AngiologyPub Date : 2025-11-01Epub Date: 2025-02-17DOI: 10.1177/00033197251320141
Selim Aydemir, Sidar Şiyar Aydın, Onur Altınkaya, Emrah Aksakal, Murat Özmen
{"title":"Evaluation of Hematological and Biochemical Parameters that Predict the No-reflow Phenomenon in Patients Undergoing Primary Percutaneous Coronary Intervention.","authors":"Selim Aydemir, Sidar Şiyar Aydın, Onur Altınkaya, Emrah Aksakal, Murat Özmen","doi":"10.1177/00033197251320141","DOIUrl":"10.1177/00033197251320141","url":null,"abstract":"<p><p>Acute coronary syndromes (ACS) are one of the most common causes of morbidity and mortality worldwide. Primary percutaneous coronary intervention (pPCI) is the main treatment strategy to restore myocardial perfusion. However, the no-reflow phenomenon (NRP) may block coronary flow. The present study focused on assessing and contrasting predictive parameters for NRP in ACS patients. Our research is a retrospective analysis. We assessed the parameters significantly associated with NRP using Cox regression and Receiver operating characteristic (ROC) Curve analysis. The study included 5122 patients who met the criteria. The average age of the patients was 63.9 + 13.2, and 74.4% were male. It was observed that NRP developed in 1.8% of all patients. Age, hemoglobin (Hb), white blood cell (WBC), glucose and low density lipoprotein cholesterol (LDL-C) were determined to be independent predictors of NRP. The power of these parameters to predict NRP was similar, and WBC was the most predictive (Area Under Curve (AUC): 0.605 95% CI: 0.539-0.671, <i>P</i> = .001). We believe that the use of these simple, practical, and routinely used hematological and biochemical parameters will help us predict the risk of developing NRP before pPCI. This information should improve management.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"999-1009"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial Intelligence and Machine Learning for Risk Prediction of Abdominal Aortic Aneurysm Growth and Rupture.","authors":"Jia Guo, Fabien Lareyre, Regent Lee, Martin Teraa, Hervé Delingette, Juliette Raffort","doi":"10.1177/00033197251379127","DOIUrl":"https://doi.org/10.1177/00033197251379127","url":null,"abstract":"<p><p>Artificial intelligence (AI) and machine learning (ML) are emerging tools in the management of abdominal aortic aneurysms (AAA). They have offered new tools to develop advanced imaging analysis and prediction models. This narrative review summarizes studies exploring AI/ML models to evaluate the risk of AAA growth and rupture. We provide an overview and critical analysis on methodology used, identify current limits and propose future directions for research and implementation in surgical practice.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251379127"},"PeriodicalIF":2.2,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relation Between CHA2DS2-VASc Score, Initial TIMI Flow Grades and In-Hospital Mortality in Patients Presenting with Acute Myocardial Infarction.","authors":"Funda Ozlem Pamuk, Hatice Mediha Kına, Esra Dönmez, Ceren Yağmur Doğru, Hatice Selçuk","doi":"10.1177/00033197251378891","DOIUrl":"https://doi.org/10.1177/00033197251378891","url":null,"abstract":"<p><p>The CHA<sub>2</sub>DS<sub>2</sub>-VASc score includes classical risk factors (e.g., Congestive heart failure/Left ventricle dysfunction, Hypertension, Age, Diabetes mellitus, Stroke/Transient ischemic attack/Thromboembolism, Vascular disease and Sex) for coronary artery disease. We investigated the association between initial thrombolysis in myocardial infarction (TIMI) flow of the culprit artery and CHA<sub>2</sub>DS<sub>2</sub>-VASc score and in-hospital clinical outcomes in patients presenting with acute myocardial infarction (AMI). Initial and postprocedural TIMI flow grades were recorded in patients hospitalized with first diagnosis of AMI. The initial TIMI flow grades and CHA<sub>2</sub>DS<sub>2</sub>VASC scores were compared with the post-procedural TIMI flow grades. Patients (n = 750) were included retrospectively; 56.7% was in the low flow (TIMI 0-1) and 43.3% was in the high flow (TIMI 2-3) group. The CHA<sub>2</sub>DS<sub>2</sub>-VASc score was higher (<i>P</i> < .001) in the low flow group. The best CHA<sub>2</sub>DS<sub>2</sub>-VASc score cut-off value was 3 to predict initial TIMI flow. Median CHA<sub>2</sub>DS<sub>2</sub>-VASc score was 4 in-hospital mortality group (<i>P</i> < .001) and this score was an independent predictor of in-hospital mortality. The CHA<sub>2</sub>DS<sub>2</sub>-VASc score was an independent predictor of low initial TIMI flow and in-hospital mortality. Patients with high preprocedural CHA<sub>2</sub>DS<sub>2</sub>-VASc tended to have low coronary flow grades and higher mortality rates.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251378891"},"PeriodicalIF":2.2,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-10-17DOI: 10.1177/00033197251376093
Eugenio Caradonna, Francesco Setacci, Jessica Lanza, Fulvio Ferrara, Carlo Setacci, Massimo Danese, Gaetano Lanza
{"title":"Autologous Cell Therapy for Chronic Limb Threatening Ischemia: Towards Personalized Medicine.","authors":"Eugenio Caradonna, Francesco Setacci, Jessica Lanza, Fulvio Ferrara, Carlo Setacci, Massimo Danese, Gaetano Lanza","doi":"10.1177/00033197251376093","DOIUrl":"https://doi.org/10.1177/00033197251376093","url":null,"abstract":"<p><p>Peripheral Artery Disease (PAD) with Chronic Limb Threatening Ischemia (CLTI) is a severe condition at risk of amputation, and often conventional surgical and endovascular procedures and/or medical therapy are insufficient. The present review considers current knowledge regarding autologous cell therapy and regenerative medicine for PAD with CLTI. We evaluated cell-based therapies in the recent literature, that are pivotal in treating vascular disorders by promoting angiogenesis, vascular restoration, and tissue regeneration; furthermore, we provided an overview of the relevant main clinical studies. Clinical conditions and risk factors of patients correlate with the performance of autologous cell-based therapies and the probability of success. Nevertheless, the current evidence indicates that these therapies are promising, necessitating further research. Autologous cell therapy and regenerative medicine can offer additional support for treating PAD with CLTI. These advanced techniques are becoming more tailored and substantial for their application in clinical practice. Personalized Medicine represents a contemporary paradigm that calls for consideration of individual patient's clinical conditions, risk factors, and biomarkers.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251376093"},"PeriodicalIF":2.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-10-09DOI: 10.1177/00033197251377325
Fei Yuan, Maomao Liu, Yunfeng Yan, Nan Liu, Shuzheng Lyu
{"title":"Reperfusion for Proximal Left Circumflex Artery Chronic Total Occlusion Benefits Patients With Diabetes: A Retrospective Cohort Study.","authors":"Fei Yuan, Maomao Liu, Yunfeng Yan, Nan Liu, Shuzheng Lyu","doi":"10.1177/00033197251377325","DOIUrl":"https://doi.org/10.1177/00033197251377325","url":null,"abstract":"<p><p>Diabetes with chronic total arterial occlusion carries a poor prognosis. Little is known about patients with diabetes and stable left circumflex artery (LCX) chronic total occlusion (LCX-CTO). We aimed to determine whether stable LCX-CTO should be recanalized in patients with diabetes. We analyzed patients with LCX-CTO, diabetes, and stable clinical symptoms (i.e., silent ischemia or symptomatic stable angina), who underwent successful revascularization (SR) or medical therapy (MT). The primary endpoint was major adverse cardiac events. Propensity score-matched analyses and Cox regression were performed. The proximal LCX-CTO subpopulation was analyzed. A stratified subgroup analysis was conducted for the primary endpoint. We enrolled 620 patients, stratified into MT (448, 72.26%) and SR groups (172, 27.74%). After a median 44-month follow-up, univariate and multivariable models showed that SR offered no clinical benefits regarding major adverse cardiac events (adjusted hazard ratio [aHR]: 0.860, 95% confidence interval [CI]: 0.520-1.423, <i>P</i> = .558). This was consistent for other clinical endpoints as well. However, in the subpopulation with proximal LCX-CTO, SR was superior in terms of cardiac (aHR: 0.284, 95% CI: 0.082-0.984) and all-cause mortality (aHR: 0.455, 95% CI: 0.167-1.239). Revascularization should be attempted in patients with diabetes who have proximal LCX-CTO.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251377325"},"PeriodicalIF":2.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-10-07DOI: 10.1177/00033197251379122
Laith Alhuneafat, Omar Obeidat, Mohammed Ayyad, Ahmad Alayyat, Waqas Rasheed, Ahmad Maaita, Fares Ghanem, Zaid Shahrori, Anas Alameh, Ahmad Al-Abdouh, Pedro Villablanca, Ahmad Jabri
{"title":"Inpatient Tricuspid Valve Transcatheter and Surgical Inpatient Outcomes: A Propensity Matched Analysis.","authors":"Laith Alhuneafat, Omar Obeidat, Mohammed Ayyad, Ahmad Alayyat, Waqas Rasheed, Ahmad Maaita, Fares Ghanem, Zaid Shahrori, Anas Alameh, Ahmad Al-Abdouh, Pedro Villablanca, Ahmad Jabri","doi":"10.1177/00033197251379122","DOIUrl":"https://doi.org/10.1177/00033197251379122","url":null,"abstract":"<p><p>Tricuspid regurgitation (TR) is a common valvular disorder associated with significant morbidity and mortality. While surgical repair (STVr) and replacement (STVR) are established treatments, transcatheter tricuspid valve interventions (TTVI) have emerged as less invasive alternatives. The present study compared inpatient outcomes of TTVI, STVr, and STVR using data from the National Inpatient Sample (2011-2020). A retrospective analysis identified 1830 TTVI, 76 747 STVr, and 19 625 STVR procedures. After propensity score matching, 1655 TTVI-STVr and 1286 TTVI-STVR patient pairs were included. Compared with surgery, TTVI was associated with significantly lower in-hospital mortality (2.4% vs 7.0% STVr; 2.3% vs 11.6% STVR; <i>P</i> < .001), shorter hospital stays (6.9 vs 15.6 days STVr; 7.2 vs 17.6 days STVR; <i>P</i> < .001), and reduced costs. TTVI was associated with lower in-hospital mortality, fewer complications, and shorter hospital stays compared with surgical interventions in this analysis. Given the limitations of retrospective studies, including selection bias and lack of long-term follow-up, these findings require cautious interpretation. Prospective studies are needed to compare the efficacy and durability of TTVI versus surgery for TR.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251379122"},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-10-05DOI: 10.1177/00033197251376086
Li Ke-Xin, Luo Yi-Chen, Huang Hao, Chen Yan-Ting
{"title":"SRY-Box Transcription Factor 18 Links Inflammation to Calcific Aortic Valve Progression via CD68 and NF-κB p65.","authors":"Li Ke-Xin, Luo Yi-Chen, Huang Hao, Chen Yan-Ting","doi":"10.1177/00033197251376086","DOIUrl":"https://doi.org/10.1177/00033197251376086","url":null,"abstract":"<p><p>This study investigated SOX18's role in calcific aortic valve disease (CAVD). Aortic valve specimens from 67 patients undergoing valve replacement were stratified into control (n = 18), mild (n = 20), and severe calcification (n = 29) groups based on Alizarin Red staining. Immunohistochemistry revealed SOX18 expression localized to valve interstitial cells (VICs), with significantly higher levels in calcified versus control valves (<i>P</i> < .001). Elevated SOX18 was particularly associated with the inflammatory factors CD68 and Nuclear Factor-kappa B (NF-κB) p65, suggesting a potential link between SOX18, inflammation and CAVD progression. These findings highlight SOX18 as a possible mediator in valvular calcification.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251376086"},"PeriodicalIF":2.2,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-10-01Epub Date: 2023-08-16DOI: 10.1177/00033197231196948
{"title":"Addendum to 'Effects of Chitosan on Plasma Lipids and Lipoproteins: A 4-Month Prospective Pilot Study'.","authors":"","doi":"10.1177/00033197231196948","DOIUrl":"10.1177/00033197231196948","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"917"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10005008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-10-01Epub Date: 2024-02-20DOI: 10.1177/00033197241233771
Alessandro Ruzzarin, Simone Muraglia, Enrico Fabris, Giorgio Caretta, Filippo Zilio, Andrea Pezzato, Gianluca Campo, Matthias Unterhuber, Luca Donazzan
{"title":"Impact of Contrast-Associated Acute Kidney Injury on One-Year Outcomes in Very Elderly STEMI Patients: Insights From a Multicenter Registry in Northern Italy.","authors":"Alessandro Ruzzarin, Simone Muraglia, Enrico Fabris, Giorgio Caretta, Filippo Zilio, Andrea Pezzato, Gianluca Campo, Matthias Unterhuber, Luca Donazzan","doi":"10.1177/00033197241233771","DOIUrl":"10.1177/00033197241233771","url":null,"abstract":"<p><p>Data about contrast-associated acute kidney injury (CA-AKI) in oldest old (age ≥85 years) ST-elevation myocardial infarction (STEMI) patients are scarce. We evaluated the incidence and the 1-year prognostic impact of CA-AKI in this population. Patients were included in a multicenter real-world registry, and CA-AKI was defined according to KDIGO (Kidney Disease Improving Global Outcomes) criteria. Major adverse cardiac and cerebrovascular events (MACCEs) were defined as the composite of all-cause death, stroke, unplanned coronary revascularization, and heart failure hospitalization. The primary outcome was the incidence and impact of CA-AKI on MACCEs at 1 year follow-up. Out of 461 STEMI patients (mean age 88.6 ± 2.9 years), 102 (22.1%) patients developed CA-AKI. Chronic kidney disease was the strongest predictor of CA-AKI (odds ratio [OR]: 4.52, 95% CI: 2.81-7.30, <i>P</i> < .01). The CA-AKI cohort showed a higher risk of MACCEs (adjusted HR: 1.75, 95% CI: 1.13-2.71, <i>P</i> = .01), driven mainly by all-cause death (adjusted hazard ratio [HR]: 2.39, 95% CI: 1.41-4.07, <i>P</i> = .01) and followed by heart failure hospitalization (adjusted HR: 2.01, 95% CI: 1.08-3.76, <i>P</i> = .01). Among oldest old STEMI, CA-AKI was frequent and associated with a higher incidence of MACCEs at 1-year follow-up.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"886-893"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139911877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-10-01Epub Date: 2024-07-23DOI: 10.1177/00033197241265252
Atsushi Sugiura, Leonard Taube, Arthur Hartmann, Christian Schaefer, Marwan Hamiko, Sebastian Zimmer, Georg Nickenig, Nadjib Schahab
{"title":"Reply Letter to: Carotid Artery Stenosis as a Predictor for Stroke Following Transcatheter Aortic Valve Implantation.","authors":"Atsushi Sugiura, Leonard Taube, Arthur Hartmann, Christian Schaefer, Marwan Hamiko, Sebastian Zimmer, Georg Nickenig, Nadjib Schahab","doi":"10.1177/00033197241265252","DOIUrl":"10.1177/00033197241265252","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"915-916"},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}