Annals of Medical Research最新文献

{"title":"The Effects of Consanguineous Marriage on Small Kidney in Chronic Kidney Disease\u0000Small Kidneys in Chronic Kidney Disease","authors":"Semahat rali","doi":"10.5455/annalsmedres.2022.12.368","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.368","url":null,"abstract":"Aim: To determine the effects of small kidney and consanguineous marriage in chronic kidney disease (CKD). Materials and Methods: Patients with a vertical kidney size of 100 mm or less, who applied to the outpatient clinic between September 2021 and 2022, were included in the study. Urinary ultrasonography and renal function tests were recorded one year apart. Two groups, with and without relatives, were compared. SPSS 22.0 program was used for statistics. p< .05 was considered significant. Results: The parents of 50 of the 94 cases with small kidney included in the study were related and 44 of them were not related. 57.4% were female, mean age was 49.86. Urea, creatinine, e-GFR, hemoglobin, albumin, phosphorus, calcium, PTH, ferritin, and urinary USG used in chronic kidney disease progression follow-up were compared between the groups with and without parental consanguinity. Conclusion: Early application of prevention measures with ultrasound detection of small kidney related to consanguineous marriage at an earlier age before kidney dysfunction is established will slow down the progression.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80375548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral respiratory tract infection in Gaucher disease, a rare disease: A case study of 24 patients in Malatya-Turkey","authors":"A. M. Res, B. Yaprak, H. Aladag, M. Aladağ","doi":"10.5455/annalsmedres.2022.12.382","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.12.382","url":null,"abstract":"People with chronic diseases have a higher rate of morbidity and mortality from SARS-CoV-2 infection. A rare lysosomal storage disease is Gaucher disease. Chronic myeloid cell immune activation is caused by a decline in acid -glucosidase activity and an accumulation of inflammatory glycosphingolipids in Gaucher disease. Unknown is how SARS-CoV-2 affects rare disease populations like Gaucher disease. Myeloid cell immune activation in Gaucher's disease may predispose to severe effects of this infection. The only study conducted in Turkey so far is this one. People with chronic diseases have a higher rate of morbidity and mortality from SARS-CoV-2 infection. A rare lysosomal storage disease is Gaucher disease. Chronic myeloid cell immune activation is caused by a decline in acid -glucosidase activity and an accumulation of inflammatory glycosphingolipids in Gaucher disease. Unknown is how SARS-CoV-2 affects rare disease populations like Gaucher disease. Myeloid cell immune activation in Gaucher's disease may predispose to severe effects of this infection. The only study conducted in Turkey so far is this one. Eight of our patients reported having contact with someone who had COVID-19 infection or was suspected of having the infection, and in three of these cases (37.5%) the patient reported having at least one symptom of infection. Out of the 18 patients who were tested, 4 (22.2%) had a positive result. Positive test results were associated with more symptoms in patients (3.8 vs 0.3, p0.001) than negative test results. In Gaucher patients, symptoms or positive test results were not correlated with age, gender, BMI, comorbidity, genotype, previous splenectomy, or enzyme replacement therapy. All of our patients only received supportive care; none of them required intensive care or specialized treatment. Our research revealed that there was a low risk of serious side effects in other chronic patients following SARS-CoV-2 infection in Gaucher patients. In this regard, studies with larger case series are required.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87729431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of nutritional counseling service provided within primary health care at a district level","authors":"M. Sezerol, Zeynep Alta","doi":"10.5455/annalsmedres.2023.01.037","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.037","url":null,"abstract":"Objective: It was aimed to investigate the effectiveness of nutritional counseling services provided in the diabetes and obesity unit of primary health care services for the control of obesity. Materials and Methods: This study is a retrospectively descriptive research. People applied to the diabetes and obesity unit of a District Health Directorate in Istanbul between 01.01.2017-01.04.2022 constitute the population. Analysis about the first application (height, weight, sociodemographics) was made with 3259 people; weight loss was evaluated within 1282 people. Mean, standard deviation, median, minimum, maximum values, numbers (n) and percentages (%) were used for descriptive data. The Mann Whitney U was used if the data not normally distributed. Chi-square test was used for categorical variables. Multivariate analysis is made with Cox-regression analysis. Statistical significance level was p<0.05. Results: 2973 (91.2%) of the participants were women. The median age was 38.0 (15.0-83.0). Height, weight and BMI median values were 158.0 cm (116.0-190.0), 83.6 kg (56.0-160.2), 33.0 kg/m2 (25.0-64.7), respectively. Weight and BMI loss was observed in 90.8% of the patients. The median weight and BMI loss loss were 2.7 kg (-21.40-56.10) and 1.1 kg/m2 (-8.79-22.69). According to univariate analysis, weight loss percentage of 5% and above was significantly higher in those with low educational status, but this significance was not observed in multivariate analysis. Conclusion: Weight loss was achieved 90.8% of the participants. While it is encouraging to benefit from nutritional counseling at a high percentage; it is important to understand the barriers to weight loss for participants who cannot benefit.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88079805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the clinical course, laboratory and radiological findings of COVID-19 infection between male, female and pregnant patients in demographically homogeneous groups","authors":"Hilal zsoy, Serhat nal, S. L, Behiye Oral","doi":"10.5455/annalsmedres.2022.08.256","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.256","url":null,"abstract":"Objective: This study examines for any differences in the clinical course, laboratory and radiological findings of COVID-19 infection between male, female and pregnant patients in similar age groups. Materials and Methods: This retrospective study involved a review of the data of patients treated between March 2020 and May 2021, included a total of 528 cases (193 pregnant females, 170 non-pregnant females and 165 males) aged 18–40 years with RT-PCR-confirmed COVID-19. Results: A comparison of the three demographically homogeneous groups revealed more common symptomatic infection at admission in the male patient group than in the other two patient groups (p<0.001), as well as a longer hospital stay (p<0.001) and higher incidences of moderate and severe pneumonia (p<0.001) based on radiological findings. In contrast, no significant difference was noted in the intensive care unit admission and mortality rates of the three groups. Conclusion: The results of our study reveal that females have some degree of protection against severe presentations of COVID-19 infection when compared to men. The heterogeneity of immunocompetence and immune response can help to understand the different COVID-19 responses of males and females, and can be used as a guide for disease prognosis and gender-specific treatments.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89222577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between osteochondral lesion of the talus and the foot arch angles in adults: A retrospective study","authors":"M. Boz, Abdullah ahin, Mehmet ek","doi":"10.5455/annalsmedres.2022.10.300","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.10.300","url":null,"abstract":"Objective: The current study aimed to compare the arch angles of the foot, Achilles tendinopathy, subcutaneous fat tissue thickness of the heel, and epin calcanei (EC) in patients with osteochondral lesion of the talus (OLT). Methods:The magnetic resonance images (MRI) of the ankle performed by the radiology clinic between March 2020 and October 2021 were examined.Based on the MRI findings, the patients diagnosed with OLT were included in the study group (n = 55) and those not diagnosed with OLT formed the control group (n = 118). All the patients included in the study were investigated for their demographic characteristics and presence of EC. Weight-bearing lateral X-ray images were used to measure the lateral talus-first metatarsal angle (Meary’s angle), lateral talocalcaneal angle (LTCA), and calcaneal inclination angle (also known as the calcaneal pitch). Results: The study and control groups had no significant difference in terms of gender distribution (P = 0.575). The patients in the study group had a significantly higher mean age than the control group (P < 0.001). Evaluation of the arch angles of the foot showed the patients with OLT to have higher LTCA and calcaneal pitch angles and greater subcutaneous fat thicknesses (p < 0.001, p < 0.001, and p = 0.004, respectively). In addition, the study group showed higher rates of patients with EC and Achilles tendinopathy (p = 0.076 and p = 0.019, respectively).Conclusion: Our study demonstrated that sex had no effect on OLT incidence, whereas changes in the LTCA and pitch angles elevated the risk of OLT. Furthermore, increased age was found to be associated with a higher risk of OLT formation. We also showed that Achilles tendinopathy and EC were significantly higher in patients with OLT.A considerable number of future studies are needed to establish whether this significant relationship is causal.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91527138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects Of Shunt Types Used In Idiopathic Normal Pressure Hydrocephalus On Patients' Clinical Outcomes","authors":"M. Akyol, E. Çetin","doi":"10.5455/annalsmedres.2022.11.333","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.11.333","url":null,"abstract":"Background: Idiopathic normal pressure hydrocephalus (iNPH) is a surgically reversible neurological disorder in adults. It is a neurological condition characterized by ventricular enlargement detected on cranial imaging as well as gait disturbance, cognitive decline and urinary incontinence, with no other reason to explain the clinical findings. Ventricular shunting, predominantly ventriculoperitoneal (VP) shunt, has been shown to be successful in relieving symptoms in patients. In this study, we aimed to investigate the effects of two VP shunts used in the iNPH patients treated in our clinic. Methods: Clinical and laboratory records of 28 patients who underwent VP shunting due to iNPH were reviewed retrospectively via the Enlyl system. A programmable shunt was inserted in 9 (32.1%) and a medium-pressure shunt was inserted in 19 (67.9%) patients. Results: There was no significant difference between the two shunt types with regard to patient age, gender, and preoperative tests (p>0.05). However, the prevalence of ataxic gait was significantly higher in the Programmable Shunt group compared to the Medium-Pressure Shunt group (p<0.05). On the other hand, no significant difference was found between the shunt types with regard to postoperative examination findings and additional neurological disorders (p>0.05 for both). Conclusion: In the present study, no significant difference was observed between the shunt types with regard to clinical outcomes and thus both types of shunts were revealed as viable options.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90160155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of multivariate statistical methods to detect risk factors for Type 2 diabetes mellitus","authors":"ipek ek, Saim Lu, ibrahim ahin","doi":"10.5455/annalsmedres.2022.09.276","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.09.276","url":null,"abstract":"Aim: The goal of this study is to compare the performances of Logistic Regression (LR), Artificial Neural Networks (ANN) and Decision Tree models, which are machine learning classification methods, in the diagnosis of Type 2 Diabetes Mellitus (DM) and to determine the most successful method. It is also the examination of risk factors affecting Type 2 DM using these models. Method: The study's data was collected from patients who visited the Diabetes and Thyroid polyclinic at the Inonu University Faculty of Medicine Turgut Ozal Medical Center, Department of Internal Medicine. The k-Nearest Neighbor algorithm, which is one of the missing value assignment methods, was used to eliminate the problems related to missing values. Sensitivity, accuracy, precision, specificity, AUC F1-score, and classification error were used as performance evaluation criteria. Evolutionary algorithm parameter optimization method was used to optimize the parameters of the ANN model. Missing value assignment, modeling and parameter optimization were done with Rapidminer Studio Free version 8.1. Results: Among the three methods applied in the diagnosis of Type 2 DM, the ANN gave the best classification performance. The accuracy, sensitivity, selectivity, precision, F1-score, AUC and classification error values obtained from this method are respectively; 98.94%, 100%, 97.73%, 98.04%, 99.01%, 0.978 and 1.06. For the ANN method, the importance values of the gender, long-term drug use, family history, concomitant disease, cortisone use, stress factor, high blood pressure, smoking, high cholesterol, heart disease, exercise status, carbohydrate use, alcohol consumption, vegetable use, meat use, age, weight, height, starting age, daily bread consumption, LDL, HDL, Total Cholesterol, Triglyceride, Fasting blood sugar the importance values of independent variables are respectively; 0.017, 0.009, 0.013, 0.017, 0.008, 0.016, 0.008, 0.006, 0.053, 0.024, 0.023, 0.040, 0.007, 0.020, 0.007, 0.046, 0.083, 0.049, 0.024, 0.066, 0.084, 0.083, 0.020, 0.031, 0.244. Conclusion: According to the performance criteria obtained from the three classification models used to predict Type 2 DM; it has been found that the best classification performance belongs to the ANN model. According to the ANN method, the three most important risk factors that may cause Type 2 DM were found to be fasting blood glucose, LDL, and HDL, respectively.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88821892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between balance and flu-like symptoms: a medical condition that needs attention","authors":"Serhat Kaya","doi":"10.5455/annalsmedres.2023.01.039","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.01.039","url":null,"abstract":"Objective: In general, while upper respiratory tract viruses cause flu-like complaints, balance problems associated with these viruses are often overlooked. It has been a long time since the first appearance of Covid-19, but unfortunately, there is still no fully effective treatment for this disease. Along with balance manifestations, especially several vestibular symptoms such as dizziness, vertigo, and tinnitus are described as common clinical manifestations in COVID-19. In our study, we investigated the effects of Covid-19 on the balance system with routine balance tests and we tried to localize a possible disorder in the balance system. Materials and Methods: Volunteers were divided into two groups. The number of volunteers in each group was thirty. The first group consisted of SARS-CoV-2-positive patients and the second group consisted of healthy people. Spontaneous nystagmus determination, Romberg test, Fukuda stepping test (FST), head thrust test (HTT), head shake test (HST), finger-nose test, and tandem walking test were applied. Results: The lateral fall in the Romberg test, rotation in the FST, and nystagmus in the HST are significant in Group 1 (p<0.001), (p<0.001), (p<0.03). The relationship between the fall side in the Romberg test and the direction of rotation in the FST were found to be significant in Group 1 (p<0.001). Similarly, the relationship between the direction of rotation in the FST and the nys-tagmus direction in the HST, and the direction of the saccadic correction in the HTT were found to be sig-nificant (p<0.026), (p<0.010). Conclusion: In SARS-CoV-2 positive patients, the balance system, especially the peripheric vestibular system, may be affected even if the patients do not have obvious complaints about balance. Routine balance tests that can be performed quickly in the outpatient clinic can be used effectively for the evaluation of balance.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83085672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Motor and Sensory Parameters in Patients with Lumbar Disc Herniation","authors":"Bar Zorbozan, M. Yener, Belgin Bama","doi":"10.5455/annalsmedres.2023.03.067","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.03.067","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82014496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing And Detecting Risk Factors For The Diagnosis Of Angina Pectoris With Machine Learning","authors":"O. Ozhan, ipek ek, Zeynep Al","doi":"10.5455/annalsmedres.2023.02.043","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.02.043","url":null,"abstract":"Aim: To classify angina pectoris (AP) in women by applying the Bagged CART approach, which is one of the machine learning (ML) methods, to the open-access AP dataset. Another aim is to reveal the risk factors associated with AP in women through modeling. Materials and Methods: In the current study, modeling was done with the Bagged CART technique utilizing an open-access data set containing the factors associated with AP. Model results were assessed with accuracy (ACC), sensitivity (Sen), balanced accuracy (BACC), positive predictive value (PPV), specificity (Spe), negative predictive value (NPV), and F1-score performance criteria. In addition, a 5-fold cross-validation approach was applied in the modeling phase. Finally, variable importance was derived with modeling. Results: ACC, BACC, Sen, Spe, PPV, NPV, and F1-score from Bagged CART modeling were 98.5%, 98.5%, 99.0%, 98.0%, 98.0%, 99.0%, and 98.5%, respectively. Depending on the variable importance values calculated for the input variables investigated in the current study, age, family history of myocardial infarction: yes, the average number of cigarettes smoked per day smoking status: current, family history of angina: yes, hypertensive condition: moderate, smoking status: ex, hypertensive condition: mild, family history of stroke: yes, whether the woman has diabetes: yes were obtained as the most important variables associated with AP. Conclusion: With the ML model used, the AP dataset was classified successfully, and the associated risk factors were revealed. ML models can be used as clinical decision support systems for early diagnosis and treatment.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90540835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}