Association between dietary carotenoid intake and vertebral fracture in people aged 50 years and older: a study based on the National Health and Nutrition Examination Survey

IF 3.1 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Yuchen Zheng, Wenyu Zhou, Jian Zhang, Tao Lan, Rui Zhang
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Abstract

Summary

This study discussed the association between dietary intake of carotenoids and vertebral fractures by analyzing the target data, concluding a result of negative association and providing valuable information on vertebral fracture.

Objective

This study is to explore the association between dietary intake of carotenoids and vertebral fractures.

Methods

Data of individuals aged ≥ 50 years from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) database were used in this cross-sectional study. Information on dietary carotenoid intake was obtained from the first 24-h dietary recall interview. Vertebral fractures were assessed using dual-energy x-ray absorptiometry (DXA). The weighted multivariable logistic regression model was established to assess the association between dietary carotenoid intake and risk of vertebral fracture. Subgroup analysis of fracture history and menopausal status was performed for further analysis of this relationship.

Results

Of the 2053 eligible study subjects, there were 1021 men and 1032 women. Increased β-carotene intake was associated with decreased odds of vertebral fracture in women (odds ratio (OR) = 0.77, 95% confidence interval (CI) 0.60–0.99, P = 0.047), after adjusting for covariates. In men without a history of fracture, lutein and zeaxanthin intake was negatively associated with increased odds of vertebral fracture (OR = 0.70, 95% CI 0.50–0.99, P = 0.048). In women without a history of fracture, increased β-carotene intake was associated with decreased odds of vertebral fracture (OR = 0.78, 95% CI 0.61–0.99, P = 0.047). In postmenopausal women, β-carotene intake was also negatively associated with increased odds of vertebral fracture (OR = 0.77, 95% CI 0.60–0.99, P = 0.048).

Conclusion

This research concludes a negative association between dietary carotenoid intake, especially β-carotene, and vertebral fractures in women, revealing a potential dietary prevention tactic for vertebral fractures in the future.

膳食类胡萝卜素摄入量与50岁及以上人群椎体骨折的关系:一项基于全国健康与营养检查调查的研究
本研究通过对目标数据的分析,探讨了膳食类胡萝卜素摄入量与椎体骨折之间的关系,得出了负相关的结论,为椎体骨折提供了有价值的信息。目的探讨类胡萝卜素膳食摄入与椎体骨折的关系。方法采用2013-2014年全国健康与营养调查(NHANES)数据库中年龄≥50岁的个体数据进行横断面研究。膳食类胡萝卜素摄入量的信息来自第一次24小时的饮食回忆访谈。采用双能x线吸收仪(DXA)评估椎体骨折。建立加权多变量logistic回归模型,评估膳食类胡萝卜素摄入量与椎体骨折风险之间的关系。为了进一步分析这种关系,对骨折史和绝经状态进行亚组分析。结果在2053名符合条件的研究对象中,有1021名男性和1032名女性。在调整协变量后,增加β-胡萝卜素摄入量与降低女性椎体骨折的几率相关(优势比(OR) = 0.77, 95%可信区间(CI) 0.60-0.99, P = 0.047)。在没有骨折史的男性中,叶黄素和玉米黄质的摄入与椎体骨折的几率增加呈负相关(OR = 0.70, 95% CI 0.50-0.99, P = 0.048)。在没有骨折史的女性中,β-胡萝卜素摄入量增加与椎体骨折发生率降低相关(OR = 0.78, 95% CI 0.61-0.99, P = 0.047)。在绝经后妇女中,β-胡萝卜素的摄入也与椎体骨折的几率增加负相关(OR = 0.77, 95% CI 0.60-0.99, P = 0.048)。结论:本研究得出膳食类胡萝卜素(尤其是β-胡萝卜素)摄入量与女性椎体骨折呈负相关,揭示了未来椎体骨折的潜在饮食预防策略。
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来源期刊
Archives of Osteoporosis
Archives of Osteoporosis ENDOCRINOLOGY & METABOLISMORTHOPEDICS -ORTHOPEDICS
CiteScore
5.50
自引率
10.00%
发文量
133
期刊介绍: Archives of Osteoporosis is an international multidisciplinary journal which is a joint initiative of the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA. The journal will highlight the specificities of different regions around the world concerning epidemiology, reference values for bone density and bone metabolism, as well as clinical aspects of osteoporosis and other bone diseases.
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