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Archiv fur dermatologische Forschung最新文献

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The behaviour of collagen peptidase in the serum of different dermatoses. 不同皮肤病患者血清中胶原肽酶的行为。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
G W Korting, B Morsches
{"title":"The behaviour of collagen peptidase in the serum of different dermatoses.","authors":"G W Korting,&nbsp;B Morsches","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 150 patients with different dermatoses and 15 controls the activity of collagen peptidase in serum was determined. No relation to specific skin diseases was found. Negative findings were also observed in the group of collagenoses: only 4 of 14 patients with progressive systemic sclerosis showed an increase of this enzyme activity. These negative results seem noteworthy because it thus is demonstrated that alterations of collagen structure are not necessaryly associated with alterations of collagen peptidase activity.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 3","pages":"191-7"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11449741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human melanoma FUHS-1. Description of a new cell line. 人类黑色素瘤FUHS-1。描述一个新的细胞系。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
V Misgeld, C Meisel
{"title":"Human melanoma FUHS-1. Description of a new cell line.","authors":"V Misgeld,&nbsp;C Meisel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Presented is a new established cell line, which was cultivated from a melanoma originating from a melanosis praeblastomatosa circumscripta of the leg. Recently subculture No. 105 was reached after a period of 31 month. Medium of primary culture was TC Medium Eagle spinner modified, followed from subculture No. 1 by MEM/Hanks/0.35 g/l NaHCO3. From subculture No. 6 NCTC 135 was applied simultaneously-each respective supplements. The cells grow as monolayer; absolute plating efficiency of the established cell line lies by 800/0; epithelial-like and dendritic melanin-producing cells are prominent. The number of chromosomes is considerably fluctuating; the karyotype of the established cell line lies within the range of subtriploidy. Sizewise a marker in submedian position of centromer is to be compared with one of group.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 3","pages":"205-20"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12270525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophage migration inhibition test in untreated syphilis. 未经治疗的梅毒巨噬细胞迁移抑制试验。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
J Bowszyc
{"title":"Macrophage migration inhibition test in untreated syphilis.","authors":"J Bowszyc","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two modifications of macrophage migration inhibition test, one of George and Vaughan and the other one of Svejcar, were performed on a total of 78 cases of untreated syphilis at various stages. As specific antigens were used: Treponema Pallidum ultrasonate and cardiolipin. Inhibition of migration was observed in 87 percent patients with primary syphillis and in all patients with late and late congenital syphilis. After improving and standardisation of the technique of Treponema Pallidum antigen-the migration inhibition test may be recommended as a specific in vitro-test for detection of cell mediated immunity in syphilis.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 3","pages":"227-34"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12270526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of ultraviolet light on human chromosomes (author's transl)]. [紫外线对人类染色体的影响(作者译)]。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
H Hole, M Dreiss
{"title":"[Effect of ultraviolet light on human chromosomes (author's transl)].","authors":"H Hole,&nbsp;M Dreiss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphocytes were cultured in quartz flasks and irradiated by UV light. Time of exposure and moment of application varied. After UV treatment, pulverization of the chromosomes occurred and larger nuclear fragments which might be products of an abnormally proceeding mitosis with chromatin confluence were observed. The usual chromosome aberrations such as breaks, special segments, abnormal chromosomes and polyploidy have been rarely observed, but are found more often in those cultures where pulverization and nuclear fragments are less abundant. A number of mitoses in the irradiated cultures, however, shows no chromosomal aberrations. The ratio of unaffected to unaffected mitoses is dose-dependent. Chromosome fragmentation can result from UV irradiation occurring at any instance during the time of culture. One finds maximum and minimum amounts of damage when a constant dose is applied at various times.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"252 1","pages":"23-38"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12310073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thiamine pyrophosphatase and acid phosphatase. Their ultrastructural localization in rat skin. 硫胺素焦磷酸酶和酸性磷酸酶。它们在大鼠皮肤中的超微结构定位。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
M E Itoiz, B M de Rey, R L Cabrini
{"title":"Thiamine pyrophosphatase and acid phosphatase. Their ultrastructural localization in rat skin.","authors":"M E Itoiz,&nbsp;B M de Rey,&nbsp;R L Cabrini","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ultrastructural localization of TPPase and AcPase in rat skin was studied. AcPase appeared localized in the lysosomes of the basal layer and in the keratinosomes of spinous, granulous and corneum layers. A diffuse reaction was also present in the granulous cells cytoplasm. Only the keratinosomes in the superficial layer were TPPase positive, specially those of the intercellular spaces of the proximal horny cells. The Golgi apparatus of all skin cells reacted strongly towards TPP. Membranous structures with TPPase and AcPase activity were evident within horny cells and seem to be infolded portions of the cell membrane which keep their enzymatic activity.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"252 2","pages":"131-7"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12325367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chrysanthemum allergy. Pt. II: Experimental studies on the causative agents. 菊花过敏。第二部分:病原菌的实验研究。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
K H Schulz, B M Hausen, L Wallhöfer, P Schmidt-Löffler
{"title":"Chrysanthemum allergy. Pt. II: Experimental studies on the causative agents.","authors":"K H Schulz,&nbsp;B M Hausen,&nbsp;L Wallhöfer,&nbsp;P Schmidt-Löffler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experimental studies on allergic contact dermatitis due to Chrysanthemum indicum 1. (Chrysanthemum x-morifolium) (chrysanthemum of the florists) have indicated the following results: 1. In 5 patients with allergic contact dermatitis from chrysanthemum oil of turpentine and its sensitizing compounds gave no patch test responses. No relationship between contact allergy due to chrysanthemus and to turpentine oil could be determined. 2. The pyrethrins, constituents with insecticidal activity, derived from certain Chrysanthemum species and often suspected as the causative agents, play no role in chrysanthemum allergy. 3. Tests on sensitized guinea pigs (pirl bright white strain) with flowers of chrysanthemum as well as with the two sesquiterpene lactones parthenolide and alantolactone, derived from different Composite species, gave positive patch test reactions. The results showed that parthenolide produced stronger reactions than alantolactone. 4. By thin layer chromatography neither parthenolide, nor alantolactone or pyrethrosin could be detected in extracts of chrysanthemum flowers of the florists. But the investigations indicated that several other terpenic compounds are present, which gave positive color reactions to certain lactone reagents. Five of them showed strong positive patch test reactions in our patients as well as in sensitized guinea pigs. Further studies are required to identify these compounds.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 3","pages":"235-44"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12270527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of arsenic on the incorporation of 14C-thymidine into DNAP of phytohaemagglutinin-treated lymphocytes (author's transl)]. [砷对植物血凝素处理淋巴细胞dna中14c -胸苷结合的影响[作者译]。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
J Petres, D Baron, J Enderle
{"title":"[Effect of arsenic on the incorporation of 14C-thymidine into DNAP of phytohaemagglutinin-treated lymphocytes (author's transl)].","authors":"J Petres,&nbsp;D Baron,&nbsp;J Enderle","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In lymphocyte cultures stimulated with PHA Na2HAsO4 is able, independent of the arsenic doses used (10 mug, 30 mug, 50 mug/ml culture medium), to increase the 14C-thymidine incorporation in acid precipitable biopolymers. The increase was 17 plus or minus 4% at 1 hr exposure to arsenic, compared with control cultures which were not exposed to arsenic. The administration of 30 mug and 50 mug Na2HAsO4/ml medium at incubation periods between 2 and 18 hrs resulted in a decrease in the radioactive incorporation rate into the DNA which was dependent on dose and time. Using 10 mug Na2HAsO4 per ml medium, the 1 hr stimulation is followed by an inhibition (up to approximately 35%, control equals 100%), which lasts for approximately 3 hrs. This is followed by an increase in the 14C-thymidine incorporation into the DNA for a further 2 hrs. The course of the inhibition curve with 10 mug Na2HAsO4 and with exposure times between 6 and 18 hrs the decreases again dependent on dose and time. As an explanation of the stimulation of the 14C-thymidine utilisation by arsenic, we suppose an increased repair activity. This may lead to a situation where (labelled) bases which are added outside the synthesis phase are incorporated into the DNA. The inhibition of 14C-thymidine incorporation which is dependent on dosage and time, with larger doses of arsenic can be explained by a prevailing influence of enzymes of the synthesis system (e.g. polymer arsenic), while the unusual course of the inhibition curve under the influence of 10 mug Na2HAsO4 shows that an activation and inhibition of enzyme systems (synthesis and repair) which is displaced in time is taking place. Apart from this, disturbances of regulation processes of the DNA replication and the initiation overlap can also be suspected as a cause of the phenomena observed.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 4","pages":"301-9"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12299057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of salicylic acid on epidermal cell proliferation kinetics in psoriasis. Autoradiographic in vitro-investigations(author's transl)]. 水杨酸对银屑病表皮细胞增殖动力学的影响。放射自显影体外研究[作者简介]。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
H Pullmann, K J Lennartz, G K Steigleder
{"title":"[The effect of salicylic acid on epidermal cell proliferation kinetics in psoriasis. Autoradiographic in vitro-investigations(author's transl)].","authors":"H Pullmann,&nbsp;K J Lennartz,&nbsp;G K Steigleder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Salicylic acid in the therapeutic concentrations from 0.5 to 10% does not affect the rate of proliferation of psoriatic epidermal cells. In 18 patients suffering from psoriasis the H3-I (H3-thymidine labelling index) was determined using autoradiographic in vitro labelling techniques. In 12 of these patients double-labelling with C14-and H3-thymidine was used to determine the H3-I, the DNA-synthesis time (ts) and the duration of the cell-cycle (tc). No significant changes were observed following external application of salicyclic acid in white Vaseline in concentrations of 0.5, 2 and 10% for one week.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 4","pages":"271-5"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12299201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Determination of DNase activity in the sweat and the urine. Micro disc-electrophoretic assay in health and mucoviscidosis disease (author's transl)]. 汗液和尿液中dna酶活性的测定。健康和黏液变性疾病的微盘电泳测定[作者简介]。
Archiv fur dermatologische Forschung Pub Date : 1974-07-01
J D Beck, J Zöllner, R K Zahn
{"title":"[Determination of DNase activity in the sweat and the urine. Micro disc-electrophoretic assay in health and mucoviscidosis disease (author's transl)].","authors":"J D Beck,&nbsp;J Zöllner,&nbsp;R K Zahn","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"250 1","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"1974-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15952627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bleomycin: cellular and vascular alteration in a patient (author's transl)]. [博莱霉素:患者细胞和血管的改变(作者简介)]。
Archiv fur dermatologische Forschung Pub Date : 1974-07-01
M Hagedorn, J Petres, C Mittermayer
{"title":"[Bleomycin: cellular and vascular alteration in a patient (author's transl)].","authors":"M Hagedorn,&nbsp;J Petres,&nbsp;C Mittermayer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"250 1","pages":"71-80"},"PeriodicalIF":0.0,"publicationDate":"1974-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15245480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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