D. Kavvadas, A. Kavvada, K Ziampa, Kyriazidi Ma, D Rousis, M. Chatzidimitriou
{"title":"Human Papillomavirus: A Gender-Based Report on the Knowledge of College Students in Northern Greece","authors":"D. Kavvadas, A. Kavvada, K Ziampa, Kyriazidi Ma, D Rousis, M. Chatzidimitriou","doi":"10.36648/1989-8436.11.3.110","DOIUrl":"https://doi.org/10.36648/1989-8436.11.3.110","url":null,"abstract":"Title: This study was performed to evaluate the level of basic knowledge of students in Northern Greece regarding human papillomavirus matters, considering each gender’s aspect. Background: In every society it is fundamental that young adults should receive proper education for all Sexual Transmitted Diseases. This study aims on highlighting the necessity of aggressive campaigns, for informing students on HPV. Via a short survey, we performed a key evaluation of the knowledge of students to conclude on whether campaigns for informing students on HPV should be organized by the state. Methods and Findings: A questionnaire type of survey was undertaken to evaluate the level of basic knowledge of the sample regarding HPV. The questionnaire comprised of 11 questions. The first two questions were to determine specific characteristics of the sample; the third was about the participant’s belief of being well educated on HPV, while the rest of them were to evaluate their actual knowledge of the activity, pathogenesis and the national vaccination program against HPV. Five hundred sixty-one students of Northern Greece participated in the study (398 females and 161 males). Regarding their knowledge on HPV, most of the participants declared to be well informed with a rate of 76.1%. Indicatively, it appeared to be an independence regarding gender (p=0.44) about whether HPV can cause cancer to both sexes. As to vaccination, 50.7% of the participants, regardless gender, believed that HPV vaccine is effective on men (p=0.34). Conclusion: Students in Northern Greece seemed to be insufficiently informed about the general activity of HPV, pathogenicity, and vaccine’s effectiveness (p=0.00001). Similar surveys should be launched in the whole country for a proper evaluation to be obtained. The outcome of these studies could be rather beneficial in organizing educational campaigns for students of Greece and, if it is needed, to other countries as well.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83153556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adeoti Om, Olaleye Om, Adeoye Ka, Adesina Da, Olaoye Oj, A. Ba
{"title":"Molecular Typing of 16S rRNA of Azadirachta indica and Ocimum gratissimum Resistant Pseudomonas spp. from Sabe in Oke-Ogun, Nigeria","authors":"Adeoti Om, Olaleye Om, Adeoye Ka, Adesina Da, Olaoye Oj, A. Ba","doi":"10.36648/1989-8436.11.4.117","DOIUrl":"https://doi.org/10.36648/1989-8436.11.4.117","url":null,"abstract":"The aim of this study was to present the molecular typing of bacteria which were resistant to extract of the leaves of Ocimum gratissimum and Azadirachta indica and to investigate whether there was any relationship between non-sensitivity to antibiotics and the extract of plants of four isolates: Salmonella typhii, Escherichia coli, Pseudomonas aeruginosa and Pseudomonas monteilii. Four solvents used for the extraction of the active ingredients of the plants were Ethanol, N-Hexane, Water, Ethanol and Water combined in five different concentrations. The four microorganisms listed above were isolated from raw milk, Borehole water and soil. The isolates were variously subjected to conventional morphological, biochemical tests and subsequently molecular screening (Polymerase Chain Reaction (PCR) and Sanger sequencing method). Pseudomonas aeruginosa (KF530797) and Pseudomonas monteilii (KJ676707) identified were subjected to BLAST using pairwise alignment technique from NCBI database. The two plant extracts had earlier been documented as resistant to Escherichia coli and Salmonella spp. which were earlier isolated from milk and water, respectively. There was no zone of inhibition as observed in all concentrations of plant extract considered except a noticeable clear zone of inhibition against synthetic antibiotics in the order of Ofloxacin and Gentamycin. Although suspected gene markers from the two-soil isolate were suspected to be amplified around 1400 bp. The 16S rRNA sequences of Pseudomonas aeruginosa (94.43%) was somewhat more variable than Pseudomonas monteilii (99.93%) indicating a pairwise alignment of Pseudomonas monteilii to be more conserved than P. aeruginosa.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76069756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Rajkumari, A MuraliBalasubramaniam, Gauri Ch, S. Ran, Goutham Ranjith Nambiar, Harin, K hini
{"title":"Knowledge Risk Attitude Assessment Related To HIV/AIDS among BDS Students in Chennai, Tamil Nadu","authors":"S. Rajkumari, A MuraliBalasubramaniam, Gauri Ch, S. Ran, Goutham Ranjith Nambiar, Harin, K hini","doi":"10.36648/1989-8436.11.3.111","DOIUrl":"https://doi.org/10.36648/1989-8436.11.3.111","url":null,"abstract":"Background: Acquired Immuno Deficiency Syndrome (AIDS) awareness is comparatively low in densely populated countries like India. India stands as the third largest country with HIV positive patients, with Tamil Nadu in the 6th position state wise. In this study a survey was conducted to assess the knowledge, attitude and risk related to AIDS among the undergraduate dental students in Chennai city, intended to create awareness among the youth thereby preventing the incidence of AIDS. Method: A dichotomous self-administered questionnaire consisting of 16 questions was approved by Institutional Human Ethical Committee and it was distributed to 432 dental students in Chennai, the filled forms were later evaluated. Result: This study reveals that the overall knowledge on AIDS among the study population was satisfactory. The knowledge on basics of AIDS is 84.12%, cause of AIDS is 88.3%, source of information about AIDS is 66.62% and knowledge on people at risk of developing AIDS is 79.72%, while knowledge on prevention and management of AIDS is 88.12%. Conclusion: This study infers that overall knowledge about AIDS is better among the boys than the girls. Health education must be made mandatory at schools, colleges, community level to defend from the globally endangering disease.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84480635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Profile of Adult Patients Suffering from Scrub Typhus in Kasturba Hospital Wardha, Central India: A Study of 125 Patients","authors":"Neeraj Dodake, Jain Ap, M. Bhagat","doi":"10.36648/1989-8436.11.1.102","DOIUrl":"https://doi.org/10.36648/1989-8436.11.1.102","url":null,"abstract":"Background: Scrub Typhus is among the commonest causes of Acute Undifferentiated Fever during the monsoon in central India but there is a gap in knowledge regarding the data of the clinical profile in tropical rural area. Objective: To study the clinical profile of adult patients admitted with scrub typhus during the monsoon in rural central India. Material and methods: A Hospital based retrospective study was carried out in the 125 patients admitted to Medicine department of MGIMS during the monsoon period of June to September 2017. The History, clinical features, Lab profile, Treatment, complications and outcomes were studied closely. The data was retrieved from the Hospital Information System. The Outcome was studied in association with the severity of presentation, complications and treatment given. Diagnosis depended on recognizing the syndrome of non-specific symptoms of fever and cough, while diagnosis was confirmed using the IgM Scrub Typhus Rapid Chromatographic Test, which was considered as a Gold Standard in our study. Statistical analysis was done by descriptive and inferential statistics using chi-square test and software SPSS 22.0 version, EPI Info version 7 and Graph Pad Prism 6.0 version. Results: The clinical illness was characterized by Fever with chills (60.8%) and Cough (68.8%). The Disease was mostly acute (97%) presenting with a history of less than 10 days. The most characteristic physical sign was fever which was present in almost 60 percent of cases and the traditionally mentioned rash called Eschar was found in only 38 percent of patients. ARDS, nephropathy, Liver failure and Multi organ dysfunction occurred in 16%, 20%, 20% and 13.6% respectively. Though Scrub typhus occurs secondary to a chigger bite, only 6 patients out of 125 gave the actual history of insect bite. 9 patients out of 125 (7.2%) succumbed to death. Early treatment with Doxycycline shortened the duration of illness. No relapses occurred in those patients who received Doxycycline or Azithromycin for at least 7 days. Conclusion: Serious complications can occur if Scrub typhus is not recognized promptly. Early institution of Doxycycline can save lives in the patients of acute undifferentiated fever pending investigations. General physicians should be Scrub typhus minded to suspect and accurately treat the patients of fever.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"15 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91493743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Covid-19: A Review about One of the Worst Known Pandemics of the Century","authors":"C. Das","doi":"10.36648/1989-8436.11.4.121","DOIUrl":"https://doi.org/10.36648/1989-8436.11.4.121","url":null,"abstract":"The current outbreak of the novel coronavirus SARSCOV-2 known as COVID-19 is one of the biggest known pandemics to have occurred. Much of the information regarding the SARS-COV 2 has been obtained owing to its similarities to the SARS virus. The spike proteins of the virus attack the ACE 2 receptors present mainly in the respiratory tract. The human body reacts vigorously to the infection by releasing a vast amount of interferon and interleukins which transform into a cytokine storm leading to an acute respiratory distress syndrome. Studies show that people with comorbidities are subject to a greater risk of catching the infection. A large section of these people has underlying cardiovascular diseases and blood pressure. An interesting hypothesis about ACE inhibitors possibly up regulating the ACE 2 receptors and exposing patients to a greater risk is also being studied upon. While the search for a vaccine for COVID-19 is ongoing, convalescent plasma therapy has emerged as an effective therapy for severely affected patients. Anti-viral drugs such as chloroquine, hydroxychloroquine, and remdesivir are also being tried as potential medications. Scientists have advised the intake of vitamin C and vitamin D in adequate doses daily, as studies have shown patients taking these vitamin supplements have lesser risks to catching pneumonia. This review article takes a deep look at how the SARS-COV 2 virus works, its primary symptoms while also briefing about the prophylaxis and medications.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84577859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adeoti Om, Adedoja Sa, Adedokun Eo, Olaoye Oj, Abiola Ao, Okesipe Fo
{"title":"Efficacy of Chewing Sticks Extract on the Agent of Dental Carries Isolates","authors":"Adeoti Om, Adedoja Sa, Adedokun Eo, Olaoye Oj, Abiola Ao, Okesipe Fo","doi":"10.36648/1989-8436.11.1.101","DOIUrl":"https://doi.org/10.36648/1989-8436.11.1.101","url":null,"abstract":"The preferred part or parts are cleaned with water to remove dirts then cut to a convenient length which varies from 15-30 cm long and tied into a bundle. The aim of this study was to determine the efficacy of chewing stick on the biological agents of dental carries isolates. Aqueous extracts of five different chewing stick Fagaraxanthoxyloides pako ata, Vernonia amygdalina pako ewuro, Anogeissus leiocarpa pako ayin, Azadirachta indica pako dogoyaro, Prosopis africana mesquite from different location-Sango, Gbawojo market in Saki Oyo State, were tested against isolated microorganisms from the plaque sample of five different individuals of dental carries without previous antibiotic history. The colonial, morphological microscopic and biochemical identification of the isolates were also performed. All the extracts from the selected chewing stick showed good antimicrobial activity against all the isolated microorganisms. It was observed that extract from Anogeissus leiocarpa at 500 mg/ml showed a maximum zone of inhibition (27 mm) against Klebsiella while extract of V. amygdalina at 500 mg/ml produced a maximum zone of inhibition of (28 mm) against Streptococcus but extract of Fagaraxanth oxyloides exhibited a maximum zone of inhibition (27 mm) against E. coli and extract of Azadirachta indica and Prosopis africana produced a maximum zone of inhibition of (23 mm and 33 mm) respectively at 500 mg/ml. The present study confirmed the use of these Chewing stick in oral hygiene since their potential anti plaque effect is likely to complement the mechanical plaque removing property of chewing sticks. The results of the study possess inhibitory potentials against bacteria present in dental plaque mainly on aerobes. Chewing stick could be recommended in community for oral health program because they are readily available and cheaper.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86802097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Biological Activity of Aqueous and Methanolic Extracts of Juglans regia on Yeasts and Pathologic Bacteria","authors":"F. N. Jafer, L. Naser","doi":"10.36648/1989-8436.11.3.113","DOIUrl":"https://doi.org/10.36648/1989-8436.11.3.113","url":null,"abstract":"Background: The plant extract can be used as a natural alternative to control of pathogenic yeasts and bacteria in general and to reduce the risk of antibiotic-resistant pathogens. Methods: Diffusion agar method was used to examine the antifungal and antibacterial activity of both aqueous and methanolic Juglans regia extracts. For yeasts, The MIC values were determined by the standard serial dilution assay using serial dilutions of the aqueous and methanolic extracts (300,200,100, 50, 25) µg/L). The MIC for bacteria was done using Muller-Hinton agar. The concentrations of the extracts tested were (500, 250, 100, 50) µg/ml. Results: Juglans regia extracts showed activities against Malassezia furfur yeast, Methanolic extract exhibits more activity than aqueous extract. The Minimum Inhibition Concentrated rate (MIC) for Malassezia furfur methanolic extract was 75 µg/ml. The extracts also examined on Candida albicans opportunistic yeast in the mouth and found to be more active than M. furfur were MIC 50 µg/ml. The biological activity of aqueous and methanolic extracts were also examined against six pathogenic bacteria isolated from patients suffering from different diseases from several hospitals in Basrah, including Staphylococcus aureus, Escherichia coli, Salmonella typhi, Proteus mirabilis, pseudomonas aeruginosa and Vibrio parahaemolyticus. The Methanolic extract showed an effective effect in inhibiting all bacterial species compared with the aqueous extract. Conclusion: This study provides the possibility of using a natural plant such as Juglans regia as antimicrobial agent for many pathogenic yeasts and bacteria.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82608823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Gabisonia, M. Loladze, M. Zarnadze, N. Kekenadze, Mariam Lomidze, N. Tamarashvili, G. Gabisonia, T. Beridze, M. Pkhaladze, R. Mirzikashvili, Irakli Chkhetia
{"title":"Study of E. coli Pathogens Causing Intestinal Infections and Use of Bacteriophage Preparation-Coli Phage","authors":"T. Gabisonia, M. Loladze, M. Zarnadze, N. Kekenadze, Mariam Lomidze, N. Tamarashvili, G. Gabisonia, T. Beridze, M. Pkhaladze, R. Mirzikashvili, Irakli Chkhetia","doi":"10.36648/1989-8436.11.1.99","DOIUrl":"https://doi.org/10.36648/1989-8436.11.1.99","url":null,"abstract":"According to the data of World Health Organization (WHO) about 2 billion of people get sick with intestinal infections annually. The pathogens which spread through food and water are the main causes of the sickness and mortality; they lead to death of about 1.8 million each year. Resulting from the mentioned problem, it carries particular importance to conduct microbiological and molecular research of bacterial pathogens causing intestinal infections. One of the main pathogens, which spread through waters, is variety of Salmonella, pathogenically Escherichia coli and Shigella. Monitoring the food and water related pathogens would facilitate the process of downsizing their frequency in the environment, which on its own would reduce the risk of spreading diseases caused by the mentioned pathogen amongst humans. Early identification of these pathogens has the vital importance for quick and effective treatment.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79980515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antimicrobial Resistance Pattern of Methicillin-Resistant Staphylococcus aureus (MRSA) Strains Isolated from Clinical Specimens in Kathmandu, Nepal","authors":"Shakti Regmi, J. Amatya, S. N. Labh","doi":"10.36648/1989-8436.11.4.116","DOIUrl":"https://doi.org/10.36648/1989-8436.11.4.116","url":null,"abstract":"Background: Methicillin-resistant Staphylococcus aureus (MRSA) refers to a group of Gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus and is responsible for several difficult-to-treat infections in humans. It constitutes the most severe contemporary challenges to the treatment of hospital-acquired infections Objective: This study was conducted to determine the prevalence of MRSA among clinical isolates of Methicillinresistant Staphylococcus aureus bacterium and determine the antimicrobial susceptibility pattern. Methods: A cross-sectional study was carried out from March to September 2018 at Everest Hospital, Kathmandu, Nepal, in which 526 samples isolated from various clinical specimens. Methicillin-resistant Staphylococcus aureus (MRSA) identified by using the Cefoxitin (30 μg) disc diffusion method followed by the Clinical and Laboratory Standards Institute (CLSI 2015) guidelines. Results: Most of the MRSA was isolated from pus, which collected from OPD patients. Antibiotic sensitivity pattern showed that all Methicillin-resistant Staphylococcus aureus isolates were sensitive to vancomycin teicoplanin, linezolid, and none of the isolates were sensitive to antibiotic penicillin. At the end of the final observations, 33.8% of clinical samples were positive to S. aureus growth. Conclusion: In this study, the prevalence of MRSA isolates was less as compared to other studies routine screening of MRSA by cefoxitin disc and determining the complete antimicrobial susceptibility profile of these isolates to treat these infections effectively.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76839250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Chatzidimitriou, P. Chatzivasileiou, G. Sakellariou, Kyriazidi Ma, D. Chatzidimitriou, F. Chatzopoulou, D Rousis, E Katsifa, E. Vagdatli, Lialiaris Th
{"title":"Carbapenem-Resistant Klebsiella pneumoniae Strains: Susceptibility to Novel Antibiotics and Molecular Detection of the Resistance Mechanisms - A Study from Two Greek Tertiary Teaching Hospitals","authors":"M. Chatzidimitriou, P. Chatzivasileiou, G. Sakellariou, Kyriazidi Ma, D. Chatzidimitriou, F. Chatzopoulou, D Rousis, E Katsifa, E. Vagdatli, Lialiaris Th","doi":"10.36648/1989-8436.11.3.108","DOIUrl":"https://doi.org/10.36648/1989-8436.11.3.108","url":null,"abstract":"Objectives: We evaluated the carbapenem resistance mechanisms of Klebsiella pneumoniae strains isolated in two Greek tertiary teaching hospitals and their susceptibility to currently used and novel antimicrobial agents. Materials and methods: Forty-seven carbapenem resistant K. pneumoniae strains were collected in G. Papanikolaou and Ippokrateio hospital of Thessaloniki from 1/11/2016 to 5/1/2018 and 26/1/2017 to 19/4/2017 respectively. Strain identification and antimicrobial susceptibility was conducted by Vitek 2 system (Biomerieux France). Susceptibility against new antimicrobial agents was examined by disk diffusion method. Polymerase chain reaction (PCR) was used for the detection of blaKPC, blaVIM, blaNDM and blaOXA-48 genes. Results: The EDTA-boronic acid disk synergy test performed on the 24 K. pneumoniae strains from G. Papanikolaou hospital demonstrated that 8 (33.3%) yielded positive for metallo-b-lactamases (MBL) and 16 (66.6%) for K. pneumoniae carbapenemases (KPC) production. Gentamycin demonstrated the highest in vitro activity (82.6%) among the 23 K. pneumoniae strains from Ippokrateio hospital followed by colistin (73.9%) and tigecycline (69.5%). All strains from G. Papanikolaou hospital were sensitive to colistin whereas the 70.8% of them displayed susceptibility to gentamycin. Ceftazidime/ avibactam showed the highest sensitivity (76.6%) in all strains followed by eravacyclin (66.6%). The blaKPC gene was present in 30 strains (63.8%), the blaNDM in 11 (23.4%) and the blaVIM in 6 (12.8%). The blaOXA-48 gene was not detected. Conclusions: Well established antimicrobial agents such as colistin, gentamycin and tigecycline and novel antibiotics like ceftazidime/avibactam and eravacycline may be reliable options for the treatment of invasive infections caused by KPC-producing pathogens.","PeriodicalId":8142,"journal":{"name":"Archives of Clinical Microbiology","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79283156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}