Archives of Medical Science最新文献

{"title":"Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011-2018.","authors":"Shenghua Yao, Dan Xu","doi":"10.5114/aoms/181508","DOIUrl":"10.5114/aoms/181508","url":null,"abstract":"<p><strong>Introduction: </strong>Currently, knowledge on relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease (CKD) is lacking. The aim of the study was to ex-plore the relationships between blood concentrations of heavy metals and the occurrence of CKD.</p><p><strong>Material and methods: </strong>Data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 were used to investigate the relationships between blood concentrations of mercury, lead, cadmium, selenium, and manganese and the occurrence of CKD using a weighted logistic recession analysis. Restrictive cubic spline analysis was applied to assess the dose-response relationship. The sample population was divided into four groups based on the quartiles of heavy metal concentrations (Q1: < 25^th percentile, Q2: 25^th-50^th percentile, Q3: 50^th-75^th percentile, Q4: ≥ 75^th percentile).</p><p><strong>Results: </strong>A total of 15,450 participants were included. With regard to blood lead concentrations, the odds ratio (OR) for CKD in Q4 relative to Q1 was 1.36 (95% confidence interval [CI]: 1.20-1.61), indicating an increased oc-currence of CKD in Q4. With regard to blood cadmium concentrations, the ORs for CKD in Q2, Q3, and Q4 were 1.06 (95% CI: 0.92-1.22), 1.21 (95% CI: 1.05-1.39), and 1.52 (95% CI: 1.31-1.76), respectively. Non-linear dose-response relationships were identified between blood cadmium and lead concentrations and the occurrence of CKD. Further, blood lead and cadmium concentrations showed statistically significant interaction effects with age, hypertension, and obesity on CKD.</p><p><strong>Conclusions: </strong>Higher cadmium and lead concentrations in blood are asso-ciated with increased occurrence of CKD, especially in older adults, people with hypertension, and people with obesity.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 6","pages":"1822-1830"},"PeriodicalIF":3.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Polish recommendations for the management of familial hypercholesterolemia in children and adolescents.","authors":"Małgorzata Myśliwiec, Marta Bandura, Anna Wołoszyn-Durkiewicz, Matylda Hennig, Mieczysław Walczak, Jarosław Peregud-Pogorzelski, Jolanta Sykut-Cegielska, Maria Miszczak-Knecht, Krzysztof Chlebus, Bartosz Wasąg, Agnieszka Zmysłowska, Maciej Banach","doi":"10.5114/aoms/196329","DOIUrl":"10.5114/aoms/196329","url":null,"abstract":"<p><p>Familial hypercholesterolemia (FH) is the most common monogenic disease leading to the accelerated development of atherosclerotic cardiovascular disease (ASCVD). Despite increasing medical knowledge, diagnostic testing, and a growing number of therapeutic options, the effectiveness of detecting and treating FH remains highly insufficient. Only early detection (as early as possible) and optimal treatment in pediatric patients will lead to a significant reduction in morbidity and mortality from atherosclerotic cardiovascular disease (ASCVD) in later years. We present the guidelines for the management of FH in children and adolescents in Poland. This document is an update of the 2014 Position Paper of the Lipid Expert Forum.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 6","pages":"1741-1753"},"PeriodicalIF":3.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High levels of uric acid upregulate endothelin receptors: the role of MAPK pathways in an <i>in vitro</i> study.","authors":"Yu-Jiao Han, Sen Li","doi":"10.5114/aoms/193455","DOIUrl":"10.5114/aoms/193455","url":null,"abstract":"<p><strong>Introduction: </strong>Uric acid (UA) is the end product of the metabolism of purine compounds. There is overwhelming evidence linking hyperuricaemia (high levels of UA) and cerebrovascular diseases, but the effect of high levels of UA on cerebral vessels is not fully understood. The aim of this research is to clarify how UA affects the endothelin (ET) receptor in rat cerebral arteries and the related mechanism.</p><p><strong>Material and methods: </strong>In an <i>in vitro</i> setting, segments of rat cerebral arteries (<i>n</i> = 12) were exposed to high levels of UA, either alone or in conjunction with MAPK pathway inhibitors. ET agonists were used to induce contractions that were then measured with a myograph. ET receptor expression was measured using RT-PCR (<i>n</i> = 6), western blot (<i>n</i> = 3), or immunohistochemistry (<i>n</i> = 3) to quantify mRNA and protein levels.</p><p><strong>Results: </strong>The study revealed that high levels of UA notably increase ET_A and ET_B receptor-induced contractions and boosted the expression of ET receptors in cerebral arteries when compared to fresh or cultured alone, suggesting that UA enhances ET_A and ET_B receptors. Additionally, the up-regulation of ET_B receptors induced by UA was inhibited by the p38 inhibitor SB203580, the JNK inhibitor SP600125, and the ERK1/2 inhibitor U0126. SB203580 significantly blocked the increase in ET_A receptor-mediated contractions induced by UA and the upregulation of ET_A receptor. Neither SP600125 nor U0126 had such an effect.</p><p><strong>Conclusions: </strong>High levels of UA stimulate the up-regulation of ET receptors in rat cerebral arteries <i>in vitro</i> through MAPK pathways. This study may offer novel perspectives on hyperuricaemia-associated cerebrovascular diseases.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"21 4","pages":"1602-1611"},"PeriodicalIF":3.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activities and breast cancer: a Mendelian randomization study.","authors":"Lishan Ding, Qingliang Chen, Hao Liang, Meng Shen, Ming Zheng, Zhaojun Li","doi":"10.5114/aoms/195271","DOIUrl":"10.5114/aoms/195271","url":null,"abstract":"<p><strong>Introduction: </strong>Previous research suggests a potential association between physical activity (PA) and breast cancer (BC), but the causal relationship remains uncertain. The aim of this study was to explore the causal relationship between PA and BC through Mendelian randomization (MR) analysis.</p><p><strong>Material and methods: </strong>Genome-wide association studies utilizing data from the UK Biobank baseline were employed to analyze PA phenotypes, encompassing 460,376 participants. Summary data for BC, comprising 122,977 cases and 105,974 controls, were obtained from the BC Association Consortium. The cases were further categorized based on estrogen receptor status into estrogen receptor-positive breast cancer (ER+ BC) and estrogen receptor-negative breast cancer (ER- BC). The inverse variance weighted method was employed as the primary approach for two-sample MR. Additionally, the MR-PRESSO (MR-Pleiotropy RESidual Sum and Outlier) method was utilized to eliminate outliers. Tests for heterogeneity and pleiotropy were conducted to enhance result accuracy. Furthermore, multivariable Mendelian randomization was performed, adjusting for potential confounders to ensure result stability.</p><p><strong>Results: </strong>MR analysis was employed to assess the causal link between PA and BC. Two-sample MR analysis revealed a genetic prediction indicating that walking for pleasure was associated with decreased risk of ER+ BC (odds ratio (OR) = 0.302, 95% CI = 0.105-0.872, <i>p</i> = 0.027), while other physical activities were not significantly correlated with BC, ER+ BC and ER- BC. These findings remained reliable and consistent in the sensitivity analysis, including Cochran's Q and MR-Egger regression. Furthermore, reverse MR analysis suggested that BC did not exert a notable impact on PA.</p><p><strong>Conclusions: </strong>Our findings suggest that engaging in leisure walking is associated with a reduced risk of ER+ BC. Nevertheless, additional research is warranted to comprehensively elucidate the underlying mechanisms and strengthen the causal relationship.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 6","pages":"1957-1967"},"PeriodicalIF":3.0,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomere length across the spectrum of metabolic health: an analysis from the LIPIDOGEN2015 study.","authors":"Maciej Banach, Martyna Fronczek, Anna Goc, Mateusz Lejawa, Ewa Boniewska-Bernacka, Tadeusz Osadnik, Anna Pańczyszyn, Joanna K Strzelczyk, Natalia Pawlas, Marek Gierlotka, Marcin Goławski, Karol Krystek, Agnieszka Gach, Kamila Osadnik, Jacek Jóźwiak","doi":"10.5114/aoms/195465","DOIUrl":"10.5114/aoms/195465","url":null,"abstract":"<p><strong>Introduction: </strong>Telomere length is a cellular aging marker and correlates with various cardiovascular disease (CVD) risk factors. The current study assessed the association between obesity, metabolic syndrome (MetS), and telomere length.</p><p><strong>Material and methods: </strong>The LIPIDOGRAM&LIPIDOGEN2015 study was conducted in primary care in 2015-2016. Patients recruited to the LIPIDOGEN2015 cohort (<i>n</i> = 1788) were a random subset of patients of the LIPIDOGRAM2015 (<i>n</i> = 13,724) study. For the aims of this analysis, the recruited patients were divided into four groups based on the presence of MetS: healthy slim (HS), metabolically healthy obese (MHO), non-obese with MetS (NOMS), and metabolically unhealthy obese (MUO). Relative telomere length (RTL) was measured using quantitative polymerase chain reaction (qPCR).</p><p><strong>Results: </strong>1516 patients (85% of the total group; 59.7% female, mean age 50.3 years) were included in the final analyses. Increases in body mass index (BMI), waist circumference, prevalence of diabetes mellitus, hypertension, dyslipidemia, and history of myocardial infarction moving from HS to MUO were observed. The MUO group exhibited the highest triglyceride and lowest high-density lipoprotein (HDL-C) levels. In the univariate regression analyses, NOMS (<i>p</i> = 0.038) and MUO (<i>p</i> = 0.003) were associated with significantly decreased RTL. After adjusting for age, gender, education, smoking, place of residence, and myocardial infarction, the association was no longer statistically significant.</p><p><strong>Conclusions: </strong>Despite the lack of statistical significance in the multivariate analysis, the univariate results suggest that both MUO and NOMS phenotypes contribute to the shortening of telomere length. These results may also indicate that MetS, irrespectively of obesity occurrence, is responsible for the shortened lifespan.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"21 4","pages":"1213-1221"},"PeriodicalIF":3.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized arterial calcifications in a twin recipient treated with etidronate: description of a case report within a narrative review.","authors":"Carla Giuseppina Corti, Luisa Federica Nespoli, Alessandro Campari, Eleonora Gnan, Massimiliano Ruscica, Stefano Carugo","doi":"10.5114/aoms/194435","DOIUrl":"10.5114/aoms/194435","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1695-1700"},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the causal relationship between hyperlipidaemia and exercise intensity: based on two-sample Mendelian randomisation.","authors":"Yijian Chu","doi":"10.5114/aoms/194192","DOIUrl":"10.5114/aoms/194192","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1701-1704"},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withdrawn: Long non-coding RNA SNHG1 promotes cell proliferation and invasion of hepatocellular carcinoma by acting as a molecular sponge to modulate miR-195.","authors":"Shuai Zhang, Xiaoding Song","doi":"10.5114/aoms/196465","DOIUrl":"10.5114/aoms/196465","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.5114/aoms.2019.81311.].</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1740"},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the STING inflammatory pathway in hepatic damage in psoriasis with type 2 diabetes mellitus.","authors":"Shulin Huang, Kun Xie, Xiaohong Li, Xiangjin Xu, Pin Chen","doi":"10.5114/aoms/183672","DOIUrl":"10.5114/aoms/183672","url":null,"abstract":"<p><strong>Introduction: </strong>Studies have suggested a potential association between patients who have both psoriasis and diabetes and liver damage. However, the exact nature of this link has not yet been fully established. The objective of the current study was to examine the potential exacerbation of liver damage due to the coexistence of psoriasis and type 2 diabetes mellitus (T2DM) and to explore the impact of interferon gene stimulating factor (STING) on related damage.</p><p><strong>Material and methods: </strong>Four patient groups were recruited: normal individuals, individuals with diabetes, those with psoriasis, and those with both diabetes and psoriasis. Relevant indicators were collected to facilitate the investigation. Furthermore, a mouse model of psoriasis combined with T2DM was established. The expression levels of STING and inflammatory factors downstream of the pathway were detected in both the skin and liver tissues of the model mice.</p><p><strong>Results: </strong>Based on our findings, patients with both psoriasis and T2DM exhibit abnormal liver function and increased STING expression in the skin (<i>p</i> < 0.05). In <i>the in vivo</i> experiments, liver tissues from model mice exhibited significantly elevated expression of STING and its downstream inflammatory factors, including NF-κB p65, interferon-β, interleukin (IL)-17A, and IL-23 (<i>p</i> < 0.05). The STING inhibitor-treated group displayed reduced skin damage and improved liver histopathology (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The findings of the current study indicate that the STING inflammatory pathway is upregulated in the liver tissues of individuals with psoriasis and T2DM.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1426-1441"},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation.","authors":"M Hidayat Budi Kusumo, Adi Prayitno, Soetrisno, Abdurahman Laqif","doi":"10.5114/aoms/183465","DOIUrl":"10.5114/aoms/183465","url":null,"abstract":"<p><strong>Introduction: </strong>Mesenchymal stem cells (MSCs) have promising regenerative properties in tissue repair and anti-inflammatory responses. This study aimed to investigate the effects of MSCs and their combination with micronized purified flavonoid fraction (MPFF) in a croton oil-induced hemorrhoids model on tissue edema, inflammation, and underlying molecular mechanisms.</p><p><strong>Material and methods: </strong>MSCs were isolated and characterized for their adherence, differentiation capacity, and immunophenotyping. Croton oil-induced hemorrhoid mouse models were established to assess tissue edema, inflammation, tumor necrosis factor (TNF-α) expression, transforming growth factor-β (TGF-β) expression, collagen ratio, and MMP-9 activity. The effects of MSCs and their combination with MPFF (diosmin-hesperidin) were evaluated through histological examinations, western blot analysis, and gelatin zymography.</p><p><strong>Results: </strong>Characterization confirmed the MSCs' plastic adherence, osteogenic differentiation potential, and immunophenotype (positive for CD90 and CD29, negative for CD45 and CD31). Treatment with MSCs alone or in combination with MPFF significantly reduced tissue edema, inflammation, TNF-α expression, and MMP-9 activity. Additionally, MSCs increased TGF-β expression, and collagen type I/III ratio, and accelerated wound healing by resolving inflammation.</p><p><strong>Conclusions: </strong>These findings suggest that MSCs play a crucial role in modulating TNF-α, TGF-β, collagen remodeling, and MMP-9 activity, highlighting their promising role in hemorrhoid treatment and wound healing processes. Further research is warranted to fully elucidate the intricate mechanisms and optimize MSC-based therapies for clinical applications in hemorrhoidal disease management.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1556-1566"},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}