ages and conditions affecting bone density in younger participants). A vehicle with a Hologic® Horizon W densitometer traveled to each municipality.
Results
A total of 1522 participants underwent densitometry (51.8% men). Peak bone mass is reached at ages 20–39 years in both sexes at all sites. BMD was positively associated with height, BMI, and physical activity and negatively with smoking (p < 0.05). The distribution of BMD by age and sex was comparable to MRPO and NHANES III. We found that 54.4% of postmenopausal women and men ≥ 50 years had osteopenia, while osteoporosis was observed in 10.7%, with higher prevalence in women (18.6% vs. 2.6%) and increasing with age. Using MRPO criteria, osteoporosis prevalence rose to 14.8%.
Conclusion
The BMD of the OsteoSER study population is similar to that of MRPO and NHANES III. Physical activity positively influences peak bone mass, while smoking has detrimental effects.
期刊介绍：
Archives of Osteoporosis is an international multidisciplinary journal which is a joint initiative of the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA. The journal will highlight the specificities of different regions around the world concerning epidemiology, reference values for bone density and bone metabolism, as well as clinical aspects of osteoporosis and other bone diseases.
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