Archives of Medical Science最新文献

{"title":"C-reactive protein-albumin-lymphocyte (CALLY) index in chronic kidney disease and mortality: insights into inflammation, nutrition, and immune status.","authors":"Yanhong Sun, Qi Sun, Chujie Zheng, Ting Wu, Yamei Bai","doi":"10.5114/aoms/216398","DOIUrl":"10.5114/aoms/216398","url":null,"abstract":"<p><strong>Introduction: </strong>The C-reactive protein-albumin-lymphocyte (CALLY) index represents a novel composite biomarker integrating inflammatory, nutritional, and immune parameters. We aimed to examine the relationship between CALLY index and chronic kidney disease (CKD) prevalence.</p><p><strong>Material and methods: </strong>This cross-sectional analysis utilized data from the National Health and Nutrition Examination Survey. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m² and/or urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g. Multivariable logistic regression and restricted cubic spline (RCS) analyses assessed the relationship between CALLY index and CKD risk. Among CKD patients, Cox proportional hazards models evaluated associations of the CALLY index with all-cause and cardiovascular mortality.</p><p><strong>Results: </strong>Among the 26 996 participants, 4997 individuals were diagnosed with CKD. Participants with CKD demonstrated lower CALLY index values compared to those without CKD. Multivariable logistic regression indicated that, compared to the lowest quartile, the highest quartile showed 29.5% reduced CKD risk (OR = 0.705, 95% CI: 0.589-0.845, <i>p</i> < 0.001). The RCS model demonstrated a significant L-shaped association between CALLY index and CKD prevalence. Among CKD patients, higher CALLY index significantly predicted better survival outcomes for both all-cause and cardiovascular mortality.</p><p><strong>Conclusions: </strong>The CALLY index demonstrates inverse associations with CKD risk and mortality, suggesting its potential utility as a comprehensive biomarker for CKD risk stratification and prognosis assessment.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 3","pages":"1389-1398"},"PeriodicalIF":3.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13426185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic LMNA variant identified in a family with dilated cardiomyopathy and arrhythmias highlights cascade screening importance.","authors":"Lihuimei Zhou, Jiafu Li","doi":"10.5114/aoms/219140","DOIUrl":"10.5114/aoms/219140","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"579-581"},"PeriodicalIF":3.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gabapentinoid use and inpatient falls in hospitalized adults: a propensity score-matched case-control study.","authors":"Ji Hyun Moon, Yeonja Kim, Hyeju Lee, Nam-Jun Cho, Kyomin Choi","doi":"10.5114/aoms/219138","DOIUrl":"10.5114/aoms/219138","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"536-539"},"PeriodicalIF":3.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological analysis and preventive strategies of paediatric burns inpatients in a Hangzhou hospital from 2020 to 2024: a retrospective study.","authors":"Yichong Zhou, Yefeng Dai, Xiaojie Yue, Yuxin Liu, Li Lin","doi":"10.5114/aoms/218625","DOIUrl":"10.5114/aoms/218625","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"563-568"},"PeriodicalIF":3.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication adherence in vascular prevention: findings from the SIFHON-ADH survey in Argentina.","authors":"Matias J Alet, Maria S Rodriguez-Perez, Sebastián F Ameriso","doi":"10.5114/aoms/218810","DOIUrl":"10.5114/aoms/218810","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"531-535"},"PeriodicalIF":3.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging and coronary artery calcification: a Mendelian randomization study.","authors":"Mateusz Lejawa, Marcin Goławski, Mateusz Olek, Nikodem Baron, Jacek J Jozwiak, Beata Maksym, Natalia Pawlas, Tadeusz Osadnik, Maciej Banach","doi":"10.5114/aoms/217629","DOIUrl":"10.5114/aoms/217629","url":null,"abstract":"<p><strong>Introduction: </strong>Coronary artery calcification (CAC) is a recognized marker of atherosclerosis and cardiovascular disease (CVD) risk. While CAC is closely linked to aging, its potential as a marker of biological aging remains uncertain. Telomere length (TL), epigenetic aging markers, and dental deterioration parameters have been proposed as indicators of biological aging. However, the extent to which these biological aging indicators are associated with CAC remains unclear.</p><p><strong>Material and methods: </strong>Two-sample and three-sample Mendelian randomization (MR) analyses were conducted to investigate the potential causal effects of TL, epigenetic aging markers (intrinsic epigenetic age acceleration [IEAA], phenotypic age [PhenoAge]), and dental deterioration traits on CAC. Summary-level statistics from large-scale genome-wide association studies (GWASs) were obtained and analyzed using appropriate MR methods.</p><p><strong>Results: </strong>Genetically determined longer TL was significantly associated with lower CAC levels (IVW <i>p</i> < 0.001), supporting TL as a protective factor against atherosclerosis progression (as measured by CAC). Other analyses confirmed the robustness of this finding (MR-Egger <i>p</i> = 0.03, WME <i>p</i> = 0.004). A three-sample MR analysis provided further evidence for this association (IVW <i>p</i> < 0.01). However, neither epigenetic aging markers nor dental deterioration parameters exhibited a significant causal relationship with CAC.</p><p><strong>Conclusions: </strong>This study supports an inverse causal relationship between TL and CAC, reinforcing CAC as a biomarker of biological aging. Epigenetic aging markers and dental deterioration parameters were not significantly linked to CAC. Future studies should explore additional aging-related traits and refine the genetic instruments for epigenetic aging and dental health to further elucidate their potential roles in vascular aging.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"345-354"},"PeriodicalIF":3.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological and social determinants of early childhood development assessed with ASQ-3: a Bulgarian nursery-based study.","authors":"Tatyana D Itova","doi":"10.5114/aoms/218490","DOIUrl":"10.5114/aoms/218490","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"569-571"},"PeriodicalIF":3.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national incidence, mortality, DALY, and prevalence rates of orofacial clefts in children and adolescents from 1990 to 2021, with predictions to 2050.","authors":"Bowen Dai, Yuqi Song, Xiaoyu Yu, Dongxu Li, Xiaoming Li","doi":"10.5114/aoms/218229","DOIUrl":"10.5114/aoms/218229","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 1","pages":"555-562"},"PeriodicalIF":3.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal imaging of the tongue as an indicator of lipid profile parameters in patients with type 2 diabetes mellitus: a pilot study.","authors":"Daria Wziątek-Kuczmik, Aleksandra Mrowiec, Agata Stanek, Maciej L Dryjski, Iwona Niedzielska, Armand Cholewka","doi":"10.5114/aoms/218009","DOIUrl":"10.5114/aoms/218009","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia and associated carbohydrate, protein, and lipid metabolism disturbances. Poor glycemic control exacerbates the risk of numerous complications, including cardiovascular diseases. Although the oral cavity is among the systems affected by diabetic pathology, its potential to reflect systemic lipid metabolism and cardiovascular risk remains unclear.</p><p><strong>Material and methods: </strong>This study investigated correlations between biochemical lipid markers and thermal parameters obtained from infrared imaging of the tongue to evaluate cardiovascular risk in T2DM patients. The study cohort comprised 29 individuals with T2DM and 12 healthy controls, following application of inclusion and exclusion criteria. Lipid profile parameters and related ratios were analyzed alongside thermal measurements recorded 2 and 10 min after oral cavity cooling.</p><p><strong>Results: </strong>Statistically significant positive correlations were identified between tongue surface temperature and lipid-related ratios at 2 min: triglycerides (TG) (<i>r</i> = 0.47, <i>p</i> = 0.002), total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio (<i>r</i> = 0.55, <i>p</i> < 0.001), and low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio (<i>r</i> = 0.54, <i>p</i> < 0.001). No significant correlations were observed between glycated hemoglobin (HbA1c), TC, or LDL-C and temperature parameters (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>These findings suggest that thermographic assessment of tongue surface temperature may provide a non-invasive biomarker reflecting lipid metabolism alterations and cardiovascular risk in T2DM patients, supporting its potential utility in early disease diagnosis.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 3","pages":"1338-1346"},"PeriodicalIF":3.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13426184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis E virus (HEV) as an emerging challenge in Poland: a narrative review of epidemiological and clinical data.","authors":"Piotr Grabarczyk, Aleksandra Kalińska, Aneta Kopacz, Ewa Sulkowska, Anna Parfieniuk-Kowerda, Jerzy Jaroszewicz","doi":"10.5114/aoms/214289","DOIUrl":"10.5114/aoms/214289","url":null,"abstract":"<p><p>Manuscripts on hepatitis E virus (HEV) epidemiology in Poland indexed in PubMed were analyzed in the context of current clinical and biological knowledge and epidemiological data from other regions of Europe and worldwide. The analyzed data indicate a high frequency of IgG HEV in Poland compared to other European countries and parts of the world, on average exceeding 40%. In some regions, almost 60% of the population has evidence of prior infection. It has been estimated based on the frequency of acute phase markers that at least 113,000 residents may acquire HEV infection annually. These findings support the need to improve availability of HEV diagnostics, increase physicians' awareness, and take into account HEV infection as an etiological factor of numerous diseases. Preventive measures, especially in high-risk groups, as well as further research on the clinical significance of HEV and on effective therapeutic management, should be considered.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 3","pages":"1275-1291"},"PeriodicalIF":3.6,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13426170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}