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Annual review of medicine最新文献

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CD70: An Emerging Anticancer Target in Renal Cell Carcinoma and Beyond. CD70：肾细胞癌及其他癌症的新抗癌靶点
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-070623-045906
Peter D Zang, Arkhjamil Angeles, Sumanta K Pal
{"title":"CD70: An Emerging Anticancer Target in Renal Cell Carcinoma and Beyond.","authors":"Peter D Zang, Arkhjamil Angeles, Sumanta K Pal","doi":"10.1146/annurev-med-070623-045906","DOIUrl":"10.1146/annurev-med-070623-045906","url":null,"abstract":"<p><p>CD70 is an emerging target for anticancer therapies. It is an ideal antigen target given its limited expression in normal physiologic tissues and propensity to be aberrantly expressed in a variety of malignancies, thus limiting off-target toxicities. It is also heavily involved in immune homeostasis, and disruption of this pathway can help overcome tumor-related immune cell exhaustion. Recent phase I/II trials using cellular therapies targeting CD70, such as chimeric antigen receptor-T cells, have shown promising effectiveness and safety in treating relapsed or refractory renal cell carcinoma. Noncellular therapies targeting CD70, such as antibody-drug conjugates, monoclonal antibodies, radionuclides, and cytokines, are currently under investigation, with early data showing encouraging results as well. Efforts are already underway to further improve and optimize CD70-based therapies.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"257-266"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on HIV Chemoprevention. 艾滋病毒化学预防的最新情况。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 DOI: 10.1146/annurev-med-042823-013707
Cheríe S Blair, Mary Catherine Cambou, Raphael J Landovitz
{"title":"Update on HIV Chemoprevention.","authors":"Cheríe S Blair, Mary Catherine Cambou, Raphael J Landovitz","doi":"10.1146/annurev-med-042823-013707","DOIUrl":"10.1146/annurev-med-042823-013707","url":null,"abstract":"<p><p>Despite rapid advances in the field of HIV prevention and treatment, unacceptably high global HIV incidence rates highlight the ongoing need for effective HIV prevention interventions for populations at risk for HIV acquisition. This article provides an updated review of the current data surrounding HIV prevention strategies, including treatment as prevention (TasP), preexposure prophylaxis (PrEP), and postexposure prophylaxis (PEP), as well as advances in sexually transmitted infection biomedical prevention. This review provides an overview of the multiple PrEP modalities that are available globally, such as oral PrEP, injectable cabotegravir, and the dapivirine vaginal ring, and describes their respective clinical trials, efficacies, and regulatory approvals. We also discuss ongoing research into novel PrEP agents, such as broadly neutralizing antibodies, and efforts toward HIV vaccine development.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":"76 1","pages":"43-56"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertension Management in Pregnancy. 妊娠期高血压管理。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-050423-085626
Kimberly Ryan, Lidija McGrath, Kathleen Brookfield
{"title":"Hypertension Management in Pregnancy.","authors":"Kimberly Ryan, Lidija McGrath, Kathleen Brookfield","doi":"10.1146/annurev-med-050423-085626","DOIUrl":"10.1146/annurev-med-050423-085626","url":null,"abstract":"<p><p>Chronic hypertension and preeclampsia spectrum disorders in pregnancy are important contributors to long-term maternal morbidity and mortality. Due to physiologic changes during pregnancy and the postpartum period, blood pressure expectations differ between primary care providers and obstetricians. The goal of this article is to describe the pathophysiology and definitions of hypertension in the obstetric context and review current evidence for management during pregnancy and the postpartum period. Longitudinal follow-up with a primary care provider after delivery is crucial for long-term cardiovascular risk reduction in hypertensive patients.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"315-326"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep Health Disparities. 睡眠健康差异。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-070323-103130
Seyni Gueye-Ndiaye, Susan Redline
{"title":"Sleep Health Disparities.","authors":"Seyni Gueye-Ndiaye, Susan Redline","doi":"10.1146/annurev-med-070323-103130","DOIUrl":"10.1146/annurev-med-070323-103130","url":null,"abstract":"<p><p>Sleep is an important and potentially modifiable determinant of many severe health outcomes. Sleep health disparities exist and are exemplified by reported differential rates of prevalence, severity, and outcomes among minority groups and low-socioeconomic-status backgrounds. In this review we highlight the concept of sleep health, review the evidence for disparities in sleep health, examine risk factors and consequences of poor sleep health, and discuss policy implications.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"403-415"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Long-Term Risks of the Use of Proton Pump Inhibitors and Potassium-Competitive Acid Blockers. 使用质子泵抑制剂和钾竞争性酸阻滞剂的新长期风险。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-050223-112834
Katarina Jankovic, Ian M Gralnek, Halim Awadie
{"title":"Emerging Long-Term Risks of the Use of Proton Pump Inhibitors and Potassium-Competitive Acid Blockers.","authors":"Katarina Jankovic, Ian M Gralnek, Halim Awadie","doi":"10.1146/annurev-med-050223-112834","DOIUrl":"10.1146/annurev-med-050223-112834","url":null,"abstract":"<p><p>Acid-related disorders represent a significant global health burden. Pharmacological treatment of these conditions has at times been challenged and limited by incomplete effectiveness, antibiotic resistance, adverse medication effects and/or interactions, and disease recurrence. Since the early 1990s, the mainstay of treatment has been proton pump inhibitors (PPIs). Recently, the US Food and Drug Administration issued a clearance for vonoprazan, a potassium-competitive acid blocker (PCAB). PCABs are a new class of acid-suppressing agents that may overcome some of these challenges. The aim of this review is to evaluate and compare the emerging long-term risks of PPI and PCAB therapies.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"143-153"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RASopathies in Cardiac Disease. 心脏病中的 RAS 病变。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-042823-013552
Saravanakkumar Chennappan, Maria Irene Kontaridis
{"title":"RASopathies in Cardiac Disease.","authors":"Saravanakkumar Chennappan, Maria Irene Kontaridis","doi":"10.1146/annurev-med-042823-013552","DOIUrl":"10.1146/annurev-med-042823-013552","url":null,"abstract":"<p><p>RASopathies are a group of clinically overlapping autosomal dominant disorders caused primarily by mutations in genes that reside along the canonical Ras-mitogen-activated protein kinase signaling cascade. Though individually rare, collectively, these disorders constitute one of the largest families of congenital disorders worldwide, particularly for infantile hypertrophic cardiomyopathy. Significantly, despite almost five decades of RASopathy research, therapeutic options remain limited and focused primarily on treating symptoms rather than disease etiology. Targeting the genes causal to these disorders, and the nodal pathways critical for their regulation, however, has been challenging. In this review, we highlight these challenges, particularly with respect to congenital heart defects and cardiac diseases and discuss limitations and future directions for approaches to new therapeutic strategies.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"301-314"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic Approaches for Managing Small Intestinal Disease. 内镜下治疗小肠疾病的方法
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-060123-120109
Fady F Youssef, Laurel L Branch, Mark Kowalczyk, Thomas J Savides
{"title":"Endoscopic Approaches for Managing Small Intestinal Disease.","authors":"Fady F Youssef, Laurel L Branch, Mark Kowalczyk, Thomas J Savides","doi":"10.1146/annurev-med-060123-120109","DOIUrl":"10.1146/annurev-med-060123-120109","url":null,"abstract":"<p><p>The endoscopic evaluation and management of small intestinal diseases continue to evolve and expand. The advent of small bowel wireless capsule endoscopy and deep enteroscopy with either a double- or single-balloon enteroscope now allows complete endoscopic visualization of the entire small intestine and enables access for endoscopic interventions such as biopsies or hemostasis for most of the small bowel. New endoscopic techniques are available to treat proximal malignant small bowel obstruction, including intraluminal stents and endoscopic gastrojejunal stents. Emerging technologies also aim to improve weight loss and diabetes management via small bowel endoscopic interventions.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"155-165"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary Management of Acute Ischemic Stroke. 急性缺血性脑卒中的当代管理。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-050823-094312
James P Ho, William J Powers
{"title":"Contemporary Management of Acute Ischemic Stroke.","authors":"James P Ho, William J Powers","doi":"10.1146/annurev-med-050823-094312","DOIUrl":"10.1146/annurev-med-050823-094312","url":null,"abstract":"<p><p>In the past decade, adding mechanical thrombectomy (MT) of intracranial arterial occlusions to intravenous (IV) thrombolysis has revolutionized the treatment of acute ischemic stroke (AIS) by expanding the therapeutic window to 24 h. Treatment decisions require establishing a high probability of AIS; confirming time since last known well (LKW); assessing severity of the neurological deficit; determining any contraindications to IV thrombolysis; and performing neuroimaging, usually noncontrast computed tomography (NCCT), to exclude intracerebral hemorrhage. If time since LKW is less than 4.5 h, patients with disabling stroke without contraindications can proceed immediately to IV thrombolysis while the decision about MT is under way. For some patients, the MT decision can be made on the basis of clinical assessment, NCCT, and CT angiography showing a large vessel occlusion. Others may require additional neuroimaging. Patients who are not candidates for IV thrombolysis within 4.5 h or MT should be immediately evaluated for eligibility for extended-window IV thrombolysis or early antiplatelet treatment.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"417-429"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Risks of Living Kidney Donation: State of the Evidence and Strategies to Resolve Knowledge Gaps. 活体肾脏捐献的长期风险：证据的状态和解决知识差距的策略。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 DOI: 10.1146/annurev-med-050223-112648
Vidya A Fleetwood, Ngan N Lam, Krista L Lentine
{"title":"Long-Term Risks of Living Kidney Donation: State of the Evidence and Strategies to Resolve Knowledge Gaps.","authors":"Vidya A Fleetwood, Ngan N Lam, Krista L Lentine","doi":"10.1146/annurev-med-050223-112648","DOIUrl":"10.1146/annurev-med-050223-112648","url":null,"abstract":"<p><p>Living-donor kidney transplantation is the preferred treatment for kidney failure. In the United States, rates of living kidney donation have been stagnant, which is partly related to concerns over medical and financial risks. Recent research has better characterized the risks of living kidney donation, although the field is limited by a lack of robust registries. Available evidence supports small increases in the risks of end-stage kidney disease and hypertensive disorders of pregnancy in living donors. For most donors, the 15-year risk of kidney failure is less than 1%, but for certain populations this risk may be higher. New tools such as genetic kidney disease panels may assist with risk stratification. Living kidney donors generally have similar or improved psychosocial health following donation compared to prior to donation and nondonor experience. Postdonation care allows for preventative care measures to mitigate risk as well as ongoing surveillance of donor outcomes. Continuing efforts to capture and report outcomes of living donation are necessary to safely expand living donation worldwide.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":"76 1","pages":"357-372"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Oral Selective Estrogen Receptor Degraders Redefine Management of Estrogen Receptor-Positive Breast Cancer. 新的口服选择性雌激素受体降降剂重新定义雌激素受体阳性乳腺癌的治疗。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 DOI: 10.1146/annurev-med-052423-122001
Neha Pathak, Mafalda Oliveira
{"title":"New Oral Selective Estrogen Receptor Degraders Redefine Management of Estrogen Receptor-Positive Breast Cancer.","authors":"Neha Pathak, Mafalda Oliveira","doi":"10.1146/annurev-med-052423-122001","DOIUrl":"10.1146/annurev-med-052423-122001","url":null,"abstract":"<p><p>Oral selective estrogen receptor degraders (SERDs) are pure estrogen receptor antagonists that have the potential to overcome common resistance mechanisms to endocrine therapy in estrogen receptor-positive breast cancer. There are currently five oral SERDs in published and ongoing clinical trials-elacestrant, camizestrant, giredestrant, imlunestrant, and amcenestrant-with more in development. They offer a reasonably well-tolerated oral therapy option with low discontinuation rates in studies. This review summarizes the currently available literature on this new class of drugs.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":"76 1","pages":"243-255"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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