Annals of Nuclear Medicine最新文献

{"title":"Prognostic impact of stage reclassification and N2 subclassification in the ninth edition of TNM classification for non-metastatic lung cancer.","authors":"Muhammet Halil Baltacioglu, Demet Nak, Pelin Sahin Oguz, Ogün Bulbul","doi":"10.1007/s12149-026-02198-w","DOIUrl":"https://doi.org/10.1007/s12149-026-02198-w","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of simulation settings, time-activity curve integration range, and imaging time points on full Monte Carlo-based ¹⁷⁷Lu-DOTATATE dosimetry.","authors":"Shu Kimura, Noriaki Miyaji, Kenta Miwa, Tensho Yamao, Masaki Masubuchi, Naochika Akiya, Kaito Wachi, Arata Komatsu, Ryuichi Nishii, Kohei Nakanishi, Yuto Kamitaka, Kosuke Yamashita, Takuya Furuta, Tatsuhiko Sato","doi":"10.1007/s12149-026-02197-x","DOIUrl":"https://doi.org/10.1007/s12149-026-02197-x","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenosine FDG PET/CT reveals potentially viable myocardium in ischemic cardiomyopathy.","authors":"Mutlay Keskin","doi":"10.1007/s12149-026-02196-y","DOIUrl":"https://doi.org/10.1007/s12149-026-02196-y","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-metastatic castration-resistant prostate cancer in the epoch of PSMA-ligand PET/CT: twilight?","authors":"Pipitsa N Valsamaki, Georgios Tsakaldimis","doi":"10.1007/s12149-026-02195-z","DOIUrl":"https://doi.org/10.1007/s12149-026-02195-z","url":null,"abstract":"<p><p>The introduction of prostate-specific membrane antigen-ligand positron emission tomography/computerised tomography (PSMA-ligand PET/CT) into clinical practice has altered the prevalence of non‑metastatic (by conventional imaging) castration-resistant prostate cancer (nmCRPC). We herewith briefly review the biochemical and imaging parameters in nmCRPC and mainly focus on decoding disease localization using PSMA- ligand PET. The effective restaging with more accurate PSMA PET-based disease identification and characterization potentially signifies the entrance of the nmCRPC stage in the twilight zone. Moreover, it seems plausible that the small fraction of the nmCRPC invisible even on PSMA PET may constitute a latent phase of occult growth of the tumor cells. Supposedly, triggering of PSMA overexpression on the PCa cells under androgen deprivation therapy (ADT) through certain anticancer or other therapies such as protein kinase inhibitors (PKIs), dutasteride, or cholesterol-lowering regimes, might further hasten visualisation of micrometastases on PSMA-ligand PET, eventually transforming the nmCRPC stage into a defined, potentially curable target.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPECT and PET imaging of Alzheimer’s disease revisited: from biomarkers to artificial intelligence-based prediction","authors":"Ioannis Tsougos,&nbsp;Varvara Valotassiou,&nbsp;Dimitra Tsivaka,&nbsp;Maria Satra,&nbsp;George Angelidis,&nbsp;John Papatriantafyllou,&nbsp;Emmanouil Panagiotidis,&nbsp;Efthimios Dardiotis,&nbsp;George Hadjigeorgiou,&nbsp;Panagiotis Georgoulias","doi":"10.1007/s12149-026-02194-0","DOIUrl":"10.1007/s12149-026-02194-0","url":null,"abstract":"<div>\u0000 \u0000 <p>In Alzheimer’s disease (AD), PET and SPECT enable in-vivo imaging of β-amyloid, tau, cerebral metabolism, and neuroinflammation. However, classical interpretation, including visual reads, ROI summaries, and SUVR thresholds, remains limited by reader variability, dependence on reference regions, and cross-site heterogeneity. Building upon our previous review on SPECT and PET imaging in AD, this article revisits molecular neuroimaging through the lens of artificial intelligence (AI), integrating advances from radiomics and classical machine learning to deep learning that support more quantitative and predictive use of PET/SPECT. Methods are organized by clinical objective, including diagnostic and differential classification, segmentation for region-wise measurement, automated quantification, image enhancement and reconstruction (attenuation correction, denoising, super-resolution, low-dose/short-scan recovery), and prognostic modeling (conversion and cognitive decline). We summarize key data resources, benchmarking, and standardization /harmonization strategies that improve generalization across scanners and tracers. Finally, we outline practical requirements for translation: models should provide well-calibrated probabilities, indicate when predictions are uncertain, offer outputs consistent with AD-relevant biology, report performance across relevant subgroups, and follow transparent reporting standards with clinically usable outputs, supporting earlier detection and more consistent monitoring in AD.</p>\u0000 </div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 5","pages":"480 - 495"},"PeriodicalIF":2.5,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-026-02194-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesion-level quantitative Lu-177 PSMA SPECT/CT SUV metrics are associated with interim treatment response in mCRPC: a PET-correlated study.","authors":"Berkay Çağdaş, Elif Kardelen Çağdaş, Alptuğ Özer Yüksel, Hüseyin Şan, Nilüfer Yildirim","doi":"10.1007/s12149-026-02193-1","DOIUrl":"https://doi.org/10.1007/s12149-026-02193-1","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of energy deposition pixel kernel convolution for planar dosimetry in ¹⁷⁷Lu therapy.","authors":"Phornpailin Pairodsantikul, Mizuki Matsushita, Mei Takahashi, Kyeong Min Kim, Hiroshi Watabe, Monchaya Nivorn, Paramest Wongsa, Miho Shidahara","doi":"10.1007/s12149-026-02191-3","DOIUrl":"https://doi.org/10.1007/s12149-026-02191-3","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic and therapeutic value of FDG PET/CT for infectious diseases in FUO/IUO patients.","authors":"Peixuan Wu, Keji Hao, Yuan Li, Yue Wang, Yan Gao, Qian Wang","doi":"10.1007/s12149-026-02190-4","DOIUrl":"https://doi.org/10.1007/s12149-026-02190-4","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphatic mapping and sentinel lymph node biopsy in urinary bladder cancer: A SPECT/CT-based experience.","authors":"Amin Saber Tanha, Ramin Sadeghi, Hamidreza Ghorbani, Salman Soltani, Atena Aghaee, Leili Zarifmahmoudi, Keyvan Sadri, Hasan Mehrad-Majd, Mohammad Asl Zare","doi":"10.1007/s12149-026-02181-5","DOIUrl":"https://doi.org/10.1007/s12149-026-02181-5","url":null,"abstract":"<p><strong>Objective: </strong>Sentinel lymph node (SLN) mapping in bladder cancer has the potential to improve nodal staging while minimizing the morbidity associated with pelvic lymph node dissection (PLND). However, its feasibility, diagnostic accuracy, and influencing factors-including tumor stage, neoadjuvant chemotherapy (NAC), and imaging modality-remain under investigation.</p><p><strong>Materials and methods: </strong>In this prospective study, 35 patients with T1-T4 urothelial carcinoma undergoing radical cystectomy and bilateral PLND were enrolled. Preoperative cystoscopic peritumoral injection of ^99mTc-phytate was followed by planar lymphoscintigraphy and SPECT/CT. Intraoperative SLN detection utilized a handheld gamma probe. SLN identification was compared with standard PLND findings using patient- and hemipelvis-based analyses to determine detection rates, sensitivity, and false-negative rates.</p><p><strong>Results: </strong>A total of 54 SLNs were identified in 24 patients (37 hemipelves). Patient-based detection rates were 68.6% for intraoperative gamma probe, 51.4% for SPECT/CT, and 45.7% for planar imaging. Hemipelvis-based detection rates were 52.9%, 40.0%, and 34.3%, respectively. Detection rates were highest in T1-T2, NAC-positive patients, with 100% intraoperative localization. Histopathological analysis identified nodal metastases in seven patients; SLNs were identified in four patients, three of whom showed concordant SLN involvement, while one showed no SLN involvement. The patient-based false-negative rate was 25%, while hemipelvis-based analysis showed no false negatives. Aberrant SLNs outside the standard PLND template were identified in 6% of patients, highlighting variable lymphatic drainage.</p><p><strong>Conclusion: </strong>SLN mapping in bladder cancer is technically feasible and identifies atypical drainage patterns, with performance influenced by tumor stage, NAC, and imaging modality. SLN mapping may complement PLND by improving anatomical staging and may ultimately allow more tailored or minimally invasive lymphadenectomy in selected patients.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Subcutaneous/cutaneous uptake in the cancer-affected breast on 18F-FDG PET/CT: association with post-surgical prognosis in breast cancer patients","authors":"Yurika Kitano,&nbsp;Kanae K. Miyake,&nbsp;Tomomi W. Nobashi,&nbsp;Takayoshi Ishimori,&nbsp;Ryusuke Nakamoto,&nbsp;Sho Koyasu,&nbsp;Masako Kataoka,&nbsp;Yasuhide Takeuchi,&nbsp;Masakazu Toi,&nbsp;Yuji Nakamoto","doi":"10.1007/s12149-026-02188-y","DOIUrl":"10.1007/s12149-026-02188-y","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 4","pages":"460 - 464"},"PeriodicalIF":2.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}