Archives of Medical Science最新文献_第9页

Predictive value of the BDH2-MN2 nomogram model for prognosis at 3 months after receiving intravenous thrombolysis in patients with acute ischemic stroke. 急性缺血性脑卒中患者接受静脉溶栓治疗后 3 个月预后的 BDH2-MN2 提名图模型预测价值。

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/176740

Yinglei Li, Ning Li, Lingyun Xi, Litao Li

{"title":"Predictive value of the BDH2-MN2 nomogram model for prognosis at 3 months after receiving intravenous thrombolysis in patients with acute ischemic stroke.","authors":"Yinglei Li, Ning Li, Lingyun Xi, Litao Li","doi":"10.5114/aoms/176740","DOIUrl":"https://doi.org/10.5114/aoms/176740","url":null,"abstract":"Introduction: The present study focused on developing a nomogram model to predict the 3-month survival of patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis with tissue plasminogen activator (tPA).Material and methods: A total of 709 patients were enrolled in the present study, including 496 patients in the training set and 213 patients in the validation set. All data were statistically analyzed using R software. We applied LASSO regression analysis to construct nomograms by screening statistically significant predictors from all variables.The model discrimination was evaluated based on the area under the receiver operating characteristic curve (AUC-ROC).Results: LASSO regression analysis was conducted for all variables, which revealed BNP, DNT, HCY, HDL, MHR, NHR and post-thrombolysis NIHSS as independent predictors of adverse outcomes at 3 months after intravenous thrombolysis. Accordingly, these seven factors were incorporated in the nominated BDH2-MN2 nomogram. The resulting AUC-ROC values determined for the training and validation sets were 0.937 (95% CI: 0.822-0.954) and 0.898 (95% CI: 0.748-0.921), respectively.Conclusions: A robust BDH2-MN2 (BNP, DNT, HCY, HDL, MHR, NHR and post-thrombolysis NIHSS) nomogram model was successfully developed and validated. The developed nomogram enables prediction of adverse outcomes of individual AIS patients receiving intravenous thrombolysis with alteplase for 3 months.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 4","pages":"1143-1152"},"PeriodicalIF":3.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nomogram for predicting reflux esophagitis with routine metabolic parameters: a retrospective study. 利用常规代谢参数预测反流性食管炎的提名图：一项回顾性研究。

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-04-30 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/175536

Tao He, Xiaoyu Sun, Zhijun Duan

{"title":"Nomogram for predicting reflux esophagitis with routine metabolic parameters: a retrospective study.","authors":"Tao He, Xiaoyu Sun, Zhijun Duan","doi":"10.5114/aoms/175536","DOIUrl":"https://doi.org/10.5114/aoms/175536","url":null,"abstract":"Introduction: The prevalence of reflux esophagitis (RE) is relatively high around the world. We investigated routine metabolic parameters for associations with RE prevalence and severity, creating a user-friendly RE prediction nomogram.Material and methods: We included 10,881 individuals who had upper gastrointestinal endoscopy at a hospital. We employed univariate and multivariate logistic regression for independent risk factors related to RE prevalence, and conducted ordinal logistic regression for independent prognostic factors of RE severity. Subsequently, a nomogram was constructed using multivariate logistic regression analysis, and its performance was assessed through the utilization of receiver operating characteristic (ROC) curves, calibration curves, decision curve analysis (DCA), and clinical impact curve (CIC) analysis.Results: In this study, 43.8% (4769 individuals) had confirmed RE. Multivariate analysis identified BMI, age, alcohol use, diabetes, Helicobacter pylori, systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC), albumin, uric acid (UA), fT3, and fT4 as independent RE risk factors (p < 0.05). The personalized nomogram used 17 factors to predict RE, with an AUC of 0.921 (95% CI: 0.916-0.926), specificity 84.02%, sensitivity 84.86%, and accuracy 84.39%, reflecting excellent discrimination. Calibration, decision, and CIC analyses affirmed the model's high predictive accuracy and clinical utility. Additionally, ordinal logistic regression linked hypertension, diabetes, HDL-C, LDL-C, TG, and TC to RE severity.Conclusions: Our study highlights the association between the routine metabolic parameters and RE prevalence and severity. The nomogram may be of great value for the prediction of RE prevalence.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 4","pages":"1089-1100"},"PeriodicalIF":3.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of nutrition and healthy lifestyle, for individuals in primary prevention: recent data, gaps in evidence and future directions. 营养和健康生活方式对个人在初级预防中的作用：最新数据、证据差距和未来方向。

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-04-30 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/187841

Theodora Metsovitis, Marco Bernardi, Eric Bruckert, Federica Fogacci, Arrigo Cicero, Sebastian Garcia-Zamora, Luigi Spadafora, Denis Angoulvant, Giuseppe Biondi-Zoccai, Pierre Sabouret

{"title":"Role of nutrition and healthy lifestyle, for individuals in primary prevention: recent data, gaps in evidence and future directions.","authors":"Theodora Metsovitis, Marco Bernardi, Eric Bruckert, Federica Fogacci, Arrigo Cicero, Sebastian Garcia-Zamora, Luigi Spadafora, Denis Angoulvant, Giuseppe Biondi-Zoccai, Pierre Sabouret","doi":"10.5114/aoms/187841","DOIUrl":"10.5114/aoms/187841","url":null,"abstract":"All recent guidelines on cardiovascular prevention have highlighted the role of a healthy diet and lifestyle advocating an holistic approach to reduce the cardiovascular burden among the population. Despite these efforts, registries have reported that only a minority of healthcare professionals provide advice on diet and lifestyle, and, in most cases, counseling is suboptimal for several reasons. Cardiovascular benefits linked to lifestyle and nutrition seem to be underestimated by many patients and doctors. This overview aims to summarize well-established benefits related to lifestyle and nutrition, discuss the current debates in this field in order to improve awareness among the medical community and promote better implementation of non-pharmaceutical measures to prevent the occurrence of atherothrombotic events, by reducing cardiovascular risk factors such as hypertension, diabetes, dyslipidemia, and obesity.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1385-1399"},"PeriodicalIF":3.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global burden of osteoarthritis from 1990 to 2019 attributable to high body mass index. 1990年至2019年归因于高体重指数的全球骨关节炎负担。

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-04-28 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/187150

Shiming Yang, Licheng Zhou, Wanchen Gong, Bin Guo, Linfeng Wang

{"title":"Global burden of osteoarthritis from 1990 to 2019 attributable to high body mass index.","authors":"Shiming Yang, Licheng Zhou, Wanchen Gong, Bin Guo, Linfeng Wang","doi":"10.5114/aoms/187150","DOIUrl":"10.5114/aoms/187150","url":null,"abstract":"Introduction: The aim was to examine data from the Global Burden of Disease Study (GBD) 2019 to determine the global burden of osteoarthritis (OA) from 1990 to 2019 that is attributable to high body mass index (BMI).Material and methods: Disability-adjusted life years (DALYs) and age-standardized DALY rates, and their corresponding estimated annual percentage changes (EAPCs), were used to compare estimated OA burdens between countries and regions. Moreover, a comparative risk assessment framework was used to estimate the risks attributable to high BMI in terms of DALYs.Results: From 1990 to 2019, the age-standardized DALY rate for OA attributable to high BMI increased significantly (EAPC = 1.45, 95% CI: 1.44-1.47). Moreover, from 1990 to 2019, the age-standardized DALY rate and number of DALYs for OA attributable to high BMI increased less in women than in men. From 1990 to 2019, the age-standardized DALY rate for OA attributable to high BMI increased the most in South Asia (EAPC = 3.94). From 1990 to 2019, among 204 countries worldwide, the age-standardized DALY rate for OA attributable to high BMI increased the most in Equatorial Guinea (EAPC = 7.42). Also, the burden was higher in high-sociodemographic index (SDI) regions than in low-SDI regions.Conclusions: The global burden of OA attributable to high BMI increased significantly from 1990 to 2019. In particular, this burden was higher in women than in men; primarily affected middle-aged and older adults; and was generally greater in high-SDI regions than in low-SDI regions.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 6","pages":"1841-1853"},"PeriodicalIF":3.0,"publicationDate":"2024-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The genetic causal association between hip or knee osteoarthritis and frailty: a two-sample Mendelian randomization analysis. 髋关节或膝关节骨关节炎与虚弱之间的遗传因果关系：双样本孟德尔随机分析。

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/176741

Jinlei Zhou, Yanlei Li, Yanze Lin, Fei Wang, Jinlong Tian, Yongguang Wang, Qing Bi, Changxing Wang, Tingxiao Zhao

{"title":"The genetic causal association between hip or knee osteoarthritis and frailty: a two-sample Mendelian randomization analysis.","authors":"Jinlei Zhou, Yanlei Li, Yanze Lin, Fei Wang, Jinlong Tian, Yongguang Wang, Qing Bi, Changxing Wang, Tingxiao Zhao","doi":"10.5114/aoms/176741","DOIUrl":"https://doi.org/10.5114/aoms/176741","url":null,"abstract":"Introduction: Osteoarthritis of the hip or knee has been reported to be linked to an increased risk of frailty. However, a definitive conclusion about whether hip or knee osteoarthritis increases susceptibility to frailty remains elusive.Material and methods: The instrumental variables (IVs) used in this analysis were sourced from publicly available genome-wide association study (GWAS) datasets. We used a two-sample Mendelian randomization analysis to evaluate the plausible causal nexus between hip or knee osteoarthritis and frailty.Results: We included a total of 25 single-nucleotide polymorphisms (SNPs) as instrumental variables through rigorous and comprehensive screening. The results of this analysis suggested that hip or knee osteoarthritis is associated with an elevated risk of frailty. These results remained robust and consistent across multiple calculation methods, including inverse variance weighted (OR = 1.082, 95% CI: 1.0532-1.1125, p = 1.36 × 10-8), MR-Egger regression (OR = 1.175, 95% CI: 1.0162-1.3604, p = 0.040), weighted median estimation (OR = 1.078, 95% CI: 1.0365-1.1219, p = 1.831 × 10-4), weighted mode analysis (OR = 1.089, 95% CI: 1.0078-1.1771, p = 0.041) and simple mode analysis (OR = 1.093, 95% CI: 1.0112-1.1830, p = 0.034). Cochran's Q test showed no evidence of heterogeneity among the IV estimates derived from individual variants, and the MR-Egger regression analysis indicated that the presence of horizontal pleiotropy was unlikely to introduce bias into the results (intercept: -0.0044, p = 0.549).Conclusions: Two-sample Mendelian randomization analysis effectively identified hip or knee osteoarthritis as a contributing risk factor for frailty.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 3","pages":"938-946"},"PeriodicalIF":3.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated expression of NLRP3 promotes cigarette smoke-induced airway inflammation in chronic obstructive pulmonary disease. NLRP3 表达的升高促进了慢性阻塞性肺病患者由香烟烟雾诱发的气道炎症。

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/176805

Min Wang, Junjie Peng, Mei Yang, Jun Chen, Yongchun Shen, Lin Liu, Lei Chen

{"title":"Elevated expression of NLRP3 promotes cigarette smoke-induced airway inflammation in chronic obstructive pulmonary disease.","authors":"Min Wang, Junjie Peng, Mei Yang, Jun Chen, Yongchun Shen, Lin Liu, Lei Chen","doi":"10.5114/aoms/176805","DOIUrl":"https://doi.org/10.5114/aoms/176805","url":null,"abstract":"Introduction: NOD-like receptor protein 3 (NLRP3) is implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Here, we explored the role of NLRP3 in cigarette smoke (CS)-induced airway inflammation in COPD.Material and methods: NLRP3 expression level was assessed with the microarray data in GEO datasets and validated in serum by ELISA from a case-control cohort. Male C57BL/6J mice were randomly divided into: saline, CS, MCC950 (a specific NLRP3 inhibitor, 10 mg/kg) and CS + MCC950 (5 mg/kg and 10 mg/kg) groups (n = 5 per group). All mice were exposed to CS or air for 4 weeks. Then, broncho-alveolar lavage (BAL) fluid and lung tissues were collected for cell counting, ELISA, HE staining and RNA sequencing with validation by real-time qPCR.Results: Compared to non-smokers, NLRP3 expression was significantly elevated in the lung tissues and sera of COPD smokers. CS remarkably induced airway inflammation in mice, characterized by an increase of inflammatory cells and proinflammatory cytokines in BAL fluid and HE inflammatory score, which were ameliorated by MCC950 treatment dose-dependently. Subsequently, 84 candidate genes were selected following RNA sequencing, and five hub genes (Mmp9, IL-1α, Cxcr2, Cxcl10, Ccr1) were then identified by PPI and MCODE analyses, which were confirmed by real-time qPCR. GO and KEGG analysis suggested that the five genes were enriched in a complicated network of inflammatory processes and signaling pathways.Conclusions: NLRP3 expression is elevated in lungs and sera of COPD smokers. Inhibition of NLRP3 significantly attenuates CS-induced airway inflammation in mice via inactivation of multiple hub genes and their related inflammatory processes and signaling pathways.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 4","pages":"1281-1293"},"PeriodicalIF":3.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diarrhea-predominant irritable bowel syndrome as a masquerade for systemic mastocytosis: review article and illustrating case report. 腹泻为主的肠易激综合征是系统性肥大细胞增多症的伪装：综述文章和说明性病例报告。

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/176943

Mansour Aljabry

引用次数: 0

CENPN contributes to pancreatic carcinoma progression through the MDM2-mediated p53 signaling pathway. CENPN通过mdm2介导的p53信号通路参与胰腺癌的进展。

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-04-15 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/171956

Ming Xu, Jie Tang, Qiong Sun, Jing Meng, Guoyu Chen, Yunli Chang, Yao Yao, Jieru Ji, Hao Luo, Lingling Chen, Minxue Lu, Weiwei Shi

{"title":"CENPN contributes to pancreatic carcinoma progression through the MDM2-mediated p53 signaling pathway.","authors":"Ming Xu, Jie Tang, Qiong Sun, Jing Meng, Guoyu Chen, Yunli Chang, Yao Yao, Jieru Ji, Hao Luo, Lingling Chen, Minxue Lu, Weiwei Shi","doi":"10.5114/aoms/171956","DOIUrl":"10.5114/aoms/171956","url":null,"abstract":"Introduction: We undertook an in-depth investigation of the data pertaining to pancreatic adenocarcinoma (PAAD) to identify potential targets for the development of precision therapies.Material and methods: The construction of a protein-protein interaction (PPI) network was based on overlapping differentially expressed genes (DEGs) identified in the GSE16515, GSE32676, and GSE125158 datasets. A subsequent bioinformatic analysis was performed on the interconnected genes within the PPI network, leading to the identification of the central gene, CENPN. In vitro experimentation such as CCK8 and Transwell experiments was employed to elucidate the impact of CENPN expression patterns on PAAD cell proliferation, migration, and invasion. Furthermore, the investigation revealed through comprehensive enrichment analysis that the pivotal signaling pathway associated with CENPN is the p53 signaling pathway.Results: Following a comprehensive bioinformatic analysis of 161 concordant differentially expressed genes (DEGs) across three microarray datasets, CENPN emerged as the central gene under investigation. Overexpression of CENPN in pancreatic adenocarcinoma (PAAD) was associated with unfavorable patient outcomes and heightened sensitivity to four PAAD therapies: gemcitabine, docetaxel, paclitaxel, and sunitinib. Reduced CENPN expression impeded PAAD cell proliferation, migration, and invasion; however, these effects were counteracted upon upregulation of CENPN expression. Additionally, CENPN interacted with MDM2, promoting PAAD progression by targeting the p53 signaling pathway.Conclusions: The findings of our study substantiate that CENPN is associated with the pathogenesis of PAAD. Consequently, CENPN appears to be a promising candidate for targeted precision therapy in clinical applications.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1655-1671"},"PeriodicalIF":3.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between childhood psychological abuse and social media addiction among college students: the mediating role of fear of missing out and the moderating role of left-behind experience. 大学生童年心理虐待与社交媒体成瘾之间的关系："害怕错过 "的中介作用和 "留守经验 "的调节作用。

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-04-10 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/174649

Peng-Cheng Wei, Hai-Qin Yu

{"title":"The relationship between childhood psychological abuse and social media addiction among college students: the mediating role of fear of missing out and the moderating role of left-behind experience.","authors":"Peng-Cheng Wei, Hai-Qin Yu","doi":"10.5114/aoms/174649","DOIUrl":"https://doi.org/10.5114/aoms/174649","url":null,"abstract":"Introduction: Mobile social media is a new type of online media that is participatory, open, and communicative, among other characteristics. Due to the increasing popularity of social media, this technology has become an indispensable part of people's social lives. This study aims to examine the relationship between childhood psychological maltreatment and social media addiction among university students as well as the mediating role of fear of missing out and the moderating effect of left-behind experience in this context.Material and methods: A voluntary anonymous online survey of 1694 university students was conducted using the Childhood Psychological Maltreatment Scale, the Fear of Missing Out Scale, and the Social Media Addiction Scale.Results: First, significant positive correlations were observed between childhood psychological maltreatment and both fear of missing out and social media addiction among university students. Fear of missing out partially mediated the relationship between childhood psychological maltreatment and social media addiction. Second, left-behind experience was found to moderate the direct path from childhood psychological maltreatment to social media addiction as well as the first half of the mediating effect of missed anxiety.Conclusions: Childhood psychological maltreatment can predict social media addiction among university students not only directly but also indirectly through the mediating role of missed anxiety. The direct effect of childhood psychological maltreatment on social media addiction is moderated by left-behind experience. The first half of the mediating role of missed anxiety is also moderated by left-behind experience.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 3","pages":"798-805"},"PeriodicalIF":3.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective study on the effect of statins on mortality and antimicrobial resistance among patients with Staphylococcus aureus bloodstream infection. 他汀类药物对金黄色葡萄球菌血流感染患者死亡率和抗菌药耐药性影响的回顾性研究。

IF 3.8 4区医学

Archives of Medical Science Pub Date : 2024-03-30 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/187004

Jianwei Su, Yixuan Wang, Wanping Zhong, Mengzhi Wang, Yanhong Wang

{"title":"A retrospective study on the effect of statins on mortality and antimicrobial resistance among patients with Staphylococcus aureus bloodstream infection.","authors":"Jianwei Su, Yixuan Wang, Wanping Zhong, Mengzhi Wang, Yanhong Wang","doi":"10.5114/aoms/187004","DOIUrl":"https://doi.org/10.5114/aoms/187004","url":null,"abstract":"Introduction: There is insufficient evidence in statin on the treatment of Staphylococcus aureus (SA) infection, we observe and analyze the clinical outcomes and antibiotic resistance of SA bloodstream infections in patients who received statins.Methods: A retrospective study was carried out in SA bloodstream infection of hospitalized patients from January 2018 to August 2023. The 30-day attributable mortality, 30-day all-cause mortality and clinical data of patients who received statins and non-statins were compared.Results: A total of 74 patients with SA bloodstream infection were included, 32 (43.2%) patients received treatment with statins and 42 (56.8%) with non-statins. The incidence of methicillin-resistant SA (MRSA) was significantly lower in the statins group (15.6% vs. 38.1%, p = 0.034), however, no significant differences were observed in the mortality rate (p = 0.410).Conclusions: This study revealed the superiority of statins in reducing incidence of MRSA among SA bloodstream infection patients, but statins do not improve the 30-day mortality rate.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"675-678"},"PeriodicalIF":3.8,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0