Abdulrahman A Housawi, Shazada Junaid S Qazi, Abdulhalem A Jan, Rashid A Osman, Mashil M Alshamrani, Talal A AlFaadhel, Fayez F AlHejaili, Jaffar A Al-Tawfiq, Ahmed A Wafa, Abdulmageed E Hamza, Moustafa A Hassan, Suliman A Alharbi, Hamza Albasheer, Majed M Almohmmdi, Salem A Alsisi, Michal Mankowski, Joris Van de Klundert, Amal M Alhelal, Fatima H Sala, Ali Kheyami, Bader A Alhomayeed
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引用次数: 1
Abstract
Background: Since the occurrence of coronavirus disease in 2019 (COVID-19), the global community has witnessed its exponential spread with devastating outcomes within the general population and specifically within hemodialysis patients.
Objectives: Compare the state of immunity to SARS-CoV-2 among hemodialysis patients and staff.
Design: Cross-sectional study with a prospective follow-up period.
Setting: Hemodialysis centers in Madinah region.
Patients and methods: We prospectively tested for SARS-CoV-2 antibodies in dialysis patients using dialysis centers staff as controls. The participants were tested on four occasions when feasible for the presence of anti-SARS-CoV-2 antibodies. We also analyzed factors that might be associated with seropositivity.
Main outcome measures: SARS-CoV-2 positivity using immunoglobulin G (IgG) levels SAMPLE SIZE: 830 participants, 677 patients and 153 dialysis centers staff as controls.
Results: Of the total participants, 325 (257 patients and 68 staff) were positive for SARS-CoV-2 IgG antibodies, for a prevalence of 38.0% and 44.4% among patients and staff, respectively (P=.1379). Participants with a history of COVID-19 or related symptoms were more likely to have positive IgG (P<.0001). Surprisingly, positivity was also center-dependent. In a multivariable logistic regression, a history of infection and related symptoms contributed significantly to developing immunity.
Conclusion: The high prevalence of SARS-CoV-2 antibody among hemodialysis patients and previously asymptomatic staff suggested past asymptomatic infection. Some centers showed more immunity effects than others.
Limitations: Unable to collect four samples for each participant; limited to one urban center.
期刊介绍：
The Annals of Saudi Medicine (ASM) is published bimonthly by King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. We publish scientific reports of clinical interest in English. All submissions are subject to peer review by the editorial board and by reviewers in appropriate specialties. The journal will consider for publication manuscripts from any part of the world, but particularly reports that would be of interest to readers in the Middle East or other parts of Asia and Africa. Please go to the Author Resource Center for additional information.
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