Archives of Medical Science最新文献

Generalized arterial calcifications in a twin recipient treated with etidronate: description of a case report within a narrative review.

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/194435

Carla Giuseppina Corti, Luisa Federica Nespoli, Alessandro Campari, Eleonora Gnan, Massimiliano Ruscica, Stefano Carugo

引用次数: 0

Withdrawn: Long non-coding RNA SNHG1 promotes cell proliferation and invasion of hepatocellular carcinoma by acting as a molecular sponge to modulate miR-195.

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/196465

Shuai Zhang, Xiaoding Song

引用次数: 0

Analysis of the causal relationship between hyperlipidaemia and exercise intensity: based on two-sample Mendelian randomisation.

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/194192

Yijian Chu

引用次数: 0

Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation.

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/183465

M Hidayat Budi Kusumo, Adi Prayitno, Soetrisno, Abdurahman Laqif

{"title":"Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation.","authors":"M Hidayat Budi Kusumo, Adi Prayitno, Soetrisno, Abdurahman Laqif","doi":"10.5114/aoms/183465","DOIUrl":"10.5114/aoms/183465","url":null,"abstract":"Introduction: Mesenchymal stem cells (MSCs) have promising regenerative properties in tissue repair and anti-inflammatory responses. This study aimed to investigate the effects of MSCs and their combination with micronized purified flavonoid fraction (MPFF) in a croton oil-induced hemorrhoids model on tissue edema, inflammation, and underlying molecular mechanisms.Material and methods: MSCs were isolated and characterized for their adherence, differentiation capacity, and immunophenotyping. Croton oil-induced hemorrhoid mouse models were established to assess tissue edema, inflammation, tumor necrosis factor (TNF-α) expression, transforming growth factor-β (TGF-β) expression, collagen ratio, and MMP-9 activity. The effects of MSCs and their combination with MPFF (diosmin-hesperidin) were evaluated through histological examinations, western blot analysis, and gelatin zymography.Results: Characterization confirmed the MSCs' plastic adherence, osteogenic differentiation potential, and immunophenotype (positive for CD90 and CD29, negative for CD45 and CD31). Treatment with MSCs alone or in combination with MPFF significantly reduced tissue edema, inflammation, TNF-α expression, and MMP-9 activity. Additionally, MSCs increased TGF-β expression, and collagen type I/III ratio, and accelerated wound healing by resolving inflammation.Conclusions: These findings suggest that MSCs play a crucial role in modulating TNF-α, TGF-β, collagen remodeling, and MMP-9 activity, highlighting their promising role in hemorrhoid treatment and wound healing processes. Further research is warranted to fully elucidate the intricate mechanisms and optimize MSC-based therapies for clinical applications in hemorrhoidal disease management.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1556-1566"},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the STING inflammatory pathway in hepatic damage in psoriasis with type 2 diabetes mellitus.

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/183672

Shulin Huang, Kun Xie, Xiaohong Li, Xiangjin Xu, Pin Chen

{"title":"The role of the STING inflammatory pathway in hepatic damage in psoriasis with type 2 diabetes mellitus.","authors":"Shulin Huang, Kun Xie, Xiaohong Li, Xiangjin Xu, Pin Chen","doi":"10.5114/aoms/183672","DOIUrl":"10.5114/aoms/183672","url":null,"abstract":"Introduction: Studies have suggested a potential association between patients who have both psoriasis and diabetes and liver damage. However, the exact nature of this link has not yet been fully established. The objective of the current study was to examine the potential exacerbation of liver damage due to the coexistence of psoriasis and type 2 diabetes mellitus (T2DM) and to explore the impact of interferon gene stimulating factor (STING) on related damage.Material and methods: Four patient groups were recruited: normal individuals, individuals with diabetes, those with psoriasis, and those with both diabetes and psoriasis. Relevant indicators were collected to facilitate the investigation. Furthermore, a mouse model of psoriasis combined with T2DM was established. The expression levels of STING and inflammatory factors downstream of the pathway were detected in both the skin and liver tissues of the model mice.Results: Based on our findings, patients with both psoriasis and T2DM exhibit abnormal liver function and increased STING expression in the skin (p < 0.05). In the in vivo experiments, liver tissues from model mice exhibited significantly elevated expression of STING and its downstream inflammatory factors, including NF-κB p65, interferon-β, interleukin (IL)-17A, and IL-23 (p < 0.05). The STING inhibitor-treated group displayed reduced skin damage and improved liver histopathology (p < 0.05).Conclusions: The findings of the current study indicate that the STING inflammatory pathway is upregulated in the liver tissues of individuals with psoriasis and T2DM.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1426-1441"},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal associations of ambient particulate matter 10 and Alzheimer's disease: result from a two-sample multivariable Mendelian randomization study.

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/185360

Zehan Huang, Guodong He, Shuo Sun, Yingqing Feng, Yuqing Huang

{"title":"Causal associations of ambient particulate matter 10 and Alzheimer's disease: result from a two-sample multivariable Mendelian randomization study.","authors":"Zehan Huang, Guodong He, Shuo Sun, Yingqing Feng, Yuqing Huang","doi":"10.5114/aoms/185360","DOIUrl":"10.5114/aoms/185360","url":null,"abstract":"Introduction: Alzheimer's disease (AD) and ambient particulate matter 10 (PM10) have been associated in epidemiological studies. However, the relationship between PM10 and risk of AD has not been proven to be causal. Thus we used two-sample multivariable Mendelian randomization (MR) to examine this relationship.Material and methods: Genome-wide association studies (GWAS) for PM10 from UK Biobank, AD from EBI GWAS and IEU OpenGWAS were used for discovery and replication, respectively. Pooled meta-analysis of the inverse variance weighted (IVW) method was the main method. Sensitivity analyses included MR-Egger regression, weighted median, weighted mode and leave-one-out methods. The multivariable MR model adjusted for education. The MR estimates of causality association were expressed as odds ratios (OR) and corresponding 95% confidence intervals (CI).Results: There were in total 17 and 19 genetic variants associated with PM10 in the discovery and replication steps, respectively. In the univariate MR, pooled meta-analysis of genetically predicted PM10 was associated with a 99% increased risk of AD (95% CI: 1.25, 3.15, p = 0.004) per 1 standard deviation (SD) increment of PM10 by IVW, and in the multivariable MR with pooled meta-analysis, we found that each SD increase in PM10 was associated with a 127% increase in the risk of AD (95% CI: 1.33, 3.86, p = 0.002) after accounting for education levels.Conclusions: Increased PM10 levels were found to be significantly related to an increased risk of AD. This study provided evidence of genetic prediction of a causal relationship between PM10 and the risk of AD, suggesting that air pollution control may have significant implications for the prevention of AD.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1604-1618"},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Income level is associated with differences in primary and secondary stroke prevention in China.

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/178269

Huiming Ren, Junrong Ma, Xu Guo, Ruijie Zhang, Liyuan Pu, Tian Zhao, Fangfang Zeng, Chang Shu, Liyuan Han, Yunzhi Wang, Qiang Li, Xiaojie Wang

{"title":"Income level is associated with differences in primary and secondary stroke prevention in China.","authors":"Huiming Ren, Junrong Ma, Xu Guo, Ruijie Zhang, Liyuan Pu, Tian Zhao, Fangfang Zeng, Chang Shu, Liyuan Han, Yunzhi Wang, Qiang Li, Xiaojie Wang","doi":"10.5114/aoms/178269","DOIUrl":"10.5114/aoms/178269","url":null,"abstract":"Introduction: The aim of this study was to assess differences in the effects of income level on the primary and secondary prevention of stroke in the Chinese population.Material and methods: This was a population-based study using data from a China Kadoorie Biobank survey that began in 2004 in 10 geographical regions. Community residents (n = 512,715) aged 30-79 years were recruited. Stroke was determined by the self-reporting of a doctor's diagnosis, and participants with a high risk of stroke were identified using the model developed in the Prediction for ASCVD Risk in China study.Results: The final numbers of people included in this study were 8,884 with stroke and 218,972 with a high risk of stroke. The participants' income level was positively associated with high levels of physical activity and the consumption of a healthy diet, but negatively associated with the control of alcohol consumption (all p < 0.05). In addition, positive associations were observed between the control of smoking and the use of antiplatelet and antihypertensive medication for primary prevention (all p < 0.05), but there was a negative association with the control of blood pressure (p < 0.001).Conclusions: Low-income individuals were less likely to control smoking and their diet and use preventive medications, while high-income individuals were less likely to control their alcohol consumption and blood pressure. Moreover, medication use was low for both primary and secondary prevention in high-income individuals.","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1472-1483"},"PeriodicalIF":3.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of cataract surgery with risk of dementia: a meta-analysis and systematic review of cohort studies with 720,075 participants.

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/193394

Qin Li, Liangqiong Zhu

引用次数: 0

Diagnostic value of circulating bone turnover markers osteocalcin, cathepsin K, and osteoprotegerin for osteoporosis in middle-aged and elderly postmenopausal women.

IF 3 4区医学

Archives of Medical Science Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/193198

Lei Zhang, Jiaxiang Cheng, Hang Su, Zhaoxia Wang, Weiyi Dai

引用次数: 0

Metabolism score for visceral fat (METS-VF): an innovative and powerful predictor of stroke.