Annals of Nuclear Medicine最新文献

{"title":"The anatomical distribution of metabolic tumor burden provides prognostic information beyond whole-body ¹⁸F-FDG PET/CT metrics in de novo metastatic HER2-positive breast cancer.","authors":"Ayşegül Aksu, Amine İrem Ağartıoğlu, Zeynep Gülsüm Güç, Kadir Alper Küçüker, Ayşegül Özdal, Bülent Turgut","doi":"10.1007/s12149-026-02286-x","DOIUrl":"https://doi.org/10.1007/s12149-026-02286-x","url":null,"abstract":"<p><strong>Objective: </strong>Whole-body PET metrics quantify the magnitude of metastatic burden but ignore its anatomical distribution. Whether resolving metabolic burden according to anatomical compartment provides incremental prognostic information beyond conventional whole-body PET metrics remains unknown. We therefore tested whether the anatomical distribution of metabolic burden carries prognostic information beyond aggregate whole-body load in de novo metastatic HER2-positive breast cancer.</p><p><strong>Methods: </strong>Fifty-seven consecutive treatment-naive patients who underwent baseline ¹⁸F-FDG PET/CT before first-line anti-HER2 therapy were retrospectively analyzed. Compartment-specific metabolic parameters and clinical variables were evaluated using multivariable Cox regression. Model discrimination was internally validated over 1000 bootstrap resamples, and the incremental value of compartment-specific burden over whole-body metrics was evaluated with likelihood-ratio tests.</p><p><strong>Results: </strong>Twenty patients (35.1%) died during a median follow-up of 50.4 months. LN_MTV, Bone_TLG, and HR status independently predicted OS, yielding a model with a modest optimism-corrected C-index of 0.685 when the entire variable-selection sequence was repeated within each bootstrap resample. Adding compartment-specific metabolic burden improved models based on whole-body MTV or TLG (p = 0.003 and p = 0.001, respectively), whereas whole-body MTV provided no additional prognostic information once compartment-specific burden was considered (p = 0.90). Bone_TLG, but not binary bone involvement, independently predicted OS, and its prognostic contribution increased over time.</p><p><strong>Conclusion: </strong>In this exploratory analysis, the anatomical distribution of metabolic tumor burden appeared to carry prognostic information beyond conventional whole-body PET metrics. These findings are hypothesis-generating, and prospective multicenter validation is warranted before compartment-specific metabolic phenotyping could inform clinical risk stratification in HER2-positive metastatic breast cancer.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy-specific attenuation and half-value layers of BaSO₄-loaded rubber for Lu-177 gamma-ray shielding.","authors":"Hajime Monzen, Kohei Hanaoka, Kenta Sakaguchi, Shunta Hirano, Naoto Miyazaki, Ryuji Honjo, Takuya Uehara, Makoto Hosono","doi":"10.1007/s12149-026-02283-0","DOIUrl":"https://doi.org/10.1007/s12149-026-02283-0","url":null,"abstract":"<p><strong>Objective: </strong>With the expanding use of lutetium-177 (Lu-177) radiopharmaceutical therapy, reducing occupational radiation exposure has become increasingly important. Conventional bedside shielding mainly relies on lead, which is heavy and difficult to handle. This study evaluated the gamma-ray shielding performance of lightweight and flexible barium sulfate (BaSO₄)-loaded rubber.</p><p><strong>Methods: </strong>BaSO₄-loaded rubber (density, 2.3 g/cm³) was fabricated with nominal thicknesses of 5, 8, 10, 13, and 15 mm; pieces were also stacked to achieve thicknesses of 20, 30, and 51 mm. Energy spectra of a Lu-177 source were acquired using a SPECT/CT system. Attenuation rates at the 113- and 208-keV photopeaks were measured, and half-value layers (HVLs) were determined by exponential fitting.</p><p><strong>Results: </strong>Attenuation of both the 113- and 208-keV photopeaks increased with increasing rubber thickness. Scatter radiation around 55 keV was almost completely eliminated by 5-8 mm of shielding. At a thickness of 5 mm, attenuation rates were 51.5% for the 113-keV photopeak and 21.5% for the 208-keV photopeak, increasing to 95.0% and 89.1%, respectively, at 51 mm. Exponential fitting yielded HVLs of 5.0 mm for the 113-keV photopeak and 14.7 mm for the 208-keV photopeak.</p><p><strong>Conclusions: </strong>BaSO₄-loaded rubber provided effective shielding against Lu-177 gamma rays, particularly at 113 keV. Owing to its light weight, flexibility, and cost-effectiveness, it represents a promising alternative to conventional shielding materials. The energy-specific attenuation characteristics and HVL data obtained in this study provide useful design information for bedside shielding panels and syringe shielding devices used in Lu-177 therapy.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of fibroblast activation protein inhibitor-based radionuclide theranostics in sarcoma: a systematic review.","authors":"Yihong Chen, Yaofeng Xiao, Zhe Zhang, Maohua Rao, Zhenyu Yang, Zi Wang, Yu Zhang, Yue Feng, Liang Cai","doi":"10.1007/s12149-026-02260-7","DOIUrl":"https://doi.org/10.1007/s12149-026-02260-7","url":null,"abstract":"<p><p>Sarcomas represent a heterogeneous group of malignant neoplasms arising from mesenchymal tissue and remain challenging to diagnose and treat. Fibroblast activation protein (FAP), highly expressed in the tumor microenvironment, has emerged as a attractive target for molecular imaging. This review aims to evaluate the role of fibroblast activation protein inhibitors (FAPI) in sarcoma diagnosis and therapy. Following PRISMA guidelines, we searched PubMed, Embase, and Web of Science for studies published between 2018 and 2025 investigating FAPI in sarcoma imaging or treatment. Diagnostic study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). Twelve studies comprising 398 patients met inclusion criteria. Six diagnostic studies (361 patients, 2,477 lesions) reported a pooled detection rate of 89.7% for all sarcoma lesions and 91.3% for distant metastases with FAPI positron emission tomography (PET), higher than [¹⁸F]fluorodeoxyglucose (FDG) PET (72.1% and 74.0%, respectively). In high-grade sarcomas, the mean/median maximum standardized uptake value (SUVmax) for FAPI PET ranged from 9.5 to 30.2; in low-grade tumors, from 6.4 to 21.1. Five therapeutic studies involving 34 patients assessed FAPI radionuclide therapy (RLT) using Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1), showing a disease control rate of 64.7%. grade ≥ 3 adverse events occurred in only two patients. FAPI PET demonstrates clear advantages over [¹⁸F]FDG PET for systemic lesion detection and may improve sarcoma staging accuracy. FAPI RLT shows great promise as a safe and effective treatment modality. Further studies are needed to confirm its usefulness in grading, staging, and treating sarcoma.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procedure-related uptake on CXCR4 PET/CT: a frequent pitfall independent of time and anatomical site.","authors":"Sebastian E Serfling, Yingjun Zhi, Takahiro Higuchi, Philipp E Hartrampf, Andreas K Buck, Rudolf A Werner","doi":"10.1007/s12149-026-02276-z","DOIUrl":"https://doi.org/10.1007/s12149-026-02276-z","url":null,"abstract":"<p><strong>Introduction: </strong>As a pan-tumor tracer, chemokine receptor 4 (CXCR4)-directed [⁶⁸Ga]Ga-PentixaFor is frequently utilized in patients with hematological malignancies. We aimed to evaluate the impact of recent surgical and interventional procedures on uptake.</p><p><strong>Methods: </strong>Patients undergoing [⁶⁸Ga]Ga-PentixaFor PET/CT after prior surgical or interventional procedures were analyzed. Uptake at the procedural site was assessed visually and quantitatively (by applying maximum standardized uptake values [SUV_max], target-to-background ratios [TBR]). Quantitative parameters were compared across anatomical region groups (bone, organ, (sub-)cutaneous, muscle). We stratified patients demonstrating uptake in procedural sites into an early (0-30 days) and late group (≥ 31 days between intervention and [⁶⁸Ga]Ga-PentixaFor PET). In patients with available [¹⁸F]FDG PET/CT, quantitative correlation analyses between both radiotracers were also performed.</p><p><strong>Results: </strong>Among 425 [⁶⁸Ga]Ga-PentixaFor PET/CT examinations, 87 prior invasive procedures (20.5%) were identified. In 53 patients allocated to the early group, 29 subjects demonstrated uptake (54.7%), while in the late group, 22 out of 34 subjects revealed tracer accumulation at procedural sites (64.7%). Across the predefined temporal intervals, uptake rates varied numerically but did not differ significantly overall (p = 0.071). [⁶⁸Ga]Ga-PentixaFor SUV_max (ρ = -0.03, p = 0.807) and TBR (ρ = 0.02, p = 0.876) showed no significant association between time since procedure. On a compartment level, SUV_max (p = 0.482) and TBR (p = 0.696) revealed no significant differences across investigated anatomical regions. In cases with available [¹⁸F]FDG PET (21/51 [41.2%]), quantitative uptake in procedural sites correlated significantly between both radiotracers (SUV_max: ρ = 0.55, p = 0.016; TBR: ρ = 0.68, p = 0.001), indicating that different inflammatory signatures at procedural sites may be captured by both radiotracers.</p><p><strong>Conclusions: </strong>Post-procedural CXCR4 uptake occurs frequently, with no statistically significant overall association with time since intervention or involved anatomical compartment.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of global gray matter volume and cortical thickness with cognitive function stratified by amyloid PET status.","authors":"Yujiro Nakaoka, Koji Sohara, Hiroshi Matsuda, Sunao Mizumura, Masaya Suda, Shogo Imai, Tetsuro Sekine, Takahiro Ando, Aruki Tanaka, Akiko Ishiwata, Amane Tateno, Michihiko Koeda, Tomonari Saito, Satoshi Suda, Akiko Yamazaki, Hiromitsu Hayashi, Shinichiro Kumita","doi":"10.1007/s12149-026-02281-2","DOIUrl":"https://doi.org/10.1007/s12149-026-02281-2","url":null,"abstract":"<p><strong>Objective: </strong>Structural magnetic resonance imaging (MRI) measures may relate to cognition differently depending on the underlying biological context. We examined the associations of global gray matter volume and cortical thickness with cognitive performance after stratification by amyloid positron emission tomography (PET) status.</p><p><strong>Methods: </strong>This cross-sectional study included 113 participants (mean age 76.3 ± 7.8 years; 68.1% female) who underwent amyloid PET, structural MRI, and Mini-Mental State Examination (MMSE). Amyloid burden was quantified on the Centiloid scale, with positivity defined as > 25 (44 amyloid-negative, 69 amyloid-positive). Global gray matter volume normalized by total intracranial volume (GM/TIV) and global cortical thickness were derived with CAT12/SPM12. Multivariable linear regression was used to assess associations with the MMSE score after adjustment for age, sex, and amyloid burden, with prespecified stratification by amyloid status. Formal interaction analyses tested effect modification.</p><p><strong>Results: </strong>In the overall cohort, GM/TIV was independently associated with the MMSE score (β = 0.35, p = 0.007), whereas cortical thickness was not (β = 0.02, p = 0.844). In exploratory stratified analyses, GM/TIV was associated with the MMSE score in amyloid-positive participants (β = 0.48, p = 0.003) but not in amyloid-negative participants (β = 0.05, p = 0.835). Age was associated with the MMSE score in amyloid-negative participants (β = -0.33, p = 0.041) but not in amyloid-positive participants (β = 0.11, p = 0.377). Formal interaction analyses were not significant.</p><p><strong>Conclusions: </strong>In this cohort, global GM/TIV was associated with cognitive performance more consistently than global cortical thickness. Exploratory stratified analyses suggested different association patterns according to amyloid PET status; however, formal interaction analyses were not significant. These findings should therefore be interpreted cautiously and validated in larger longitudinal studies.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of high-purity germanium detectors and gamma-ray water monitors in radioactive wastewater management for targeted radionuclide therapy.","authors":"Noriaki Miyaji, Yuma Ihara, Rintaro Sato, Shigenori Yabe, Katsuyuki Kikori, Naochika Akiya, Kaito Wachi, Akemi Minami, Kosuke Yamashita, Tensho Yamao, Takashi Ohba, Koki Hasegawa, Kenta Miwa, Noboru Oriuchi","doi":"10.1007/s12149-026-02279-w","DOIUrl":"https://doi.org/10.1007/s12149-026-02279-w","url":null,"abstract":"<p><strong>Objective: </strong>Gamma-ray water monitors (GWMs) are widely used for radioactive wastewater monitoring but can be inaccurate in mixed radionuclide conditions. This study compared radioactivity concentrations measured using a GWM and a high-purity germanium (HPGe) detector and evaluated the validity of derived conversion factors.</p><p><strong>Methods: </strong>Wastewater containing ¹³¹I and ¹⁷⁷Lu with ^177mLu impurity was sampled from storage tanks in a targeted radionuclide therapy facility. We then measured radioactivity concentrations using GWM and HPGe detectors. GWM reproducibility was evaluated, and the effects of sampling location and stirring were assessed. Conversion factors were derived from paired measurements and applied to independent samples.</p><p><strong>Results: </strong>Radioactivity concentrations did not differ significantly between sampling locations or before and after stirring. GWM measurements showed high reproducibility (CV = 1.7%) but consistently produced higher radioactivity concentrations than the HPGe detector. Summed concentration limit ratios were 30.9 and 3.0 for the GWM and the HPGe detectors, respectively, whereas a conversion factor-based estimate was 13.9.</p><p><strong>Conclusion: </strong>Conversion factors reduced the gap between GWM and HPGe detection and provided estimates closer to HPGe-based values, facilitating more efficient discharge management in targeted radionuclide therapy facilities.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operation duration and outcomes in parathyroidectomy: a comparative analysis of Tc-99m-MAA radioguided occult lesion localization, intravenous Tc-99m sestamibi gamma-probe guidance, and standard approaches.","authors":"Mustafa Cayci, İlker Çordan, Sabri Ozden, Burak Demir","doi":"10.1007/s12149-026-02274-1","DOIUrl":"https://doi.org/10.1007/s12149-026-02274-1","url":null,"abstract":"<p><strong>Purpose: </strong>The surgical management of primary hyperparathyroidism (PHPT) has shifted toward minimally invasive, targeted approaches. In this retrospective study the clinical outcomes, safety, and operative durations of three distinct surgical techniques were compared: radioguided occult lesion localization (ROLL), intravenous Tc-99 m sestamibi gamma-probe guidance (IV MIBI), and standard minimally invasive parathyroidectomy.</p><p><strong>Methods: </strong>This study is a single-center retrospective analysis of 178 patients who underwent surgery for parathyroid adenomas. Patients were categorized into three surgical cohorts: ROLL (n = 100), IV MIBI (n = 42), and standard minimally invasive parathyroidectomy (n = 36). Primary endpoints included operative duration, preoperative and 24-hour postoperative serum parathyroid hormone (PTH) and calcium levels, complication rates, and long-term surgical cure rates. A multivariate linear regression model was utilized to adjust for potential baseline confounding variables.</p><p><strong>Results: </strong>The median operative duration was significantly shorter in the ROLL group (47 min) compared to both the IV MIBI group (87.5 min, p < 0.001) and the standard group (84 min, p < 0.001). Patients in the standard cohort presented with significantly higher preoperative PTH levels and larger adenoma diameters. Upon adjusting for confounders, the surgical method and preoperative PTH levels also remained independent predictors of operative duration (p < 0.05). There were no statistically significant differences among the groups regarding rates of early postoperative hypoparathyroidism or hypocalcemia. During long-term follow-up, very high cure rates were observed in all groups: a 100% cure rate was achieved in the ROLL group, whereas persistent hyperparathyroidism was observed in two patients in the IV MIBI group and one patient in the standard group.</p><p><strong>Conclusion: </strong>The ROLL technique is an effective targeted surgical approach for PHPT. By minimizing background tissue uptake and providing precise intralesional navigation, ROLL was associated with shorter operative duration with similar surgical cure rates when compared to systemic IV gamma-probe guidance and standard minimally invasive parathyroidectomy. However, prospective trials with larger cohorts are needed to confirm these clinical advantages.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement between SPECT/CT-derived autoplanar imaging and conventional planar imaging in ^99mTc-PYP scintigraphy.","authors":"Osamu Manabe, Toshinori Saitou, Keiya Morimoto, Hiroki Kawakami, Tadao Aikawa, Masateru Kawakubo, Koya Denda, Keiko Takahashi-Hayashi, Noriko Oyama-Manabe","doi":"10.1007/s12149-026-02280-3","DOIUrl":"https://doi.org/10.1007/s12149-026-02280-3","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the agreement and reproducibility of SPECT/CT-derived AutoPlanar imaging compared with conventional planar imaging in ^99mTc-pyrophosphate (^99mTc-PYP) scintigraphy for transthyretin amyloidosis cardiomyopathy (ATTR-CM).</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 54 patients with suspected ATTR-CM who underwent ^99mTc-PYP scintigraphy. Conventional planar imaging and SPECT/CT acquisition were performed at 1 h and 3 h after tracer injection. AutoPlanar images were generated from reconstructed SPECT/CT datasets. Visual assessment using the Perugini grading scale and semiquantitative evaluation using the heart-to-contralateral chest (H/CL) ratio were compared between conventional planar and AutoPlanar imaging.</p><p><strong>Results: </strong>Exact agreement in Perugini scores between conventional planar and AutoPlanar imaging was observed in 90.7% of patients at 1 h and 98.1% at 3 h, with quadratic weighted κ values of 0.938 and 0.992, respectively. H/CL ratios demonstrated excellent agreement between the two imaging methods, with correlation coefficients of 0.987 at both imaging time points. Using H/CL ratio cutoffs of ≥ 1.5 at 1 h and ≥ 1.3 at 3 h, agreement for H/CL-based positive/negative classification was 98.1% and 96.3%, respectively.</p><p><strong>Conclusion: </strong>SPECT/CT-derived AutoPlanar imaging showed excellent agreement with conventional planar imaging for both visual and semiquantitative assessment in ^99mTc-PYP scintigraphy. AutoPlanar imaging showed excellent agreement with conventional planar imaging and may serve as an alternative image display method for visual and semiquantitative assessment in ^99mTc-PYP scintigraphy.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction-dependent differences in brain [18F]FDG PET: a large-scale same-acquisition comparison of Q.Clear and VUE Point FX.","authors":"Agostino Chiaravalloti, Daniele di Biagio, Nicola D'Ascenzo, Nicoletta Urbano, Alessandro Martorana, Orazio Schillaci","doi":"10.1007/s12149-026-02278-x","DOIUrl":"https://doi.org/10.1007/s12149-026-02278-x","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether Q.Clear and VUE Point FX (VPFX) reconstructions obtained from the same brain [18 F]fluorodeoxyglucose positron emission tomography ([18 F]FDG PET) acquisition are quantitatively interchangeable, and to characterise the regional, reference-region and noise-texture dependence of any differences.</p><p><strong>Methods: </strong>We retrospectively analysed paired Q.Clear and VPFX reconstructions from 1,145 clinical brain PET folders. The reviewed protocol used a 10-min acquisition, Q.Clear QCFX-S with beta 150, SharpIR and no z-axis filter, and VPFX-S with 3 iterations, 16 subsets and a 4.0-mm filter. Digital Imaging and Communications in Medicine metadata were audited, and 1,022 readable same-examination pairs were processed in MATLAB R2026a and statistical parametric mapping version 25. A common transform estimated from mean(Q.Clear, VPFX) was applied to both reconstructions. Absolute and standardised uptake value ratio (SUVR) differences normalised to whole brain, cerebellum and pons were assessed voxel-wise and in Automated Anatomical Labelling atlas 3 regions. DICOM-derived local high-frequency and robust global coefficients of variation (CVs) were also compared.</p><p><strong>Results: </strong>Q.Clear increased the whole-brain, cerebellar and pontine reference means by 0.953%, 0.595% and 0.818%, respectively. Absolute regional differences were heterogeneous; after normalisation, most cortical and limbic Q.Clear-minus-VPFX differences were negative. The medial temporal whole-brain-normalised difference was - 0.00625 (Cohen dz -2.09), equivalent to approximately - 0.69% at an illustrative VPFX SUVR of 0.90. Covariate-adjusted voxel-wise T maps were nearly identical to no-covariate maps (r = 0.9996-0.9999; sign concordance > = 99.96%). Local high-frequency CV was lower with VPFX in 689 pairs and with Q.Clear in 333, whereas robust global CV was lower with Q.Clear in 903 pairs, with one tie.</p><p><strong>Conclusions: </strong>Q.Clear and VPFX were not quantitatively interchangeable under the evaluated protocol. The study establishes protocol-specific reconstruction-dependent differences, not the direction of quantitative accuracy, because no ground truth was available. Harmonised reconstruction and validation are required when quantitative brain PET data are compared or pooled.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 Hisada Prize (Award for Articles in Annals of Nuclear Medicine)","authors":"Kazunari Ishii","doi":"10.1007/s12149-026-02275-0","DOIUrl":"10.1007/s12149-026-02275-0","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 10","pages":"1151 - 1152"},"PeriodicalIF":2.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}