Annals of Saudi Medicine最新文献

{"title":"Preoperative thromboelastography in the prediction of post-tonsillectomy hemorrhage by coblation tonsillectomy: a post-hoc analysis.","authors":"Qian Liu,&nbsp;Yanping Zhang,&nbsp;Yanlu Liu","doi":"10.5144/0256-4947.2022.377","DOIUrl":"https://doi.org/10.5144/0256-4947.2022.377","url":null,"abstract":"<p><strong>Background: </strong>Post-tonsillectomy hemorrhage (PTH) affects around 4% of patients after tonsillectomy. We hypothesized that preoperative thromboelastography (TEG) might identify patients at higher risk of PTH.</p><p><strong>Objective: </strong>Investigate whether evaluation of coagulation function by preoperative TEG might help to predict PTH after tonsillectomy by coblation tonsillectomy (TE).</p><p><strong>Design: </strong>Post-hoc analysis of randomized controlled study.</p><p><strong>Setting: </strong>Otolaryngology Department between January 2017 and August 2019.</p><p><strong>Patients and methods: </strong>This post-hoc analysis included adults who underwent coblation TE for benign tonsillar disorders. Routine blood tests and TEG were performed preoperatively. The TEG parameters evaluated included coagulation reaction time (R) and maximum thrombus amplitude (MA).</p><p><strong>Main outcome measures: </strong>The main outcome was PTH during the 4-week postoperative period.</p><p><strong>Sample size and characteristics: </strong>284 RESULTS: The 19 patients (6.7%) that experienced PTH had a higher prevalence of diabetes mellitus, lower use of intraoperative suturing, fewer patients with grade I and II tonsillar enlargement, a higher white blood cell count, lower platelet count, lower fibrinogen level, lower R value, and a lower MA value than patients without PTH (all <i>P</i><.05). Multivariate logistic regression revealed that diabetes mellitus (<i>P</i><.053), fibrinogen level ≤2.735 g/L (<i>P</i><.027), R≤6.55 min (<i>P</i><.011) and MA≤59.15 mm (<i>P</i><.012) were independently associated with PTH. A regression model incorporating these four factors predicted PTH with a sensitivity of 73.7% and specificity of 83.8%.</p><p><strong>Conclusion: </strong>Preoperative evaluation of diabetes mellitus history, fibrinogen level, and TEG parameters might help to identify patients at higher risk of PTH after coblation TE.</p><p><strong>Limitations: </strong>Single-center study with a small sample size; possibly underpowered statistically. TEG measurements might not accurately reflect coagulation function, and a validation cohort was unavailable.</p><p><strong>Conflict of interest: </strong>None. CHINESE CLINICAL TRIAL REGISTRY NUMBER OF STUDY USED IN THIS ANALYSIS: ChiCTR2000032171. http://www.chictr.org.cn/showprojen.aspx?proj=52553.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/67/0256-4947.2022.377.PMC9706718.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of pediatric rigid esophagoscopy for foreign body removal before and after coin currency implementation in Saudi Arabia in 2017.","authors":"Abdulaziz Wafi,&nbsp;Mousa Wafi,&nbsp;Turki Hakami,&nbsp;Nasser Waleed Alabida,&nbsp;Raed Almutairi,&nbsp;Alsaleh Saad,&nbsp;Ibrahim Sumaily","doi":"10.5144/0256-4947.2022.415","DOIUrl":"https://doi.org/10.5144/0256-4947.2022.415","url":null,"abstract":"<p><strong>Background: </strong>Foreign body (FB) ingestion is a common problem in children, which can lead to severe complications. Coins are the most common FB ingested. Since coin currency was recently implemented in Saudi Arabia, we decided to assess whether any changes have occurred in the incidence of FB removal by esophagoscopy.</p><p><strong>Objectives: </strong>Incidence of rigid esophagoscopy for ingested FB removal before and after coin currency implementation.</p><p><strong>Design: </strong>Medical record review SETTINGS: Main referral hospital in Jazan region.</p><p><strong>Patients and methods: </strong>Our study included pediatric patients who underwent rigid esophagoscopy for removal of FB between February 2015 and July 2020 in the otorhinolaryngology department. We reported the incidence, age, gender, and type of FB. As the coin currency implementation started on December 2, 2017, the data were analyzed before and after this date.</p><p><strong>Main outcome measures: </strong>Annual incidence of pediatric rigid esophagoscopy for removal of ingested FB and type of the FB.</p><p><strong>Sample size: </strong>124 patients RESULTS: The median age and interquartile range was 6.0 (5.0) years. After implementation of coins in 2017, 104 cases were reported over 32 months; before that date, 20 cases were reported over 34 months. Coins were the FB in 2 cases (10%) before implementation of coins and in 83 cases (79.8%) after implementation (<i>P</i>=.0001).</p><p><strong>Conclusions: </strong>The annual incidence of pediatric esophagoscopy for FB removal has increased more than five times since implementation of coin currency. This increase is exclusively related to the increase in coins as a FB.</p><p><strong>Limitations: </strong>Retrospective study.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/d0/0256-4947.2022.415.PMC9706717.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10396948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring the effect of TNF-alpha inhibitors on laboratory parameters and adverse effects in different diseases: a retrospective, single-center study.","authors":"Abdulaziz N Madani,&nbsp;Fahad M Al-Saif,&nbsp;Lama R Alzamil,&nbsp;Aljohara M Almazroua,&nbsp;Nuha A Alfurayh,&nbsp;Sara D Aldokhayel,&nbsp;Qais A Almuhaideb,&nbsp;Nouf S Alballa,&nbsp;Nujud A Daham,&nbsp;Abdulrahman A Alkharashi","doi":"10.5144/0256-4947.2022.309","DOIUrl":"https://doi.org/10.5144/0256-4947.2022.309","url":null,"abstract":"<p><strong>Background: </strong>The introduction of biological treatments has revolutionized the management of moderate-to-severe psoriasis. Multiple clinical trials have established the efficacy of biological agents in the treatment of moderate-to-severe psoriasis. Nevertheless, there are no clear indications for optimal monitoring intervals during treatment.</p><p><strong>Objectives: </strong>Collect and analyze laboratory evaluation data from patients receiving biological therapy to provide a better understanding of the need for laboratory investigations before and during treatment with biological agents, and to analyze adverse events and other factors.</p><p><strong>Design: </strong>Retrospective cohort SETTINGS: Tertiary care center in Riyadh, Saudi Arabia.</p><p><strong>Patients and methods: </strong>Data were collected from the electronic medical records of patients attending the dermatology, rheumatology, and gastroenterology clinics from June 2014 to June 2019. The laboratory parameters of patients who have received one of the TNF-alpha inhibitors (adalimumab, etanercept, or infliximab) were collected starting at baseline and up to at least one year from treatment initiation.</p><p><strong>Main outcome measures: </strong>The time points at which patients developed significantly abnormal laboratory results during treatment with one of the TNF-alpha inhibitors.</p><p><strong>Sample size: </strong>250 patients RESULTS: Most patients were treated with adalimumab (38.4%); a similar proportion (38%) with infliximab, whereas only 23.6% were treated with etanercept. The majority of the significant abnormal laboratory results occurred at baseline, 3-6 and 9-12 months. Most abnormalities were among patients using infliximab, followed by etanercept, and then adalimumab. The median number of laboratory abnormalities for dermatology patients was significantly lower than that for gastroenterology patients (<i>P</i><.001), and for rheumatology patients (<i>P</i>=.002).</p><p><strong>Conclusions: </strong>Because dermatology patients showed a lower median number of laboratory abnormalities than patients treated by other specialties in our study, we believe that dermatology patients require less frequent laboratory monitoring. Therefore, we recommend laboratory evaluation at baseline, after 3-6 months, 1 year from the beginning of treatment, and annually thereafter for patients using TNF-alpha inhibitor agents. However, more frequent testing might be warranted according to patient comorbidities, concomitant medications, and physician judgment.</p><p><strong>Limitations: </strong>Single center and retrospective design.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/17/0256-4947.2022.309.PMC9557780.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and clinical profiles of Saudi patients with hyperprolactinemia in a single tertiary care center.","authors":"Moeber Mahzari,&nbsp;Khalid Saad Alhamlan,&nbsp;Nawaf Abdulaziz Alhussaini,&nbsp;Turki Abdullah Alkathiri,&nbsp;Abdulmohsen Nasser Al Khatir,&nbsp;Abdulaziz Mohammed Alqahtani,&nbsp;Emad Fayez Masuadi","doi":"10.5144/0256-4947.2022.334","DOIUrl":"https://doi.org/10.5144/0256-4947.2022.334","url":null,"abstract":"<p><strong>Background: </strong>Prolactin is a hormone of the pituitary gland whose main function is the production of milk. Hyperprolactinemia is defined as an increase in prolactin levels above 25 μg/L in women and 20 μg/L in men. Causes of hyperprolactinemia include pituitary tumors, especially prolactinomas. Hyperprolactinemia can manifest clinically with a variety of symptoms, including galactorrhea and menstrual irregularities in women and erectile dysfunction in men. There are limited data on the epidemiology of hyperprolactinemia in the Middle East region.</p><p><strong>Objectives: </strong>Description of the epidemiology and clinical features of hyperprolactinemia in a cohort from Saudi Arabia.</p><p><strong>Design: </strong>Medical record review SETTING: Tertiary medical center in Riyadh PATIENTS AND METHODS: The study included adult patients with hyperprolactinemia in King Abdulaziz Medical City in Riyadh. The patients were treated in endocrinology clinics from 2015 to 2019. Patients of both sexes older than 14 years were enrolled in the study. Patients with insufficient follow-up were excluded. Data were collected on demographic characteristics, symptoms, prolactin level, cause of high prolactin level, and treatment.</p><p><strong>Main outcome measures: </strong>The frequency of different etiologies and symptoms in patients with hyperprolactinemia.</p><p><strong>Sample size: </strong>295 patients RESULTS: The majority of patients with hyperprolactinemia were female 256 (86.8%). Hyperprolactinemia was diagnosed more frequently in patients in the age groups 21-30 years (42.6%) and 31-40 years (24.1%). The majority of the study population was obese or overweight: 136 (46.3%) and 74 (25.2%), respectively. Most of the cases were symptomatic (192, 65.1%). In women, the most common symptom was oligomenorrhea (35%). In men, infertility and erectile dysfunction were the most common clinical symptoms (50% and 44.7%, respectively). Idiopathic causes were the most common etiology (108, 36.6%), followed by pituitary adenomas (81, 27.5%). The majority of patients were treated (184,62.4%), with cabergoline being the most commonly used medication (173, 94.0%).</p><p><strong>Conclusion: </strong>The demographic and clinical presentations and causes of hyperprolactinemia in male and female Saudi patients were similar to that in studies in other populations.</p><p><strong>Limitations: </strong>Single-center retrospective chart review study.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/cd/0256-4947.2022.334.PMC9557783.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and classification of accessory navicular bone: a medical record review.","authors":"Ghadeer Abdullah Alsager,&nbsp;Khalid Alzahrani,&nbsp;Fahad Alshayhan,&nbsp;Raghad A Alotaibi,&nbsp;Khalid Murrad,&nbsp;Orfan Arafah","doi":"10.5144/0256-4947.2022.327","DOIUrl":"https://doi.org/10.5144/0256-4947.2022.327","url":null,"abstract":"<p><strong>Background: </strong>The accessory navicular bone (ANB) is one of the most common accessory bones in the foot. Certain pathologies, such as posterior tibial tendon insufficiency are associated with ANB, and should be differentiated from midfoot and hindfoot fractures such as navicular tuberosity avulsion fractures. There are few studies addressing the prevalence and types of ANB in Saudi Arabia.</p><p><strong>Objectives: </strong>Determine the prevalence and morphological variations of ANB and its relation with age and sex in patients visiting foot and ankle clinics.</p><p><strong>Design: </strong>Medical record review SETTING: Orthopedic foot and ankle clinic at a university hospital.</p><p><strong>Patients and methods: </strong>The presence of ANB was retrospectively analyzed in radiographs from patients who presented to the orthopedic foot and ankle at our university hospital from February 2010 to December 2020. The patients were stratified according to sex, age, and diagnosis. For each ANB, recorded information included site, size, classification, subtypes, and symptomatology. Purposive sampling was used to select the patients for the study (non-probability sampling).</p><p><strong>Main outcome measures: </strong>Prevalence of ANB in patients attending a foot and ankle clinic.</p><p><strong>Sample size: </strong>117 patients and 194 feet.</p><p><strong>Results: </strong>ANB was analyzed in 1006 radiographs from 503 patients. ANB was detected in 117 (23.3%) patients and 194 (19.3%) feet Prevalence was significantly higher in females (67.5%) than in males (32.5%) (Z=5.359, <i>P</i><.001). The ages ranged from 19 to 86 years, with a mean age of 48.26 (14.5) years. The most common site was bilateral (77 patients, 65.8 %). Type I was the most common type, with a prevalence of 42.1%. There were no significant differences in types in relation to sex, but all types and subtypes differed significantly from each other.</p><p><strong>Conclusion: </strong>ANB was common among patients presenting to the foot and ankle clinic, with an overall prevalence of 23.3%. It should be considered among the differential diagnosis in chronic foot pain, and should be differentiated from midfoot and hindfoot fractures. Further studies with a larger, randomized sample are needed, for more accuracy and to confirm the reported results.</p><p><strong>Limitations: </strong>Retrospective chart review, non-probability sampling, and use of plain radiographs.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/ea/0256-4947.2022.327.PMC9557784.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of strain elastography and shear wave elastography in differentiating benign and malignant breast lesions.","authors":"Rafia Shahzad,&nbsp;Ismat Fatima,&nbsp;Tooba Anjum,&nbsp;Abubaker Shahid","doi":"10.5144/0256-4947.2022.319","DOIUrl":"https://doi.org/10.5144/0256-4947.2022.319","url":null,"abstract":"<p><strong>Background: </strong>Conventional B-mode breast ultrasonography, though the primary modality to determine benign or malignant nature of a solid breast lesion, sometimes encounters overlapping sonographic morphological features in a single lesion. Elastography leads to improvement by evaluating the structural aspects and characterization of the lesion as benign or malignant on the basis of multi-parametric assessment.</p><p><strong>Objective: </strong>Determine the role of strain elastography (SE) and shear wave elastography (SWE) in differentiating benign and malignant breast lesions.</p><p><strong>Design: </strong>Cross sectional SETTING: Radiology department of hospital PATIENTS AND METHODS: Patients meeting inclusion criteria referred to our hospital for ultrasonography followed by biopsy or surgical excisions were examined with B-mode ultrasonography and by both strain and shear wave elastography.</p><p><strong>Main outcome measures: </strong>Mean values of SE and SWE in benign and malignant breast lesions, determination of cutoff using AUC curves and sensitivity and specificity of both techniques.</p><p><strong>Sample size: </strong>One hundred breast lesions from 95 consecutive patients.</p><p><strong>Results: </strong>The mean (SD) strain elastography ratio in the overall patient population was 4.1 (2.0). Cutoff for benign vs. malignant lesions was 2.86 on the ROC curve. The AUC was 0.911 (95%CI; 0.835-0.988: SE, 0.039) with a sensitivity of 95.8% and a specificity of 89.3%. For the SWE kPa values, the ROC curve showed the AUC was 0.929 (95% CI, 0.870-0.988; SE: 0.030, <i>P</i><.001). Assigning 45.3 as a cut off value provided a sensitivity of 95.8% with a specificity of 85.7%; the positive predictive value was 94.5% and the negative predictive value was 89.6%. The Breast Imaging Reporting and Data System (BI-RADS) category alone was able to differentiate between benign and malignant lesions with a sensitivity of 91.7% and a specificity 100% keeping the cut off value between 4a and 4b. The area under the ROC curve was 0.979. Combining the three (BI-RADS + SE + SWE) distinguished benign vs. malignant lesions with a sensitivity up to 100% and specificity up to 96.3%.</p><p><strong>Conclusion: </strong>Combining SE and SWE as a complementary tool with conventional B-mode ultrasonography has a significant potential for better characterization of solid breast lesions and decreasing unnecessary biopsies of BI-RADS IVa lesions.</p><p><strong>Limitations: </strong>Single institution study.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/1c/0256-4947.2022.319.PMC9557788.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time in therapeutic range for virtual anticoagulation clinic versus in-person clinic during the COVID-19 pandemic: a crossover study.","authors":"Zaid Alanazi,&nbsp;Nawaf Almutairi,&nbsp;Latifah AlDukkan,&nbsp;Amr A Arafat,&nbsp;Monirah A Albabtain","doi":"10.5144/0256-4947.2022.305","DOIUrl":"https://doi.org/10.5144/0256-4947.2022.305","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 infection affects the quality of the medical services globally. The pandemic required changes to medical services in several institutions. We established a virtual clinic for anticoagulation management during the pandemic using the Whatsapp application.</p><p><strong>Objectives: </strong>Compare anticoagulation management quality in virtual versus in-person clinics.</p><p><strong>Design: </strong>A retrospective crossover study SETTINGS: Specialized cardiac care center PATIENTS AND METHODS: The study included patients who presented to Prince Sultan Cardiac Center in Riyadh for anticoagulation management during the pandemic from March 2020 to January 2021. We compared time in therapeutic range (TTR) in the same patients during virtual and in-person clinics. All international normalized ratio (INR) measures during the virtual clinic visits and prior ten INR measures from the in-person clinic were recorded. Patients who had no prior follow-up in the in-person clinic were excluded.</p><p><strong>Main outcome measure: </strong>TTR calculated using the Rosendaal method.</p><p><strong>Sample size: </strong>192 patients RESULTS: The mean age was 58.6 (16.6) years and 116 (60.4%) were males. Patients were diagnosed with atrial fibrillation (n=101, 52.6%), mechanical mitral valve (n=88, 45.8%), mechanical aortic valve (n=79, 41%), left ventricular thrombus (n=5, 2.6%) and venous thromboembolism (n=8, 4.2%). Riyadh residents represented 56.7% of the study population (n=93). The median (IQR) percent TTR was 54.6 (27.3) in the in-person clinic versus 50.0 (33.3) (<i>P</i>=.07).</p><p><strong>Conclusion: </strong>Virtual clinic results were comparable to in-person clinics for anticoagulation management during the COVID-19 pandemic.</p><p><strong>Limitations: </strong>Number of INR measures during the virtual clinic visits, retrospective nature and single-center experience.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/aa/0256-4947.2022.305.PMC9557787.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of expelled droplets through traditional Islamic face coverings.","authors":"Norah Alkhateeb, Reem Almubarak, Shatha Aldurayb, Mashael Alanazi, Fai Alsuliman, Reem Aljabr, Michael R Gardner","doi":"10.5144/0256-4947.2022.299","DOIUrl":"10.5144/0256-4947.2022.299","url":null,"abstract":"<p><strong>Background: </strong>Expelled droplet count is an important factor when investigating the efficacy of face coverings since higher droplet counts indicate an increased possibility of disease transmission for airborne viruses such as COVID-19. While there is some published work relating facemask style to expelled droplet count during speech, there is no published data regarding the effectiveness of traditional Islamic face coverings such as the ghutra and niqab commonly worn by men and women in the Arabian Peninsula.</p><p><strong>Objectives: </strong>Measure the effectiveness of worn traditional Islamic face coverings in reducing expelled droplet count during speech.</p><p><strong>Design: </strong>Experimental study SETTING: Biomedical engineering department at a university in Saudi Arabia.</p><p><strong>Materials and methods: </strong>Using a previously described low-cost method for quantifying expelled droplets, this study compares droplet counts through commonly worn traditional Islamic face coverings and conventional three-ply surgical masks worn during speech. The device records scattered light from droplets (>5 μm diameter) as they pass through a laser light sheet (520 nm), and then video processing yields droplet counts.</p><p><strong>Main outcome measures: </strong>Percent reduction in the number of expelled droplets passing through face coverings during speech compared to no face covering MAIN OUTCOME MEASURES: 9-15 recorded samples per face covering (n=3) plus no face covering control (n=1) in three females.</p><p><strong>Results: </strong>The average percent reduction for each mask type compared to no mask trial was 76% for the cotton ghutra, 93% for the niqab, and 95% for the surgical mask. The niqab and ghutra had relatively high variability in droplet reduction.</p><p><strong>Conclusions: </strong>Traditional Islamic face coverings block some expelled droplets, but at lower rates than surgical masks. High standard deviations within facemask groups with high variability in fit (i.e., the cotton ghutra) further denote the importance of fit in face covering effectiveness. Some protection from airborne viruses is likely with traditional Islamic face coverings compared to no mask, but the amount of protection depends on the fit of the face covering.</p><p><strong>Limitations: </strong>Detectable droplets limited to particles greater than 5 μm diameter with forward expulsion direction.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c8/1a/0256-4947.2022.299.PMC9557785.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetes mellitus on periprocedural and 18-month clinical outcomes in Korean patients requiring rotational atherectomy: results from the ROCK Registry.","authors":"Su Nam Lee,&nbsp;Donggyu Moon,&nbsp;Sung-Ho Her,&nbsp;Won Young Jang,&nbsp;Keon-Woong Moon,&nbsp;Ki-Dong Yoo,&nbsp;Kyusup Lee,&nbsp;Jae Hwan Lee,&nbsp;Jang Hoon Lee,&nbsp;Sang Rok Lee,&nbsp;Seung-Whan Lee,&nbsp;Kyeong Ho Yun,&nbsp;Hyun-Jong Lee,&nbsp;Ik Jun Choi","doi":"10.5144/0256-4947.2022.291","DOIUrl":"https://doi.org/10.5144/0256-4947.2022.291","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus (diabetes) increases the risk of severe coronary artery calcification, which increases the complexity of percutaneous coronary intervention requiring rotational atherectomy (RA) by interfering with lesion preparation, and limiting final stent expansion.</p><p><strong>Objective: </strong>Investigate 30-day and 18-month clinical outcomes in patients with and without diabetes treated with percutaneous coronary intervention requiring RA.</p><p><strong>Design: </strong>Medical record review SETTING: Multicenter registry in South Korea PATIENTS AND METHODS: The ROtational atherectomy in Calcified lesions in Korea (ROCK) registry was a large, retrospective, multicenter study to assess RA treatment of severe coronary artery calcification.</p><p><strong>Main outcome measures: </strong>The primary endpoint was target-vessel failure including cardiac death, target-vessel myocardial infarction, and target-vessel revascularization.</p><p><strong>Sample size: </strong>540 patients followed for a median of 16.1 months.</p><p><strong>Results: </strong>Of the 540 patients, 305 had diabetes (56.5%). The diabetes group had a significantly higher frequency of multivessel disease; comorbidities such as hypertension, dyslipidemia, and chronic kidney disease; and lower ejection fraction of the left ventricle compared to the non-diabetes group (n=235). There were no significant differences in procedure success and complications observed between the two groups. Target vessel failure at 30 days between the diabetes and non-diabetes groups was not statistically significant in a multivariate Cox regression analysis (1.6% vs. 2.6%, adjusted hazard ratio [HR] 0.595, 95% confidence interval [CI] 0.154-2.300, <i>P</i>=.451). During an 18-month follow-up, the risk of target vessel failure was higher (12.5% vs. 8.9%) but the difference was not statistically significant (adjusted HR 1.393, 95% CI 0.782-2.482, <i>P</i>=.260).</p><p><strong>Conclusions: </strong>Patients with diabetes have a risk of complications comparable to patients without diabetes, and 30-day and 18-month clinical outcomes are similar in severe coronary artery calcification requiring RA, despite having more comorbidities.</p><p><strong>Limitations: </strong>Retrospective design. Sample size not based on power calculation.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/65/0256-4947.2022.291.PMC9557786.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of total versus partial graft excision: Which is the better choice to manage arteriovenous dialysis graft infection?","authors":"Thawatchai Tullavardhana,&nbsp;Anuwat Chartkitchareon","doi":"10.5144/0256-4947.2022.343","DOIUrl":"https://doi.org/10.5144/0256-4947.2022.343","url":null,"abstract":"<p><strong>Background: </strong>Arteriovenous graft infection (AVGI) is a major cause of hemodialysis access failure. Delayed diagnosis and inappropriate treatment may lead to increased morbidity (3-35%) and mortality up to 12%.</p><p><strong>Objectives: </strong>Compare the postoperative outcomes of total graft excision (TGE) and partial graft excision (PGE) in the treatment of AVGI.</p><p><strong>Designs: </strong>Systematic review and meta-analysis METHODS: The dataset was defined by searching PubMed, EMBASE, Google Scholar, and the Cochrane database for articles outlining the terms arteriovenous graft infection, infected dialysis graft, TGE and PGE published between 1995-2020. The data analysis evaluated the outcomes of TGE and PGE in the management of AVGI. The meta-analysis was performed using Review Manager Software version 5.4.1.</p><p><strong>Main outcome measures: </strong>30-day mortality, recurrent infection, and reoperation rate.</p><p><strong>Sample size: </strong>Eight studies, including 555 AVGI, and 528 patients.</p><p><strong>Results: </strong>PGE showed a significant increase in recurrent graft infection rate (OR=0.23,95% CI=0.13-0.41, <i>P</i><.00001) and re-operation rate for control of infection (OR=0.14,95% CI=0.03-0.58, <i>P</i><.007). However, the 30-day mortality rate did not differ significantly between the groups (OR=0.92,95% CI=0.39-2.17, <i>P</i>=.85).</p><p><strong>Conclusions: </strong>TGE remains a safe and effective surgical method for the management of AVGI. PGE is associated with a higher risk of graft infection and need for re-operation. As a result, PGE should only be considered in carefully selected patients.</p><p><strong>Limitation: </strong>Risk of bias due to the differences in patient characteristics.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/29/0256-4947.2022.343.PMC9557782.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10807888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}