Arab Journal of Urology最新文献

{"title":"Oncological safety of simultaneous transurethral resection of high-grade urothelial carcinoma of the bladder and benign prostatic hyperplasia.","authors":"Ben Valery Sionov,&nbsp;Matvey Tsivian,&nbsp;Pavel Bakaleyschik,&nbsp;Ami Abraham Sidi,&nbsp;Alexander Tsivian","doi":"10.1080/2090598X.2022.2142365","DOIUrl":"https://doi.org/10.1080/2090598X.2022.2142365","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the oncological safety of simultaneous resection of bladder tumor and prostate in the presence of non-muscle invasive high-grade urothelial carcinoma of the bladder (UCB).</p><p><strong>Materials and methods: </strong>Between 2007 and 2019, 170 men with high-grade UCB who had a follow-up of at least 12 months were included in the study, including 123 with transurethral resection of bladder tumor (TURBT) only and 47 with simultaneous TURBT and transurethral resection of the prostate (TURP). We recorded and compared patients' clinicopathological parameters, recurrence, and progression rates during the follow-up period, as well as time to UCB recurrence in the bladder and the prostatic urethra/fossa.</p><p><strong>Results: </strong>Baseline demographic and pathological characteristics were comparable between the groups. At a median follow-up of 31 months in both groups, there were no significant differences in recurrence rates in the bladder and the prostatic urethra/fossa in either group (34.1% and 7.3% vs. 36.2 and 6.4%, p=0.402, p=0.363). No statistically significant differences were found between the two groups in terms of follow-up time, elapsed time to recurrence, or and progression in the bladder or prostatic urethra/fossa.</p><p><strong>Conclusions: </strong>Simultaneous TURBT and TURP in the presence of high-grade UCB appears to be oncologically safe in selected patients.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"21 2","pages":"102-107"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10248696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombosis of the deep dorsal vein of the penis caused by vaccine-induced thrombotic thrombocytopenia: First reported case.","authors":"Mounir Jamali,&nbsp;Amine Cherraqi,&nbsp;Alexis Melang Mvomo,&nbsp;Youness Boukhlifi,&nbsp;Mohammed Alami,&nbsp;Ahmed Ameur","doi":"10.1080/2090598X.2022.2127236","DOIUrl":"https://doi.org/10.1080/2090598X.2022.2127236","url":null,"abstract":"<p><p>The first described case of deep dorsal vein thrombosis of the penis secondary to vaccine-induced thrombotic thrombocytopenia (VITT), a complication of COVID adenoviral vector vaccines. The patient reported pain in the penis one month after vaccination. On ultrasound, a deep dorsal vein thrombosis was found and a biological workup was ordered to confirm the VITT trail. Anticoagulant therapy was immediately initiated and the patient responds well while suffering from erectile dysfunction. VITT is a potentially serious event that can be life-threatening; every practitioner should know how to deal with it.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"21 1","pages":"36-39"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9315932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early versus delayed penile prosthesis insertion for refractory ischemic priapism.","authors":"Baher Salman, Eid Elsherif, Mohamed Elgharabawy, Atef Badawy","doi":"10.1080/2090598X.2022.2135290","DOIUrl":"10.1080/2090598X.2022.2135290","url":null,"abstract":"<p><strong>Objectives: </strong>Penile prosthesis insertion is a well-established therapeutic option in refractory ischemic priapism but there is a lack of standardization regarding the timing of surgery, the type of prosthesis (malleable or inflatable), as well as the possible complications. In this study, we retrospectively compared early versus delayed penile prosthesis insertion in patients with refractory ischemic priapism.</p><p><strong>Methods: </strong>42 male patients who presented with refractory ischemic priapism during the period between January 2019 and January 2022 were included in this study. All patients had malleable penile prosthesis insertion by four highly experienced consultants. Patients were divided into two groups based on the time of the prosthesis insertion. 23 patients had immediate insertion of the prosthesis within the first week of the onset of priapism while the remaining 19 patients had delayed prosthesis insertion three months or later after the onset of priapism. The outcome as well as the intra- and the postoperative complications were recorded.</p><p><strong>Results: </strong>Postoperative complications such as prosthesis erosion and infection were higher among the early insertion group while the delayed insertion group had higher incidence of intraoperative complications such as corporal perforation and urethral injury. The insertion of the prosthesis was much more difficult among the delayed insertion group due to fibrosis which made dilatation of the corpora very difficult. The length and the width of the penile implant were significantly higher among the early insertion group as compared to the delayed insertion group.</p><p><strong>Conclusions: </strong>Early penile prosthesis insertion for refractory ischemic priapism is a safe and effective treatment option as delayed prosthesis insertion is more difficult and challenging due to corporal fibrosis and is associated with higher complication.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"21 2","pages":"76-81"},"PeriodicalIF":1.5,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of closure versus non-closure of the intraoral buccal mucosa graft site in urethroplasties. A systematic review and meta-analysis.","authors":"Yavuz Güler","doi":"10.1080/2090598X.2022.2097613","DOIUrl":"10.1080/2090598X.2022.2097613","url":null,"abstract":"<p><strong>Aim: </strong>To assess postoperative oral morbidity through meta-analysis of comparative studies for closure or non-closure of the buccal mucosa graft harvest area in patients undergoing urethroplasty.</p><p><strong>Methods: </strong>A systematic literature review was conducted in January 2022. Randomized controlled studies were assessed according to the Cochrane collaboration guidelines. Postoperative pain, difficult mouth opening, alteration of oral salivation, perioral numbness, and tolerance of solid and liquid intake results were assessed. Standard mean differences and risk ratios with 95% confidence intervals were estimated for relative risk. Assessment was performed with subgroup analyses according to time points.</p><p><strong>Results: </strong>This meta-analysis included 373 patients in 7 randomized studies. The oral pain overall pooled effect estimates were investigated for the time points of day 0-1, day 3-7 and months 1-6. According to corrected effect estimates after sensitivity analysis, at the day 0-1 time point, the non-closure group was significantly superior compared to the closure group. But there was no difference at the other time points and in total. The overall pooled effect estimates for difficult mouth opening were investigated at 4 time points (day 1, days 5-7, months 1-3 and months 6). After sensitivity analysis, the overall pooled effect estimates at 6 months were significantly superior for the non-closure group. There were no significant differences between the non-closed and closed groups based on the overall pooled-effect estimates for oral numbness, salivary secretion alteration, and tolerance of liquid and solid food variants.</p><p><strong>Conclusion: </strong>The non-closure group was more advantageous in terms of oral pain in the early postoperative period. There were no differences between the groups in terms of alteration of salivation, oral numbness and toleration of liquid/solid food. Although the non-closed group seems more advantageous in terms of ease in mouth movements, more studies are needed to prove this.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"21 1","pages":"18-30"},"PeriodicalIF":1.3,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9315931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage minimally invasive robotic and laparoscopic pyeloplasty in adults: a systematic review.","authors":"Mai Elaarag, Hind Alashi, Maya Aldeeb, Ibrahim Khalil, Ahmad R Al-Qudimat, Abdelhamed Mansour, Abdulla A Al-Ansari, Omar M Aboumarzouk","doi":"10.1080/2090598X.2022.2082208","DOIUrl":"10.1080/2090598X.2022.2082208","url":null,"abstract":"<p><strong>Introduction: </strong>A UPJO is a blockage of the ureter that affects urine flow. UPJO is mainly treated by an open approach, however, in recent years minimally invasive techniques are taking place. These techniques include robotic and laparoscopic pyeloplasty. Some patients require a redo after a primary intervention. A systematic review was conducted through the examinations of the efficacy and safety of a robotic redo pyeloplasty in adult patients from previous literature reviews.</p><p><strong>Methods: </strong>A literature search was made through PubMed. A selection process was done based on our eligibility criteria. The data were represented numerically, listed on tables and analyzed cumulatively using Microsoft Excel.</p><p><strong>Results: </strong>Twenty studies were included in this review, of which nine were studies on robotic outcomes () (157 patients), 10 on laparoscopic (210 patients), and one review by Zhang et al., focused on both types of surgeries. Two papers (24 patients) from the robotic studies and one paper (21 patients) from the laparoscopic studies were excluded from the intra and post-operative characteristics because not enough data were available and were only included for the success and complication rates. The success rate for the robotic studies was 88.5% while the laparoscopic studies had a success rate of 91%. However, the robotic studies had a complication rate of (11.8%) while the laparoscopic studies had a complication rate of (15.9%). Conversion surgery was required in one patient undergoing laparoscopic surgery.</p><p><strong>Conclusion: </strong>The minimally invasive methods are becoming more viable in adult patients with rUPJO, considering its effectiveness and fast recovery. This can lead to a new era of robotic assisted surgeries to becoming the gold standard.<b>Abbreviations:</b> Systematic review: Redo robotic and laparoscopic pyeloplasty in adults; UPJO = Ureteropelvic junction obstruction; rUPJO = redo ureteropelvic junction obstruction.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"20 4","pages":"204-211"},"PeriodicalIF":1.3,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of low-intensity extracorporeal shock wave therapy versus on-demand tadalafil for erectile dysfunction.","authors":"Fouad Zanaty,&nbsp;Atef Badawy,&nbsp;Hossam Kotb,&nbsp;Fatma Elsarfy,&nbsp;Baher Salman","doi":"10.1080/2090598X.2022.2090134","DOIUrl":"https://doi.org/10.1080/2090598X.2022.2090134","url":null,"abstract":"<p><strong>Objective: </strong>To compare outcomes of low-intensity extracorporeal shock wave therapy (LIESWT) versus 20 mg of Tadalafil in Erectile dysfunction (ED) patients.</p><p><strong>Materials and methods: </strong>We performed a prospective study of 51 men with ED. Twenty-five were in the LIESWT group and 26 in the Tadalafil group. Patients in the LIESWT group received 6 sessions (2 per week) with an average of 6,000 shocks per session with the PiezoWave² unit. Other patients self-administered Tadalafil on demand. The outcomes were assessed using the International Index of Erectile Function (IIEF-5) score, Erection Hardness Score (EHS) and Self-Esteem And Relationship (SEAR) questionnaire before, at 6 and 12 weeks after treatment. Treatment-related side effects and costs were recorded too.</p><p><strong>Results: </strong>The mean age in the LIESWT group was 43.7 years old, and in the Tadalafil group was 47 years old. After the 6 and 12-week follow-ups, both groups showed significant improvement when comparing the baseline values to the follow-up variables for all IIEF-5, EHS, and SEAR (P < 0.05). There was a notable statistical difference between the two groups regarding the side effects, as the shockwave group was with mild side effects (8%), while the Tadalafil group (44%) of patients had side effects (p < 0.05). This cost difference is statistically significant (p < 0.001). LIESWT is more costly compared to Tadalafil.</p><p><strong>Conclusion: </strong>LIESWT has a comparable short-term therapeutic efficacy with higher safety outcomes than on-demand 20 mg of Tadalafil for ED patients.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"20 4","pages":"189-194"},"PeriodicalIF":1.5,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The two-tales of smoking: aberrations in sperm parameters and failure in assisted reproduction.","authors":"M A Arshad,&nbsp;A Zil-E-Ali,&nbsp;M T Iqbal,&nbsp;A Majzoub","doi":"10.1080/2090598X.2022.2090135","DOIUrl":"https://doi.org/10.1080/2090598X.2022.2090135","url":null,"abstract":"According to the American Society for Reproductive Medicine, failure to achieve pregnancy after regular and unprotected sexual intercourse for 12 months is defined as infertility. It is known that 15% of all couples attempting natural conception face difficulty and male infertility is believed to contribute to almost 50% of cases [1]. Evidence suggests that among male-related risk factors leading to infertility, smoking plays a significant contribution. With the exception of few controversial studies, the negative impact of smoking on semen quality including sperm count, motility, and morphology is well documented [2–4]. In a metaanalysis done by Bundhun et al., the authors revealed that oligospermia (relative risk: 1.29, P = 0.02) and morphological defects (mean difference [MD]: 2.44, P = 0.001) were significantly higher among smokers compared with non-smokers [5]. Another metaanalysis by Sharma et al. including 5865 participants similarly reported significant reduction in sperm count (MD: −9.72 × 106/ml), motility (MD: −3.48%), and morphology (MD: −1.37%) among participants exposed to cigarette smoking versus non-smokers. The authors further revealed that the effect size was higher in infertile men and in those with moderate/heavy exposure than the general population [6]. Among the various mechanisms linking smoking with altered semen parameters, seminal oxidative stress is most commonly investigated. This imbalance in redox potential is the result of aggravated production of reactive oxygen species (ROS) coupled with minimal antioxidant repairing mechanisms in the spermatozoa [7]. Oxidative stress can impair sperm quality as it can incite lipid peroxidation, aggravate abortive apoptosis and result in high sperm DNA fragmentation. The degree of oxidative stress is directly related to higher rates and duration of cigarettes consumed by the smoker [2,8]. The alteration in essential minerals such as zinc is another mechanism with which smoking can impair semen quality. Zinc is vital for the process of spermatogenesis and its deficiency may halt the process and additionally impact serum testosterone production [8,9]. Liu et al. reported lower levels of zinc in the semen of smokers who also had significantly lower sperm parameters compared with non-smokers [10]. Another study by Bazid et al. identified significant negative correlation between seminal zinc levels and smoking index and a significant positive correlation between zinc levels and sperm motility and viability [11]. Some authors have advocated that the harmful effects of cigarette smoking may be attributed to nicotine rather than the toxic compounds contained within it. Animal and human studies have reported significantly negative effects for nicotine and its metabolites (cotinine/trans-3’hydroxycotinine) on semen parameters, particularly motility and viability [12,13]. These findings indicate that nicotine in inhalational or oral form could affect fertility. However, these changes were no","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"20 4","pages":"195-196"},"PeriodicalIF":1.5,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound versus fluoroscopy-guided ureteroscopy for distal ureteric stones in adults.","authors":"Ahmed Reda,&nbsp;Yaser Mahmoud Abdelsalam,&nbsp;Mohamed Loay Shehata,&nbsp;Salah El-Din Shaker,&nbsp;Mohammad Abbas Faragallah","doi":"10.1080/2090598X.2022.2087021","DOIUrl":"https://doi.org/10.1080/2090598X.2022.2087021","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the safety and efficacy of ultrasound (US) as alternative to fluoroscopy for guidance of ureteroscopy (URS) during treatment of distal ureteric stones in adults.</p><p><strong>Materials and methods: </strong>This study enrolled 80 patients older than 18 years presented with a single distal ureteric radio-opaque stone of ≤15 mm in longest diameter. Patients were randomized and allocated into two groups: the fluoroscopy group and the ultrasound group (n = 40 patients in each group). Patients with bilateral ureteric stones, solitary kidney, ureteric congenital anomalies, history of failed ureteroscopy, history of ureteric surgery, patients with uremia and pregnant women were excluded. Patients' demographics, stone characteristics, operative data, stone-free status, hospital stay and complications were evaluated in both groups.</p><p><strong>Results: </strong>No statistically significant difference between both groups was found regarding patients' demographics and stone characteristics. Also there was no statistically significant difference in comparing fluoroscopy group versus ultrasound group regarding operative time (29.48 ± 15.3 versus 31.28 ± 18.24 min; P = 0.83), stone-free rate (97.5% versus 95%; P = 1.0), overall complications (15% versus 12.5%; P = 0.75), or hospital stay (1.17 ± 0.6 versus 1.02 ± 0.16 days; P = 0.12). Four patients (10%) in the ultrasound group required the addition of fluoroscopy beside ultrasound.</p><p><strong>Conclusion: </strong>Ultrasound is effective in guidance during ureteroscopy for distal ureteric stones. It was comparable to fluoroscopy in terms of stone free rate, operative time, overall complications, and hospital stay. However, fluoroscopy must be available to be used when needed.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"20 4","pages":"197-203"},"PeriodicalIF":1.5,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthotopic kidney transplantation survival and complications: systematic review and meta-analysis.","authors":"Carlos Alfredo Castillo-Delgado, Herney Andrés García-Perdomo, Mireia Musquera, Antonio Alcaraz","doi":"10.1080/2090598X.2022.2090133","DOIUrl":"10.1080/2090598X.2022.2090133","url":null,"abstract":"<p><strong>Purpose: </strong>To determine graft and patient survival and adverse events in patients who undergo orthotopic kidney transplantation.</p><p><strong>Methods: </strong>We performed a systematic review and meta-analysis. We search in Medline, Embase, and Central from inception to nowadays. We included observational studies with patients who undergo orthotopic kidney transplantation. The primary outcomes were overall patient and graft survival. We pooled the information in a frequency meta-analysis with a 95% CI. We analyzed bias with the STROBE statement.</p><p><strong>Results: </strong>Of the 106 papers initially retrieved, four met the inclusion criteria. Vascular and urinary tract complications were reported in 19% and 15%, respectively. The overall patient survival was 92% 95%CI (88% to 95%), I2 = 0%, and the overall graft survival was 88% 95 CI (83% to 91%), I2 = 0%.</p><p><strong>Conclusion: </strong>Our analysis showed a high survival rate in patients and kidney grafts after orthotopic kidney transplantation, with a similar complication rate compared to a heterotopic kidney transplant.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"20 4","pages":"212-218"},"PeriodicalIF":1.3,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testicular cancer among Saudi adults: Hands on a nationwide Cancer Registry over 10 years.","authors":"Yasser A Noureldin,&nbsp;Muhannad Q Alqirnas,&nbsp;Meshal F Aljarallah,&nbsp;Omar B Alfraidi,&nbsp;Mohammad A Alghafees,&nbsp;Yahia Ghazwani,&nbsp;Abdullah Alkhayal","doi":"10.1080/2090598X.2022.2084902","DOIUrl":"https://doi.org/10.1080/2090598X.2022.2084902","url":null,"abstract":"<p><strong>Background/objective: </strong>Testicular cancer (TC) is one of the most curable solid malignancies affecting young adults. The objective of this study was to identify factors affecting survival of Saudi adults who were diagnosed with testicular cancer over 10 years.</p><p><strong>Methods: </strong>This was a retrospective study with data extracted from the Saudi Cancer Registry for Saudi Adults diagnosed with TC from 2008 to 2017. We collected demographic information, including age, marital status, region of residency, year of diagnosis, and the survival status. In addition, the tumor factors included the basis of diagnosis, the origin of the tumor, histopathological group and subtype, and tumor behavior, stage, and laterality were collected.</p><p><strong>Results: </strong>A total of 869 patients were included, with a median age of 30 (<b>IQR</b>: 25-38). The highest percentage of the cases was 37.5% (326) in the Central region, followed by the Western region 24.6% (214). The primary site of the tumor was the testis 96.9% (842), 3.1% (27) in the undescended testis. The histopathological examination revealed seminoma in 44.8% (389), 33.5% (291) mixed germ cell tumor, 8.4% (73) embryonal carcinoma, 6.1% (53) teratoma, 2.6% (23) yolk sac tumor, 1.6% (14) choriocarcinoma, 0.3% (3) Leydig cell tumor, and 2.6% (23) sarcomas. Kaplan-Meier analysis revealed significant association between survival and the age groups (p = 0.001), histopathology group (p 0.04), histopathology subtypes (p = 0.01), and the stage of the tumor (p < 0.001).</p><p><strong>Conclusions: </strong>A notable increase in the incidence of TC among Saudi adults was seen, with a mortality rate of 5.4% over a period of 10 years. Longer survival was associated with age groups, seminomatous germ cell tumor, and lower tumor stage.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"20 4","pages":"182-188"},"PeriodicalIF":1.5,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40690234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}