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Archiv fur dermatologische Forschung最新文献

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[The effect of some solvents on the epidermis (author's transl)]. [某些溶剂对表皮的影响(作者译)]。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
K Nagy-Vezekényi, I Z Nagy, E Török
{"title":"[The effect of some solvents on the epidermis (author's transl)].","authors":"K Nagy-Vezekényi,&nbsp;I Z Nagy,&nbsp;E Török","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ultrastructure of epidermis pretreated with 0,1 N sofium hydroxide, ether-ethanol mixture and 0,5 M sodium thioglycolate was studied. Sodium hydroxide dissolves the keratohyalin granules and the inter fibrillar material in the keratin. It has no effect on the epidermal and keratin fibers and on the marginal dense band of the horny cells. It \"produces\" a keratin pattern in the psoriatic horny layer. After sodium thioglycolate treatment the keratohyalin disappears, the epidermal and keratin fibers show a periodicity and the cementing material in the horny cells is more opaque. After lipid extraction the structure of keratohyalin becomes inhomogenous. The effect is somewhat similar to that of sodium thioglycolate but there is no periodicity in the horny layer. The intercellular contact layers of desmosomes as well as the Selby-Odland bodies disappear after each kind of treatment, The different effect of sodium thioglycolate on the horny layer and on the keratohyalin implies that the material of the keratohyalin and of the cementing substance are not identical.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"252 1","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12310075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Family studies for detection of latent psoriatics by assay of alterations in steroid metabolism (author's transl)]. [通过类固醇代谢改变检测潜伏性银屑病的家族研究[作者译]。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
H Holzmann, G Hoffmann, P Schwarz, B Morsches, G W Oertel, J Fränz
{"title":"[Family studies for detection of latent psoriatics by assay of alterations in steroid metabolism (author's transl)].","authors":"H Holzmann,&nbsp;G Hoffmann,&nbsp;P Schwarz,&nbsp;B Morsches,&nbsp;G W Oertel,&nbsp;J Fränz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In psoriasis changes of the DHEA metabolism could be demonstrated. These genetically determined basic alterations may represent an important factor for the manifestation of psoriasis. They consist of a decreased penetration of DHEA through the cell membrane and an increased reduction of DHEA to ADIOL, leading to a reduced DHEA/ADIOL ratio. In the present investigations the question was whether the assay of these parameters may aid in the detection of latent psoriasis. For this purpose 31 members form 6 unselected families of psoriatics (8 manifested psoriatics, 18 potential psoriatics, 5 clinically and anamnestically healthy family members by marriage) as well as 6 further controls were examined. It could be shown that those changes in the DHEA metabolism, which are evident in manifested psoriatics also occur at least in part of potential psoriatics. However, both parameters investigated do not always behave the same way. Hence, from the present data a satisfactory diagnosis of latent psoriasis does not seem possible. Still, the estimation of the above parameters may aid in the attempts to define latent psoriasis. Further investigations of such families are warranted for final elucidation of this problem.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"252 2","pages":"151-9"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11344786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural studies in epidermolysis bullosa heriditaria. I. Dominant dystrophic type of Pasini. 遗传性大疱性表皮松解症的超微结构研究。1 .帕西尼显性营养不良型。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
I Hashimoto, I Anton-Lamprecht, T Gedde-Dahl, U W Schnyder
{"title":"Ultrastructural studies in epidermolysis bullosa heriditaria. I. Dominant dystrophic type of Pasini.","authors":"I Hashimoto,&nbsp;I Anton-Lamprecht,&nbsp;T Gedde-Dahl,&nbsp;U W Schnyder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ultrastructural examination was performed in 8 biopsies from 4 patients with the Pasini type of epidermolysis bullosa dystrophica dominans. The biopsies were taken from: 1. clinically normal skin from nonpredilection areas, 2. intact skin from predilection areas, 3. involved skin and 4. experimentally frictioned skin. The main ultrastructural alterations detected are as follows: hypoplasia of anchoring fibrils, split or blister formation between basal lamina and dermis, hernia-like protrusion of basal cells, sub- and intraepidermal deposition of fibrillar bodies, and duplications of basal lamina. Among them, the constantly observed finding in all of the four biopsy groups in the structural defect of anchoring fibrils, namely, that the anchoring fibrils are rudimentary and reduced in number. Presence of the structural defect of anchoring fibrils in clinically normal skin from nonpredilection areas in patients with the Pasini type of epidermolysis bullosa dystrophica dominans indicates that this defect is not a secondary change following repeated mechanical trauma, but a primary, genetically determined event.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"252 3","pages":"167-78"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12334066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous hydroxystereoid dehydrogenases and rat-hair cycle. 皮肤羟基类固醇脱氢酶与鼠毛循环。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
F Crovato, R Bertamino, G Moretti
{"title":"Cutaneous hydroxystereoid dehydrogenases and rat-hair cycle.","authors":"F Crovato,&nbsp;R Bertamino,&nbsp;G Moretti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The histochemical activity pattern of a number of hydroxysteroid dehydrogenases was studied during a provoked hair cycle in the rat skin. The intensity of reaction was high with dehydroepiandrosterone, estradiol, androsterone and pregnenolone, and none with 11-beta-hydroxyprogesterone, testosterone, dihydrotestosterone, 17-alpha-hydroxypregnenolone and 17-alpha-hydroxyprogesterone. Reactivity also varied with the hair cycle. The reactive sit-s were the acini of sebaceous glands and the hair sheaths.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 4","pages":"325-8"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11343109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hydrotherapy in cauterization wounds. A histologic study (author's transl)]. 烧灼伤口的水疗法。组织学研究[作者译]。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
M Rothmann, F Vakilzadeh, M Rupec
{"title":"[Hydrotherapy in cauterization wounds. A histologic study (author's transl)].","authors":"M Rothmann,&nbsp;F Vakilzadeh,&nbsp;M Rupec","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Investigations have have been carried out in guinea pigs to test the usefullness of hydrotherapy. Concentrated sulfuric acid was applied to the skin for a period of 30 sec and 5 min. After this the skin was washed with tap water for 1 hr. The treated area was then subjected to macroscopic and microscopic examination. When the acid was applied for 30 sec, followed by rinsing, an almost complete restitution of the skin was found on the test area macroscopically and microscopically. Significant differences were also observed after an exposition of 5 min in comparison with untreated control animals.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 4","pages":"281-8"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12299055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of high dosis of D-penicillamine and paramethasone on mechanical properties of rat connective tissue (author's transl)]. [大剂量d -青霉胺和参米松对大鼠结缔组织力学性能的影响[作者译]。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
L Friedrich, D Wuppermann, F Zimmermann
{"title":"[Effect of high dosis of D-penicillamine and paramethasone on mechanical properties of rat connective tissue (author's transl)].","authors":"L Friedrich,&nbsp;D Wuppermann,&nbsp;F Zimmermann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Male albino rats are treated with high doses of D-penicillamine (2000 mg/kg/day orally), paramethasone (50 mu-g/kg/day orally), and with a combination of equal doses of D-penicillamine and paramethasone for a period of 4 weeks. At the end of treatment the mechanical properties of dorsal skin and aorta of the experimental animals are determined. 4 weeks of treatment with D-penicillamine or paramethasone, respectively, leads to a decrease in the skin thickness of the experimental animals. With simultaneous administration of both substances the decrease in skin thickness is about the same. Load resulting in rupture is considerably reduced by D-penicillamine, while only a slight decrease is seen with paramethasone. Simultaneous administration of both substances results in considerable decrease in load resulting in rupture, similar to the effect produced by D-penicillamine. Tensile strength which is not influenced by paramethasone treatment, decreases after treatment with D-penicillamine as well as after simultaneous administration of D-penicillamin and paramethasone. Load resulting in rupture of the aorta remains uninfluenced under the experimental conditions. Comparison of the groups shows that simultaneous administration of D-penicillamine and paramethasone leads to the same results as those which may be obtained with sole administration of D-penicillamine. This suggests that the effect of D-penicillamine on the mechanical properties of the rat skin is not influenced by an additional high dose of paramethasone under the experimental conditions chosen.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"252 2","pages":"161-6"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12325369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The ultrastructure of papillae filiformes of human tongue (author's transl)]. 人类舌头丝状乳头的超微结构(作者译)。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
P Schenk, J Wersäll
{"title":"[The ultrastructure of papillae filiformes of human tongue (author's transl)].","authors":"P Schenk,&nbsp;J Wersäll","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The fine structural morphology of the filiform papillae of the human tongue is investigated by transmission and scanning electron microscopy. Separation of the epithelium from the connective tissue by treatment with trypsin allows the demonstration of the three-dimensional structure of the primary and secondary connective tissue papillae and of the papillary epithelium. The distal surface of each primary connective tissue papilla is studded with secondary connective tissue papillae. Their lamellated surface structure corresponds with a complex system of cytoplasmic processes of the basal epithelial cells. The complicated surface architecture of the epithelial-connective tissue junction may suggest a close structural and functional relationship between the two types of tissues. There are two distinct cell populations forming the epithelial papilla, which differ in ultrastructural morphology from the basal cell layer to the surface of the epithelium. A dual pattern of keratinization, phylogenetically analogous to the hard and soft keratinization in rodent tongues, is found also in filiform papillai of the human tongue. The final product of epithelial differentiation is a type of keratin different from that in epidermal keratinocytes and in other regions of the oral cavity. The variability in size, shape and association with other organelles suggests the heterogenous nature of lingual keratohyaline granules. The predominance of Odland bodies of lamellated or of spoke type varies with the degree of keratinization of different regions of the papillary epithelium.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"252 2","pages":"91-109"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12345712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of fumaric acid monoethylester on the synthesis of nucleic acids and proteins of PHA-stimulated human lymphocytes (author's transl)]. 【富马酸单乙基酯对pha刺激的人淋巴细胞核酸和蛋白质合成的影响(作者译)】。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
J Petres, K W Kalkoff, D Baron, R Geiger, I Kunick
{"title":"[The effect of fumaric acid monoethylester on the synthesis of nucleic acids and proteins of PHA-stimulated human lymphocytes (author's transl)].","authors":"J Petres,&nbsp;K W Kalkoff,&nbsp;D Baron,&nbsp;R Geiger,&nbsp;I Kunick","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fumaric acid monoethylester (FAME) inhibits the incorporation of 14C-Thymidin, 14C-Uridin, 14C-Alanin and 14C-Leucin into acid-insoluble biopolymers of cultivated PHA-stimulated human lymphocytes. At high concentrations of FAME (500 mug/ml culture medium) the inhibition of nucleic acid synthesis is 6 times higher on the average than the inhibition of protein synthesis. However, the application of the cis-isomer, maleic acid monoethylester (MAME), results in an increase of the incorporation rate of the labelled precursors into the RNA and DNA. This is 3.5--9.3 times higher than after application of FAME. The results demonstrate the specific inhibition by FAME. The rate of labelling of nucleic acids is decreased above 10 mug FAME/ml culture medium and in the case of MAME above 50 mug/ml medium. As an explanation of the specific action of FAME its influence on the enzymes of the nucleic acid synthesis, the citric acid cycle or a faulty synthesis of enzymes are discussed.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 4","pages":"295-300"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12299056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[DNA cytophotometry on cells of dermatofibrosarcoma protuberans (author's transl)]. 【皮肤纤维肉瘤隆突细胞的DNA细胞光度法(作者译)】。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
D Kleinhans
{"title":"[DNA cytophotometry on cells of dermatofibrosarcoma protuberans (author's transl)].","authors":"D Kleinhans","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Determination of DNA content was performed by Feulgen staining of tumour cell smears and DNA measurement with an integrating microdensitometer, In 3 cases of Dermatofibrosarcoma protuberans there was a DNA distribution in the range of 2 c: only a few cells showed a DNA content in the range between 2 c and 4 c; no atypical DNA distribution curves were found. The rate of proliferation in these cases of Dermatofibrosarcoma protuberans is small, there are no cytophotometric indices for malignancy.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"252 1","pages":"63-8"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11271363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of prednisolon on cell metabolism of candida. 强的松龙对念珠菌细胞代谢的影响。
Archiv fur dermatologische Forschung Pub Date : 1975-01-01
O H Paetzold, A Wiese
{"title":"Effect of prednisolon on cell metabolism of candida.","authors":"O H Paetzold,&nbsp;A Wiese","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In vitro effects of 2 water-soluble prednisolon-derivatives on 10 Candida albicans and 10 Candida tropicals species were investigated. Tests were performed during resting and proliferation phases. Changes of cell metabolism were measured by O2-consumption by the Warburg technique. With increasing corticosteroid concentrations (10-10000 gammaml) a dose dependent increase of cell respiration was found with and without addition of nutritive substrates. Even high concentrations of corticosteroid did not cause an antimetabolic effect. The tests did not yield different results for the two Candida species examined.</p>","PeriodicalId":8114,"journal":{"name":"Archiv fur dermatologische Forschung","volume":"251 3","pages":"181-9"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11449740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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