Annals of Nutrition and Metabolism最新文献

{"title":"Impact of Protein Intake after Intensive Care Unit on Discharge Destination for Critically Ill Patients: A Single-Center Prospective Observational Study.","authors":"Yoshifumi Katsumata, Tomoaki Yatabe, Hajime Kuroiwa, Hideki Iwata, Shota Oda, Takashi Kawano","doi":"10.1159/000540301","DOIUrl":"10.1159/000540301","url":null,"abstract":"<p><strong>Introduction: </strong>Although nutritional therapy may be able to enable intensive care unit (ICU) survivors to return home instead of being discharged to a rehabilitation facility, post-ICU discharge nutritional therapy lacks investigation. This study evaluated the impact of nutritional therapy after ICU on discharge destination in critically ill patients.</p><p><strong>Methods: </strong>We enrolled consecutive adult patients who spent &gt;72 h in the ICU from December 2020 to March 2023. The primary outcome was discharge destination. Energy and protein intake during the ICU stay and on days 7 and 14 after ICU discharge were evaluated. The target protein intake during the intensive treatment and general ward phases were 0.8 and 1.0 g/kg/day, respectively. Patients were categorized into home discharge (group A) and rehabilitation transfer (group B) groups. Factors affecting the discharge destination were evaluated using logistic regression analysis.</p><p><strong>Results: </strong>Of the 183 patients included, 134 belonged to group A and 49 to group B. In group A, more patients reached the protein intake target than in group B. Logistic regression analysis identified achieving the protein intake target as an independent predictor of home discharge.</p><p><strong>Conclusion: </strong>Further studies are required to confirm the relationship between nutritional therapy during general ward and patient outcomes.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data.","authors":"Kateřina Koudelková, Petr Waldauf, Petr Wohl, Michal Šenkyřík, Petr Beneš, Pavel Kohout, Jiří Vejmelka, Jan Maňák, Pavel Těšínský, František Novák, Eva Meisnerová, Filip Fencl, Jan Gojda","doi":"10.1159/000538232","DOIUrl":"10.1159/000538232","url":null,"abstract":"<p><strong>Introduction: </strong>Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the data collected on HPN patients in the Czech Republic over the past 30 years.</p><p><strong>Methods: </strong>National registry data were collected using a standardised online form based on the OASIS registry (Oley - A.S.P.E.N. Information System) across all centres providing HPN in the Czech Republic. Data collected prospectively from adult patients in the HPN program were analysed in the following categories: epidemiology, demographics, underlying syndrome, diagnosis, complications, and teduglutide therapy prevalence.</p><p><strong>Results: </strong>The registry identified a total of 1,838 adult patient records, reflecting almost 1.5 million individual catheter days. The prevalence of HPN has risen considerably over the last few decades, currently reaching 5.5 per 100,000 population. The majority of patients have short bowel syndrome and GI obstruction, with cancer being the most prevalent underlying disease. Catheter-related bloodstream infections have been the most prevalent acute complication. However, the incidence in 2022 was only 0.15 per 1,000 catheter days. The study also observed an increase in the prevalence of patients on palliative HPN over the last decade.</p><p><strong>Conclusion: </strong>This study presents a thorough analysis of data from the Czech REgistr Domaci NUtricni Podpory (REDNUP) registry. It shows an increasing prevalence of HPN, namely, in the palliative patient group. The sharing of national data can improve understanding of this rare condition and facilitate the development of international guidelines.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140108978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FINUT 2024 Conference Abstracts.","authors":"","doi":"10.1159/000541491","DOIUrl":"https://doi.org/10.1159/000541491","url":null,"abstract":"<p><p>This supplement compiles most of the special lectures, symposia sessions, oral communications, and poster communications abstracts of the FINUT 2024 Conference, taking place in Medellin Colombia on October 24-26, 2024, under the motto \"Nutrition at the forefront of a sustainable planet\" This third edition of the FINUT Conference has as a specific objective the continuity of the space for the exchange and discussion of ideas and integration of new teams in which all the stakeholders that influence the areas of food, nutrition, health, and sustainability in Ibero-America participate to face the main challenges of the region, and thus offer solutions aimed at improving the health status of the population, considering the impact of social inequalities in Ibero-America. The scientific program of the FINUT 2024 Conference includes 45 parallel symposia, 10 special lectures, 4 \"with-science\" meals, and the presentations of 41 oral communications and 210 poster communications. The four main thematic areas of the Conference are: • Healthy nutrition in the life cycle and clinical nutrition • Nutritional epidemiology and public health challenges in Ibero-America • Safe, healthy, sustainable, and social nutrition • Methods and tools in nutrition The Ibero-American Nutrition Foundation (FINUT) which was established in 2011. FINUT is a non-profit and financially self-supporting entity; our vision is to promote research and training, identify problems of public interest and provide scientific answers; and involve all stakeholders in our cause. Every other year the FINUT Conference allows us to meet in person with the FINUT community and continue the education, information, and research activities in food sciences, nutrition, and health that are carried out virtually daily. We are deeply grateful to the Organizing Committee, the Local Committee, and all the entities represented therein, for their commitment and effort, the Scientific Committee members for their dedicated work and participation in the scientific program, and the University of Antioquia for their interest in hosting this event in Medellin and for all the support received by its authorities, directors, and professors during the organization and execution of the event. We thank all the sponsors who have supported and participated in carrying out this science-based, international event. Our most sincere thanks to the delegates (professionals, academics, researchers, clinicians, and students) who have once again trusted FINUT and who, with their participation, have made it possible to showcase scientific development in food, nutrition, health, and sustainability of the Ibero-American region at the FINUT Conference. ¡See you at the FINUT 2026 Conference!</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Neutral Amino Acids Moderate the Effects of Metabolic Syndrome on Cognitive Performance in Middle-Aged Adults.","authors":"Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle A Gallagher, Barbara Strasser, Dietmar Fuchs, Hirofumi Tanaka, Andreana P Haley","doi":"10.1159/000538273","DOIUrl":"10.1159/000538273","url":null,"abstract":"<p><strong>Introduction: </strong>Two large neutral amino acids (LNAA), tryptophan and tyrosine, are precursors to cerebral neurotransmitters and are involved in cognitive function. Higher levels of LNAA in young adults are associated with improved cognition, although these associations appear to reverse over time. Given that exposure to metabolic syndrome (MetS) may induce premature cognitive aging, the current project aims to fill the gap in the literature by examining the effect of LNAA on cognitive performance in midlife adults with metabolic risks.</p><p><strong>Methods: </strong>Eighty-eight adults, ages 40-61 years, participated in this cross-sectional study. LNAA metabolites were quantified, MetS components were measured using high-performance liquid chromatography, and MetS components were assessed in the laboratory. Composite verbal memory and executive functioning scores were computed using principal component analysis. We used linear regression models to test the interaction between LNAA and MetS while covarying for sex, age, and education.</p><p><strong>Results: </strong>The kynurenine/tryptophan ratio moderated the relation between MetS and verbal memory, even after adjusting for relevant covariates. Tyrosine metabolites were not significant moderators of the association between MetS and executive functioning.</p><p><strong>Conclusion: </strong>Our findings suggest that the detected weaker memory performance in adults with a high number of MetS components may be related to relative tryptophan depletion and possible decreases in serotonin production. Further investigation is warranted to examine the potential role of LNAA in associations between cognitive performance and metabolic risks over time.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11305933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a School-Based Intervention on Sugar-Sweetened Beverage Intake Substitution by Water in Mexican Scholars.","authors":"Laura Gabriela Téllez Olvera, Lilia Castillo Martínez, Bárbara da Silva Nalin de Souza, Rosely Sichieri, Liliana Ruíz Arregui, Wendy D Rodríguez Garcia, Guadalupe Silvia García de la Torre","doi":"10.1159/000538142","DOIUrl":"10.1159/000538142","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of overweight and obesity in children has increased in recent years, associated with substituting plain water intake with sugar-sweetened beverages. The aim of the study was to evaluate the impact of a school-based intervention that aimed to replace sugar-sweetened beverages with water on Mexican scholars.</p><p><strong>Methods: </strong>We included 314 children aged 9-11 from three public schools of the State of Hidalgo, Mexico, randomized to intervention (two schools from the municipality of Apan; six classes with 146 participants) or control group (one school from the municipality of Emiliano Zapata; six classes with 168 participants) and followed for 6 months. The intervention consisted of placing drinking fountains at schools and classrooms with nutritional education lessons to increase water consumption and decrease sugar-sweetened beverages. Mixed models for repeated measures were used to assess the impact of the intervention.</p><p><strong>Results: </strong>At the end of the study, water consumption was higher (200 mL/day, p = 0.005), and flavored milk consumption was lower (94 mL/day, p = 0.044) in the intervention group compared with the control group. There was also a statistically significant reduction in energy (p = 0.016) and sugar intake (p = 0.007).</p><p><strong>Conclusions: </strong>The school-based intervention favorably modified the consumption pattern of sugar-sweetened beverages and water in Mexican students.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth Patterns of 11-29-Month-Old Children Consuming Young Child Formula: Secondary Analysis of a Randomized, Controlled Study.","authors":"Outi Sirkka, Jacques Bindels, Pantipa Chatchatee, Pensri Kosuwon, Way S Lee, Nipat SimaKachorn, Maya Marintcheva-Petrova, Marieke Abrahamse-Berkeveld","doi":"10.1159/000539037","DOIUrl":"10.1159/000539037","url":null,"abstract":"<p><strong>Introduction: </strong>The impact of young child formula (YCF) consumption on children's growth, particularly under suboptimal conditions, has scarcely been studied. In the current study, weight-for-age (WAZ), length-for-age (LAZ), and BMI-for-age (BAZ) z-score development was evaluated in children from five different countries (n = 668) who participated in a double-blind, randomized, controlled trial.</p><p><strong>Methods: </strong>The children (1-3 years old) were randomized to one of two intervention YCFs (with presence or absence of prebiotics and n-3 LCPUFAs) during 52 weeks of intervention. Additional stratified analyses evaluated the growth patterns of underweight, overweight, or stunted children.</p><p><strong>Results: </strong>No apparent differences in anthropometric measurements were observed between the intervention groups. In both YCF intervention groups, mean WAZ, LAZ and BAZ development was indicative of adequate growth during the intervention period. Stratified analyses showed stable WAZ and BAZ development among children with a healthy weight or overweight at baseline. Among underweight and stunted children, normalization in mean weight (∼1 SD) and length (∼0.8 SD) gain, respectively, was observed.</p><p><strong>Conclusion: </strong>The current study suggests that consumption of YCF, either or not containing prebiotics and n-3 LCPUFAs, is associated with adequate growth among young children. This association may depend on the child's baseline nutritional status. Future studies to assess the potential role of YCF in supporting adequate weight/length gain among children at risk for undernutrition are warranted.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMI Z-Score (SDS) versus Calculated Body Fat Percentage: Association with Cardiometabolic Risk Factors in Obese Children and Adolescents.","authors":"Christine Joisten, Stefanie Wessely, Nicole Prinz, Susanna Wiegand, Bettina Gohlke, Sabine Keiser, Paula Moliterno, Jens Nielinger, Gabriel Torbahn, Hagen Wulff, Reinhard W Holl","doi":"10.1159/000535216","DOIUrl":"10.1159/000535216","url":null,"abstract":"<p><strong>Introduction: </strong>BMI or BMI-standardized deviation score (SDS) in children and adolescents is still the standard for weight classification. [BMJ. 2019;366:4293] developed a formula to calculate body fat percentage (%BF) based on age, sex, height, weight, and ethnicity. Using data from the German/Austrian APV registry, we investigated whether the calculated %BF is superior to BMI-SDS in predicting arterial hypertension, dyslipidaemia, and impaired glucose metabolism.</p><p><strong>Methods: </strong>94,586 children and adolescents were included (12.5 years, 48.3% male). Parental birth country (BC) was used to depict ethnicity (15.8% migration background); 95.67% were assigned to the ethnicity \"white.\" %BF was calculated based on the Hudda formula. The relationship between BMI-SDS or %BF quartiles and outcome variables was investigated by logistic regression models, adjusted for age, sex, and migration background. Vuong test was applied to analyse predictive power.</p><p><strong>Results: </strong>58.4% had arterial hypertension, 33.5% had dyslipidaemia, and 11.6% had impaired glucose metabolism. Boys were significantly more often affected, although girls had higher calculated %BF (each p &lt; 0.05). After adjustment, both models revealed significant differences between the quartiles (all p &lt; 0.001). The predictive power of BMI-SDS was superior to %BF for all three comorbidities (all p &lt; 0.05).</p><p><strong>Discussion: </strong>The prediction of cardiometabolic comorbidities by calculated %BF was not superior to BMI-SDS. This formula developed in a British population may not be suitable for a central European population, which is applicable to this possibly less heterogeneous collective. Additional parameters, especially puberty status, should be taken into account. However, objective determinations such as bioimpedance analysis may possibly be superior to assess fat mass and cardiometabolic risk than calculated %BF.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10857797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138827946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Effects of Intermittent Fasting in the Aging Brain.","authors":"Hao Dong, Shiyan Wang, Chenji Hu, Mao Wang, Tao Zhou, Yue Zhou","doi":"10.1159/000538782","DOIUrl":"10.1159/000538782","url":null,"abstract":"<p><strong>Background: </strong>A major risk factor for neurodegenerative disorders is old age. Nutritional interventions that delay aging, such as calorie restriction (CR) and intermittent fasting (IF), as well as pharmaceuticals that affect the pathways linking nutrition and aging processes, have been developed in recent decades and have been shown to alleviate the effects of aging on the brain.</p><p><strong>Summary: </strong>CR is accomplished by alternating periods of ad libitum feeding and fasting. In animal models, IF has been shown to increase lifespan and slow the progression and severity of age-related pathologies such as cardiovascular and neurodegenerative diseases and cancer. According to recent research, dietary changes can help older people with dementia retain brain function. However, the mechanisms underlying the neuroprotective effect of IF on the aging brain and related questions in this area of study (i.e., the potential of IF to treat neurodegenerative disorders) remain to be examined.</p><p><strong>Key messages: </strong>This review addresses the hypothesis that IF may have translational potential in protecting the aged brain while summarizing the research supporting the putative neuroprotective mechanisms of IF in animal models. Additionally, given the emerging understanding of the connection between aging and dementia, our investigations may offer a fresh perspective on the use of dietary interventions for enhancing brain function and preventing dementia in elderly individuals. Finally, the absence of guidelines regarding the application of IF in patients hampers its broad utilization in clinical practice, and further studies are needed to improve our knowledge of the long-term effects of IF on dementia before it can be widely prescribed. In conclusion, IF may be an ancillary intervention for preserving memory and cognition in elderly individuals.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Inflammation, Glycocalyx Biomarkers, and Endothelial Function in Children with Hypercholesterolemia.","authors":"Belén Pastor-Villaescusa, Julia Meier, Fabienne Ruske, Christine Prell, Juliane Gruenzner, Miriam Koenig, André Jakob, Berthold Koletzko, Claudia Nussbaum","doi":"10.1159/000536042","DOIUrl":"10.1159/000536042","url":null,"abstract":"<p><strong>Introduction: </strong>Hypercholesterolemia is a risk factor for premature arteriosclerosis. Inflammation and oxidative stress are thought to contribute to endothelial dysfunction preceding vasculopathy. We investigated the association between inflammation, glycocalyx biomarkers, endothelial function, and vascular parameters in children with hypercholesterolemia.</p><p><strong>Methods: </strong>In 22 patients (LDL-cholesterol &gt;130 mg/dL; median age [IQR]: 13 [2.3] years) and 22 controls (13 [2.5] years), tumor necrosis factor-alpha (TNF-α), oxidized cholesterol (oxLDL), and glycocalyx biomarkers (Syndecan-1, Hyaluronan) were measured using immunoassays. Endothelial function was assessed by peripheral arterial tonometry, sublingual glycocalyx and microcirculation by videomicroscopy and carotid intima-media thickness by ultrasound.</p><p><strong>Results: </strong>OxLDL was significantly higher in patients (78.9 [38.2] vs. 50.3 [16.6] U/L, p = 0.002), whereas all other experimental parameters were comparable between groups. Multivariate analysis revealed a significant association of Syndecan-1 with TNF-α (β = 0.75, p &lt; 0.001) and with hypercholesterolemia (β = 0.31, p = 0.030). The interaction term combining TNF-α and hypercholesterolemia showed a significant effect (p = 0.034). Sex was an independent predictor of endothelial function.</p><p><strong>Conclusion: </strong>The combined effect of hypercholesterolemia and inflammation on glycocalyx perturbation and the impact of sex in the premature development of arteriosclerosis deserve further evaluation. Therapeutic approaches tackling low-grade systemic inflammation may offer potential to prevent or delay progression of cardiovascular disease and cardiovascular complications.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"14th EFAD Congress: \"Dietetic care, a human right: moving forward into a new era\".","authors":"","doi":"10.1159/000535909","DOIUrl":"10.1159/000535909","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}