CD70:肾细胞癌及其他癌症的新抗癌靶点

IF 15.1 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Peter D Zang, Arkhjamil Angeles, Sumanta K Pal
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引用次数: 0

摘要

CD70 是一种新兴的抗癌疗法靶点。它是一个理想的抗原靶点,因为它在正常生理组织中的表达有限,而在各种恶性肿瘤中却有异常表达的倾向,从而限制了脱靶毒性。它还在很大程度上参与了免疫平衡,破坏这一途径有助于克服与肿瘤相关的免疫细胞衰竭。最近的I/II期试验显示,使用CD70靶向细胞疗法(如嵌合抗原受体-T细胞)治疗复发或难治性肾细胞癌具有良好的有效性和安全性。以 CD70 为靶点的非细胞疗法,如抗体-药物共轭物、单克隆抗体、放射性核素和细胞因子,目前正在研究之中,早期数据也显示出令人鼓舞的结果。目前正在努力进一步改进和优化基于 CD70 的疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CD70: An Emerging Anticancer Target in Renal Cell Carcinoma and Beyond.

CD70 is an emerging target for anticancer therapies. It is an ideal antigen target given its limited expression in normal physiologic tissues and propensity to be aberrantly expressed in a variety of malignancies, thus limiting off-target toxicities. It is also heavily involved in immune homeostasis, and disruption of this pathway can help overcome tumor-related immune cell exhaustion. Recent phase I/II trials using cellular therapies targeting CD70, such as chimeric antigen receptor-T cells, have shown promising effectiveness and safety in treating relapsed or refractory renal cell carcinoma. Noncellular therapies targeting CD70, such as antibody-drug conjugates, monoclonal antibodies, radionuclides, and cytokines, are currently under investigation, with early data showing encouraging results as well. Efforts are already underway to further improve and optimize CD70-based therapies.

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来源期刊
Annual review of medicine
Annual review of medicine 医学-医学:内科
CiteScore
24.90
自引率
0.00%
发文量
58
期刊介绍: The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.
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