Annals of Thoracic and Cardiovascular Surgery最新文献_第5页

Up-to-Date, Skeletonized or Pedicle Bilateral Internal Mammary Artery; Does It Matter? 双侧乳腺内动脉，骨化或带蒂;这有关系吗?

IF 1.3 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-04-20 DOI: 10.5761/atcs.ra.22-00094

Haralabos Parissis, Mondrian Parissis

{"title":"Up-to-Date, Skeletonized or Pedicle Bilateral Internal Mammary Artery; Does It Matter?","authors":"Haralabos Parissis, Mondrian Parissis","doi":"10.5761/atcs.ra.22-00094","DOIUrl":"https://doi.org/10.5761/atcs.ra.22-00094","url":null,"abstract":"Purpose: In this article, we reported on the up-to-date literature regarding skeletonized bilateral internal mammary artery (BIMA) flow and the effect on sternal perfusion. We also reviewed the pros and cons of the skeletonization technique versus the conventional pedicle technique for harvesting the BIMA.Methods: We performed an up-to-date review using the PubMed database, with a specific focus on the contemporary published literature.Results: BIMA skeletonization can preserve the sternal microcirculation, minimize tissue damage, and maintain blood supply to the chest wall at the tissue level. This effect is also apparent in diabetics. Deep sternal wound infection (DSWI) rates are significantly less with skeletonization versus the conventional pedicle technique and are comparable to single internal mammary artery harvesting.Conclusions: Contemporary large-scale studies demonstrate that skeletonization of the BIMA increases conduit length, provides superior flow, reduces the incidence of DSWIs, and improves late survival. Hopefully, this review will increase awareness of the compelling evidence in favor of using skeletonized internal mammary arteries and stimulate increased uptake of BIMA revascularization surgery.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"29 2","pages":"53-69"},"PeriodicalIF":1.3,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/42/4d/atcs-29-053.PMC10126765.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9343071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of Left Subclavian Artery Selective Coverage without Revascularization in Thoracic Endovascular Aortic Repair for Type B Aortic Dissections. B型主动脉夹层胸腔内主动脉修复术中左锁骨下动脉选择性覆盖无血运重建的安全性。

IF 1.3 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-04-20 DOI: 10.5761/atcs.oa.22-00146

Mingyu Sun, Yasong Wang, Tienan Zhou, Xuanze Liu, Quanmin Jing, Haiwei Liu, Xiaozeng Wang

{"title":"Safety of Left Subclavian Artery Selective Coverage without Revascularization in Thoracic Endovascular Aortic Repair for Type B Aortic Dissections.","authors":"Mingyu Sun, Yasong Wang, Tienan Zhou, Xuanze Liu, Quanmin Jing, Haiwei Liu, Xiaozeng Wang","doi":"10.5761/atcs.oa.22-00146","DOIUrl":"https://doi.org/10.5761/atcs.oa.22-00146","url":null,"abstract":"Purpose: Whether to proceed left subclavian artery (LSA) revascularization in patients with LSA coverage due to insufficient proximal landing zone (PLZ) during thoracic endovascular aortic repair (TEVAR) remains controversial.Methods: A total of 903 patients who received TEVAR were retrospectively analyzed. LSA could be covered if the PLZ was less than 15 mm accompanied with 1) a dominant or balanced right vertebral artery, 2) a complete circle of Willis, and 3) a left vertebral artery with a diameter ≥3 mm and without severe stenosis.Results: LSA selective coverage was necessary for 35.0% (316/903) of the patients to extend the PLZ. Patients presented with weakness, pain, cooling and discoloration of the left upper extremity (LUE), and pulselessness of the left brachial artery were more in the LSA-covered group. The ischemia of LUE occurred more often in patients with LSA covered completely than in those with LSA covered partially. Functional arm status showed no significant difference in the arm, shoulder, and hand questionnaire scores at 12 months postoperative between the LSA-covered group and LSA-uncovered group, or between the LSA-covered completely group and LSA-covered partially group.Conclusion: It was safe to cover the LSA origin without revascularization if the PLZ was less than 15 mm accompanied with careful evaluation (description in method).","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"29 2","pages":"70-77"},"PeriodicalIF":1.3,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/ca/atcs-29-070.PMC10126769.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9350336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mechanical Tricuspid Valves Have Higher Rate of Reintervention: A Single Center Experience. 机械三尖瓣有更高的再介入率:单中心经验。

IF 1.3 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-04-20 DOI: 10.5761/atcs.oa.22-00086

Turki B Albacker, Amr A Arafat, Abdulaziz M Alotaibi, Haneen Alghosoon, Khalid D Algarni

{"title":"Mechanical Tricuspid Valves Have Higher Rate of Reintervention: A Single Center Experience.","authors":"Turki B Albacker, Amr A Arafat, Abdulaziz M Alotaibi, Haneen Alghosoon, Khalid D Algarni","doi":"10.5761/atcs.oa.22-00086","DOIUrl":"https://doi.org/10.5761/atcs.oa.22-00086","url":null,"abstract":"Purpose: We compared the composite outcome of tricuspid valve (TV) reintervention or heart failure (HF) admission in patients who underwent tricuspid valve replacement (TVR) with tissue vs. mechanical valves.Patients and methods: The study included 159 patients who underwent TVR from 2009 to 2019. We grouped the patients according to the valve's type into tissue valve group (n = 139) and mechanical valve group (n = 20).Results: The mean age of patients was 52.4 ± 12.8 years, and 117 patients were females (73.6%). Hospital mortality occurred in 20 patients (12.6%); all of them were in the tissue valve group. The composite outcome of reintervention and HF readmission occurred in 8 patients with mechanical valves (40%) vs. 24 patients with tissue valves (17.3%), (P = 0.018). Predictors of reintervention and HF admission were female (subdistributional hazard ratio [SHR]: 1.38-34.3, P = 0.019), stroke (SHR: 1.25-8.76, P = 0.016), hypertension (SHR: 1.13-5.36, P = 0.024), and mechanical valves (SHR: 1.6-10.7, P = 0.003). In post hoc analysis, the difference in the composite outcome was derived from the difference in the reintervention rate that was higher in mechanical valves. Survival did not differ significantly between groups (P = 0.12).Conclusion: Mechanical TVs have a higher rate of composite outcome of reintervention or HF readmission than tissue TVs that are related mainly to higher rate of reintervention.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"29 2","pages":"78-85"},"PeriodicalIF":1.3,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/46/atcs-29-078.PMC10126767.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9705469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Multifocal Cholesterol Granulomas of the Thymus: A Case Report of Positron Emission Tomography- Positive Benign Tumor of the Anterior Mediastinum. 胸腺多灶性胆固醇肉芽肿:前纵隔正电子发射断层扫描阳性良性肿瘤1例。

IF 1.3 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-04-20 DOI: 10.5761/atcs.cr.21-00198

Mikito Suzuki, Hirotoshi Horio, Azusa Yamada, Reiko Shimizu, Toshiyuki Shima, Masahiko Harada, Tsunekazu Hishima

{"title":"Multifocal Cholesterol Granulomas of the Thymus: A Case Report of Positron Emission Tomography- Positive Benign Tumor of the Anterior Mediastinum.","authors":"Mikito Suzuki, Hirotoshi Horio, Azusa Yamada, Reiko Shimizu, Toshiyuki Shima, Masahiko Harada, Tsunekazu Hishima","doi":"10.5761/atcs.cr.21-00198","DOIUrl":"https://doi.org/10.5761/atcs.cr.21-00198","url":null,"abstract":"Cholesterol granulomas of the thymus are extremely rare benign entities. Herein, we describe a case of cholesterol granuloma in a 45-year-old man who presented with multifocal anterior mediastinal lesions on computed tomography (CT). Positron emission tomography (PET)-CT revealed increased fluorodeoxyglucose uptake, with a maximum standardized uptake value of 8.3. Diffusion-weighted magnetic resonance imaging (MRI) revealed extreme hypointensity. He underwent total thymectomy by median sternotomy for presumed multiple thymoma. On histopathological analysis, cholesterol granuloma of the thymus was confirmed, and the patient had an uneventful postoperative course without recurrence for 28 months. Cholesterol granuloma of the thymus is a PET-CT-positive benign tumor with unique histological findings. The MRI findings were indicative of hypocellularity associated with a benign entity, whereas the PET-CT findings corresponded to granulomatous inflammation. Therefore, concurrent use of PET-CT and MRI can be helpful in distinguishing between benign cholesterol granulomas and malignant anterior mediastinal tumors.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"29 2","pages":"103-106"},"PeriodicalIF":1.3,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/6e/atcs-29-103.PMC10126764.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9406425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

I-Composite Graft with Right Internal Thoracic Artery and Right Gastroepiploic Artery in Coronary Artery Bypass Grafting. 右胸内动脉与右胃网膜动脉复合移植在冠状动脉搭桥术中的应用。

IF 1.3 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-04-20 DOI: 10.5761/atcs.oa.22-00171

Makoto Shirakawa, Masami Ochi, Yosuke Ishii

{"title":"I-Composite Graft with Right Internal Thoracic Artery and Right Gastroepiploic Artery in Coronary Artery Bypass Grafting.","authors":"Makoto Shirakawa, Masami Ochi, Yosuke Ishii","doi":"10.5761/atcs.oa.22-00171","DOIUrl":"https://doi.org/10.5761/atcs.oa.22-00171","url":null,"abstract":"Purpose: When added to the internal thoracic artery (ITA), the right gastroepiploic artery (GEA) has been used as an in-situ graft or an I-composite right ITA-right GEA graft in coronary artery bypass grafting (CABG). We aimed to verify its potential.Methods: We evaluated 104 patients who underwent first isolated CABG with this I-composite graft. The number of distal anastomoses, graft flow (GF) and pulsatility index (PI) during surgery, and graft patency in the early term regarding this I-composite graft were evaluated.Results: The number of total distal anastomoses and distal anastomoses with arterial grafts were 4.17 ± 0.81 and 3.63 ± 0.81, respectively. This I-composite graft achieved 2.38 ± 0.69 distal anastomoses. GF tended to increase according to the increased number of distal anastomoses (p = 0.241), and the PI maintained a low score regardless of the number of distal anastomoses (p = 0.834). Graft patency was 95.5%; moreover, the number of distal anastomoses with this I-composite graft did not affect early-term graft patency.Conclusion: Right GEA utility was expanded as this I-composite graft in addition to in-situ graft. This I-composite graft has an adequate flow capacity for revascularization in non-left anterior descending coronary artery lesions.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"29 2","pages":"86-92"},"PeriodicalIF":1.3,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/9c/atcs-29-086.PMC10126763.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9720107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Operative Timing and Feasibility of Mitral Valve Repair in Active Infective Endocarditis. 活动性感染性心内膜炎二尖瓣修复术的手术时机和可行性。

IF 1.1 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-02-20 Epub Date: 2022-11-03 DOI: 10.5761/atcs.oa.22-00135

Tadashi Omoto, Atsushi Aoki, Kazuto Maruta, Tomoaki Masuda

{"title":"Operative Timing and Feasibility of Mitral Valve Repair in Active Infective Endocarditis.","authors":"Tadashi Omoto, Atsushi Aoki, Kazuto Maruta, Tomoaki Masuda","doi":"10.5761/atcs.oa.22-00135","DOIUrl":"10.5761/atcs.oa.22-00135","url":null,"abstract":"Purpose: We studied the association between operative timing and the feasibility of mitral valve (MV) repair in active infective endocarditis (IE).Methods: Forty-nine active IE patients who underwent MV operation were classified according to operative timing: within 48 hours (Term I: n = 7), between 3 and 14 days (Term II: n = 22), and ≥15 days (Term III: n = 20). Patient profiles, operative outcomes, and feasibility of MV repair were evaluated. Complexity score and severity score were used to define the feasibility of MV repair depending on the extent of infected lesion and technical difficulties.Results: There were no differences in basic profile in the three groups. Rate of major complications was higher in Term I (86%) than II (41%, p = 0.031) and III (25%, p = 0.005). In-hospital mortality was also higher in Term I (43%) than II (9%, p = 0.039) and III (5%, p = 0.015). The three groups did not differ by feasibility of MV repair calculated by the two-score system or by frequency of MV repair (I: 57%, II: 59%, and III: 55%).Conclusions: Morbidity and mortality were high in urgent cases. Feasibility of MV repair is associated with the extent of infected lesion and technical difficulties, and not with operative timing.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"29 1","pages":"23-28"},"PeriodicalIF":1.1,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/4a/atcs-29-023.PMC9939675.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9318644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary Cardiac Metastasis from Esophageal Cancer. 食道癌的孤立性心脏转移灶

IF 1.3 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-02-20 Epub Date: 2021-09-07 DOI: 10.5761/atcs.cr.21-00149

Miho Akabane, Masayuki Urabe, Yu Ohkura, Shusuke Haruta, Masaki Ueno, Harushi Udagawa

{"title":"Solitary Cardiac Metastasis from Esophageal Cancer.","authors":"Miho Akabane, Masayuki Urabe, Yu Ohkura, Shusuke Haruta, Masaki Ueno, Harushi Udagawa","doi":"10.5761/atcs.cr.21-00149","DOIUrl":"10.5761/atcs.cr.21-00149","url":null,"abstract":"A 72-year-old woman with past medical history of rectal cancer resection (adenocarcinoma, pT3N1aM0) presented with a 2-month history of dysphagia. Imaging studies found a thoracic esophageal cancer, for which subtotal esophagectomy with gastric conduit reconstruction via retrosternal route followed by chemoradiotherapy were performed (squamous cell carcinoma, pT4N1M0, RM1). Seven months after the esophagectomy, a contrast-enhanced computed tomography (CT) demonstrated a new asymptomatic mass inside the right atrium. A thrombus or a tumorous lesion was suspected. Positron emission tomography (PET)/CT showed abnormal uptake in the mass. After a thorough discussion by a multidisciplinary oncology group, we performed 1-week anticoagulant therapy first, resulting in mass enlargement. Then tumorectomy was carried out. The final pathological findings revealed that the mass was squamous cell carcinoma, yielding the diagnosis of cardiac metastasis from esophageal cancer. The patient's postoperative course was unremarkable. PET/CT may help to estimate malignancy and to omit invasive heart surgery.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"29 1","pages":"44-48"},"PeriodicalIF":1.3,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/f8/atcs-29-044.PMC9939676.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10758909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inadvertently Swallowed Needle Pierced the Pulmonary Artery in an Adult. 误吞针头刺穿成人肺动脉。

IF 1.3 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-02-20 DOI: 10.5761/atcs.cr.21-00161

Xiaoyi Dai, Shengjun Wu

引用次数: 0

Development of Paraneoplastic Neuromyelitis Optica after Lung Resection in a Patient with Squamous Cell Carcinoma. 鳞状细胞癌患者肺切除术后视神经脊髓炎的发展。

IF 1.3 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-02-20 DOI: 10.5761/atcs.cr.21-00144

Shunsuke Eba, Shuhei Nishiyama, Hirotsugu Notsuda, Hisashi Oishi, Masafumi Noda, Masashi Aoki, Yoshinori Okada

{"title":"Development of Paraneoplastic Neuromyelitis Optica after Lung Resection in a Patient with Squamous Cell Carcinoma.","authors":"Shunsuke Eba, Shuhei Nishiyama, Hirotsugu Notsuda, Hisashi Oishi, Masafumi Noda, Masashi Aoki, Yoshinori Okada","doi":"10.5761/atcs.cr.21-00144","DOIUrl":"https://doi.org/10.5761/atcs.cr.21-00144","url":null,"abstract":"Neurological paraneoplastic syndrome is a relatively rare condition in patients with malignant tumors. Recently, it has been reported that anti-Aquaporin 4 (AQP4) antibody is highly specific for neuromyelitis optica. The patient was a 76-year-old man. He underwent right upper lobectomy for squamous cell carcinoma of the lung. Although the immediate postoperative course was uneventful, neurological symptoms became apparent from postoperative day (POD) 4. Magnetic resonance imaging showed longitudinally extended edematous lesions in the spinal cord, and a cerebrospinal fluid examination was positive for anti-AQP4 antibody, leading to the diagnosis of paraneoplastic neuromyelitis optica. Despite multiple rounds of steroid pulse therapy and plasma exchange, the neurological symptoms worsened and the patient died on POD 46. The development of neuromyelitis optica in the early postoperative period could be related to the influence of surgical stress or epidural anesthesia.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"29 1","pages":"49-52"},"PeriodicalIF":1.3,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/c0/atcs-29-049.PMC9939678.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Circ_0006220 Contributes to NSCLC Progression through miR-342-3p/GOT2 Axis. Circ_0006220通过miR-342-3p/GOT2轴促进NSCLC进展。

IF 1.3 4区医学

Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-02-20 DOI: 10.5761/atcs.oa.22-00090

Jichun Tang, Xuan Li, Lili Zhao, Jiajun Hui, Ning Ding

{"title":"Circ_0006220 Contributes to NSCLC Progression through miR-342-3p/GOT2 Axis.","authors":"Jichun Tang, Xuan Li, Lili Zhao, Jiajun Hui, Ning Ding","doi":"10.5761/atcs.oa.22-00090","DOIUrl":"https://doi.org/10.5761/atcs.oa.22-00090","url":null,"abstract":"Purpose: Dysregulated circular RNAs (circRNAs) have shown crucial modulatory functions in tumorigenesis, containing non-small cell lung cancer (NSCLC). The purpose of this study was to explore the biological functions and regulatory theory of circ_0006220 in NSCLC.Methods: Reverse transcription-quantitative polymerase chain reaction and Western blot assay were conducted to measure RNA and protein expression, respectively. A total of 73 cases of NSCLC tumor samples were collected for expression analysis, and A-549 and NCI-H1299 cell lines were used for functional experiments. Cell proliferation was assessed by cell counting kit-8 assay, colony formation assay, 5-ethynyl-2'-deoxyuridine assay, and flow cytometry. Cell apoptosis, motility, and angiogenesis ability were analyzed by flow cytometry, transwell assays, and capillary-like network formation assay. Dual-luciferase reporter assay and RNA immunoprecipitation assay were conducted to verify the target relationships.Results: Circ_0006220 was highly expressed in NSCLC tissues and cell lines. Circ_0006220 silencing inhibited the proliferation, migration, invasion, and angiogenesis but induced the apoptosis of NSCLC cells. Circ_0006220 acted as a microRNA-342-3p (miR-342-3p) sponge, and circ_0006220 knockdown-induced changes on the phenotypes of NSCLC cells were largely overturned by the knockdown of miR-342-3p. miR-342-3p interacted with the 3' untranslated region of glutamic-oxaloacetic transaminase 2 (GOT2), and GOT2 overexpression largely diminished miR-342-3p overexpression-mediated influences in NSCLC cells. Circ_0006220 could up-regulate GOT2 expression by sponging miR-342-3p.Conclusion: Circ_0006220 promoted the malignant behaviors of NSCLC cells through mediating the miR-342-3p/GOT2 regulation cascade.","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"29 1","pages":"11-22"},"PeriodicalIF":1.3,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/bd/atcs-29-011.PMC9939679.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10781956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1