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lncRNA PCA3 plays a key role in colon cancer occurrence and development. lncRNA PCA3在结肠癌的发生发展中起关键作用。
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-11-05 eCollection Date: 2026-01-01 DOI: 10.5114/aoms.2020.100674
Yan Pan, Lijing Zhu, Juan Pu, Wanpeng Wang, Weihe Qian
{"title":"lncRNA PCA3 plays a key role in colon cancer occurrence and development.","authors":"Yan Pan, Lijing Zhu, Juan Pu, Wanpeng Wang, Weihe Qian","doi":"10.5114/aoms.2020.100674","DOIUrl":"10.5114/aoms.2020.100674","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the effects of the lncRNA PCA3 in colon cancer and the associated mechanisms.</p><p><strong>Material and methods: </strong>Adjacent normal and cancer tissues were collected from colon cancer patients, and their PCA3 expression was measured by ISH and RT-qPCR assays. The correlations of PCA3 with clinical pathology and prognosis were also analysed. In addition, PCA3 and si-PCA3 were transfected into colon cancer cells (HT-29 and SW620). Moreover, cell proliferation, apoptosis, number of invading cells, and wound healing rate were determined by MTT, flow cytometry, Transwell, and wound healing assays. The relative protein expression was evaluated by western blotting.</p><p><strong>Results: </strong>Compared with that in normal tissues, PCA3 expression was significantly increased in colon cancer (<i>p</i> < 0.001). High PCA3 expression was correlated with malignant pathology and poor prognosis in patients. Compared with that in HCoEpic cells, PCA3 gene expression was significantly upregulated in SW480, HT-29, SW620, and HCT116 cells (all <i>p</i> < 0.01). With PCA3 transfection, cell proliferation increased, apoptosis decreased, and the number of invading cells and wound healing rate increased. In addition, RhoC, Bcl-2 and MMP-2 proteins increased, while Bax was suppressed. With the transfection of si-PCA3, which knocked down PCA3 expression, cell proliferation decreased, apoptosis increased, and the number of invading cells and wound healing rate decreased. Furthermore, RhoC, Bcl-2, and MMP-2 proteins decreased, while Bax increased.</p><p><strong>Conclusions: </strong>PCA3 is an oncogene in colon cancer. <i>In vitro</i> analysis indicates that knockdown of PCA3 suppresses the biological activities of colon cancer cells via the regulation of RhoC.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"190 1","pages":"1717-1737"},"PeriodicalIF":3.6,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13426163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71052691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological trends and future projections of vertebral fracture in BRICS countries: a GBD 2023 study. 金砖国家椎体骨折的流行病学趋势和未来预测：GBD 2023研究
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-08-31 eCollection Date: 2026-01-01 DOI: 10.5114/aoms/231346
Ri-Peng Zhang
{"title":"Epidemiological trends and future projections of vertebral fracture in BRICS countries: a GBD 2023 study.","authors":"Ri-Peng Zhang","doi":"10.5114/aoms/231346","DOIUrl":"https://doi.org/10.5114/aoms/231346","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2496-2499"},"PeriodicalIF":3.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary renal parenchymal squamous cell carcinoma: a case report and literature review. 原发性肾实质鳞状细胞癌1例报告并文献复习。
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-08-31 eCollection Date: 2026-01-01 DOI: 10.5114/aoms/235877
Lingze Hu, Dilare Aximu, Qianqian Yang, Liejun Mei, Fenfang Zhou
{"title":"Primary renal parenchymal squamous cell carcinoma: a case report and literature review.","authors":"Lingze Hu, Dilare Aximu, Qianqian Yang, Liejun Mei, Fenfang Zhou","doi":"10.5114/aoms/235877","DOIUrl":"https://doi.org/10.5114/aoms/235877","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2522-2533"},"PeriodicalIF":3.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allostatic load and incident stroke risk in middle-aged and older Chinese adults: a prospective cohort study from CHARLS. 中国中老年成人的适应负荷和卒中风险：CHARLS的一项前瞻性队列研究
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-08-27 eCollection Date: 2026-01-01 DOI: 10.5114/aoms/231562
Jingya Wang, Yuhan Ai, Monan Yan, Zhiqing Zhang, Wenjie Zhang
{"title":"Allostatic load and incident stroke risk in middle-aged and older Chinese adults: a prospective cohort study from CHARLS.","authors":"Jingya Wang, Yuhan Ai, Monan Yan, Zhiqing Zhang, Wenjie Zhang","doi":"10.5114/aoms/231562","DOIUrl":"https://doi.org/10.5114/aoms/231562","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2486-2489"},"PeriodicalIF":3.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focal segmental glomerulosclerosis associated with anti-synthetase syndrome: coincidental coexistence or potential causal relationship? 局灶节段性肾小球硬化与抗合成酶综合征相关：巧合共存还是潜在的因果关系？
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-08-25 eCollection Date: 2026-01-01 DOI: 10.5114/aoms/225239
Bin Qu, Ying Luo, Cheng M Zeng, Hui B Li, Jie Li
{"title":"Focal segmental glomerulosclerosis associated with anti-synthetase syndrome: coincidental coexistence or potential causal relationship?","authors":"Bin Qu, Ying Luo, Cheng M Zeng, Hui B Li, Jie Li","doi":"10.5114/aoms/225239","DOIUrl":"https://doi.org/10.5114/aoms/225239","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2507-2510"},"PeriodicalIF":3.6,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic frailty and incident cardiometabolic multimorbidity in Chinese adults. 中国成年人的动态衰弱和突发心脏代谢多发病。
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-08-25 eCollection Date: 2026-01-01 DOI: 10.5114/aoms/231563
Hao Chen, Shengnan Yue, Zhaozhi Zhang, Yiqiang Wang, Jiajuan Guo
{"title":"Dynamic frailty and incident cardiometabolic multimorbidity in Chinese adults.","authors":"Hao Chen, Shengnan Yue, Zhaozhi Zhang, Yiqiang Wang, Jiajuan Guo","doi":"10.5114/aoms/231563","DOIUrl":"https://doi.org/10.5114/aoms/231563","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2475-2478"},"PeriodicalIF":3.6,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steroidal mineralocorticoid receptor antagonist use and all-cause mortality in patients with heart failure: insights from the HEROES study. 心力衰竭患者使用甾体矿皮质激素受体拮抗剂和全因死亡率：来自HEROES研究的见解
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-08-25 eCollection Date: 2026-01-01 DOI: 10.5114/aoms/231569
Iwona Gorczyca-Głowacka, Michał Tarnowski, Anna Furman-Niedziejko, Agnieszka Major, Przemysław Leszek
{"title":"Steroidal mineralocorticoid receptor antagonist use and all-cause mortality in patients with heart failure: insights from the HEROES study.","authors":"Iwona Gorczyca-Głowacka, Michał Tarnowski, Anna Furman-Niedziejko, Agnieszka Major, Przemysław Leszek","doi":"10.5114/aoms/231569","DOIUrl":"https://doi.org/10.5114/aoms/231569","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2469-2474"},"PeriodicalIF":3.6,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary detection and characterization of microplastics in human coronary atherosclerotic plaques. 人类冠状动脉粥样硬化斑块中微塑料的初步检测和表征。
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-08-24 eCollection Date: 2026-01-01 DOI: 10.5114/aoms/230932
Jianfeng Long, Kang Zhou
{"title":"Preliminary detection and characterization of microplastics in human coronary atherosclerotic plaques.","authors":"Jianfeng Long, Kang Zhou","doi":"10.5114/aoms/230932","DOIUrl":"https://doi.org/10.5114/aoms/230932","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2461-2464"},"PeriodicalIF":3.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teclistamab for ultrahigh-risk multiple myeloma with isolated central nervous system relapse. 特司他单抗治疗孤立性中枢神经系统复发的高危多发性骨髓瘤。
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-08-21 eCollection Date: 2026-01-01 DOI: 10.5114/aoms/230992
Huan Xie, Ran Luo, Dongfeng Zeng
{"title":"Teclistamab for ultrahigh-risk multiple myeloma with isolated central nervous system relapse.","authors":"Huan Xie, Ran Luo, Dongfeng Zeng","doi":"10.5114/aoms/230992","DOIUrl":"https://doi.org/10.5114/aoms/230992","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2518-2521"},"PeriodicalIF":3.6,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Stand up to stay healthy? 社论：站起来保持健康？
IF 3.6 4区 医学
Archives of Medical Science Pub Date : 2026-08-21 eCollection Date: 2026-01-01 DOI: 10.5114/aoms/226709
Amedeo Lonardo, Ralf Weiskirchen
{"title":"Editorial: Stand up to stay healthy?","authors":"Amedeo Lonardo, Ralf Weiskirchen","doi":"10.5114/aoms/226709","DOIUrl":"https://doi.org/10.5114/aoms/226709","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2095-2097"},"PeriodicalIF":3.6,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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