Annals of Medicine and Surgery最新文献

{"title":"Bioengineered urethral grafts for strictures: a perspective on advancements, functional restoration, and affordability.","authors":"Shahreena Athar Siddiqui, Maliha Khalid, Muhammad Talha, Aminath Waafira","doi":"10.1097/MS9.0000000000003675","DOIUrl":"10.1097/MS9.0000000000003675","url":null,"abstract":"<p><p>Urethral stricture is a chronic urological condition that remains challenging to manage due to the limitations of traditional treatments like dilation and urethroplasty, which are prone to recurrence and complications. Tissue-engineered urethral grafts have emerged as a promising alternative, offering durable, functional restoration with reduced donor site morbidity. Innovations in scaffold fabrication, especially 3D bioprinting and hydrogel-based bio-inks, have led to the creation of structurally and biologically compatible constructs that can regenerate native urothelial layers. However, high costs, technical complexity, and limited commercial viability have restricted their widespread clinical use. Future directions should prioritize cost-reduction strategies, scalable biomanufacturing, and head-to-head trials with current treatment standards.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 9","pages":"6236-6237"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent renal calculi in a bilateral partial duplex collecting system: a rare case managed with suction RIRS.","authors":"Aayush Bist, Maya Upadhyaya, Dhanlaxmi Giri, Prabhat Kaphle, Milan Gyawali","doi":"10.1097/MS9.0000000000003673","DOIUrl":"10.1097/MS9.0000000000003673","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Urolithiasis is a common condition, but management becomes challenging in patients with recurrent stones, anatomical variations, or a history of multiple interventions.</p><p><strong>Case presentation: </strong>A 56-year-old man with bilateral kidney stones and a duplex collecting system had a long-standing history of flank pain and had undergone several procedures, including ESWL, URSL, and PCNL. Most recently, he was presented with a right-sided renal stone.</p><p><strong>Clinical discussion: </strong>Urolithiasis in patients with duplex renal systems can lead to recurring stones, making treatment more complex. Imaging like ultrasound and CT scans help in diagnosis, and procedures like retrograde intrarenal surgery (RIRS) are effective for removal and good surgical outcome. With stone analysis and follow-up care, including hydration and dietary changes, recurrence can be minimized.</p><p><strong>Conclusion: </strong>This case highlights the challenges of managing complex, recurrent urolithiasis in a patient with a duplex collecting system.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 9","pages":"6206-6210"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoonoses in the Democratic Republic of Congo: anthrax outbreak in the province of Nord-Kivu has prompted a health alert.","authors":"Joshua Ekouo, Christian Tague, Hermann Yokolo, Lidoine Djom, Dujardin Makeda, Areeba Aamir Ali Basaria, Ismat Fatima, Aymar Akilimali","doi":"10.1097/MS9.0000000000003684","DOIUrl":"10.1097/MS9.0000000000003684","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 9","pages":"5381-5384"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of advanced CKD with extensive cystic renal disease causing bowel obstruction.","authors":"Aron Shrestha, Kshitiz Acharya, Subarna Giri, Bipashna Timla, Renish Bhattarai, Vibhav Lal","doi":"10.1097/MS9.0000000000003671","DOIUrl":"10.1097/MS9.0000000000003671","url":null,"abstract":"<p><strong>Introduction: </strong>Acquired cystic kidney disease (ACKD) occurs in patients with kidney failure, leading to renal cyst formation. Although typically asymptomatic, large cysts can cause unusual complications like gastrointestinal obstruction.</p><p><strong>Case presentation: </strong>An 18-year-old female with stage V chronic kidney disease developed abdominal distension and bowel obstruction caused by a large renal cyst. Imaging confirmed the diagnosis, and conservative management with fluid control, dialysis, and infection management was initiated.</p><p><strong>Discussion: </strong>The presentation of a renal cyst causing bowel obstruction is extremely rare, and the optimal management approach remains unclear. Diagnosis relies on imaging modalities such as ultrasound and CT, which help identify cyst characteristics and associated complications. In such cases, conservative treatment is generally preferred, focusing on symptom management through dietary modifications, while surgical intervention is considered only if symptoms persist despite medical therapy.</p><p><strong>Conclusion: </strong>This case highlights the rare presentation of bowel obstruction due to ACKD and emphasizes the importance of early imaging and a multidisciplinary approach in managing such complications.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 9","pages":"6116-6120"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level of job satisfaction among anesthetists in Khyber Pakhtunkhwa: an in-depth examination of influencing factors.","authors":"Muhammad Tayyeb, Hamid Hussain, Zeeshan Jamil, Sami Ullah Khan, Iftikhar Ud-Din, Muhammad Sheharyar, Samim Noori, Sardar Noman Qayyum","doi":"10.1097/MS9.0000000000003685","DOIUrl":"10.1097/MS9.0000000000003685","url":null,"abstract":"<p><strong>Background: </strong>Job satisfaction is an important determinant of health staff's motivation, retention, and performance. The main aim of this study was to assess the level of job satisfaction and associated factors among Anesthetists working at Khyber Pakhtunkhwa Hospital, Pakistan.</p><p><strong>Methods: </strong>A multicenter cross-sectional study was conducted from 1 March to 30 December 2022. A total of 147 anesthetists that were working in different Khyber Pakhtunkhwa hospitals were involved in this study. The structured questionnaire (Minnesota) was scored on five-point Likert scales. Data were analyzed using SPSS 26. Binary logistic regression was used to measure statistical significance between dependent and each independent variable. Variables with value of ≤0.2 on crude analysis were taken into multivariate analysis, and a value of 0.05 and 95% confidence interval (CI) was used as cutoff point.</p><p><strong>Results: </strong>A total of 147 anesthetists were involved in the study. The overall level of job satisfaction among anesthetist was 70.7% (95% CI: 58.3-88.6). Factors associated with job satisfaction among anesthetist were aged (AOR: 0.814, 95% CI: 0.316-2.097), being married (AOR: 1.312, 95% CI: 0.477-3.604), advancement (AOR: 0.797, 95% CI: 0.285-2.229), recognition (AOR: 2.438, 95% CI: 0.857-6.936), growth opportunities (AOR: 1.517, 95% CI: 0.444-5.184), work security (AOR: 1.150, 95% CI: 0.418-3.160), Fair benefit (AOR: 0.508, 95% CI 0.196-1.314) and safe working environment (AOR: 0.199, 955 CI: 0.196-1.314).</p><p><strong>Conclusion: </strong>Job satisfaction of anesthetists working different hospitals of Khyber Pakhtunkhwa was high. The only factor associated with job satisfaction was coworker relationship, advancements and achievements. and least satisfied with anesthetists recognition, organization policies, and payment and benefits.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 9","pages":"5462-5469"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Effects of music therapy on anxiety among patients undergoing cardiac procedures: a systematic review and meta-analysis\".","authors":"Asadollah Shakeri, Nazli Farnoosh, Aidin Shakeri","doi":"10.1097/MS9.0000000000003516","DOIUrl":"10.1097/MS9.0000000000003516","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 8","pages":"5340-5341"},"PeriodicalIF":1.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of fine needle aspiration of thyroid nodules and lymph nodes with 22- and 25-gauge needles: a retrospective study.","authors":"Mohammad Yahia Alzahrani, Mohammad Sayed Abdelghaffar, Tariq Hashim Adlan","doi":"10.1097/MS9.0000000000003664","DOIUrl":"10.1097/MS9.0000000000003664","url":null,"abstract":"<p><strong>Background: </strong>Approximately 15% of fine-needle aspiration biopsy (FNAB) procedures are considered inconclusive, caused by various factors such as nodule characteristics, level of expertise, and needle size. Since needle size may play a crucial role in both adequacy of FNAB samples and reduction of complications, our objective was to compare cytology specimen adequacy, blood contamination, and findings in thyroid nodules and lymph nodes using 22- and 25-gauge needles in fine-needle aspiration (FNA).</p><p><strong>Materials and methods: </strong>A retrospective comparative cohort study was conducted at King Fahad Specialist Hospital, Saudi Arabia. Data were collected from electronic medical records between January and December 2021. An ultrasound-guided FNA procedure was performed. Each nodule was sampled in three passes using a 25-gauge and a 22-gauge fine needle. A total of 153 (115 with thyroid nodules; 57 with 22-gauge and 58 with 25-gauge and 38 with lymph nodes; 21 with 22-gauge and 17 with 25-gauge) cases were included. Data analysis was done using SPSS version 26. All cases were divided into two groups: 22-gauge or 25-gauge needle group. Chi-square test and binary logistic regression were used for comparison.</p><p><strong>Results: </strong>No significant differences were found. Adequacy rates were 93.9% for thyroid and 97.4% for lymph node samples (<i>P</i> = 0.68). Conclusive diagnoses were 97.4% for thyroid and 94.7% for lymph nodes (<i>P</i> = 0.137). Bloody samples were more frequent in lymph nodes (23.7%) than thyroid (11.3%) (<i>P</i> = 0.111). Needle size did not affect adequacy, but the number of passes was a significant predictor (odds ratio: 0.068, 95% confidence interval: 0.008-0.570, <i>P</i> = 0.013).</p><p><strong>Conclusion: </strong>The study highlights the importance of the number of passes during the procedure, with a higher number of passes associated with decreased odds of obtaining an adequate sample. The needle size does not significantly impact the various variables assessed.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 9","pages":"5388-5393"},"PeriodicalIF":1.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aeroelastic flaps for dynamic airway stabilization: a novel approach to respiratory support.","authors":"Muhammad Talha, Maliha Khalid, Muhammad Khan Buhadur Ali, Aminath Waafira","doi":"10.1097/MS9.0000000000003521","DOIUrl":"10.1097/MS9.0000000000003521","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 8","pages":"5338-5339"},"PeriodicalIF":1.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDA approves Veozah (Fezolinetant) for menopausal symptoms: a new nonhormonal option.","authors":"Chukwuka Elendu, Tochukwu W Okahia, George S Blewusi, Oluwatobi O M Meduoye, Emmanuel C Ogelle, Arube R Egbo, Vivian C Nwankwo, Kingsley C Amaefule, Sopuruchukwu L Emechebe, Abdirahman A Mohamed, Oyinkansola S Ogedengbe, Ovonomor P Aggreh, Dorin I Obi, Victor I Orji, Sikiru O Bakare, Fahidah D Adediran, Fiyinfoluwa Adetoye, Babatunde A Akande, Omolara C Ogunsola, Aishat M Olanlege","doi":"10.1097/MS9.0000000000003670","DOIUrl":"10.1097/MS9.0000000000003670","url":null,"abstract":"<p><p>Menopausal vasomotor symptoms (VMS), such as hot flashes and night sweats, significantly impact the quality of life for many women. While hormone therapy remains a standard treatment, it is not suitable for all patients due to contraindications, safety concerns, or personal preferences. Fezolinetant (Veozah), a non-hormonal neurokinin-3 receptor (NK3R) antagonist, has emerged as a novel alternative for managing moderate to severe menopausal VMS. The U.S. Food and Drug Administration (FDA) approved Veozah on 12 May 2023, marking a milestone in the development of non-hormonal treatments for menopause-related symptoms. Fezolinetant modulates the activity of KNDy neurons in the hypothalamus, which plays a key role in thermoregulation. Clinical trials, including SKYLIGHT 1, SKYLIGHT 2, and SKYLIGHT 4, have demonstrated their efficacy in significantly reducing the frequency and severity of hot flashes. Additionally, long-term safety data indicate a well-tolerated profile with mild to moderate adverse effects, the most common being headache and fatigue. The approval of Veozah offers a safe and effective non-hormonal option for menopausal women who cannot or choose not to use hormone therapy. Its targeted mechanism addresses the underlying neurochemical dysregulation associated with VMS, providing rapid and sustained symptom relief. As research continues to explore its long-term impact, fezolinetant represents a promising advancement in women's health, improving the management of menopausal symptoms and enhancing overall well-being.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 9","pages":"5373-5377"},"PeriodicalIF":1.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous, transpapillary, and transmural drainage in acute cholecystitis: a comparative analysis of techniques, stent selection, and clinical.","authors":"Zim Warda Hasan, Tusneem Shehzadi, Anmol Mohan, Asad Ur Rehman, Fnu Muskan, Mariam Zia, Priyanka Mohan Lal, Hasibullah Aminpoor, Hasiba Karimi, Vikash Kumar, Usha Tejwaney, Sarwan Kumar","doi":"10.1097/MS9.0000000000003527","DOIUrl":"10.1097/MS9.0000000000003527","url":null,"abstract":"<p><p>Acute cholecystitis is a common inflammatory condition of the gallbladder, primarily caused by gallstone obstruction, leading to increased intraluminal pressure, ischemia, and infection. While laparoscopic cholecystectomy remains the standard treatment, gallbladder drainage techniques have emerged as effective alternatives for high-risk surgical patients. This review explores the indications, techniques, and comparative outcomes of various gallbladder drainage methods, including percutaneous transhepatic gallbladder drainage (PTGBD), endoscopic transpapillary gallbladder drainage (ETGBD), and endoscopic ultrasound-guided gallbladder drainage (EUS-GBD). Endoscopic ultrasound-guided transmural gallbladder drainage, particularly with lumen-apposing metal stents (LAMS), has shown high clinical success rates with fewer complications compared to traditional methods. Advances in stent technology and procedural techniques continue to improve patient outcomes. However, further research is needed to establish long-term efficacy and determine optimal patient selection criteria for different drainage methods. The review highlights the evolving landscape of gallbladder drainage and the need for standardized guidelines to optimize treatment strategies for high-risk patients.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 8","pages":"5056-5061"},"PeriodicalIF":1.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}