Applied Bionics and Biomechanics最新文献

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E-Bayesian Estimation Using Spacing Function for Inverse Lindley Adaptive Type-I Progressively Censored Samples: Comparative Study with Applications. 使用间距函数对反林德雷自适应 I 型渐进删失样本进行 E-Bayesian 估计:比较研究与应用》。
IF 1.8 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5567457
Mazen Nassar, Refah Alotaibi, Ahmed Elshahhat
{"title":"E-Bayesian Estimation Using Spacing Function for Inverse Lindley Adaptive Type-I Progressively Censored Samples: Comparative Study with Applications.","authors":"Mazen Nassar, Refah Alotaibi, Ahmed Elshahhat","doi":"10.1155/2024/5567457","DOIUrl":"10.1155/2024/5567457","url":null,"abstract":"<p><p>For the first time, this paper offers the Bayesian and E-Bayesian estimation methods using the spacing function (SF) instead of the classical likelihood function. The inverse Lindley distribution, including its parameter and reliability measures, is discussed in this study through the mentioned methods, along with some other classical approaches. Six-point and six-interval estimations based on an adaptive Type-I progressively censored sample are considered. The likelihood and product of spacing methods are used in classical inferential setups. The approximate confidence intervals are discussed using both classical approaches. For various parameters, the Bayesian methodology is studied by taking both likelihood and SFs as observed data sources to derive the posterior distributions. Moreover, the E-Bayesian estimation method is considered by using the same data sources in the usual Bayesian approach. The Bayes and E-Bayes credible intervals using both likelihood and SFs are also taken into consideration. Several Monte Carlo experiments are carried out to assess the performance of the acquired estimators, depending on different accuracy criteria and experimental scenarios. Finally, two data sets from the engineering and physics sectors are analyzed to demonstrate the superiority and practicality of the suggested approaches.</p>","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"2024 ","pages":"5567457"},"PeriodicalIF":1.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on Modeling and Motion Optimization for an Underactuated Bionic Scorpion Robot Arm 欠驱动仿生蝎子机械臂的建模和运动优化研究
IF 2.2 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-05-31 DOI: 10.1155/2024/9439878
Ning Cao, Jinsheng Liu, Feiling Shen, Xuming Pei, Yupu Liu, Hengyu Li
{"title":"Research on Modeling and Motion Optimization for an Underactuated Bionic Scorpion Robot Arm","authors":"Ning Cao, Jinsheng Liu, Feiling Shen, Xuming Pei, Yupu Liu, Hengyu Li","doi":"10.1155/2024/9439878","DOIUrl":"https://doi.org/10.1155/2024/9439878","url":null,"abstract":"Flexible screen possessing a high-contrast ratio to accomplish high-definition display can be attributed to the accuracy of polarizer assembly. Different from the existing polarizer attached onto a flexible screen, resulting in low-accuracy and nonalignment attaching behaviors, a unique approach of underactuated bionic scorpion robot arms can be developed to explore the stable capture and accurate alignment motion operations. Overall structure design and D–H kinematic simulation of bionic scorpion robot arm can be conducted to analyze virtual three-key typical motions. Motion optimization of structural parameters and corresponding motion workspaces verification can be adopted to evaluate motion range and ability. Experiments can be utilized to verify the rationality of theoretical modeling and optimization simulation of bionic scorpion robot arm. Experimental results illustrate that it is evident to demonstrate that the motion behaviors of bionic scorpion robot arm can be verified to be consistent with three key states of virtual theoretical motions. The key joints possessing minor errors may also be utilized to illustrate the relatively excellent dynamic motions existing in bionic scorpion robot arm. Further, advancing the stable motion behaviors of bionic scorpion robot arm may solve the problems of low-accuracy and misalignment polarizer attachments.","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"101-102 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141188444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motion Accuracy of Pneumatic Stepper Motor-Driven Robotic System Developed for MRI-Guided High-Intensity Focused Ultrasound Treatment of Prostate Disease 为核磁共振成像引导的高强度聚焦超声治疗前列腺疾病而开发的气动步进电机驱动机器人系统的运动精度
IF 2.2 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-05-10 DOI: 10.1155/2024/5556537
Hyunkwan Seo, Sung Kwan Hwang, Hee-Won Kim, Kyu Chan Lee
{"title":"Motion Accuracy of Pneumatic Stepper Motor-Driven Robotic System Developed for MRI-Guided High-Intensity Focused Ultrasound Treatment of Prostate Disease","authors":"Hyunkwan Seo, Sung Kwan Hwang, Hee-Won Kim, Kyu Chan Lee","doi":"10.1155/2024/5556537","DOIUrl":"https://doi.org/10.1155/2024/5556537","url":null,"abstract":"The latest advancement in high-intensity focused ultrasound (HIFU) treatment technology integrates magnetic resonance imaging (MRI) guidance for precise treatment of prostate disease. As conventional electromagnetic motors are not applicable for utilization within MRI scanners, we have developed a prototype robotic system driven by pneumatic stepper motors to control the movement of the HIFU transducer within an intrarectal probe during MRI-guided HIFU treatment procedures. These pneumatic stepper motors were constructed entirely from MRI-compatible plastic materials. Assessment of the robotic system’s MRI compatibility was conducted utilizing a 3.0T MRI scanner, revealing no discernible MRI image distortion with a minor decrease in the signal-to-noise ratio (2.8%) during the motor operation. The robotic system enabled the transducer to move inside the probe with two degrees of freedom, allowing both linear and rotational motion. The positional accuracy of the transducer movement was assessed, yielding ±0.20 and ±0.22 mm accuracies in the forward and backward linear movements, respectively, and ±0.79° and ±0.74° accuracies in the clockwise and counterclockwise rotational motions, respectively. Emulation of authentic HIFU procedures involved creating a two-dimensional array of thermal lesions in a tissue-mimicking phantom, achieving positional accuracy within ±1 mm for the generated HIFU focal spots. The prototype robotic system incorporating pneumatic stepper motors fabricated entirely from MRI-compatible plastic materials has demonstrated the requisite positional accuracy necessary for effective HIFU treatment of prostate disease, indicating substantial promise for future clinical application.","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"254 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140933852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence in Cardiology and Atherosclerosis in the Context of Precision Medicine: A Scoping Review 精准医疗背景下心脏病学和动脉粥样硬化中的人工智能:范围综述
IF 2.2 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-04-30 DOI: 10.1155/2024/2991243
Oliwia Kolaszyńska, Jacek Lorkowski
{"title":"Artificial Intelligence in Cardiology and Atherosclerosis in the Context of Precision Medicine: A Scoping Review","authors":"Oliwia Kolaszyńska, Jacek Lorkowski","doi":"10.1155/2024/2991243","DOIUrl":"https://doi.org/10.1155/2024/2991243","url":null,"abstract":"Cardiovascular diseases remain the main cause of death worldwide which makes it essential to better understand, diagnose, and treat atherosclerosis. Artificial intelligence (AI) and novel technological solutions offer us new possibilities and enable the practice of individually tailored medicine. The study was performed using the PRISMA protocol. As of January 10, 2023, the analysis has been based on a review of 457 identified articles in PubMed and MEDLINE databases. The search covered reviews, original articles, meta-analyses, comments, and editorials published in the years 2009–2023. In total, 123 articles met inclusion criteria. The results were divided into the subsections presented in the review (genome-wide association studies, radiomics, and other studies). This paper presents actual knowledge concerning atherosclerosis, in silico, and big data analyses in cardiology that affect the way medicine is practiced in order to create an individual approach and adjust the therapy of atherosclerosis.","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"91 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140835243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and Performance Analysis of a Mecanum-Built Perturbation-Based Balance Training Device 基于惯性的平衡训练装置的设计和性能分析
IF 2.2 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-03-29 DOI: 10.1155/2024/3622556
Jaison Jacob Mathunny, Hari Krishnan S, Ashokkumar Devaraj, Varshini Karthik
{"title":"Design and Performance Analysis of a Mecanum-Built Perturbation-Based Balance Training Device","authors":"Jaison Jacob Mathunny, Hari Krishnan S, Ashokkumar Devaraj, Varshini Karthik","doi":"10.1155/2024/3622556","DOIUrl":"https://doi.org/10.1155/2024/3622556","url":null,"abstract":"This study proposes a mecanum-built perturbation-based balance training device aimed at improving motor adaptive skills for fall prevention in individuals with neurological disorders or the elderly. Incorporating multidirectional fall simulations in line with modified constraint-induced movement therapy, the device’s efficacy was evaluated by measuring the distance traveled and peak acceleration under different static loads (20, 30, and 40 kg) and input accelerations (1, 2, and 3 m/s<sup>2</sup>). A pilot study with 10 subjects was conducted to assess device performance, utilizing repeated measures analysis of variance and Bonferroni’s post hoc analysis. Results indicated a load-dependent reduction in distance traveled, with an average mean difference of 0.74–1.23 cm between the 20 and 40 kg loads for trials of 9 and 18 cm, respectively. Despite varying loads, the device consistently achieved near-anticipated peak accelerations, suggesting its capability to induce effective perturbations. The study also observed a significant lateral movement preference, suggesting adjustments to pulse width modulation and time period may optimize lateral movement performance.","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"35 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140323193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Different Dual-Task Paradigm Reduce Postural Control Ability and Dynamic Stability of Healthy Young Adults during Stair Descent 不同的双重任务范式降低了健康年轻人下楼梯时的姿势控制能力和动态稳定性
IF 2.2 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-03-11 DOI: 10.1155/2024/9942042
Jiankang Yang, Shifang Yan, Chuanbao Cao
{"title":"Different Dual-Task Paradigm Reduce Postural Control Ability and Dynamic Stability of Healthy Young Adults during Stair Descent","authors":"Jiankang Yang, Shifang Yan, Chuanbao Cao","doi":"10.1155/2024/9942042","DOIUrl":"https://doi.org/10.1155/2024/9942042","url":null,"abstract":"<i>Objective</i>. This study aimed to compare the impacts of different dual-task paradigms on the postural control ability and dynamic stability of the youth during stair descent. <i>Method</i>. Twenty young adults without regular exercise habits were randomly recruited to perform stair descent tasks with three different paradigms: single-task, cognitive dual-task, and manual dual-task. Kinematic and dynamic data were collected using an 8 Vicon motion analysis system and a Kistler force plate to evaluate postural control ability and dynamic stability during stair descent. <i>Results</i>. The variation trends of lower limb joint moment were similar under the three task models. Compared with a single-task, both dual-task paradigms significantly reduced the mechanical parameters and dynamic stability during stair descent. <i>Conclusion</i>. The dual-task paradigm increases the risk of stair-related falls. Both cognitive and manual tasks have similar impacts on postural control ability and dynamic stability during stair walking. It is recommended that people avoid performing dual tasks during stair descent.","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"286 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140108156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptive Approximation Sliding-Mode Control of an Uncertain Continuum Robot with Input Nonlinearities and Disturbances 具有输入非线性和干扰的不确定连续机器人的自适应逼近滑模控制
IF 2.2 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-03-06 DOI: 10.1155/2024/8533606
Shoulin Xu
{"title":"Adaptive Approximation Sliding-Mode Control of an Uncertain Continuum Robot with Input Nonlinearities and Disturbances","authors":"Shoulin Xu","doi":"10.1155/2024/8533606","DOIUrl":"https://doi.org/10.1155/2024/8533606","url":null,"abstract":"This paper develops an adaptive nonsingular fast terminal sliding-mode control (ANFTSMC) scheme for the continuum robot subjected to uncertain dynamics, external disturbances, and input nonlinearities (e.g., actuator deadzones/faults). Concretely, a function approximation technique (FAT) is utilized to estimate unknown robot dynamics and actuator deadzones/faults online. Furthermore, a disturbance observer (DO) is devised to make up for unknown external disturbances. Then, an ANFTSMC scheme combined with FAT and DO is developed, to expedite the restoration of the stability for the continuum robot. The proposed ANFTSMC not only can retain the benefits of traditional terminal sliding-mode control (TSMC), containing easy enforcement, quick response, and robustness to uncertainties but also dispose of the latent singularity for traditional faster TSMC designs. Afterward, the simulation results show that the proposed controller can effectively improve the trajectory tracking accuracy of the continuum robot, and the tracking root-mean-square errors are 0.0115 and 0.0128 rad. Finally, the effectiveness of ANFTSMC scheme is validated by experiments.","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"301 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140045048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electromechanical Coupling Model for Ionic Liquid Gel Soft Actuators 离子液体凝胶软致动器的机电耦合模型
IF 2.2 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-02-13 DOI: 10.1155/2024/8369544
Chenghong Zhang, Chengguang Zhang, Guangping Tian, Xun Gu
{"title":"Electromechanical Coupling Model for Ionic Liquid Gel Soft Actuators","authors":"Chenghong Zhang, Chengguang Zhang, Guangping Tian, Xun Gu","doi":"10.1155/2024/8369544","DOIUrl":"https://doi.org/10.1155/2024/8369544","url":null,"abstract":"A soft robot is composed of soft materials, which exhibit continuous deformation and driving structure integration and can arbitrarily change shapes and sizes over wide ranges. It shows strong adaptability to unstructured environments and has broad application prospects in military reconnaissance, medical rescues, agricultural production, etc. Soft robots based on ionic electroactive polymers (EAPs) have low-driving voltages, large-actuation displacements, fast responses, light weights, and low powers and have become a hot research field of bionic robots. Ionic liquid gels (ILGs) are new ionic EAPs. In this study, a new soft actuator was designed based on an ILG, and the electromechanical coupling model of an ILG soft actuator was studied in detail. Based on the system transfer function method, a mechatronic coupling model for the soft actuator was developed. According to the material characteristics and current response law of the ILG-containing EAP, an equivalent circuit model was used to describe transfer of the output current and input voltage. Based on the equivalent transformer model for ionic polymer–metal composite (IPMC) actuators proposed by Claudia Bonomo, the electromechanical coupling equation and a driving equation of the ILG soft actuator were established. The least-squares method was used with the coupling model of an ILG soft actuator to identify the system parameters for the model, and the effects of the structural parameters on the end displacement and driving force of the soft actuator were analyzed.","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"2 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SHAKF-PU: Sage-Husa Adaptive Kalman Filtering-Based Pedestrian Characteristic Parameter Update Mechanism for Enhancing Step Length Estimation in Pedestrian Dead Reckoning. SHAKF-PU:基于 Sage-Husa 自适应卡尔曼滤波的行人特征参数更新机制,用于增强行人惯性推算中的步长估计。
IF 2.2 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-02-08 eCollection Date: 2024-01-01 DOI: 10.1155/2024/1150076
Chinyang Henry Tseng, Jiunn-Yih Wu
{"title":"SHAKF-PU: Sage-Husa Adaptive Kalman Filtering-Based Pedestrian Characteristic Parameter Update Mechanism for Enhancing Step Length Estimation in Pedestrian Dead Reckoning.","authors":"Chinyang Henry Tseng, Jiunn-Yih Wu","doi":"10.1155/2024/1150076","DOIUrl":"10.1155/2024/1150076","url":null,"abstract":"<p><p>Step length estimation (SLE) is the core process for pedestrian dead reckoning (PDR) for indoor positioning. Original SLE requires accurate estimations of pedestrian characteristic parameter (PCP) by the linear update, which may cause large distance errors. To enhance SLE, this paper proposes the Sage-Husa adaptive Kalman filtering-based PCP update (SHAKF-PU) mechanism for enhancing SLE in PDR. SHAKF has the characteristic of predicting the trend of historical data; the estimated PCP is closer to the true value than the linear update. Since different kinds of pedestrians can influence the PCP estimation, adaptive PCP estimation is required. Compared with the classical Kalman filter, SHAKF updates its <i>Q</i> and <i>R</i> parameters in each update period so the estimated PCP can be more accurate than other existing methods. The experimental results show that SHAKF-PU reduces the error by 24.86% compared to the linear update, and thus, the SHAKF-PU enhances the indoor positioning accuracy for PDR.</p>","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"2024 ","pages":"1150076"},"PeriodicalIF":2.2,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticle Delivery in Microvascular after Cerebral Ischemia: A Simulation Study 脑缺血后微血管中的纳米粒子输送:模拟研究
IF 2.2 4区 计算机科学
Applied Bionics and Biomechanics Pub Date : 2024-02-07 DOI: 10.1155/2024/6637846
Peiqian Chen, Bing Dong, Weiwu Yao
{"title":"Nanoparticle Delivery in Microvascular after Cerebral Ischemia: A Simulation Study","authors":"Peiqian Chen, Bing Dong, Weiwu Yao","doi":"10.1155/2024/6637846","DOIUrl":"https://doi.org/10.1155/2024/6637846","url":null,"abstract":"Nanodrug delivery systems have been used in the diagnosis and treatment of ischemic stroke. However, the delivery mechanisms of nanoparticles within microvascular after cerebral ischemia have not been systematically revealed. This study aims to investigate the binding of different nanoparticles to the walls of ischemic brain microvascular through numerical simulations. In this study, 3D models of cerebral microvascular based on ischemic pathological changes are constructed. After building the mesh of microvascular, computational fluid dynamics is used to simulate blood flow and nanoparticle delivery. The simulation results show that the total amount of binding nanoparticles with small size is higher than that with large size. The large-sized nanoparticles are more easily delivered to the stenosis. The density of the nanoparticles has no significant effect on delivery. Furthermore, the study finds that the presence of red blood cells can significantly enhance the delivery efficiency of nanoparticles. In addition to evaluating the forces exerted on the nanoparticles, the impact of the binding affinity of the modified ligand on nanoparticles to the target receptor on delivery is investigated. In summary, selecting suitable nanoparticles according to different targets will improve the delivery efficiency of nanodrugs. The microvascular delivery model of nanoparticles proposed in this study may be helpful in the design of nanoparticles for diagnosis and treatment of cerebral ischemia.","PeriodicalId":8029,"journal":{"name":"Applied Bionics and Biomechanics","volume":"21 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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