Annual review of biochemistry最新文献_第10页

Role of the TOM Complex in Protein Import into Mitochondria: Structural Views. TOM复合物在蛋白质导入线粒体中的作用:结构观点。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-02-14 DOI: 10.1146/annurev-biochem-032620-104527

Yuhei Araiso, K. Imai, T. Endo

{"title":"Role of the TOM Complex in Protein Import into Mitochondria: Structural Views.","authors":"Yuhei Araiso, K. Imai, T. Endo","doi":"10.1146/annurev-biochem-032620-104527","DOIUrl":"https://doi.org/10.1146/annurev-biochem-032620-104527","url":null,"abstract":"Mitochondria are central to energy production, metabolism and signaling, and apoptosis. To make new mitochondria from preexisting mitochondria, the cell needs to import mitochondrial proteins from the cytosol into the mitochondria with the aid of translocators in the mitochondrial membranes. The translocase of the outer membrane (TOM) complex, an outer membrane translocator, functions as an entry gate for most mitochondrial proteins. Although high-resolution structures of the receptor subunits of the TOM complex were deposited in the early 2000s, those of entire TOM complexes became available only in 2019. The structural details of these TOM complexes, consisting of the dimer of the β-barrel import channel Tom40 and four α-helical membrane proteins, revealed the presence of several distinct paths and exits for the translocation of over 1,000 different mitochondrial precursor proteins. High-resolution structures of TOM complexes now open up a new era of studies on the structures, functions, and dynamics of the mitochondrial import system. Expected final online publication date for the Annual Review of Biochemistry, Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46544251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

High-resolution Single-molecule Magnetic Tweezers. 高分辨率单分子磁性镊子。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-02-14 DOI: 10.1146/annurev-biochem-032620-104637

Hyun-Kyu Choi, Hyun Gyu Kim, M. Shon, Tae-Young Yoon

{"title":"High-resolution Single-molecule Magnetic Tweezers.","authors":"Hyun-Kyu Choi, Hyun Gyu Kim, M. Shon, Tae-Young Yoon","doi":"10.1146/annurev-biochem-032620-104637","DOIUrl":"https://doi.org/10.1146/annurev-biochem-032620-104637","url":null,"abstract":"Single-molecule magnetic tweezers deliver magnetic force and torque to single target molecules, permitting the study of dynamic changes in biomolecular structures and their interactions. Because the magnetic tweezer setups can generate magnetic fields that vary slowly over tens of millimeters-far larger than the nanometer scale of the single molecule events being observed-this technique can maintain essentially constant force levels during biochemical experiments while generating a biologically meaningful force on the order of 1-100 pN. When using bead-tether constructs to pull on single molecules, smaller magnetic beads and shorter submicrometer tethers improve dynamic response times and measurement precision. In addition, employing high-speed cameras, stronger light sources, and a graphics programming unit permits true high-resolution single-molecule magnetic tweezers that can track nanometer changes in target molecules on a millisecond or even submillisecond time scale. The unique force-clamping capacity of the magnetic tweezer technique provides a way to conduct measurements under near-equilibrium conditions and directly map the energy landscapes underlying various molecular phenomena. High-resolution single-molecule magnetic tweezers can thus be used to monitor crucial conformational changes in single-protein molecules, including those involved in mechanotransduction and protein folding. Expected final online publication date for the Annual Review of Biochemistry, Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48194579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS-cGAMP-STING Pathway. 天然免疫cGAS cGAMP STING通路的生物化学、细胞生物学和病理生理学。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-02-14 DOI: 10.1146/annurev-biochem-040320-101629

C. Ritchie, Jacqueline A. Carozza, Lingyin Li

{"title":"Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS-cGAMP-STING Pathway.","authors":"C. Ritchie, Jacqueline A. Carozza, Lingyin Li","doi":"10.1146/annurev-biochem-040320-101629","DOIUrl":"https://doi.org/10.1146/annurev-biochem-040320-101629","url":null,"abstract":"In the decade since the discovery of the innate immune cyclic GMP-AMP synthase (cGAS)- 2'3'-cyclic GMP-AMP (cGAMP)- stimulator of interferon genes (STING) pathway, its proper activation and dysregulation have been rapidly implicated in many aspects of human disease. Understanding the biochemical, cellular, and regulatory mechanisms of this pathway is critical to developing therapeutic strategies that either harness it to boost defense or inhibit it to prevent unwanted inflammation. In this review, we first discuss how the second messenger cGAMP is synthesized by cGAS in response to double-stranded DNA and cGAMP's subsequent activation of cell-type-dependent STING signaling cascades with differential physiological consequences. We then review how cGAMP as an immunotransmitter mediates tightly controlled cell-cell communication by being exported from producing cells and imported into responding cells via cell-type-specific transporters. Finally, we review mechanisms by which the cGAS-cGAMP-STING pathway responds to different sources of mislocalized double-stranded DNA in pathogen defense, cancer, and autoimmune diseases. Expected final online publication date for the Annual Review of Biochemistry, Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":""},"PeriodicalIF":16.6,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49418859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Influence of Nonspecific Interactions on Protein Associations: Implications for Biochemistry In Vivo. 非特异性相互作用对蛋白质关联的影响:体内生物化学的意义。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-02-14 DOI: 10.1146/annurev-biochem-040320-104151

G. Rivas, A. Minton

引用次数: 17

Summing up. 总结。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2021-12-06 DOI: 10.2307/j.ctv6gqt8x.21

K. Bloch

引用次数: 0

Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol. 胆固醇合成限速酶HMG CoA还原酶的翻译后调控。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2021-06-20 DOI: 10.1146/annurev-biochem-081820-101010

Marc M Schumacher, Russell A DeBose-Boyd

{"title":"Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol.","authors":"Marc M Schumacher, Russell A DeBose-Boyd","doi":"10.1146/annurev-biochem-081820-101010","DOIUrl":"https://doi.org/10.1146/annurev-biochem-081820-101010","url":null,"abstract":"The polytopic, endoplasmic reticulum (ER) membrane protein 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase produces mevalonate, the key intermediate in the synthesis of cholesterol and many nonsterol isoprenoids including geranylgeranyl pyrophosphate (GGpp). Transcriptional, translational, and posttranslational feedback mechanisms converge on this reductase to ensure cells maintain a sufficient supply of essential nonsterol isoprenoids but avoid overaccumulation of cholesterol and other sterols. The focus of this review is mechanisms for the posttranslational regulation of HMG CoA reductase, which include sterol-accelerated ubiquitination and ER-associated degradation (ERAD) that is augmented by GGpp. We discuss how GGpp-induced ER-to-Golgi trafficking of the vitamin K2 synthetic enzyme UbiA prenyltransferase domain-containing protein-1 (UBIAD1) modulates HMG CoA reductase ERAD to balance the synthesis of sterol and nonsterol isoprenoids. We also summarize the characterization of genetically manipulated mice, which established that sterol-accelerated, UBIAD1-modulated ERAD plays a major role in regulation of HMG CoA reductase and cholesterol metabolism in vivo.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":"659-679"},"PeriodicalIF":16.6,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39251972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

It's Better To Be Lucky Than Smart. 聪明不如幸运。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2021-06-20 Epub Date: 2021-01-20 DOI: 10.1146/annurev-biochem-011520-105008

H R Kaback

{"title":"It's Better To Be Lucky Than Smart.","authors":"H R Kaback","doi":"10.1146/annurev-biochem-011520-105008","DOIUrl":"https://doi.org/10.1146/annurev-biochem-011520-105008","url":null,"abstract":"Bacterial cytoplasmic membrane vesicles provide a unique experimental system for studying active transport. Vesicles are prepared by lysis of osmotically sensitized cells (i.e., protoplasts or spheroplasts) and comprise osmotically intact, unit-membrane-bound sacs that are approximately 0.5-1.0 μm in diameter and devoid of internal structure. Their metabolic activities are restricted to those provided by the enzymes of the membrane itself, and each vesicle is functional. The energy source for accumulation of a particular substrate can be determined by studying which compounds or experimental conditions drive solute accumulation, and metabolic conversion of the transported substrate or the energy source is minimal. These properties of the vesicle system constitute a considerable advantage over intact cells, as the system provides clear definition of the reactions involved in the transport process. This discussion is not intended as a general review but is concerned with respiration-dependent active transport in membrane vesicles from Escherichia coli. Emphasis is placed on experimental observations demonstrating that respiratory energy is converted primarily into work in the form of a solute concentration gradient that is driven by a proton electrochemical gradient, as postulated by the chemiosmotic theory of Peter Mitchell.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":"1-29"},"PeriodicalIF":16.6,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38774863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Mechanisms of Vertebrate DNA Interstrand Cross-Link Repair. 脊椎动物DNA链间交联修复机制。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2021-06-20 Epub Date: 2021-04-21 DOI: 10.1146/annurev-biochem-080320-112510

Daniel R Semlow, Johannes C Walter

引用次数: 53

The Roots of Genetic Coding in Aminoacyl-tRNA Synthetase Duality. 氨基酰基- trna合成酶二元性遗传编码的根源。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2021-06-20 Epub Date: 2021-03-29 DOI: 10.1146/annurev-biochem-071620-021218

Charles W Carter, Peter R Wills

{"title":"The Roots of Genetic Coding in Aminoacyl-tRNA Synthetase Duality.","authors":"Charles W Carter, Peter R Wills","doi":"10.1146/annurev-biochem-071620-021218","DOIUrl":"https://doi.org/10.1146/annurev-biochem-071620-021218","url":null,"abstract":"Codon-dependent translation underlies genetics and phylogenetic inferences, but its origins pose two challenges. Prevailing narratives cannot account for the fact that aminoacyl-tRNA synthetases (aaRSs), which translate the genetic code, must collectively enforce the rules used to assemble themselves. Nor can they explain how specific assignments arose from rudimentary differentiation between ancestral aaRSs and corresponding transfer RNAs (tRNAs). Experimental deconstruction of the two aaRS superfamilies created new experimental tools with which to analyze the emergence of the code. Amino acid and tRNA substrate recognition are linked to phase transfer free energies of amino acids and arise largely from aaRS class-specific differences in secondary structure. Sensitivity to protein folding rules endowed ancestral aaRS-tRNA pairs with the feedback necessary to rapidly compare alternative genetic codes and coding sequences. These and other experimental data suggest that the aaRS bidirectional genetic ancestry stabilized the differentiation and interdependence required to initiate and elaborate the genetic coding table.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":"349-373"},"PeriodicalIF":16.6,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25528567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

PI(4,5)P₂ Clustering and Its Impact on Biological Functions. PI(4,5)P2聚类及其对生物功能的影响

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2021-06-20 Epub Date: 2021-01-13 DOI: 10.1146/annurev-biochem-070920-094827

Yi Wen, Volker M Vogt, Gerald W Feigenson

{"title":"PI(4,5)P2 Clustering and Its Impact on Biological Functions.","authors":"Yi Wen, Volker M Vogt, Gerald W Feigenson","doi":"10.1146/annurev-biochem-070920-094827","DOIUrl":"https://doi.org/10.1146/annurev-biochem-070920-094827","url":null,"abstract":"Located at the inner leaflet of the plasma membrane (PM), phosphatidyl-inositol 4,5-bisphosphate [PI(4,5)P2] composes only 1-2 mol% of total PM lipids. With its synthesis and turnover both spatially and temporally regulated, PI(4,5)P2 recruits and interacts with hundreds of cellular proteins to support a broad spectrum of cellular functions. Several factors contribute to the versatile and dynamic distribution of PI(4,5)P2 in membranes. Physiological multivalent cations such as Ca2+ and Mg2+ can bridge between PI(4,5)P2 headgroups, forming nanoscopic PI(4,5)P2-cation clusters. The distinct lipid environment surrounding PI(4,5)P2 affects the degree of PI(4,5)P2 clustering. In addition, diverse cellular proteins interacting with PI(4,5)P2 can further regulate PI(4,5)P2 lateral distribution and accessibility. This review summarizes the current understanding of PI(4,5)P2 behavior in both cells and model membranes, with emphasis on both multivalent cation- and protein-induced PI(4,5)P2 clustering. Understanding the nature of spatially separated pools of PI(4,5)P2 is fundamental to cell biology.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":"681-707"},"PeriodicalIF":16.6,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38749869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15