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Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level.
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/176674
Monika Pazgan-Simon, Anna Szymanek-Pasternal, Joanna Górka-Dynysiewicz, Anna Nowicka, Krzysztof Simon, Ewa Grzebyk, Michał Kukla
{"title":"Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level.","authors":"Monika Pazgan-Simon, Anna Szymanek-Pasternal, Joanna Górka-Dynysiewicz, Anna Nowicka, Krzysztof Simon, Ewa Grzebyk, Michał Kukla","doi":"10.5114/aoms/176674","DOIUrl":"10.5114/aoms/176674","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to evaluate chemerin levels as a potentially useful marker in diagnosing early-stage hepatocellular carcinoma (HCC) as well as in HCC staging.</p><p><strong>Material and methods: </strong>The cohort comprised 76 patients: 45 people with cirrhosis and HCC (including 13 with a single HCC lesion in the liver and 32 with metastatic lesions/spread of HCC in the liver) and 21 people with isolated cirrhosis. The control group included 10 clinically healthy people.</p><p><strong>Results: </strong>The degree of liver failure in the whole cohort was assessed using the Child-Turcotte-Pugh (CTP) score (class A - 34, class B - 28, class C - 4) and using the MELD score (≤ 12 points - 45 and > 12 points - 21 people). Serum chemerin level in patients with liver cirrhosis only was 53.30 ng/ml, in patients with a single HCC lesion 77.01 ng/ml, and in patients with disseminated HCC 83.58 ng/ml. In the control group, the chemerin level was 82.20 μg/ml. When patients with cirrhosis and with/without HCC were divided according to their CTP scores, the level of chemerin was as follows: class A - 83.90 μg/ml, class B - 61 μg/ml, class C - 30.10 μg/ml. For MELD scores ≤ and > 12 it was 75 μg/ml and 58 μg/ml, respectively. For BCLC staging the results were as follows: A - 20.10 μg/ml, B - 20.20 μg/ml, C -19.44 μg/ml.</p><p><strong>Conclusions: </strong>Chemerin increases with the number of neoplastic lesions and decreases with the progression of liver failure as assessed using the CTP score.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1504-1510"},"PeriodicalIF":3.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure.
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/184153
Dan Liu, Li Liu, Nan Li, Yiling Zhou, Hongmei Huang, Jidong He, Heling Yao, Xiangyang Chen, Xiaochi Tang, Miye Wang, Ying Qi, Si Wang, Ye Zhu, Haoming Tian, Zhenmei An, Sheyu Li
{"title":"Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure.","authors":"Dan Liu, Li Liu, Nan Li, Yiling Zhou, Hongmei Huang, Jidong He, Heling Yao, Xiangyang Chen, Xiaochi Tang, Miye Wang, Ying Qi, Si Wang, Ye Zhu, Haoming Tian, Zhenmei An, Sheyu Li","doi":"10.5114/aoms/184153","DOIUrl":"10.5114/aoms/184153","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to explore the prognostic value of the aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio in non-surgical patients with type 2 diabetes hospitalized for heart failure.</p><p><strong>Material and methods: </strong>Using a large electronic medical record-based cohort of diabetes in China (WECODe), we gathered data on non-surgical hospitalized patients with type 2 diabetes and heart failure from 2011 to 2019. Baseline AST/ALT ratio was calculated. The primary outcomes were all-cause death within 30 days after discharge, composite cardiac events, major acute kidney injury, and major systemic infection. A multivariable Cox proportional regression model was utilized to evaluate the association between the AST/ALT ratio and outcomes.</p><p><strong>Results: </strong>This retrospective cohort included 8,073 patients (39.4% women) with type 2 diabetes hospitalized for heart failure. The median age was 71 years. Higher AST/ALT ratio was associated with higher risks of poor endpoints (with per standard deviation increment in AST/ALT ratio, for death within 30 days after discharge: adjusted hazard ratio [HR] = 1.35, 95% confidence interval [CI], 1.21 to 1.50; for composite cardiac events: HR = 1.18, 95% CI: 1.06 to 1.31). Compared to patients in the lowest quartile for the AST/ALT ratio, those in the highest quartile have elevated risk of death within 30 days after discharge and major systemic infection (HRs [95% CIs] 1.61 [1.18 to 2.19] and 1.28 [1.06 to 1.56], respectively). Subgroup analyses and sensitivity analyses confirmed the robustness of the findings.</p><p><strong>Conclusions: </strong>Type 2 diabetes patients hospitalized for heart failure with the AST/ALT ratio in the highest quartile face a poor short-term prognosis.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1416-1425"},"PeriodicalIF":3.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between gastroesophageal reflux disease and metabolic syndrome: a bidirectional two-sample Mendelian randomization analysis.
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/193708
Tao He, Xiaoling Geng, Xue Lin, Yufei Li, Zhijun Duan
{"title":"Association between gastroesophageal reflux disease and metabolic syndrome: a bidirectional two-sample Mendelian randomization analysis.","authors":"Tao He, Xiaoling Geng, Xue Lin, Yufei Li, Zhijun Duan","doi":"10.5114/aoms/193708","DOIUrl":"10.5114/aoms/193708","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1715-1719"},"PeriodicalIF":3.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intragastric botulinum toxin injection: a promising alternative for obesity treatment?
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/178334
Hakan Balbaloglu, Ilhan Tasdoven, Ipek Yorgancioglu
{"title":"Intragastric botulinum toxin injection: a promising alternative for obesity treatment?","authors":"Hakan Balbaloglu, Ilhan Tasdoven, Ipek Yorgancioglu","doi":"10.5114/aoms/178334","DOIUrl":"10.5114/aoms/178334","url":null,"abstract":"<p><strong>Introduction: </strong>Over the past 50 years, the rise in obesity has prompted a search for new treatments. Intragastric injections of botulinum toxin A (BT-A), a safer alternative to surgery, show promise in reducing weight and caloric intake by inducing early satiety. This study examines their efficacy for weight loss.</p><p><strong>Material and methods: </strong>From 2021 to 2023, we conducted a retrospective analysis of patients who underwent intragastric BT-A injections in a general surgery endoscopy unit. The inclusion criteria were being aged 18-65 and having a body mass index (BMI) over 25 kg/m<sup>2</sup>. Patients with specific medical conditions or incomplete records were excluded. We monitored patient weight and BMI values before the procedure and at monthly intervals, with further assessments conducted in the sixth month, including appetite and patient satisfaction.</p><p><strong>Results: </strong>Our study on 67 patients, predominantly female (82.1%), aged 35.5 ±9.0 years with a mean BMI of 33.5 ±3.3 kg/m², examined BT-A injections' effectiveness. 58.2% received injections in both gastric antrum and fundus regions, showing greater weight loss (mean: 10.7 ±7.0 kg) than those treated in the antrum alone. Side effects occurred in 16.4%, with various symptoms. High dietary compliance (80.6%) correlated with weight loss, especially among those reporting intense satiety. Patient satisfaction positively correlated with weight loss, highlighting treatment efficacy and patient response to dual-region injections.</p><p><strong>Conclusions: </strong>Our study suggested that intragastric BT-A injections in the antrum and fundus are effective and safe for satiety and weight loss, with few side effects. Individual responses vary, and diet adherence is crucial. More studies are needed to assess the treatment's efficacy in obesity.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1400-1406"},"PeriodicalIF":3.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CSF1 mediating 3-hydroxyhexanoate in endometrial cancer: a Mendelian randomization study.
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-10-17 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/193392
Hu Jiazhen, Fan Bozhen
{"title":"CSF1 mediating 3-hydroxyhexanoate in endometrial cancer: a Mendelian randomization study.","authors":"Hu Jiazhen, Fan Bozhen","doi":"10.5114/aoms/193392","DOIUrl":"10.5114/aoms/193392","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1731-1735"},"PeriodicalIF":3.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipoprotein(a) and other risk factors in dyslipidemic patients with and without heart failure.
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/194684
Joanna Lewek, Bozena Sosnowska, Agata Bielecka-Dąbrowa, Karina Mierczak, Weronika Adach, Maciej Banach
{"title":"Lipoprotein(a) and other risk factors in dyslipidemic patients with and without heart failure.","authors":"Joanna Lewek, Bozena Sosnowska, Agata Bielecka-Dąbrowa, Karina Mierczak, Weronika Adach, Maciej Banach","doi":"10.5114/aoms/194684","DOIUrl":"10.5114/aoms/194684","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 5","pages":"1705-1709"},"PeriodicalIF":3.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical errors can cost lives. 医疗失误可能导致生命损失。
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-08-31 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/192727
Consolato M Sergi
{"title":"Medical errors can cost lives.","authors":"Consolato M Sergi","doi":"10.5114/aoms/192727","DOIUrl":"https://doi.org/10.5114/aoms/192727","url":null,"abstract":"","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 4","pages":"1378-1383"},"PeriodicalIF":3.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sanguiin inhibits cerebral hemorrhage in rats by protecting the blood-brain barrier. 丹参素通过保护血脑屏障抑制大鼠脑出血。
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-08-31 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/193019
Liguo Zhang, Jing Li, Yisong Zhang, Hengzhu Zhang
{"title":"Sanguiin inhibits cerebral hemorrhage in rats by protecting the blood-brain barrier.","authors":"Liguo Zhang, Jing Li, Yisong Zhang, Hengzhu Zhang","doi":"10.5114/aoms/193019","DOIUrl":"https://doi.org/10.5114/aoms/193019","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to observe the effect of Sanguiin on cerebral edema and behavior in a rat cerebral hemorrhage model.</p><p><strong>Methods: </strong>A rat collagenase-induced cerebral hemorrhage model was established to detect the effects of drugs on brain edema.</p><p><strong>Results: </strong>Through magnetic resonance imaging (MRI) analysis and brain weight content (BWC) determination, it was found that Sanguiin could significantly reduce the brain swelling index and BWC of the affected hemisphere after cerebral hemorrhage.</p><p><strong>Conclusions: </strong>Sanguiin can significantly improve the neurological deficits in rats with cerebral hemorrhage, and down-regulate the expression of MMP-9 after cerebral hemorrhage, suggesting that Sanguiin has a certain protective effect on the blood-brain barrier after cerebral hemorrhage.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 4","pages":"1345-1348"},"PeriodicalIF":3.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive analysis of the role of cuproptosis in periodontitis through integrated analysis of single-cell and bulk RNA sequencing. 通过单细胞和大量 RNA 测序综合分析牙周炎中杯突症的作用。
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/192414
Yuanyuan Fu, Chongbin Zhong, Junhe Cui, Shengjie Xie, Chuang Guo
{"title":"A comprehensive analysis of the role of cuproptosis in periodontitis through integrated analysis of single-cell and bulk RNA sequencing.","authors":"Yuanyuan Fu, Chongbin Zhong, Junhe Cui, Shengjie Xie, Chuang Guo","doi":"10.5114/aoms/192414","DOIUrl":"https://doi.org/10.5114/aoms/192414","url":null,"abstract":"<p><strong>Introduction: </strong>Trace mineral micronutrients are essential for periodontal health, and unbalanced levels of trace minerals are related to chronic periodontitis, including copper. We attempted to explore the relationship between cuproptosis and periodontitis.</p><p><strong>Methods: </strong>Bulk RNA-seq and single-cell RNA sequencing data were used to analyze expression of cuproptosis-related genes (CRGs) in periodontitis. A mouse periodontitis model was established to verify the expression of key genes.</p><p><strong>Results: </strong>Cuproptosis-related genes were differentially expressed in periodontitis. RT-PCR results confirmed the alteration of five key genes in the mouse model.</p><p><strong>Conclusions: </strong>Cuproptosis is an important player in the pathophysiological process of periodontitis.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 4","pages":"1349-1357"},"PeriodicalIF":3.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between air pollution and bone mineral density: a Mendelian randomization study. 空气污染与骨矿物质密度之间的关系：孟德尔随机研究。
IF 3 4区 医学
Archives of Medical Science Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.5114/aoms/192628
Rui Jiang, Qi Qu, Zhiyu Wang, Feng Luo, Shuanglin Mou
{"title":"Association between air pollution and bone mineral density: a Mendelian randomization study.","authors":"Rui Jiang, Qi Qu, Zhiyu Wang, Feng Luo, Shuanglin Mou","doi":"10.5114/aoms/192628","DOIUrl":"https://doi.org/10.5114/aoms/192628","url":null,"abstract":"<p><strong>Introduction: </strong>The association of air pollution with bone mineral density (BMD) has attracted increasing attention. However, establishing a causal relationship remains uncertain.</p><p><strong>Methods: </strong>We conducted a Mendelian randomization (MR) study employing PM<sub>2.5</sub>, PM<sub>2.5-10</sub>, PM<sub>10</sub>, nitrogen dioxide, and nitrogen oxides as exposures and BMD as the outcome to explore the causality between air pollution and the occurrence of decreased BMD.</p><p><strong>Results: </strong>By employing the IVW method, we identified a negative causality between air pollution (PM<sub>2.5</sub>, PM<sub>10</sub>, and nitrogen oxides) and BMD.</p><p><strong>Conclusions: </strong>Our findings demonstrate that PM<sub>2.5</sub>, PM<sub>10</sub> and nitrogen oxides exposure may contribute to decreased BMD.</p>","PeriodicalId":8278,"journal":{"name":"Archives of Medical Science","volume":"20 4","pages":"1334-1338"},"PeriodicalIF":3.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11494361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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