AngiologyPub Date : 2025-05-01Epub Date: 2023-12-28DOI: 10.1177/00033197231225291
Mateo Porres-Aguilar, Carolina Najera, Adriana C Mares, Ilham Benzidia, Swathi Prakash, Benjamin Crichi
{"title":"Successful Treatment With the Oral Factor Xa Inhibitor Edoxaban in Heparin-Induced Thrombocytopenia With Thrombosis.","authors":"Mateo Porres-Aguilar, Carolina Najera, Adriana C Mares, Ilham Benzidia, Swathi Prakash, Benjamin Crichi","doi":"10.1177/00033197231225291","DOIUrl":"10.1177/00033197231225291","url":null,"abstract":"<p><p>Heparin-induced thrombocytopenia with thrombosis (HITT) is a rare immune reaction to the drug heparin that causes increased blood clotting, putting patients at risk for arterial and venous thromboembolism which can have severe consequences. We present a case of HITT successfully treated with the direct oral anticoagulant (DOAC), edoxaban. A 56-year-old man had surgery to remove a colorectal mass. After discharge, he developed chest discomfort, shortness of breath, and low oxygen levels and was diagnosed with a right-sided lobar pulmonary embolism. His platelet count dropped, his tests confirmed a diagnosis of HITT, and he was initially treated with fondaparinux. After showing clinical and laboratory improvement, he was switched to edoxaban. Despite being diagnosed with colonic adenocarcinoma during follow-up, the patient's platelet count returned to normal, and he did not experience any more blood clots or serious bleeding events. The use of DOACs like edoxaban as potential therapies for HITT is promising; further research is being conducted to evaluate their effectiveness, safety, and potential benefits for treating this acquired high-risk thrombophilia.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"453-457"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-05-01Epub Date: 2024-01-09DOI: 10.1177/00033197241226881
Jiayong Qiu, Yingying Hao, Shenshen Huang, Tongsheng Wang, Xuegai He, Wei Wang, Dan Du, Yimin Mao, Yadong Yuan
{"title":"Serum Albumin for Short-Term Poor Prognosis in Patients With Acute Pulmonary Embolism: A Clinical Study Based on a Database.","authors":"Jiayong Qiu, Yingying Hao, Shenshen Huang, Tongsheng Wang, Xuegai He, Wei Wang, Dan Du, Yimin Mao, Yadong Yuan","doi":"10.1177/00033197241226881","DOIUrl":"10.1177/00033197241226881","url":null,"abstract":"<p><p>The relationship between serum albumin (ALB) and short-term prognosis in patients with acute pulmonary embolism (APE) remains unclear. We investigated the predictive value of ALB for short-term prognosis in APE patients using our hospital pulmonary embolism (PE) database (384 patients consecutively collected). Logistic regression analysis and nomograms were applied to construct the predictive model, and validation was assessed. A total of 340 APE patients were included, with a 30-day all-cause mortality rate of 8.5%. The incidence of hypoalbuminemia was 15.9%. The odds ratio (OR) for short-term mortality in patients with high ALB was 0.89 (0.886, 95% CI: 0.812-0.967). Additionally, we created a nomogram for individualized mortality risk prediction. Receiver operating characteristic (ROC) curve analysis showed that the diagnostic area under the curve (AUC) of ALB was 0.758 (95% CI 0.683-0.833), and the best cut-off value was 33.85 g/L. Optimal simplified Pulmonary Embolism Severity Index (sPESI) (ALB combined sPESI) AUC was 0.835 (95% CI 0.775-0.896). Baseline hypoalbuminemia may be an independent prognostic indicator of short-term mortality in patients with APE.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"458-465"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-05-01Epub Date: 2024-01-16DOI: 10.1177/00033197241227025
Rasha Al-Bawardy, Wael Alqarawi, Jassim Al Suwaidi, Wael Almahmeed, Mohammad Zubaid, Haitham Amin, Kadhim Sulaiman, Ahmad Al-Motarreb, Khalid Alhabib
{"title":"The Effect of Beta-Blocker Post-Myocardial Infarction With Ejection Fraction >40% Pooled Analysis From Seven Arabian Gulf Acute Coronary Syndrome Registries.","authors":"Rasha Al-Bawardy, Wael Alqarawi, Jassim Al Suwaidi, Wael Almahmeed, Mohammad Zubaid, Haitham Amin, Kadhim Sulaiman, Ahmad Al-Motarreb, Khalid Alhabib","doi":"10.1177/00033197241227025","DOIUrl":"10.1177/00033197241227025","url":null,"abstract":"<p><p>The use of beta-blockers (BB) in reduced left ventricular ejection fraction (LVEF) post-myocardial infarction (MI) is associated with reduced 1-year mortality, while their role in patients with mid-range and preserved LVEF post-MI remains controversial. We studied 31,620 patients who presented with acute coronary syndrome (ACS) enrolled in seven Arabian Gulf registries between 2005 and 2017. Patients with LVEF ≤40% were excluded. The remaining cohort was divided into two groups: BB group (<i>n</i> = 15,541) and non-BB group (<i>n</i> = 2,798), based on discharge medications. Patients in the non-BB group were relatively younger (55.3 <i>vs.</i> 57.4, <i>P</i> = .004) but higher risk at presentation; with higher Global Registry of Acute Coronary Events (GRACE) score (119.2 <i>vs</i> 109.2, <i>P</i> < .001), higher percentage of cardiogenic shock (3.5 <i>vs</i> 1.4%, <i>P</i> < .001), despite lower prevalence of comorbidities, such as hypertension and hyperlipidemia. BB use was associated with lower 1-year mortality in a multivariate logistic regression analysis, adjusting for major confounders [adjusted odds ratio (OR): 0.71 (95% CI 0.51-0.99)]. This remained the case in a sensitivity analysis using propensity score matching [adjusted OR: 0.34 (95% CI 0.16-0.73)]. In this study, using Arabian Gulf countries registries, the use of BB after ACS with LVEF >40% was independently associated with lower 1-year mortality.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"476-486"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-05-01Epub Date: 2024-02-05DOI: 10.1177/00033197241230973
Gerfried Pesau, Bernhard Zierfuss, Clemens Hoebaus, Renate Koppensteiner, Gerit-Holger Schernthaner
{"title":"Serum Trefoil Factor-3 Predicts Survival in Peripheral Artery Disease.","authors":"Gerfried Pesau, Bernhard Zierfuss, Clemens Hoebaus, Renate Koppensteiner, Gerit-Holger Schernthaner","doi":"10.1177/00033197241230973","DOIUrl":"10.1177/00033197241230973","url":null,"abstract":"<p><p>Trefoil factor 3 (TFF3) has been studied in processes leading to atherosclerosis. Data are scarce in manifest disease and missing in peripheral artery disease (PAD). This study aims to elucidate TFF3 with disease stages, degrees of atherosclerosis, and outcomes. TFF3 was measured in serum in 364 PAD patients without critical limb ischemia and mild to moderate chronic kidney disease (CKD). Mortality data were retrieved from the Austrian central death registry (median observation 9.6 years). Survival analyses were performed using Cox regression and the Kaplan-Meier method. A negative association between ankle-brachial index and TFF3 (<i>P</i> < .001) was observed, while levels were similar in asymptomatic and symptomatic PAD. TFF3 increased with history of cardiovascular and cerebrovascular disease (<i>P</i> < .001). TTF3 was associated with the estimated glomerular filtration rate (R = -0.617, <i>P</i> < .001) and urinary albumin-creatinine ratio (R = 0.229, <i>P</i> < .001). One SD increase in TFF3 showed a worsening in all-cause mortality (hazard ratio 1.68, CI 1.37-2.05) which persisted after multiple adjustment for cardiovascular risk, inflammatory, and angiogenetic markers (hazard ratio 1.35, CI 1.01-1.81). This study is the first to link TFF3 with both disease markers and outcomes in PAD. TFF3 demonstrated associations with renal function, PAD severity measured by ankle-brachial index, and additional atherosclerotic burden in PAD.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"409-415"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-05-01Epub Date: 2024-01-03DOI: 10.1177/00033197231225282
Ankit Agrawal, Suryansh Bajaj, Umesh Bhagat, Sanya Chandna, Aro Daniela Arockiam, Nicholas Chan, Elio Haroun, Rahul Gupta, Osamah Badwan, Shashank Shekhar, Shivabalan Kathavarayan Ramu, Divya Nayar, Wael Jaber, Brian P Griffin, Tom Kai Ming Wang
{"title":"Intracardiac Thrombus in COVID-19 Inpatients: A Nationwide Study of Incidence, Predictors, and Outcomes.","authors":"Ankit Agrawal, Suryansh Bajaj, Umesh Bhagat, Sanya Chandna, Aro Daniela Arockiam, Nicholas Chan, Elio Haroun, Rahul Gupta, Osamah Badwan, Shashank Shekhar, Shivabalan Kathavarayan Ramu, Divya Nayar, Wael Jaber, Brian P Griffin, Tom Kai Ming Wang","doi":"10.1177/00033197231225282","DOIUrl":"10.1177/00033197231225282","url":null,"abstract":"<p><p>COronaVIrus Disease-2019 (COVID-19) is associated with a hypercoagulable state. Intracardiac thrombosis is a potentially serious complication but has seldom been evaluated in COVID-19 patients. We assessed the incidence, associated factors, and outcomes of COVID-19 patients with intracardiac thrombosis. In 2020, COVID-19 inpatients were identified from the National Inpatient Sample (NIS) database. Data on clinical characteristics, intracardiac thrombosis, and adverse outcomes were collected. Multivariable logistic regression was used to identify factors associated with intracardiac thrombosis, in-hospital mortality, and morbidities. In 2020, 1,683,785 COVID-19 inpatients (mean age 63.8 years, 32.2% females) were studied. Intracardiac thrombosis occurred in 0.10% (1830) of cases. In-hospital outcomes included 13.2% all-cause mortality, 3.5% cardiovascular mortality, 2.6% cardiac arrest, 4.4% acute coronary syndrome (ACS), 16.1% heart failure, 1.3% stroke, and 28.3% acute kidney injury (AKI). Key factors for intracardiac thrombosis were congestive heart failure history and coagulopathy. Intracardiac thrombosis independently linked to higher risks of all-cause mortality (odds ratio [OR]: 3.32 (2.42-4.54)), cardiovascular mortality (OR: 2.95 (1.96-4.44)), cardiac arrest (OR: 2.04 (1.22-3.43)), ACS (OR: 1.62 (1.17-2.22)), stroke (OR: 3.10 (2.11-4.56)), and AKI (OR: 2.13 (1.68-2.69)), but not heart failure. While rare, intracardiac thrombosis in COVID-19 patients independently raised in-hospital mortality and morbidity risks.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"441-452"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-05-01Epub Date: 2024-05-20DOI: 10.1177/00033197241256161
Mesut Engin, Ahmet B Tatlı
{"title":"Letter: Trefoil Factor-3 and Peripheral Artery Disease: Reason or Result?","authors":"Mesut Engin, Ahmet B Tatlı","doi":"10.1177/00033197241256161","DOIUrl":"10.1177/00033197241256161","url":null,"abstract":"","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"500-501"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-05-01Epub Date: 2023-12-26DOI: 10.1177/00033197231225281
Jihee Kang, Sejun Kim, Shin-Seok Yang, Young-Wook Kim, Young-Soo Do, Kwang-Bo Park, Yang-Jin Park
{"title":"Clinical Characteristics and Management of Peripancreatic Arterial Aneurysms: A 20-year Experience.","authors":"Jihee Kang, Sejun Kim, Shin-Seok Yang, Young-Wook Kim, Young-Soo Do, Kwang-Bo Park, Yang-Jin Park","doi":"10.1177/00033197231225281","DOIUrl":"10.1177/00033197231225281","url":null,"abstract":"<p><p>Pancreaticoduodenal and gastroduodenal artery aneurysms (PDAAs and GDAAs) are rare visceral aneurysms. Considering the rupture risk regardless of size, treatment should be provided promptly. We reviewed the characteristics and management of peripancreatic aneurysms in a retrospective, single-center review of consecutive patients with PDAAs and GDAAs between 2000 and 2022. Demographics, clinical characteristics, radiologic features, treatment, and outcomes were recorded. Nineteen PDAAs and seven GDAAs were identified in 24 patients. The median sizes of the PDAAs and GDAAs were 21 mm (range: 8-50 mm) and 14 mm (range: 11-32 mm), respectively. There were 4 ruptured cases (15.4%). Ten aneurysms (38.5%) had concomitant visceral aneurysms, and 16 (61.6%) were associated with celiac pathology. Aneurysms were managed using endovascular in 12 (46.2%), surgical in 4 (15.4%), and combined methods in 3 (11.5%) cases; 7 patients (26.9%) were lost to follow-up or refused treatments. During a median 13.8-month follow-up (range: 1-147.6), two complications (7.7%) occurred including pancreatitis and coil migration into the superior mesenteric artery after embolization within 30 days. After 30 days, aorto-common hepatic artery bypass graft stenosis was identified in one PDAA. Depending on the characteristics of peripancreatic aneurysms, endovascular, surgical, and hybrid approaches might all be practical treatment options.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"424-430"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AngiologyPub Date : 2025-05-01Epub Date: 2023-12-01DOI: 10.1177/00033197231219837
Tarek A Abdelaziz, Randa H Mohamed, Sara F Saadawy
{"title":"Association of Endothelial Nitric Oxide Synthase and Angiotensin-Converting Enzyme Genes Polymorphism With In-Sent Restenosis of Bare Metal Stents vs Drug-Eluting Stents in Egyptians.","authors":"Tarek A Abdelaziz, Randa H Mohamed, Sara F Saadawy","doi":"10.1177/00033197231219837","DOIUrl":"10.1177/00033197231219837","url":null,"abstract":"<p><p>Despite its unequivocal superiority compared with balloon angioplasty, coronary stenting did not abolish restenosis. We aimed to evaluate the associations between a common single nucleotide polymorphism occurring in endothelial nitric oxide synthase (eNOS) and angiotensin-converting enzyme (ACE) genes and the risk of in-stent restenosis (ISR) of bare metal stents vs drug-eluting stents (BMS vs DES) implanted in Egyptian patients. Two hundred patients who had coronary stenting were divided into group I (<i>n</i> = 98) who received a BMS and group II (<i>n</i> = 102) who received a DES. eNOS and ACE genes polymorphism were analyzed by polymerase chain reaction (PCR). We found that the GA and AA genotypes of the eNOS gene were associated with the ISR with both BMS and DES. However, the ACE gene was not associated with ISR. We concluded that eNOS gene polymorphism is associated with ISR. Hypertension, stent length, and AA genotype of the eNOS gene were found to be independent predictors of the occurrence of ISR after both BMS and DES use.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"416-423"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138469805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Association Between the Albumin-Bilirubin Score and Contrast-Associated Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention.","authors":"Jun-Han Chen, Li-Wei Zhang, Zhi-Jie Lin, Xiao-Fang Chen, Li-Chuan Chen, Chang-Xi Wang, Kai-Yang Lin, Yan-Song Guo","doi":"10.1177/00033197241228051","DOIUrl":"10.1177/00033197241228051","url":null,"abstract":"<p><p>The albumin-bilirubin (ALBI) score is considered an effective and convenient scoring system for assessing liver function. We hypothesized that the ALBI score was predictive of contrast-associated acute kidney injury (CA-AKI) and long-term mortality in patients undergoing elective percutaneous coronary intervention (PCI). We retrospectively observed 5629 patients undergoing elective PCI. Contrast-associated acute kidney injury is defined as a 50% or 0.3 mg/dl increase in baseline serum creatinine levels within 48 h of contrast exposure. The incidence of CA-AKI was 6.2% (n = 350). After adjusting for potential confounding factors, multivariate analysis showed that the ALBI score was an independent predictor of CA-AKI (<i>P</i> = .002). A restricted cubic spline analysis confirmed approximately linear relationships between the ALBI score and risks of CA-AKI. Furthermore, at a median follow-up of 2.8 years, multivariate Cox regression analysis indicated that the ALBI score was an independent risk factor for long-term mortality (<i>P</i> < .001). The ALBI score was closely related to the occurrence of CA-AKI and long-term mortality in patients who underwent elective PCI. This score might be useful for risk stratification in high-risk patient groups to predict CA-AKI.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"487-495"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}