Archives of Medical Science最新文献

{"title":"Factors affecting pregnant women's feelings of safety and depressive symptoms during the SARS-CoV-2 pandemic.","authors":"Maria Łuczak, Katarzyna Wszołek, Karolina Chmaj-Wierzchowska, Małgorzata Pięt, Maciej Wilczak","doi":"10.5114/aoms/186356","DOIUrl":"https://doi.org/10.5114/aoms/186356","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"679-681"},"PeriodicalIF":3.8,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive fluid balance and poor outcomes after initial intensive care unit admission in sepsis resuscitation: a retrospective study.","authors":"Longxiang Su, Shengjun Liu, Yingying Yang, Huizhen Jiang, Xiangyang Ye, Li Weng, Weiguo Zhu, Xinlun Tian, Yun Long","doi":"10.5114/aoms/172160","DOIUrl":"https://doi.org/10.5114/aoms/172160","url":null,"abstract":"<p><strong>Introduction: </strong>Fluid resuscitation of patients with sepsis is crucial. This study explored the role of fluid balance in the early resuscitation of sepsis patients in the intensive care unit (ICU).</p><p><strong>Material and methods: </strong>A retrospective study of patients with sepsis using the Peking Union Medical College Hospital Intensive Care Medical Information System and Database from January 2014 to June 2020 was performed. Based on the survival status on day 28, the training cohort was divided into an alive group (<i>n</i> = 1,803) and a deceased group (<i>n</i> = 429). Univariate and multivariate analyses were used to identify risk factors, and the integrated learning XGBoost algorithm was used to construct a model for predicting outcomes. ROC and Kaplan-Meier survival curves were used to evaluate the effectiveness of the model. A verification cohort (<i>n</i> = 433) was used to verify the model.</p><p><strong>Results: </strong>Univariate analysis showed that fluid balance is an important covariate. Based on the scatterplot distribution, a significant difference in mortality was determined between groups stratified with a balance of 1000 ml. There were associations in the multivariate analysis between poor outcomes and sex, PO₂/FiO₂, serum creatinine, FiO₂, platelets, respiratory rate, SPO₂, temperature, and total fluid volume (1000 ml). Among these variables, total fluid balance (1000 ml) had an OR of 1.98 (CI: 1.41-2.77, <i>p</i> < 0.001). Therefore, the model was built with these nine factors using XGBoost. Cross validation was used to verify generalizability. This model performed better than the SOFA and APACHE II models. The result was well verified in the verification cohort. A causal forest model suggested that patients with hypoxemia may suffer from positive fluid balance.</p><p><strong>Conclusions: </strong>Sepsis fluid resuscitation in the ICU should be a targeted and goal-oriented treatment. A new prognostic prediction model was constructed and indicated that a 6-hour positive fluid balance after ICU initial admission is a risk factor for poor outcomes in sepsis patients. A 6-hour fluid balance above 1000 ml should be performed with caution.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"464-475"},"PeriodicalIF":3.8,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomeres and telomerase in endometrial cancer and hyperplasia.","authors":"Anna Pańczyszyn, Ewa Boniewska-Bernacka, Karolina Włodarczyk, Iwona Wertel, Anna Goc","doi":"10.5114/aoms/186189","DOIUrl":"https://doi.org/10.5114/aoms/186189","url":null,"abstract":"<p><strong>Introduction: </strong>The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer.</p><p><strong>Methods: </strong>Total RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length.</p><p><strong>Results: </strong>The control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length.</p><p><strong>Conclusions: </strong>Telomere extension in endometrial cancer is mediated by telomerase, but telomere length may not be an indicator of endometrioid cancer development.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"682-685"},"PeriodicalIF":3.8,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gedunin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine.","authors":"Weixiang Zhang, Yongshuai Dong, Chenkun Sun","doi":"10.5114/aoms/183651","DOIUrl":"https://doi.org/10.5114/aoms/183651","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the anti-cancer effects of gedunin, a natural compound, in a rat model of gastric carcinogenesis induced by MNNG.</p><p><strong>Methods: </strong>Fifty-four rats were randomly assigned to six groups for a 60-day study on the effects of MNNG and gedunin. Groups 1-4 received 200 mg/kg MNNG (1, 10, or 100 mg/kg), and group 5 had only 100 mg/kg gedunin.</p><p><strong>Results: </strong>Gedunin at low doses exhibited anti-cancer and protective properties against MNNG-induced damage, including reduced inflammation, and apoptosis.</p><p><strong>Conclusions: </strong>Gedunin demonstrates a U-shaped dose-response, with low doses offering protection and high doses promoting tumor growth.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"691-697"},"PeriodicalIF":3.8,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymosin β4 improves the survival of cutaneous flaps of rats and activates the Wnt/β-catenin pathway.","authors":"Xianyao Tao, Xiaoyun Pan, Mingyu Xue, Gang Zhao, Yongjun Rui","doi":"10.5114/aoms/186188","DOIUrl":"https://doi.org/10.5114/aoms/186188","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"708-712"},"PeriodicalIF":3.8,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of maxillary sinus floor elevation with or without bone grafts: a systematic review and meta-analysis of randomised controlled trials with trial sequential analysis.","authors":"Jiayi Chen, Yiping Lu, Jin Xu, Zhen Hua","doi":"10.5114/aoms/174648","DOIUrl":"https://doi.org/10.5114/aoms/174648","url":null,"abstract":"<p><strong>Introduction: </strong>Our goal was to systematically review the current evidence comparing the relative effectiveness of two maxillary sinus floor elevation (MSFE) approaches (internal and external) without bone grafts with that of conventional/grafted MSFE in patients undergoing implantation in the posterior maxilla.</p><p><strong>Material and methods: </strong>Medical databases (PubMed/Medline, Embase, Web of Science, and Cochrane Library) were searched for randomised controlled trials published between January 1980 and May 2023. A manual search of implant-related journals was also performed. Studies published in English that reported the clinical outcomes of MSFE with or without bone material were included. The risk of bias was assessed using the Cochrane Handbook Risk Assessment Tool. Meta-analyses and trial sequence analyses were performed on the included trials. Meta-regression analysis was performed using pre-selected covariates to account for substantial heterogeneity. The certainty of evidence for clinical outcomes was assessed using GRADEpro GDT online (Guideline Development Tool).</p><p><strong>Results: </strong>Seventeen studies, including 547 sinuses and 696 implants, were pooled for the meta-analysis. The meta-analysis showed no statistically significant difference between MSFE without bone grafts and conventional MSFE in terms of the implant survival rate in the short term (<i>n</i> = 11, <i>I</i>² = 0%, risk difference (RD): 0.03, 95% confidence intervals (CI): -0.01-0.07, <i>p</i> = 0.17, required information size (RIS) = 307). Although conventional MSFE had a higher endo-sinus bone gain (<i>n</i> = 13, <i>I</i>² = 89%, weighted mean difference (WMD): -1.24, 95% CI: -1.91- -0.57, <i>p</i> = 0.0003, RIS = 461), this was not a determining factor in implant survival. No difference in perforation (<i>n</i> = 13, <i>I</i>² = 0%, RD = 0.03, 95% CI: -0.02-0.09, <i>p</i> = 0.99, RIS = 223) and marginal bone loss (<i>n</i> = 4, <i>I</i>² = 0%, WMD = 0.05, 95% CI: -0.14-0.23, <i>p</i> = 0.62, no RIS) was detected between the two groups using meta-analysis. The pooled results of the implant stability quotient between the two groups were not robust on sensitivity analysis. Because of the limited studies reporting on the visual analogue scale, surgical time, treatment costs, and bone density, qualitative analysis was conducted for these outcomes.</p><p><strong>Conclusions: </strong>This systematic review revealed that both non-graft and grafted MSFE had high implant survival rates. Owing to the moderate strength of the evidence and short-term follow-up, the results should be interpreted with caution.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"384-401"},"PeriodicalIF":3.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Guidelines of the Polish Society of Laboratory Diagnostics and the Polish Lipid Association on laboratory diagnostics of lipid metabolism disorders.","authors":"Bogdan Solnica, Grażyna Sygitowicz, Dariusz Sitkiewicz, Jacek Jóźwiak, Sławomir Kasperczyk, Marlena Broncel, Anna Wolska, Grażyna Odrowąż-Sypniewska, Maciej Banach","doi":"10.5114/aoms/186191","DOIUrl":"https://doi.org/10.5114/aoms/186191","url":null,"abstract":"<p><p>Lipid disorders are the most common (even 70%) and worst monitored cardiovascular risk factor (only 1/4 of patients in Poland and in CEE countries are on the low-density lipoprotein cholesterol (LDL-C) goal). To improve this, clear and simple diagnostic criteria should be introduced for all components of the lipid profile. These are the updated guidelines of the two main scientific societies in Poland in the area - the Polish Society of Laboratory Diagnostics (PSLD) and the Polish Lipid Association (PoLA), which, in comparison to those from 2020, introduce few important changes in recommendations (two main lipid targets, new recommendations on LDL-C measurements, calculations new goals for triglycerides, new recommendations on remnants and small dense LDL) that should help the practitioners to be early with the diagnosis of lipid disorders and in the effective monitoring (after therapy initiation), and in the consequence to avoid the first and recurrent cardiovascular events.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"357-374"},"PeriodicalIF":3.8,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inheritance of Hb S and G6PD deficiency in a familiar group.","authors":"Claudia Bonini Domingos, Jonathan de Oliveira Rios, Leticia Cardoso Orlandini, Lucas Ramos Pereira","doi":"10.5114/aoms/185325","DOIUrl":"https://doi.org/10.5114/aoms/185325","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"704-707"},"PeriodicalIF":3.8,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of cancer stem cell markers in thyroid cancer: a systematic review.","authors":"Xingqiao Peng, Peiye Zhu, Qiang Zhang, Jin Li","doi":"10.5114/aoms/185169","DOIUrl":"https://doi.org/10.5114/aoms/185169","url":null,"abstract":"<p><strong>Introduction: </strong>Thyroid cancer stem cells (TCSCs) play a crucial role in the pathogenesis, metastasis, and therapeutic response of thyroid cancer, making them promising biomarkers and potential targets for clinical intervention. This systematic review aims to qualitatively assess the impact of commonly used TCSC markers on the prognosis of thyroid cancer using qualitative methods.</p><p><strong>Methods: </strong>In total, the analysis encompassed five articles.</p><p><strong>Results: </strong>Six TCSC markers were involved, among which CD133, CD44, CD24, CD15 and ALDH1 were associated with the prognosis of thyroid cancer.</p><p><strong>Conclusions: </strong>However, the utility of these TCSC markers in clinical practice for predicting the prognosis of thyroid cancer requires further research to provide additional evidence supporting their effectiveness.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 2","pages":"686-690"},"PeriodicalIF":3.8,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between coagulation biomarkers, bone turnover markers, and bone mineral density in Chinese adults aged ≥ 50 years.","authors":"Zhengming Wang, Rui Wang, Haiya Ge, Yong Gu, Sicheng Xian, Laijun Yan, Guoqing Du, Zhibi Shen, Shuaijie Lv, Hongsheng Zhan, Zhengyan Li","doi":"10.5114/aoms/184346","DOIUrl":"10.5114/aoms/184346","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis patients undergoing surgery often have significant bleeding, which is closely related to coagulation function. This study aimed to assess the correlation between bone turnover markers (BTMs), bone mineral density (BMD), and coagulation biomarkers.</p><p><strong>Material and methods: </strong>Cases meeting the inclusion criteria were included from our center from January 2020 to December 2021. The relationships between coagulation biomarkers, BTMs, and BMD were investigated by Spearman correlation analysis and canonical correlation analysis (CCA). Consequently, age, bone mass stage, 25-hydroxyvitamin D (25-(OH)D), and BMD were included as independent variables in the logistic regression model. Furthermore, the international normalized ratio (INR), fibrinogen, platelets, and D-dimer levels were set as dependent variables in the regression analysis. Finally, multivariable regressions were conducted to adjust for differences in demographics and comorbidities among groups.</p><p><strong>Results: </strong>A total of 306 patients were included in the study. Significant differences were observed in prothrombin time, fibrinogen, INR, D-dimer, and platelets (<i>p</i> < 0.05). D-dimer exhibited the most significant positive association with age and the most pronounced negative correlation with the BMD of Ward's triangle (<i>r</i> = 0.322, <i>p</i> < 0.001; <i>r</i> = -0.298, <i>p</i> < 0.001; respectively). 25-(OH)D and calcium were related to coagulation biomarkers. Multivariate analysis demonstrated that age was positively associated with D-dimer levels (odd ratio [OR] = 1.046, <i>p</i> = 0.007), while the BMD of Ward's triangle was negatively related to D-dimer levels (OR = 0.004, <i>p</i> = 0.0017).</p><p><strong>Conclusions: </strong>For the Chinese population aged 50 and above, attention should be paid to alterations in coagulation biomarkers.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 6","pages":"1854-1863"},"PeriodicalIF":3.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}