Archives of Medical Science最新文献

{"title":"The prognostic value of cancer stem cell markers in thyroid cancer: a systematic review.","authors":"Xingqiao Peng, Peiye Zhu, Qiang Zhang, Jin Li","doi":"10.5114/aoms/185169","DOIUrl":"https://doi.org/10.5114/aoms/185169","url":null,"abstract":"<p><strong>Introduction: </strong>Thyroid cancer stem cells (TCSCs) play a crucial role in the pathogenesis, metastasis, and therapeutic response of thyroid cancer, making them promising biomarkers and potential targets for clinical intervention. This systematic review aims to qualitatively assess the impact of commonly used TCSC markers on the prognosis of thyroid cancer using qualitative methods.</p><p><strong>Methods: </strong>In total, the analysis encompassed five articles.</p><p><strong>Results: </strong>Six TCSC markers were involved, among which CD133, CD44, CD24, CD15 and ALDH1 were associated with the prognosis of thyroid cancer.</p><p><strong>Conclusions: </strong>However, the utility of these TCSC markers in clinical practice for predicting the prognosis of thyroid cancer requires further research to provide additional evidence supporting their effectiveness.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"686-690"},"PeriodicalIF":3.8,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between coagulation biomarkers, bone turnover markers, and bone mineral density in Chinese adults aged ≥ 50 years.","authors":"Zhengming Wang, Rui Wang, Haiya Ge, Yong Gu, Sicheng Xian, Laijun Yan, Guoqing Du, Zhibi Shen, Shuaijie Lv, Hongsheng Zhan, Zhengyan Li","doi":"10.5114/aoms/184346","DOIUrl":"10.5114/aoms/184346","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis patients undergoing surgery often have significant bleeding, which is closely related to coagulation function. This study aimed to assess the correlation between bone turnover markers (BTMs), bone mineral density (BMD), and coagulation biomarkers.</p><p><strong>Material and methods: </strong>Cases meeting the inclusion criteria were included from our center from January 2020 to December 2021. The relationships between coagulation biomarkers, BTMs, and BMD were investigated by Spearman correlation analysis and canonical correlation analysis (CCA). Consequently, age, bone mass stage, 25-hydroxyvitamin D (25-(OH)D), and BMD were included as independent variables in the logistic regression model. Furthermore, the international normalized ratio (INR), fibrinogen, platelets, and D-dimer levels were set as dependent variables in the regression analysis. Finally, multivariable regressions were conducted to adjust for differences in demographics and comorbidities among groups.</p><p><strong>Results: </strong>A total of 306 patients were included in the study. Significant differences were observed in prothrombin time, fibrinogen, INR, D-dimer, and platelets (<i>p</i> < 0.05). D-dimer exhibited the most significant positive association with age and the most pronounced negative correlation with the BMD of Ward's triangle (<i>r</i> = 0.322, <i>p</i> < 0.001; <i>r</i> = -0.298, <i>p</i> < 0.001; respectively). 25-(OH)D and calcium were related to coagulation biomarkers. Multivariate analysis demonstrated that age was positively associated with D-dimer levels (odd ratio [OR] = 1.046, <i>p</i> = 0.007), while the BMD of Ward's triangle was negatively related to D-dimer levels (OR = 0.004, <i>p</i> = 0.0017).</p><p><strong>Conclusions: </strong>For the Chinese population aged 50 and above, attention should be paid to alterations in coagulation biomarkers.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 6","pages":"1854-1863"},"PeriodicalIF":3.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between university students' attentional impulsivity levels and psychological and physiological stress responses.","authors":"Burcu Köksal","doi":"10.5114/aoms/183946","DOIUrl":"https://doi.org/10.5114/aoms/183946","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study is to investigate the relationship between attentional impulsivity levels and physiological and psychological stress responses of university students.</p><p><strong>Methods: </strong>300 university students participated in the study. Four different data collection tools were used in the study: a personal information form, the Physiological Stress Response Inventory, and the Attentional Impulsivity Part of Barratt Impulsiveness Scale.</p><p><strong>Results: </strong>We showed that attentional impulsivity of the participants is significantly related to both physiological stress responses (<i>R</i>² = 0.04, <i>F</i>[1;267] = 11.45, <i>p</i> < 0.05) and psychological stress responses (<i>R</i>² = 0.04, <i>F</i>[1;270] = 10.40, <i>p</i> < 0.05). At the same time, there is a significant negative association between physiological stress responses and psychological stress responses (<i>r</i> = -0.68).</p><p><strong>Conclusions: </strong>The attentional impulsivity is an important variable for explaining changes in both physiological and psychological stress responses. Physiological and psychological stress responses should be considered as separate kinds of stress responses in stress response measurements.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"698-703"},"PeriodicalIF":3.8,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for cervical instability in rheumatoid arthritis: a meta-analysis.","authors":"Min Wang, Jinhua Shen, Jianghong Tan, Xiaoling Zhu, Hongxia Ma, Zhenhua Wen, Yanzhen Tian, Weimin Jiang","doi":"10.5114/aoms/173494","DOIUrl":"https://doi.org/10.5114/aoms/173494","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to evaluate the risk factors for cervical instability in rheumatoid arthritis (RA).</p><p><strong>Material and methods: </strong>Computer searches were conducted in PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure (CNKI) database, the Wan Fang database, the Chinese Scientific Journal Databases (VIP) database, and the Chinese Biomedical Literature database (CBM) from their establishment until November 2022.</p><p><strong>Results: </strong>A total of 8 articles were included in this study, including 1 cross-sectional study, 5 case-control studies, and 2 cohort study, including 3078 patients with RA. Meta-analysis results showed that: male sex (OR = 1.70, 95% CI: 1.19-2.42), course of disease (OR = 1.72, 95% CI: 1.29-2.28), long-term glucocorticosteroid use (OR = 2.84, 95% CI: 1.97-2.40), Steinbrocker staging (OR = 2.30, 95% CI: 1.61-3.28), disability at baseline (OR = 24.57, 95% CI: 5.51-109.60), peripheral joint destruction (OR = 2.24, 95% CI: 1.56-3.21), Steinbrocker stage I-IV progression to disability (OR = 20.08, 95% CI: 4.18-96.53), and previous joint surgery (OR = 1.54, 95% CI: 1.06-2.26) are the main risk factors for cervical instability in RA.</p><p><strong>Conclusions: </strong>There are many risk factors for cervical instability in RA. In clinical practice, special attention should be paid to patients who are male, have a longer course of disease, have long-term glucocorticosteroid use, have previous joint surgery, have peripheral joint damage, and develop disability in Steinbrocker stage I-IV. Attention should be paid to the high-risk groups mentioned above, and effective measures such as early screening and full monitoring should be taken to prevent the occurrence of cervical instability in RA.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"375-383"},"PeriodicalIF":3.8,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of the Myval transcatheter heart valve system in patients with severe aortic valve stenosis: a two-year follow-up observational study.","authors":"Teoman Kilic, Alfonso Ielasi, Vlasis Ninios, Levent Korkmaz, Demosthenes Panagiotakos, Gokhan Yerlikaya, Ahmet Ozderya, Carolina Montonati, Maurizio Tespili, Senol Coskun, Tayfun Sahin, Ilias Ninios, Konstantina Vlasopoulou, Ali Hakan Konus, Selim Kul, Ali Riza Akyuz","doi":"10.5114/aoms/176937","DOIUrl":"https://doi.org/10.5114/aoms/176937","url":null,"abstract":"<p><strong>Introduction: </strong>Limited data exist on long-term follow-up of severe aortic stenosis (SAS) patients who have undergone transcatheter aortic valve implantation (TAVI) with a new generation, balloon expandable Myval transcatheter heart valve (THV). Thus, we sought to investigate the performance and 2-year clinical outcome of the Myval THV system based on Valve Academic Research Consortium-3 (VARC-3) criteria.</p><p><strong>Material and methods: </strong>A multi-centre, registry-based, observational study was conducted, which included 207 consecutive degenerative SAS patients, from Turkey (<i>n</i> = 128), Italy (<i>n</i> = 58), and Greece (<i>n</i> = 21) (mean [standard deviation] 81 (7) years, 94 [45%] men; 73% NYHA III or IV; EuroSCORE II 5.2% [2.4%]); all patients underwent TAVI with Myval. Patients were followed up at 1 year and 2 years after implantation. Clinical and procedural outcomes were defined according to VARC-3 criteria.</p><p><strong>Results: </strong>Technical success was observed in 204 (99%), device success was observed in 189 (91%), early safety was observed in 161 (78%), and clinical efficacy was observed in 163 (79%) patients. The 30-day death rate was 7.7%; of these, 3.4% were due to cardiovascular reasons. All-cause and cardiovascular mortality rates were 9.7% and 4.3% at 1-year follow-up, and 17.4% and 9.7% at 2-year follow-up, respectively. Incidence of ≥ moderate paravalvular leak (PVL) at 30 days, 1 year and 2 years of follow-up were 3.4%, 4.3% and 4.8%. A total of 11.1% of patients required a permanent pacemaker implantation (PPI) at 30 days after implantation, while the cumulative rate of PPI at 2 years was 12.1%.</p><p><strong>Conclusions: </strong>In this cohort of patients with SAS, the Myval was found to be safe and effective in up to 2 years of follow-up.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"410-419"},"PeriodicalIF":3.8,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of sodium-glucose cotransporter 2 inhibitors and the incidence of uveitis in type 2 diabetes: a population-based cohort study.","authors":"Jui-Fu Chung, Po-Jen Yang, Chao-Kai Chang, Chia-Yi Lee, Jing-Yang Huang, Kai Wang, Shun-Fa Yang","doi":"10.5114/aoms/174228","DOIUrl":"https://doi.org/10.5114/aoms/174228","url":null,"abstract":"<p><strong>Introduction: </strong>To survey the potential correlation between the application of sodium-glucose cotransporter 2 (SGLT2) inhibitors and the incidence of uveitis in individuals with type 2 diabetes mellitus (T2DM).</p><p><strong>Material and methods: </strong>A retrospective cohort study using the National Health Insurance Research Database (NHIRD) was conducted. The T2DM patients using SGLT2 inhibitors and those taking other anti-diabetic medications were assigned to the SGLT2 group and the control group, respectively, with a 1 : 2 ratio via the propensity score-matching (PSM) method. The major outcome in this study is the development of uveitis according to the diagnostic codes. The Cox proportional hazard regression was adopted to yield the adjusted hazard ratio (aHR) with 95% confidence interval (CI) between the groups.</p><p><strong>Results: </strong>There were 147 and 371 new uveitis episodes in the SGLT2 and control groups after the follow-up period up to 5 years. The incidence of uveitis in the SGLT2 group (aHR = 0.736, 95% CI: 0.602-0.899, <i>p</i> = 0.0007) was significantly lower than that in the control group after adjusting for the effect of all the confounders. In the subgroup analyses, the SGLT2 inhibitors showed a higher correlation with low uveitis incidence in T2DM patients aged under 50 than T2DM individuals aged over 50 years (<i>p</i> = 0.0012), while the effect of SGLT2 inhibitors on the incidence of anterior and posterior uveitis development was similar (<i>p</i> = 0.7993).</p><p><strong>Conclusions: </strong>The use of SGLT2 inhibitors could be an independent protective factor for uveitis development in T2DM population.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"402-409"},"PeriodicalIF":3.8,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological characteristics and prognostic factors in invasive micropapillary carcinoma of the breast.","authors":"Yao-Bang Liu, Xu-Tong Gao, Ling-Yan Huang, Xin-Lan Liu","doi":"10.5114/aoms/173213","DOIUrl":"10.5114/aoms/173213","url":null,"abstract":"<p><strong>Introduction: </strong>Invasive micropapillary carcinoma (IMPC) treatment only relies on the standard treatment of nonspecific invasive breast cancer (NSIBC), and it remains controversial whether the survival of patients improves. Therefore, this study aimed to analyze the clinicopathological features of IMPC and to investigate the factors affecting its prognosis.</p><p><strong>Material and methods: </strong>This retrospective cohort study included 104 IMPC patients who met the study's inclusion criteria out of a total of 4,532 patients with invasive breast cancer between January 2015 and December 2019. A contemporaneous cohort of 230 patients with non-specific invasive breast cancer (NSIBC) who underwent surgery was identified and matched using propensity scores.</p><p><strong>Results: </strong>The survival rate for patients with IMPC ranged from 1.12% to 7.03%. Statistically significant differences were observed in the proportion of endocrine treatment, lymphatic invasion, estrogen receptor (ER)-positive rate, molecular subtypes, molecular typing, and 5-year loco-regional recurrence-free survival (LRRFS) between the two cohorts (<i>p</i> < 0.05). The univariate analysis showed that T stage, N stage, lymphatic invasion, vascular invasion, ER-positive rate, and progesterone receptor (PR)-negative rate were all prognosis risk factors (<i>p</i> < 0.05) for IMPC. Furthermore, the multivariate analysis indicated that lymphatic invasion and N stage were independent prognostic factors (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The incidence of micropapillary IMPC, among other pathological subtypes, is steadily increasing. ER-positive and PR-positive rates, as well as luminal subtypes, are frequent, with a concurrent increase in the 5-year locoregional recurrence rate. It would be interesting to compare the effect following these therapeutic modifications in larger cohorts in future studies.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"428-435"},"PeriodicalIF":3.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cardiac-Kidney-Liver (CKL) syndrome: the \"real entity\" of type 2 diabetes mellitus.","authors":"Niki Katsiki, Genovefa Kolovou, Andreas Melidonis, Maciej Banach","doi":"10.5114/aoms/183070","DOIUrl":"10.5114/aoms/183070","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"207-215"},"PeriodicalIF":3.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of 2023 and the biggest challenges for the \"Archives of Medical Science\" on its 20^th Anniversary.","authors":"Maciej Banach","doi":"10.5114/aoms/183608","DOIUrl":"10.5114/aoms/183608","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 1","pages":"1-7"},"PeriodicalIF":3.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women suffering from systemic lupus erythematosus are characterized by low blood levels of α-dicarbonyl compounds.","authors":"Agnieszka Nowak, Brygida Przywara-Chowaniec, Aleksandra Damasiewicz-Bodzek, Beata Janoszka, Magdalena Szumska, Sławomir Waligóra, Krystyna Tyrpień-Golder","doi":"10.5114/aoms/176941","DOIUrl":"https://doi.org/10.5114/aoms/176941","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease, often characterised by severe course and unclear etiopathogenesis. The reaction of protein glycoxidation, also known as glycation, may be linked to etiopathogenesis of SLE. Advanced glycation end-products (AGEs) exhibit cytotoxic properties, affect cellular signalling, impair functions of extracellular proteins, and may act as neoepitopes. Glucosone (GS), glyoxal (GO), and methylglyoxal (MGO) are examples of α-dicarbonyl compounds (α-DCs) partaking in glycoxidation. The study aimed to evaluate concentrations of these three compounds in blood serum of SLE patients, and to compare the results with healthy individuals.</p><p><strong>Material and methods: </strong>31 women suffering from SLE and 26 healthy individuals were included in the study. High-performance liquid chromatography with fluorescence detection was applied to evaluate concentrations of α-DCs in their serum samples. Correlations between the results and parameters such as disease duration time, age, glomerular filtration rate (GFR), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and creatinine were analysed.</p><p><strong>Results: </strong>The SLE patients exhibited lower concentrations of glucosone, glyoxal, and methylglyoxal than the control group. Analysis of correlations showed a difference between the examined groups.</p><p><strong>Conclusions: </strong>In women suffering from SLE the course of α-DCs metabolism is altered. SLE patients are characterised by low serum levels of α-DCs. We hypothesise that either hindered proteasomal degradation or fast consumption of α-DCs in oxidative conditions may cause the observed low concentration of these compounds.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 3","pages":"743-750"},"PeriodicalIF":3.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}