Abdulrahman A Housawi, Shazada Junaid S Qazi, Abdulhalem A Jan, Rashid A Osman, Mashil M Alshamrani, Talal A AlFaadhel, Fayez F AlHejaili, Jaffar A Al-Tawfiq, Ahmed A Wafa, Abdulmageed E Hamza, Moustafa A Hassan, Suliman A Alharbi, Hamza Albasheer, Majed M Almohmmdi, Salem A Alsisi, Michal Mankowski, Joris Van de Klundert, Amal M Alhelal, Fatima H Sala, Ali Kheyami, Bader A Alhomayeed
{"title":"Prevalence of anti-SARS-CoV-2 antibody in hemodialysis facilities: a cross-sectional multicenter study from Madinah.","authors":"Abdulrahman A Housawi, Shazada Junaid S Qazi, Abdulhalem A Jan, Rashid A Osman, Mashil M Alshamrani, Talal A AlFaadhel, Fayez F AlHejaili, Jaffar A Al-Tawfiq, Ahmed A Wafa, Abdulmageed E Hamza, Moustafa A Hassan, Suliman A Alharbi, Hamza Albasheer, Majed M Almohmmdi, Salem A Alsisi, Michal Mankowski, Joris Van de Klundert, Amal M Alhelal, Fatima H Sala, Ali Kheyami, Bader A Alhomayeed","doi":"10.5144/0256-4947.2022.229","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Since the occurrence of coronavirus disease in 2019 (COVID-19), the global community has witnessed its exponential spread with devastating outcomes within the general population and specifically within hemodialysis patients.</p><p><strong>Objectives: </strong>Compare the state of immunity to SARS-CoV-2 among hemodialysis patients and staff.</p><p><strong>Design: </strong>Cross-sectional study with a prospective follow-up period.</p><p><strong>Setting: </strong>Hemodialysis centers in Madinah region.</p><p><strong>Patients and methods: </strong>We prospectively tested for SARS-CoV-2 antibodies in dialysis patients using dialysis centers staff as controls. The participants were tested on four occasions when feasible for the presence of anti-SARS-CoV-2 antibodies. We also analyzed factors that might be associated with seropositivity.</p><p><strong>Main outcome measures: </strong>SARS-CoV-2 positivity using immunoglobulin G (IgG) levels SAMPLE SIZE: 830 participants, 677 patients and 153 dialysis centers staff as controls.</p><p><strong>Results: </strong>Of the total participants, 325 (257 patients and 68 staff) were positive for SARS-CoV-2 IgG antibodies, for a prevalence of 38.0% and 44.4% among patients and staff, respectively (<i>P</i>=.1379). Participants with a history of COVID-19 or related symptoms were more likely to have positive IgG (<i>P</i><.0001). Surprisingly, positivity was also center-dependent. In a multivariable logistic regression, a history of infection and related symptoms contributed significantly to developing immunity.</p><p><strong>Conclusion: </strong>The high prevalence of SARS-CoV-2 antibody among hemodialysis patients and previously asymptomatic staff suggested past asymptomatic infection. Some centers showed more immunity effects than others.</p><p><strong>Limitations: </strong>Unable to collect four samples for each participant; limited to one urban center.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"246-251"},"PeriodicalIF":16.4000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/7c/0256-4947.2022.229.PMC9357293.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5144/0256-4947.2022.229","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/8/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Since the occurrence of coronavirus disease in 2019 (COVID-19), the global community has witnessed its exponential spread with devastating outcomes within the general population and specifically within hemodialysis patients.
Objectives: Compare the state of immunity to SARS-CoV-2 among hemodialysis patients and staff.
Design: Cross-sectional study with a prospective follow-up period.
Setting: Hemodialysis centers in Madinah region.
Patients and methods: We prospectively tested for SARS-CoV-2 antibodies in dialysis patients using dialysis centers staff as controls. The participants were tested on four occasions when feasible for the presence of anti-SARS-CoV-2 antibodies. We also analyzed factors that might be associated with seropositivity.
Main outcome measures: SARS-CoV-2 positivity using immunoglobulin G (IgG) levels SAMPLE SIZE: 830 participants, 677 patients and 153 dialysis centers staff as controls.
Results: Of the total participants, 325 (257 patients and 68 staff) were positive for SARS-CoV-2 IgG antibodies, for a prevalence of 38.0% and 44.4% among patients and staff, respectively (P=.1379). Participants with a history of COVID-19 or related symptoms were more likely to have positive IgG (P<.0001). Surprisingly, positivity was also center-dependent. In a multivariable logistic regression, a history of infection and related symptoms contributed significantly to developing immunity.
Conclusion: The high prevalence of SARS-CoV-2 antibody among hemodialysis patients and previously asymptomatic staff suggested past asymptomatic infection. Some centers showed more immunity effects than others.
Limitations: Unable to collect four samples for each participant; limited to one urban center.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
