Archives of Medical Science最新文献

{"title":"Life expectancy in clinical practice: assessment, communication, and decision-making.","authors":"Consolato M Sergi","doi":"10.5114/aoms/226458","DOIUrl":"https://doi.org/10.5114/aoms/226458","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2511-2517"},"PeriodicalIF":3.6,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital-sinonasal interface tumors (OSITs): a preliminary anatomical classification system and surgical approach.","authors":"Anunya Deewijit, Jin Chen, Yuanjin Li, Bowen Wang, Yamin Mao, Fagang Jiang","doi":"10.5114/aoms/226688","DOIUrl":"https://doi.org/10.5114/aoms/226688","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2500-2506"},"PeriodicalIF":3.6,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum lactate dehydrogenase and prevalence of diabetic kidney disease in Chinese patients with type 1 diabetes mellitus: a cross-sectional study.","authors":"Hui Zhao, Yu Wang, Zouxi Du, Limin Tian","doi":"10.5114/aoms/225401","DOIUrl":"https://doi.org/10.5114/aoms/225401","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2479-2485"},"PeriodicalIF":3.6,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the perception and use of artificial intelligence among physicians, medical students, and other healthcare professionals.","authors":"Alicja J Główka, Jakub M Bajer, Zofia Hryniewiecka, Paulina Chomiak, Michał Silny, Maciej Owecki","doi":"10.5114/aoms/225477","DOIUrl":"https://doi.org/10.5114/aoms/225477","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2457-2460"},"PeriodicalIF":3.6,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond muscle: could GLP-1 receptor agonists offset the tendon risk of intensive lipid-lowering therapy?","authors":"Yashendra Sethi, Kunal Mahajan, Maciej Banach","doi":"10.5114/aoms/226714","DOIUrl":"https://doi.org/10.5114/aoms/226714","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2002-2005"},"PeriodicalIF":3.6,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic alterations and redox homeostasis in ferroptosis: emerging mechanisms and therapeutic implications.","authors":"Mirjana Macvanin, Dušan Spasić, Sanja Gluscevic, Tatjana Srdić-Rajić, Aleksandra Klisic","doi":"10.5114/aoms/225096","DOIUrl":"https://doi.org/10.5114/aoms/225096","url":null,"abstract":"<p><p>Ferroptosis is a programmed cell death characterized by excessive, iron-dependent accumulation of membrane lipid peroxides due to insufficient glutathione-dependent antioxidant defense. It is influenced by the metabolism of amino acids, lipids, and iron, and occurs in conditions of decreased glutathione peroxidase 4 (GPX4) activity. The increased polyunsaturated fatty acid (PUFA) content in membrane phospholipids is associated with cellular hypersusceptibility to ferroptosis. In contrast, incorporation of monounsaturated fatty acids may protect cells against ferroptotic cell death. Cellular sensitivity to ferroptosis is additionally influenced by glutamine catabolism and the xc-system-mediated import of cystine, which modulate glutathione production, and by elevated iron levels, which lead to the buildup of reactive oxygen species (ROS) that attack membrane-localized PUFAs. This review focuses on recent findings of perturbed metabolic processes in cancer that create a high iron demand and an altered lipid composition, thereby predisposing cells to ferroptosis. We analyze the therapeutic potential of pharmacological agents that can selectively trigger ferroptosis in tumor cells.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2231-2249"},"PeriodicalIF":3.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unequal burden of interstitial lung disease mortality in older US adults: a 22-year analysis and projections to 2030.","authors":"Tong Feng, Pengcheng Zheng, Yue Cao, Ding Han, Ran Duan","doi":"10.5114/aoms/224183","DOIUrl":"https://doi.org/10.5114/aoms/224183","url":null,"abstract":"<p><strong>Introduction: </strong>Interstitial lung disease (ILD) comprises a heterogeneous group of disorders characterized by progressive lung fibrosis, respiratory failure, and substantial mortality, particularly among older adults. While prior studies have described historical ILD mortality trends, comprehensive analyses incorporating future projections, detailed geographic disparities, and socioeconomic variation remain limited.</p><p><strong>Material and methods: </strong>We analyzed CDC WONDER underlying-cause-of-death data for US adults aged ≥ 65 years from 1999 to 2020. ILD deaths were identified using ICD-10 code J84, and age-adjusted mortality rates (AAMRs) per 100,000 population were calculated using the 2000 US standard population. Joinpoint regression was used to identify turning points in mortality trends, autoregressive integrated moving average (ARIMA) modeling was used to project AAMRs through 2030, and Socio-demographic Index (SDI)-based correlation and frontier analyses were used to evaluate geographic and socioeconomic disparities in ILD mortality.</p><p><strong>Results: </strong>A total of 305,452 ILD deaths were recorded among US adults aged ≥ 65 years, with an overall AAMR of 33.45 per 100,000 population. Mortality increased significantly from 1999 to 2006 and then stabilized through 2020, with ARIMA models projecting continued stability through 2030. Significant disparities persisted, with mortality rates highest among males, American Indian or Alaska Native populations, Hispanic or Latino individuals, and residents of Western and Midwestern states. State-level analyses showed that lower SDI was generally associated with higher AAMR, with several states exhibiting excess mortality relative to their socioeconomic development levels.</p><p><strong>Conclusions: </strong>Although ILD mortality among older US adults stabilized after the mid-2000s and is projected to remain stable through 2030, substantial disparities persist across sex, race/ethnicity, geography, and socioeconomic context. These findings suggest that future reductions in ILD mortality may depend less on broad population-level declines and more on targeted strategies focused on high-burden groups and regions.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"1961-1969"},"PeriodicalIF":3.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 receptor agonists and tendon healing: a systematic review and meta-analysis.","authors":"Mohammed Y Khayyat, Yasir M Khayyat","doi":"10.5114/aoms/225241","DOIUrl":"https://doi.org/10.5114/aoms/225241","url":null,"abstract":"<p><strong>Introduction: </strong>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are prescribed for cardiometabolic indications and may exert anti-inflammatory and tissue-regenerative effects. However, their effect on tendon healing and tendon-related surgical outcomes remains unclear. In this systematic review and meta-analysis, we evaluated the available preclinical and clinical evidence on the effects of GLP-1RAs on tendon healing and related musculoskeletal outcomes.</p><p><strong>Methods: </strong>A systematic search of the PubMed, Embase, Medline, Scopus, Clinical Key, Google Scholar, and Cochrane databases was conducted from database inception to December 31, 2025. Eligible studies included animal studies, human experimental studies, and retrospective clinical cohorts that evaluated GLP-1RA exposure in relation to tendon biology, tendon healing, or tendon-related orthopedic outcomes. Risk of bias was assessed using design-appropriate tools, including SYRCLE, ROBINS-I, the Newcastle-Ottawa Scale, SANRA, AMSTAR 2, and the NIH assessment tool.</p><p><strong>Results: </strong>A total of 41 studies were included: eight animal studies, three human experimental studies, six retrospective cohort studies, one prospective study, 18 review or commentary articles, and five systematic reviews. Preclinical evidence generally supported the tendon-promoting effects of GLP-1RAs through the modulation of inflammation, fibroblast activity, angiogenesis, and extracellular matrix remodeling. Quantitative synthesis of two retrospective cohorts evaluating revision risk after total shoulder arthroplasty suggested a lower risk among GLP-1RA users than non-users. However, only two studies were eligible for pooling, and significant clinical heterogeneity remained across the available cohorts.</p><p><strong>Conclusions: </strong>GLP-1RAs demonstrate biologically plausible tendon healing benefits in preclinical models, with a potentially favorable association with selected postoperative outcomes; however, causal inference remains limited by retrospective design, heterogeneity, and potential confounding factors.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"1978-2001"},"PeriodicalIF":3.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous myelodysplastic syndrome and multiple myeloma: a DDX41-associated double-hit across two lineages.","authors":"Lihong Wang, Hong Yan, Long Zhong, Haitao Xu, Dangui Chen","doi":"10.5114/aoms/226402","DOIUrl":"https://doi.org/10.5114/aoms/226402","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"2490-2495"},"PeriodicalIF":3.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends and decomposition analysis of cardiovascular disease burden in China and worldwide from 1990 to 2021, with projections to 2036.","authors":"Yue Zhang, Ning Zhang, Changjian Lin","doi":"10.5114/aoms/221929","DOIUrl":"https://doi.org/10.5114/aoms/221929","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiovascular disease (CVD) is a major public health concern, and its burden and trends require further clarification. This study aimed to compare the CVD burden between China and the global population and provide projections.</p><p><strong>Material and methods: </strong>Data on CVD metrics from the Global Burden of Disease (GBD) 2021. The Joinpoint regression model was applied to analyze long-term trends in age-standardized incidence (ASIR), prevalence (ASPR), mortality (ASMR), and age-standardized disability-adjusted life year (ASDR) rates. Decomposition analysis quantified drivers of change, and autoregressive integrated moving average models projected future trends.</p><p><strong>Results: </strong>From 1990 to 2021, ASMR and ASDR showed significant downward trends in China and globally. However, the ASIR for CVD in China increased from 783.897 to 811.813 per 100,000, while globally it declined from 878.787 to 787.04 per 100,000, with average annual percent change of 0.105% (95% CI: 0.067%, 0.144%) and -0.353% (95% CI: -0.404%, -0.301%), respectively. The upward trend of ASPR in China exceeded the global level. The crude rates of CVD metrics were low among individuals younger than 40 years and then increased with advancing age; sex differences were also observed. Decomposition analysis highlighted population aging as an important driver of increased CVD incidence in China (total population: 41.88%, male: 24.17%, female: 47.81%). Projections suggested that ASIR in China and globally will continue to rise to 825.94 and 807.96 per 100,000, respectively, by 2036, whereas ASMR and ASDR will continue to decline.</p><p><strong>Conclusions: </strong>This study revealed a complex CVD epidemiological landscape in China and globally, with increasing ASPR alongside declining ASMR and ASDR. The ASIR of CVD in China remains significant and is projected to continue increasing.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"22 4","pages":"1933-1947"},"PeriodicalIF":3.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13664277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}