Annual review of biochemistry最新文献_第9页

Biological Insight from Super-Resolution Microscopy: What We Can Learn from Localization-Based Images. 来自超分辨率显微镜的生物学洞察:我们可以从基于定位的图像中学到什么。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2018-06-20 DOI: 10.1146/annurev-biochem-060815-014801

David Baddeley, Joerg Bewersdorf

引用次数: 144

Structural Studies of Amyloid Proteins at the Molecular Level. 淀粉样蛋白的分子水平结构研究。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2017-06-27 DOI: 10.1146/annurev-biochem-061516-045104

D. Eisenberg, M. Sawaya

引用次数: 361

At the Intersection of Chemistry, Biology, and Medicine. 在化学、生物学和医学的交叉点。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2017-06-27 DOI: 10.1146/annurev-biochem-110716-121241

C. Walsh

引用次数: 16

Molecular Characteristics and Biological Functions of Surface-Active and Surfactant Proteins. 表面活性蛋白和表面活性蛋白的分子特征和生物学功能。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2017-06-27 DOI: 10.1146/annurev-biochem-061516-044847

M. Sunde, Chi L. L. Pham, A. Kwan

{"title":"Molecular Characteristics and Biological Functions of Surface-Active and Surfactant Proteins.","authors":"M. Sunde, Chi L. L. Pham, A. Kwan","doi":"10.1146/annurev-biochem-061516-044847","DOIUrl":"https://doi.org/10.1146/annurev-biochem-061516-044847","url":null,"abstract":"Many critical biological processes take place at hydrophobic:hydrophilic interfaces, and a wide range of organisms produce surface-active proteins and peptides that reduce surface and interfacial tension and mediate growth and development at these boundaries. Microorganisms produce both small lipid-associated peptides and amphipathic proteins that allow growth across water:air boundaries, attachment to surfaces, predation, and improved bioavailability of hydrophobic substrates. Higher-order organisms produce surface-active proteins with a wide variety of functions, including the provision of protective foam environments for vulnerable reproductive stages, evaporative cooling, and gas exchange across airway membranes. In general, the biological functions supported by these diverse polypeptides require them to have an amphipathic nature, and this is achieved by a diverse range of molecular structures, with some proteins undergoing significant conformational change or intermolecular association to generate the structures that are surface active.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":"86 1","pages":"585-608"},"PeriodicalIF":16.6,"publicationDate":"2017-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-biochem-061516-044847","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48676674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Telomerase Mechanism of Telomere Synthesis. 端粒合成的端粒酶机制。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2017-06-27 DOI: 10.1146/annurev-biochem-061516-045019

R. Wu, Heather E. Upton, Jacob M. Vogan, K. Collins

{"title":"Telomerase Mechanism of Telomere Synthesis.","authors":"R. Wu, Heather E. Upton, Jacob M. Vogan, K. Collins","doi":"10.1146/annurev-biochem-061516-045019","DOIUrl":"https://doi.org/10.1146/annurev-biochem-061516-045019","url":null,"abstract":"Telomerase is the essential reverse transcriptase required for linear chromosome maintenance in most eukaryotes. Telomerase supplements the tandem array of simple-sequence repeats at chromosome ends to compensate for the DNA erosion inherent in genome replication. The template for telomerase reverse transcriptase is within the RNA subunit of the ribonucleoprotein complex, which in cells contains additional telomerase holoenzyme proteins that assemble the active ribonucleoprotein and promote its function at telomeres. Telomerase is distinct among polymerases in its reiterative reuse of an internal template. The template is precisely defined, processively copied, and regenerated by release of single-stranded product DNA. New specificities of nucleic acid handling that underlie the catalytic cycle of repeat synthesis derive from both active site specialization and new motif elaborations in protein and RNA subunits. Studies of telomerase provide unique insights into cellular requirements for genome stability, tissue renewal, and tumorigenesis as well as new perspectives on dynamic ribonucleoprotein machines.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":"86 1","pages":"439-460"},"PeriodicalIF":16.6,"publicationDate":"2017-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-biochem-061516-045019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63955786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 164

Biochemistry of Catabolic Reductive Dehalogenation. 分解代谢还原脱卤的生物化学。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2017-06-20 DOI: 10.1146/annurev-biochem-061516-044829

Maeva Fincker, Alfred M Spormann

引用次数: 84

How α-Helical Motifs Form Functionally Diverse Lipid-Binding Compartments. α-螺旋基序如何形成功能多样的脂质结合区室。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2017-06-20 Epub Date: 2017-03-30 DOI: 10.1146/annurev-biochem-061516-044445

Lucy Malinina, Dinshaw J Patel, Rhoderick E Brown

{"title":"How α-Helical Motifs Form Functionally Diverse Lipid-Binding Compartments.","authors":"Lucy Malinina, Dinshaw J Patel, Rhoderick E Brown","doi":"10.1146/annurev-biochem-061516-044445","DOIUrl":"https://doi.org/10.1146/annurev-biochem-061516-044445","url":null,"abstract":"Lipids are produced site-specifically in cells and then distributed nonrandomly among membranes via vesicular and nonvesicular trafficking mechanisms. The latter involves soluble amphitropic proteins extracting specific lipids from source membranes to function as molecular solubilizers that envelope their insoluble cargo before transporting it to destination sites. Lipid-binding and lipid transfer structural motifs range from multi-β-strand barrels, to β-sheet cups and baskets covered by α-helical lids, to multi-α-helical bundles and layers. Here, we focus on how α-helical proteins use amphipathic helical layering and bundling to form modular lipid-binding compartments and discuss the functional consequences. Preformed compartments generally rely on intramolecular disulfide bridging to maintain conformation (e.g., albumins, nonspecific lipid transfer proteins, saposins, nematode polyprotein allergens/antigens). Insights into nonpreformed hydrophobic compartments that expand and adapt to accommodate a lipid occupant are few and provided mostly by the three-layer, α-helical ligand-binding domain of nuclear receptors. The simple but elegant and nearly ubiquitous two-layer, α-helical glycolipid transfer protein (GLTP)-fold now further advances understanding.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":"86 ","pages":"609-636"},"PeriodicalIF":16.6,"publicationDate":"2017-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-biochem-061516-044445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34883922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Cellular Electron Cryotomography: Toward Structural Biology In Situ. 细胞电子冷冻层析术:原位结构生物学。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2017-06-20 Epub Date: 2017-04-19 DOI: 10.1146/annurev-biochem-061516-044741

Catherine M Oikonomou, Grant J Jensen

引用次数: 122

Electric Fields and Enzyme Catalysis. 电场与酶催化作用

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2017-06-20 Epub Date: 2017-03-24 DOI: 10.1146/annurev-biochem-061516-044432

Stephen D Fried, Steven G Boxer

引用次数: 0

Extracellular Heme Uptake and the Challenge of Bacterial Cell Membranes. 细胞外血红素摄取和细菌细胞膜的挑战。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2017-06-20 Epub Date: 2017-04-19 DOI: 10.1146/annurev-biochem-060815-014214

Weiliang Huang, Angela Wilks

{"title":"Extracellular Heme Uptake and the Challenge of Bacterial Cell Membranes.","authors":"Weiliang Huang, Angela Wilks","doi":"10.1146/annurev-biochem-060815-014214","DOIUrl":"https://doi.org/10.1146/annurev-biochem-060815-014214","url":null,"abstract":"Iron is essential for the survival of most bacteria but presents a significant challenge given its limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain physiological iron levels within a narrow concentration range requires sophisticated systems to sense, regulate, and transport iron. Most bacteria have evolved mechanisms to chelate and transport ferric iron (Fe3+) via siderophore receptor systems, and pathogenic bacteria have further lowered this barrier by employing mechanisms to utilize the host's hemoproteins. Once internalized, heme is cleaved by both oxidative and nonoxidative mechanisms to release iron. Heme, itself a lipophilic and toxic molecule, presents a significant challenge for transport into the cell. As such, pathogenic bacteria have evolved sophisticated cell surface signaling and transport systems to obtain heme from the host. In this review, we summarize the structure and function of the heme-sensing and transport systems of pathogenic bacteria and the potential of these systems as antimicrobial targets.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":"86 ","pages":"799-823"},"PeriodicalIF":16.6,"publicationDate":"2017-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-biochem-060815-014214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34927832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 83