Archives of Medical Science最新文献

{"title":"Obstructive sleep apnea and selected comorbidities - a literature review of cohort studies.","authors":"Urszula Karaszewska, Agnieszka Polecka, Alicja Jelska, Andrzej Sieśkiewicz, Ewa Olszewska","doi":"10.5114/aoms/214987","DOIUrl":"https://doi.org/10.5114/aoms/214987","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is the most common type of sleep-related breathing disorder, characterized by repeated episodes of upper airway collapse and resulting hypoxia during sleep. Intermittent hypoxemia may exert a multisystemic impact and modulate the course of comorbidities. Pathophysiological mechanisms such as oxidative stress, inflammation, and endothelial dysfunction contribute to adverse health outcomes including cardiovascular disease, cerebrovascular complications, metabolic disorders, cancer, neurodegenerative conditions, or behavioral abnormalities. Treatment of OSA may mitigate progression of comorbidities and reduce the associated social and economic burden. This literature review aims to explore the relationships between OSA and selected comorbid diseases, including chronic obstructive pulmonary disease (COPD), stroke, diabetes, cancer, and hypertension, based on cohort studies in the literature.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2277-2285"},"PeriodicalIF":3.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13663668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From GWAS to TWAS: multi-omics dissection of sepsis uncovers consistent impact of <i>ATG4B</i> across tissues.","authors":"Liuzhao Zhang, Deyuan You","doi":"10.5114/aoms/217046","DOIUrl":"10.5114/aoms/217046","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"572-578"},"PeriodicalIF":3.6,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ophthalmic diseases with stroke: cohort study and Mendelian randomization analysis.","authors":"Chong Li, Jialiang Chen, Ke Li, Shaojun Zhang, Siyi Zhu","doi":"10.5114/aoms/216656","DOIUrl":"10.5114/aoms/216656","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"540-550"},"PeriodicalIF":3.6,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing CAR T-cell therapy into clinical practice for mantle cell lymphoma: real-world experience from Poland.","authors":"Anna Łojko-Dankowska, Dominik Dytfeld, Magdalena Matuszak, Andrzej Szczepaniak, Lidia Gil","doi":"10.5114/aoms/216655","DOIUrl":"10.5114/aoms/216655","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"551-554"},"PeriodicalIF":3.6,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association between oral microbiome and chronic kidney disease: two-sample Mendelian randomization.","authors":"Zhiwei Liu, Zhiyao Liu, Weixia Sun, Lixin Zhu, Tianyang Lyu","doi":"10.5114/aoms/211613","DOIUrl":"10.5114/aoms/211613","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) contributes to 1.2 million deaths annually. Oral dysbiosis may influence CKD, highlighting the need for further research on its role as a risk factor and preventive target.</p><p><strong>Material and methods: </strong>We obtained summary statistics for genome-wide association studies (GWAS) of the oral microbiome from the GWAS Catalog and CKD from the CKDGen Consortium. Inverse variance weighting (IVW) was used as the principal analysis method, supplemented by MR-Egger, weighted median, and weighted mode to assess causal relationships. Sensitivity analyses, including MR-PRESSO and Cochran's Q, validated the robustness of the results.</p><p><strong>Results: </strong>The IVW results showed that <i>Veillonella</i> species was causally associated with CKD (OR = 0.96, 95% CI (0.93-0.99)), Order <i>Fusobacteriales</i> (OR = 1.01, 95% CI (1-1.01)) and <i>Rothia</i> species (OR = 0.99, 95% CI (0.99-1)) were causally associated with urinary albumin-to-creatinine ratio (UACR); Order <i>Bacteroidales</i> (OR = 0.97, 95% CI (0.94-1)) and Species <i>micronuciformis</i> (OR = 0.95, 95% CI (0.91-0.99)) were causally associated with CKDi25; and <i>Streptococcus</i> species was causally associated with dialysis (OR = 0.82, 95% CI (0.69-0.97)). There was no significant causal association between other oral microbiome features and CKD at the genetic level. Sensitivity analysis indicated that the results were robust.</p><p><strong>Conclusions: </strong>Our study suggests that there are associations between the oral microbiome and CKD. To better understand its mechanism of action and to develop broader strategies for preventing chronic kidney disease, further research is required.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"377-386"},"PeriodicalIF":3.6,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national trends in spinal fracture burden from 1990 to 2021 and projections to 2050.","authors":"Ri-Peng Zhang, Xiao-Chen Liu","doi":"10.5114/aoms/209584","DOIUrl":"10.5114/aoms/209584","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal fractures (SF) remain a major global cause of disability. This study aimed to quantify the global incidence, prevalence, and burden of SF in 2021, along with temporal trends from 1990 to 2021. These trends are stratified by location, age, sex, and Socio-Demographic Index (SDI). Furthermore, the study provides projections for the burden of SF over the next 30 years.</p><p><strong>Material and methods: </strong>Data for this study were obtained from the 2021 Global Burden of Disease Study (GBD). To quantify temporal patterns and evaluate trends in age-standardized rates (ASR) of SF prevalence (ASPR), incidence (ASIR), and age-standardized years lived with disability (ASYR), estimated annual percentage changes (EAPCs) were calculated for the study period. The analyses were stratified by gender, 20 age categories, 21 GBD regions, 204 countries/territories, and 5 SDI quintiles. Statistical analyses and plot visualizations were performed using the R statistical package (version 4.4.2).</p><p><strong>Results: </strong>In 2021, the global burden of SF remained considerable, with a total of 3.4 million cases and an ASPR of 65.19 cases per 100,000 individuals (95% uncertainty interval [UI]: 56.89-75.28). The ASIR was 92.75 per 100,000 individuals (95% UI: 72.12-119.99), while the ASYR was 6.62 per 100,000 individuals (95% UI: 4.43-9.2). Regionally, the highest ASPR, ASIR, and ASYR were observed in high SDI regions, while the lowest rates were found in low SDI regions.</p><p><strong>Conclusions: </strong>Geographically, Australasia exhibited the highest ASIR and ASPR, while the Caribbean had the highest ASYR. Among countries, New Zealand had the highest ASIR, and Andorra showed the highest ASPR and ASYR.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"250-269"},"PeriodicalIF":3.6,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic insights into metabolic dysfunction-associated steatotic liver disease: the impact of gut microbiota and TCM constitutions.","authors":"Ximin Liu, Qiuhui Liu, Dongxue Lu, Zhiguang Sun","doi":"10.5114/aoms/210618","DOIUrl":"https://doi.org/10.5114/aoms/210618","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is intricately linked to gut microbiota dysbiosis and has been associated with different traditional Chinese medicine (TCM) constitution types. This study explored the fecal microbiota composition in MASLD patients to investigate the associations underlying the disease.</p><p><strong>Material and methods: </strong>In this study, 51 MASLD patients and 46 healthy controls were classified into seven TCM constitution groups based on high-throughput sequencing of fecal samples. Analyses were conducted to compare microbial communities, metabolite profiles, and metabolic pathways among these constitution groups. The relationships between specific microbiota and biochemical indicators were evaluated using linear discriminant analysis (LDA) effect size (LEfSe) and Spearman correlation analyses.</p><p><strong>Results: </strong>MASLD patients exhibited reduced fecal microbiota diversity compared to healthy controls, with significant variations in microbial structure among TCM constitution groups. The damp-heat constitution (DHC) and phlegm-dampness constitution (PDC) groups displayed enriched populations of specific microbial species, distinct bacterial taxa, and unique metabolite profiles. Multiple significant pathways related to amino acid, fatty acid, and carbohydrate metabolism were identified through metabolic pathway enrichment analysis. Significant correlations were observed between specific microbial taxa and biochemical indicators such as triglycerides, total cholesterol, alanine aminotransferase (ALT), and aspartate aminotransferase (AST).</p><p><strong>Conclusions: </strong>This study highlights the close association between alterations in gut microbiota, TCM constitution differences, and MASLD progression. The findings suggest that changes in microbial diversity and metabolite profiles may contribute to MASLD pathogenesis. The identification of constitution-specific microbial may provide insights into personalized intervention strategies for MASLD.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2098-2113"},"PeriodicalIF":3.6,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13663665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic profiles of IgA nephropathy, membranous nephropathy, and diabetic nephropathy.","authors":"Yasin Abdi Saed, Lili Guo, Rongshan Li","doi":"10.5114/aoms/210616","DOIUrl":"https://doi.org/10.5114/aoms/210616","url":null,"abstract":"<p><strong>Introduction: </strong>Immunoglobulin A nephropathy (IgAN), membranous nephropathy (MN), and diabetic nephropathy (DN) are prominent contributors to chronic kidney disease burden. Our main objective was to contribute to the understanding of the metabolic profiles of these three major types of nephropathies and identify potential metabolic biomarkers.</p><p><strong>Material and methods: </strong>Kidney samples of 20 sex- and age-matched patients with biopsy-proven IgAN, MN, DN, and controls without any kidney diseases were included. Ultra-high-performance liquid chromatography-mass spectrometry analysis was conducted. The <i>t</i>-test was used to evaluate the statistical significance of the identified metabolites. Metabolic pathways were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG). Specificity, sensitivity, and area under the curve (AUC) were calculated to evaluate the predictive performance of metabolites.</p><p><strong>Results: </strong>Among 557 identified differential metabolites, only 118 were found in all three comparison groups. Differential metabolites of IgAN vs. controls were significantly enriched in arachidonic acid metabolism, starch and sucrose metabolism, ferroptosis, and other pathways. In the DN group, metabolites were mainly enriched in phenylalanine, tyrosine and tryptophan biosynthesis, histidine metabolism, etc. MN-enriched pathways included steroid hormone biosynthesis, neuroactive ligand-receptor interaction, and bile secretion. In the positive mode, cumulative AUC values for comparison pairs IgAN vs. controls, MN vs controls, and DN vs controls were 0.965, 0.972, and 0.573, respectively, whereas in the negative mode the AUC values of all three pairs were slightly above 0.65.</p><p><strong>Conclusions: </strong>IgAN, MN, and DN have similar but distinct metabolic profiles. Only positive node metabolites of IgAN and MN exhibited high predictive performance.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2334-2352"},"PeriodicalIF":3.6,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of key overlapping genes between COVID-19 and acute lung injury to evaluate immune microenvironment and predictive efficiency.","authors":"Luan Jian, Pei Fei","doi":"10.5114/aoms/211889","DOIUrl":"10.5114/aoms/211889","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 2","pages":"1239-1244"},"PeriodicalIF":3.6,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assessed oral health behaviours in pregnant women: a cross-sectional study in the Polish population.","authors":"Katarzyna Domosławska-Żylińska, Piotr T Tomczyk, Katarzyna Dudzik, Agnieszka Wasiluk, Dominik Olejniczak","doi":"10.5114/aoms/211150","DOIUrl":"10.5114/aoms/211150","url":null,"abstract":"<p><strong>Introduction: </strong>Pregnant women are at increased risk of developing caries and periodontal disease due to hormonal changes during pregnancy. The main preventive measure is health awareness and behaviours supporting oral hygiene. The aim of this study was to assess oral hygiene health behaviours of pregnant women in Poland.</p><p><strong>Material and methods: </strong>The study was conducted using the computer-assisted telephone interviewing (CATI) method, in a group of 1,000 women who were in their second or third trimester of pregnancy. The Hiroshima University Dental Behaviour Inventory (HU-DBI) questionnaire was used to assess oral health behaviours. The HU-DBI index was calculated based on 12 questions verifying the respondents' oral health attitudes and behaviour.</p><p><strong>Results: </strong>The majority of the women participating in the study (62%) assessed the condition of their teeth as good or very good. At the same time, 79.7% of the women reported a history of dental caries treatment. The mean HU-DBI index was 5.6 points. The most frequently indicated health-promoting behaviour for oral hygiene was careful oral cavity brushing. Analysis of factors influencing self-assessed oral health behaviours showed significant differences in the HU-DBI index according to financial situation and educational level.</p><p><strong>Conclusions: </strong>Access to dental care should be promoted among pregnant women, regardless of their socioeconomic status. Oral health care measures for pregnant women should include education, prophylaxis, and treatment. It is important to increase the awareness of the expectant mothers that their oral health behaviour has a very strong impact on both their and their children's health, during the fetal period and from birth on.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"188-194"},"PeriodicalIF":3.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}