Niki Katsiki, Genovefa Kolovou, Andreas Melidonis, Maciej Banach
{"title":"The Cardiac-Kidney-Liver (CKL) syndrome: the \"real entity\" of type 2 diabetes mellitus.","authors":"Niki Katsiki, Genovefa Kolovou, Andreas Melidonis, Maciej Banach","doi":"10.5114/aoms/183070","DOIUrl":"10.5114/aoms/183070","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"207-215"},"PeriodicalIF":3.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Summary of 2023 and the biggest challenges for the \"Archives of Medical Science\" on its 20<sup>th</sup> Anniversary.","authors":"Maciej Banach","doi":"10.5114/aoms/183608","DOIUrl":"10.5114/aoms/183608","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"1-7"},"PeriodicalIF":3.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Women suffering from systemic lupus erythematosus are characterized by low blood levels of α-dicarbonyl compounds.","authors":"Agnieszka Nowak, Brygida Przywara-Chowaniec, Aleksandra Damasiewicz-Bodzek, Beata Janoszka, Magdalena Szumska, Sławomir Waligóra, Krystyna Tyrpień-Golder","doi":"10.5114/aoms/176941","DOIUrl":"https://doi.org/10.5114/aoms/176941","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease, often characterised by severe course and unclear etiopathogenesis. The reaction of protein glycoxidation, also known as glycation, may be linked to etiopathogenesis of SLE. Advanced glycation end-products (AGEs) exhibit cytotoxic properties, affect cellular signalling, impair functions of extracellular proteins, and may act as neoepitopes. Glucosone (GS), glyoxal (GO), and methylglyoxal (MGO) are examples of α-dicarbonyl compounds (α-DCs) partaking in glycoxidation. The study aimed to evaluate concentrations of these three compounds in blood serum of SLE patients, and to compare the results with healthy individuals.</p><p><strong>Material and methods: </strong>31 women suffering from SLE and 26 healthy individuals were included in the study. High-performance liquid chromatography with fluorescence detection was applied to evaluate concentrations of α-DCs in their serum samples. Correlations between the results and parameters such as disease duration time, age, glomerular filtration rate (GFR), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and creatinine were analysed.</p><p><strong>Results: </strong>The SLE patients exhibited lower concentrations of glucosone, glyoxal, and methylglyoxal than the control group. Analysis of correlations showed a difference between the examined groups.</p><p><strong>Conclusions: </strong>In women suffering from SLE the course of α-DCs metabolism is altered. SLE patients are characterised by low serum levels of α-DCs. We hypothesise that either hindered proteasomal degradation or fast consumption of α-DCs in oxidative conditions may cause the observed low concentration of these compounds.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 3","pages":"743-750"},"PeriodicalIF":3.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olga Paulina Sawicka, Anita Helena Kocięba-Łaciak, Dominik Gałuszka, Katarzyna Ślusarczyk, Jakub Kasperowicz
{"title":"Parents' attitudes towards children's transplantology.","authors":"Olga Paulina Sawicka, Anita Helena Kocięba-Łaciak, Dominik Gałuszka, Katarzyna Ślusarczyk, Jakub Kasperowicz","doi":"10.5114/aoms/178277","DOIUrl":"10.5114/aoms/178277","url":null,"abstract":"<p><strong>Introduction: </strong>Pediatric transplantation is an extremely complex and emotionally difficult area of pediatric medicine. The process of obtaining a pediatric donor by the staff is an extremely delicate topic, and for the family of the deceased child, often an unimaginable and painful process. The aim of the study was to analyze parents' opinions on pediatric transplantology.Methods: The research survey method was applied using an original survey questionnaire made available electronically using a Google form. The group analyzed included 203 respondents.</p><p><strong>Results: </strong>The attitude towards making transplant decisions among the respondents was positive. Education, age of parents and number of children did not influence attitudes towards pediatric transplantology.</p><p><strong>Conclusions: </strong>There is a need for social education in the field of pediatric transplantation and to facilitate access to professional psychological care for pediatric patients and/or their caregivers.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"326-331"},"PeriodicalIF":3.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saira Rafaqat, Dimitrios Patoulias, Amir Hossein Behnoush, Saima Sharif, Aleksandra Klisic
{"title":"Interleukins: pathophysiological role in acute pancreatitis.","authors":"Saira Rafaqat, Dimitrios Patoulias, Amir Hossein Behnoush, Saima Sharif, Aleksandra Klisic","doi":"10.5114/aoms/178183","DOIUrl":"10.5114/aoms/178183","url":null,"abstract":"<p><p>Acute pancreatitis (AP) is a common inflammatory state characterized by a clinical course that can lead to serious local and extrapancreatic organ malfunction and failure. Interleukins (ILs) are biologically active glycoproteins primarily produced by macrophages and lymphocytes. According to the literature, there are many ILs. However, this article represents a summary of the role of ILs in AP, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, and IL-20. The ways to modulate IL activity to reduce inflammation and improve outcomes in individuals with this condition are under investigation. Drugs that target specific ILs might be developed to mitigate the effects of AP.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"138-156"},"PeriodicalIF":3.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stanislaus Josef Mathias von Prowazek, Edler von Lanow, Rudolph Virchow, and the Upper Silesia Report.","authors":"Consolato M Sergi","doi":"10.5114/aoms/177494","DOIUrl":"10.5114/aoms/177494","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"354-356"},"PeriodicalIF":3.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bożena Sosnowska, Janina Stepinska, Przemyslaw Mitkowski, Agata Bielecka-Dabrowa, Beata Bobrowska, Jan Budzianowski, Pawel Burchardt, Krzysztof Chlebus, Piotr Dobrowolski, Mariusz Gasior, Piotr Jankowski, Jacek Kubica, Agnieszka Mickiewicz, Malgorzata Mysliwiec, Tadeusz Osadnik, Aleksander Prejbisz, Renata Rajtar-Salwa, Kristian Wita, Adam Witkowski, Robert Gil, Maciej Banach
{"title":"Recommendations of the Experts of the Polish Cardiac Society (PCS) and the Polish Lipid Association (PoLA) on the diagnosis and management of elevated lipoprotein(a) levels.","authors":"Bożena Sosnowska, Janina Stepinska, Przemyslaw Mitkowski, Agata Bielecka-Dabrowa, Beata Bobrowska, Jan Budzianowski, Pawel Burchardt, Krzysztof Chlebus, Piotr Dobrowolski, Mariusz Gasior, Piotr Jankowski, Jacek Kubica, Agnieszka Mickiewicz, Malgorzata Mysliwiec, Tadeusz Osadnik, Aleksander Prejbisz, Renata Rajtar-Salwa, Kristian Wita, Adam Witkowski, Robert Gil, Maciej Banach","doi":"10.5114/aoms/183522","DOIUrl":"10.5114/aoms/183522","url":null,"abstract":"<p><p>Lipoprotein(a) [Lp(a)] is made up of a low-density lipoprotein (LDL) particle and a specific apolipoprotein(a). The blood concentration of Lp(a) is approximately 90% genetically determined, and the main genetic factor determining Lp(a) levels is the size of the apo(a) isoform, which is determined by the number of KIV2 domain repeats. The size of the apo(a) isoform is inversely proportional to the blood concentration of Lp(a). Lp(a) is a strong and independent cardiovascular risk factor. Elevated Lp(a) levels ≥ 50 mg/dl (≥ 125 nmol/l) are estimated to occur in more than 1.5 billion people worldwide. However, determination of Lp(a) levels is performed far too rarely, including Poland, where, in fact, it is only since the 2021 guidelines of the Polish Lipid Association (PoLA) and five other scientific societies that Lp(a) measurements have begun to be performed. Determination of Lp(a) concentrations is not easy due to, among other things, the different sizes of the apo(a) isoforms; however, the currently available certified tests make it possible to distinguish between people with low and high cardiovascular risk with a high degree of precision. In 2022, the first guidelines for the management of patients with elevated lipoprotein(a) levels were published by the European Atherosclerosis Society (EAS) and the American Heart Association (AHA). The first Polish guidelines are the result of the work of experts from the two scientific societies and their aim is to provide clear, practical recommendations for the determination and management of elevated Lp(a) levels.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"8-27"},"PeriodicalIF":3.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaoliang Tang, Juan Meng, Xinghua Zhao, Wenting Sun
{"title":"Trends of ischemic heart disease mortality attributable to smoking in the five countries with the highest number of smokers during 1990-2019: an age-period-cohort analysis.","authors":"Shaoliang Tang, Juan Meng, Xinghua Zhao, Wenting Sun","doi":"10.5114/aoms/182886","DOIUrl":"10.5114/aoms/182886","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking increases the risk of various cardiovascular diseases, including ischemic heart disease (IHD). This study aimed to assess the impact of age, period, and cohort on long-term trends in IHD mortality in China, India, Indonesia, the United States, and Russia, the five countries with the highest number of smokers, from 1990 to 2019.</p><p><strong>Material and methods: </strong>The data were obtained from the Global Burden of Disease (GBD) Study 2019, and the age-standardized mortality rate (ASMR) was calculated. Joinpoint regression analysis was used to assess the magnitude and direction of trends in smoking-attributable mortality from IHD. Age-period-cohort (APC) studies were used to estimate net drift (estimated annual percentage change (EAPC)s), local drift (age-specific EAPCs), and independent trends in age, period, and cohort effects.</p><p><strong>Results: </strong>The analysis revealed a significant downward trend in ASMRs attributable to IHD as a result of smoking in the United States, India, and Russia. Indonesia and China showed an upward trend. Age effects were increasing for both country and sex, with China showing the most significant increase in the older age group; period effects were decreasing in all countries except Indonesia, and cohort effects were increasing only in Indonesia and China.</p><p><strong>Conclusions: </strong>From 1990 to 2019, mortality from IHD caused by smoking showed a downward trend in these five countries. However, the pattern of increased mortality from IHD in women caused by smoking warrants further study.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"43-53"},"PeriodicalIF":3.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global burden and epidemic trends of gout attributable to high body mass index from 1990 to 2019.","authors":"Zhaokai Jin, Zhengming Wang, Rui Wang, Sicheng Xiang, Weiqing Zhang, Yi Tang, Peijian Tong, Yong Gu, Shuaijie Lv","doi":"10.5114/aoms/175469","DOIUrl":"10.5114/aoms/175469","url":null,"abstract":"<p><strong>Introduction: </strong>Gout is an inflammatory and metabolic disease characterized by arthritis and elevation of the serum uric acid (SUA) level. More and more studies have shown that high body mass index (BMI) has become one of the most important risk factors for gout.</p><p><strong>Material and methods: </strong>We used the data of gout burden attributed to high body mass index (BMI) from global burden of disease (GBD) study 2019 to provide insights for reducing the global burden of gout.</p><p><strong>Results: </strong>From 1990 to 2019, the prevalence and DALYs of gout caused by high BMI worldwide has been increasing. The burden of gout caused by high BMI is heavier in the elderly male group and regions with high SDI worldwide.</p><p><strong>Conclusions: </strong>Our findings provide evidence for the burden of gout caused by high BMI. Developing a weight management plan and lifestyle habits for groups severely affected by gout will effectively reduce the global disease and economic burden.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"71-80"},"PeriodicalIF":3.8,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan Herzyk, Dawid Wilczek, Renata Kopczyńska, Piotr F Czempik
{"title":"A simple program to improve the appropriateness of red blood cell transfusions in non-bleeding hospital patients: a before-and-after study.","authors":"Jan Herzyk, Dawid Wilczek, Renata Kopczyńska, Piotr F Czempik","doi":"10.5114/aoms/177281","DOIUrl":"10.5114/aoms/177281","url":null,"abstract":"<p><strong>Introduction: </strong>Transfusion of red blood cells (RBCs) is not devoid of risks; nor is anemia. The aim of the study was to assess the usefulness of a program designed to improve the appropriateness of RBC transfusions in hospital patients.Methods: We retrospectively analyzed time periods before and after program implementation.</p><p><strong>Results: </strong>Before program implementation 415 out of 23492 (1.8%) patients received at least 1 RBC, whereas after implementation 162 out of 25062 (0.6%) did so. The percentage of appropriate RBC transfusions increased from 23.6 to 37.1%.</p><p><strong>Conclusions: </strong>A simple program may lead to a 3-fold decrease in transfusion rate and a significant increase in the percentage of appropriate RBC transfusions.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"317-320"},"PeriodicalIF":3.8,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}