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Annual review of medicine最新文献

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A Rational Approach to the Treatment of Acute Pulmonary Embolism. 急性肺栓塞的合理治疗方法。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-050423-085457
Michela Faggioni, Jay Giri, Lauren Glassmoyer, Taisei Kobayashi
{"title":"A Rational Approach to the Treatment of Acute Pulmonary Embolism.","authors":"Michela Faggioni, Jay Giri, Lauren Glassmoyer, Taisei Kobayashi","doi":"10.1146/annurev-med-050423-085457","DOIUrl":"10.1146/annurev-med-050423-085457","url":null,"abstract":"<p><p>Over the past decade, new modalities have emerged to treat acute pulmonary embolism (PE). However, PE remains a leading cause of morbidity and mortality worldwide. In the absence of robust clinical trial data and definitive guidelines and recommendations for a variety of clinical situations, individual patient treatment decisions have become paradoxically more challenging as innovation in the space has grown. In this review, we discuss a practical and current approach to patients diagnosed with PE, focusing on their risk stratification and treatment selection.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"327-337"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transformative Therapies for Depression: Postpartum Depression, Major Depressive Disorder, and Treatment-Resistant Depression. 抑郁症的变革性疗法：产后抑郁症、重度抑郁症和耐药性抑郁症。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-050423-095712
Elizabeth Richardson, Riah Patterson, Samantha Meltzer-Brody, Robert McClure, Amanda Tow
{"title":"Transformative Therapies for Depression: Postpartum Depression, Major Depressive Disorder, and Treatment-Resistant Depression.","authors":"Elizabeth Richardson, Riah Patterson, Samantha Meltzer-Brody, Robert McClure, Amanda Tow","doi":"10.1146/annurev-med-050423-095712","DOIUrl":"10.1146/annurev-med-050423-095712","url":null,"abstract":"<p><p>Depressive disorders present an enormous global public health burden. A notable treatment gap exists between the prevalence of depression and our ability to provide rapid-acting, effective treatment that achieves remission. Brexanolone and zuranolone, the first US Food and Drug Administration-approved drugs for postpartum depression, signify a critical advancement in addressing the unmet needs of a vulnerable patient population. Psilocybin shows promise for treatment-resistant depression and for those who have struggled to find relief with existing treatments. This review discusses transformative therapies that represent significant advancements in postpartum depression, major depressive disorder, and treatment-resistant depression.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"81-93"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Care Models for Cancer Survivors. 癌症幸存者的护理模式。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-042423-044004
Abhay Singh, Akriti G Jain, Betty K Hamilton, Alex Adjei
{"title":"Care Models for Cancer Survivors.","authors":"Abhay Singh, Akriti G Jain, Betty K Hamilton, Alex Adjei","doi":"10.1146/annurev-med-042423-044004","DOIUrl":"10.1146/annurev-med-042423-044004","url":null,"abstract":"<p><p>The population of cancer survivors is on the rise due to an increase in cancer incidence and a decline in cancer mortality. This growing survivor population creates a number of challenges. Although there have been improvements in care planning for cancer survivors, our healthcare system still lacks the delivery of coordinated care between primary care physicians and specialists. Understanding the needs of cancer survivors can help improve the current care models. In this review we describe existing survivorship care models. We also describe emerging models using some programs at the Cleveland Clinic to highlight various potential approaches.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"225-241"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Elimination of Hepatitis C Virus. 全球消除丙型肝炎病毒。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-050223-111239
Rachael L Fleurence, Harvey J Alter, Francis S Collins, John W Ward
{"title":"Global Elimination of Hepatitis C Virus.","authors":"Rachael L Fleurence, Harvey J Alter, Francis S Collins, John W Ward","doi":"10.1146/annurev-med-050223-111239","DOIUrl":"10.1146/annurev-med-050223-111239","url":null,"abstract":"<p><p>Hepatitis C virus (HCV) is predominantly transmitted through parenteral exposures to infectious blood or body fluids. In 2019, approximately 58 million people worldwide were infected with HCV, and 290,000 deaths occurred due to hepatitis C-related conditions, despite hepatitis C being curable. There are substantial barriers to elimination, including the lack of widespread point-of-care diagnostics, cost of treatment, stigma associated with hepatitis C, and challenges in reaching marginalized populations, such as people who inject drugs. The World Health Organization (WHO) has set goals to eliminate hepatitis C by 2030. Several countries, including Australia, Egypt, Georgia, and Rwanda, have made remarkable progress toward hepatitis C elimination. In the United States, the Biden-Harris administration recently issued a plan for the national elimination of hepatitis C. Global progress has been uneven, however, and will need to accelerate considerably to reach the WHO's 2030 goals. Nevertheless, the global elimination of hepatitis C is within reach and should remain a high public health priority.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"29-41"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthy and Unhealthy Aging and the Human Microbiome. 健康和不健康的衰老与人类微生物组。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-042423-042542
Kseniya Y Simbirtseva, Paul W O'Toole
{"title":"Healthy and Unhealthy Aging and the Human Microbiome.","authors":"Kseniya Y Simbirtseva, Paul W O'Toole","doi":"10.1146/annurev-med-042423-042542","DOIUrl":"10.1146/annurev-med-042423-042542","url":null,"abstract":"<p><p>An altered gut microbiome is a feature of many multifactorial diseases, and microbiome effects on host metabolism, immune function, and possibly neurological function are implicated. Increased biological age is accompanied by a change in the gut microbiome. However, age-related health loss does not occur uniformly across all subjects but rather depends on differential loss of gut commensals and gain of pathobionts. In this article, we summarize the known and possible effects of the gut microbiome on the hallmarks of aging and describe the most plausible mechanisms. Understanding and targeting these factors could lead to prolonging health span by rationally maintaining the gut microbiome.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"115-127"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probiotics in Health Care: A Critical Appraisal. 医疗保健中的益生菌：批判性评估》。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-042423-042315
Eamonn M M Quigley, Fergus Shanahan
{"title":"Probiotics in Health Care: A Critical Appraisal.","authors":"Eamonn M M Quigley, Fergus Shanahan","doi":"10.1146/annurev-med-042423-042315","DOIUrl":"10.1146/annurev-med-042423-042315","url":null,"abstract":"<p><p>Consumption of probiotic products continues to increase, perhaps driven by an interest in gut health. However, the field is filled with controversy, inconsistencies, misuse of terminology, and poor communication. While the probiotic concept is biologically plausible and in some cases mechanistically well established, extrapolation of preclinical results to humans has seldom been proven in well-conducted clinical trials. With noteworthy exceptions, clinical guidance has often been derived not from large, adequately powered clinical trials but rather from comparisons of disparate, small studies with insufficient power to identify the optimal strain. The separation of probiotics from live biotherapeutic products has brought some clarity from a regulatory perspective, but in both cases, consumers should expect scientific rigor and strong supporting evidence for health claims.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"129-141"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Approaches to Respiratory Syncytial Virus Prevention and Treatment. 呼吸道合胞体病毒防治新途径。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-061323-073934
Emmanuel B Walter, Flor M Munoz
{"title":"New Approaches to Respiratory Syncytial Virus Prevention and Treatment.","authors":"Emmanuel B Walter, Flor M Munoz","doi":"10.1146/annurev-med-061323-073934","DOIUrl":"10.1146/annurev-med-061323-073934","url":null,"abstract":"<p><p>There have been several recent advances in the prevention of lower respiratory tract disease (LRTD) due to respiratory syncytial virus (RSV) infection in older adults and young children. Three different vaccines are now approved for use in older adults; one of these vaccines is also approved for use in pregnant individuals for the prevention of LRTD due to RSV in their infants. In addition, a new monoclonal antibody is available to prevent RSV LRTD in infants born during or entering their first RSV season and in children up to 24 months of age who remain vulnerable to severe RSV disease through their second RSV season. Despite these advances in prevention efforts, specific antiviral treatment options for RSV infection remain limited. Several promising compounds remain in development.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"13-28"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Genetic Basis of Sudden Cardiac Death: From Diagnosis to Emerging Genetic Therapies. 心脏性猝死的遗传基础：从诊断到新兴基因疗法》。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-042423-042903
Enya R Dewars, Andrew P Landstrom
{"title":"The Genetic Basis of Sudden Cardiac Death: From Diagnosis to Emerging Genetic Therapies.","authors":"Enya R Dewars, Andrew P Landstrom","doi":"10.1146/annurev-med-042423-042903","DOIUrl":"10.1146/annurev-med-042423-042903","url":null,"abstract":"<p><p>Sudden cardiac death (SCD) is an abrupt, tragic manifestation of a number of cardiovascular diseases, primarily ion channelopathies and heritable cardiomyopathies. Because these diseases are heritable, genetics play a key role in the diagnosis and management of SCD-predisposing diseases. Historically, genetics have been used to confirm a diagnosis and identify at-risk family members, but a deeper understanding of the genetic causes of SCD could pave the way for individualized therapy, early risk detection, and a transformative shift toward genetically informed therapies. This review focuses on the evolving genetic landscape of SCD-predisposing diseases, the current state of gene therapy and therapeutic development, and the promise of using predictive genetics to identify individuals at risk of SCD.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"283-299"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating Tumor DNA: A Pan-Cancer Biomarker in Solid Tumors with Prognostic and Predictive Value. 循环肿瘤 DNA：具有预后和预测价值的实体瘤泛癌症生物标记物
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-100223-090016
Nadia Hitchen, Adel Shahnam, Jeanne Tie
{"title":"Circulating Tumor DNA: A Pan-Cancer Biomarker in Solid Tumors with Prognostic and Predictive Value.","authors":"Nadia Hitchen, Adel Shahnam, Jeanne Tie","doi":"10.1146/annurev-med-100223-090016","DOIUrl":"10.1146/annurev-med-100223-090016","url":null,"abstract":"<p><p>Circulating tumor DNA (ctDNA), often referred to as a liquid biopsy, represents a promising biomarker in the management of both localized and advanced solid tumors. It has garnered significant attention due to its potential to inform prognosis and guide therapeutic decisions. The clinical utility of ctDNA spans early cancer detection, minimal residual disease identification, recurrence surveillance, treatment monitoring, and precision oncology treatment decision-making in the advanced setting. Unlike conventional radiological assessments, the short half-life of ctDNA allows for more timely insights into disease dynamics. Several technological approaches are available to measure ctDNA, including next-generation sequencing and droplet digital polymerase chain reaction, although their clinical accuracy depends on multiple biological and technical factors. This review evaluates current evidence surrounding ctDNA's utility in early and advanced solid tumors.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"207-223"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biologic Medications for Severe Asthma: Implications for Understanding Pathogenic Heterogeneity and Endotypes. 治疗严重哮喘的生物药物：了解致病异质性和内型的意义。
IF 15.1 1区 医学
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1146/annurev-med-070323-103158
Richard P Ramonell, Marc C Gauthier, Anuradha Ray, Sally E Wenzel
{"title":"Biologic Medications for Severe Asthma: Implications for Understanding Pathogenic Heterogeneity and Endotypes.","authors":"Richard P Ramonell, Marc C Gauthier, Anuradha Ray, Sally E Wenzel","doi":"10.1146/annurev-med-070323-103158","DOIUrl":"10.1146/annurev-med-070323-103158","url":null,"abstract":"<p><p>Asthma is a chronic inflammatory disease of the airways long known for phenotypic heterogeneity. Phenotyping studies in asthma have led to a better characterization of disease pathogenesis, yet further work is needed to pair available treatments with disease endotypes. In this review, the biology of targeted pathways is discussed along with the efficacy of biologic therapies targeting those pathways. Results of asthma clinical trials are included, as well as results of trials in related diseases. This review then analyzes how biologics help to inform the complex immunobiology of asthma and further guide their use while identifying areas for future research.</p>","PeriodicalId":8056,"journal":{"name":"Annual review of medicine","volume":" ","pages":"339-355"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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