鳞状细胞癌患者肺切除术后视神经脊髓炎的发展。

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Shunsuke Eba, Shuhei Nishiyama, Hirotsugu Notsuda, Hisashi Oishi, Masafumi Noda, Masashi Aoki, Yoshinori Okada
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引用次数: 2

摘要

神经副肿瘤综合征在恶性肿瘤患者中是一种相对罕见的疾病。最近有报道称,抗水通道蛋白4 (AQP4)抗体对视神经脊髓炎具有高度特异性。患者为一名76岁男性。他接受了右上肺叶切除肺鳞状细胞癌。虽然术后的直接过程是平静的,但从术后一天(POD)开始,神经系统症状变得明显。mri示脊髓纵向延伸水肿病变,脑脊液抗aqp4抗体阳性,诊断为副肿瘤性视神经脊髓炎。尽管进行了多轮类固醇脉冲治疗和血浆置换,但神经系统症状恶化,患者于POD 46死亡。术后早期视神经脊髓炎的发生可能与手术应激或硬膜外麻醉的影响有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Development of Paraneoplastic Neuromyelitis Optica after Lung Resection in a Patient with Squamous Cell Carcinoma.

Development of Paraneoplastic Neuromyelitis Optica after Lung Resection in a Patient with Squamous Cell Carcinoma.

Development of Paraneoplastic Neuromyelitis Optica after Lung Resection in a Patient with Squamous Cell Carcinoma.

Neurological paraneoplastic syndrome is a relatively rare condition in patients with malignant tumors. Recently, it has been reported that anti-Aquaporin 4 (AQP4) antibody is highly specific for neuromyelitis optica. The patient was a 76-year-old man. He underwent right upper lobectomy for squamous cell carcinoma of the lung. Although the immediate postoperative course was uneventful, neurological symptoms became apparent from postoperative day (POD) 4. Magnetic resonance imaging showed longitudinally extended edematous lesions in the spinal cord, and a cerebrospinal fluid examination was positive for anti-AQP4 antibody, leading to the diagnosis of paraneoplastic neuromyelitis optica. Despite multiple rounds of steroid pulse therapy and plasma exchange, the neurological symptoms worsened and the patient died on POD 46. The development of neuromyelitis optica in the early postoperative period could be related to the influence of surgical stress or epidural anesthesia.

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来源期刊
Annals of Thoracic and Cardiovascular Surgery
Annals of Thoracic and Cardiovascular Surgery CARDIAC & CARDIOVASCULAR SYSTEMS-SURGERY
CiteScore
2.80
自引率
0.00%
发文量
56
审稿时长
4-8 weeks
期刊介绍: Information not localized
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