Annual review of biochemistry最新文献_第10页

The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function. SARS-CoV-2在细胞内的生命:复制-转录复合体的组装和功能

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 DOI: 10.1146/annurev-biochem-052521-115653

Zhiyong Lou, Zihe Rao

{"title":"The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function.","authors":"Zhiyong Lou, Zihe Rao","doi":"10.1146/annurev-biochem-052521-115653","DOIUrl":"https://doi.org/10.1146/annurev-biochem-052521-115653","url":null,"abstract":"The persistence of the coronavirus disease 2019 (COVID-19) pandemic has resulted in increasingly disruptive impacts, and it has become the most devastating challenge to global health in a century. The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants challenges the currently available therapeutics for clinical application. Nonstructural proteins (also known as replicase proteins) with versatile biological functions play central roles in viral replication and transcription inside the host cells, and they are the most conserved target proteins among the SARS-CoV-2 variants. Specifically, they constitute the replication-transcription complexes (RTCs) dominating the synthesis of viral RNA. Knowledge of themolecular mechanisms of nonstructural proteins and their assembly into RTCs will benefit the development of antivirals targeting them against existing or potentially emerging variants. In this review, we summarize current knowledge of the structures and functions of coronavirus nonstructural proteins as well as the assembly and functions of RTCs in the life cycle of the virus.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":"381-401"},"PeriodicalIF":16.6,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40150642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Structure and Mechanism of the Lipid Flippase MurJ. 脂质翻转酶murp的结构与机制

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 DOI: 10.1146/annurev-biochem-040320-105145

Alvin C Y Kuk, Aili Hao, Seok-Yong Lee

引用次数: 6

Structural Mimicry in Microbial and Antimicrobial Amyloids. 微生物和抗微生物淀粉样蛋白的结构拟态。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 DOI: 10.1146/annurev-biochem-032620-105157

Nimrod Golan, Yizhaq Engelberg, Meytal Landau

{"title":"Structural Mimicry in Microbial and Antimicrobial Amyloids.","authors":"Nimrod Golan, Yizhaq Engelberg, Meytal Landau","doi":"10.1146/annurev-biochem-032620-105157","DOIUrl":"https://doi.org/10.1146/annurev-biochem-032620-105157","url":null,"abstract":"The remarkable variety of microbial species of human pathogens and microbiomes generates significant quantities of secreted amyloids, which are structured protein fibrils that serve diverse functions related to virulence and interactions with the host. Human amyloids are associated largely with fatal neurodegenerative and systemic aggregation diseases, and current research has put forward the hypothesis that the interspecies amyloid interactome has physiological and pathological significance. Moreover, functional and molecular-level connections between antimicrobial activity and amyloid structures suggest a neuroimmune role for amyloids that are otherwise known to be pathological. Compared to the extensive structural information that has been accumulated for human amyloids, high-resolution structures of microbial and antimicrobial amyloids are only emerging. These recent structures reveal both similarities and surprising departures from the typical amyloid motif, in accordance with their diverse activities, and advance the discovery of novel antivirulence and antimicrobial agents. In addition, the structural information has led researchers to postulate that amyloidogenic sequences are natural targets for structural mimicry, for instance in host-microbe interactions. Microbial amyloid research could ultimately be used to fight aggressive infections and possibly processes leading to autoimmune and neurodegenerative diseases.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":"403-422"},"PeriodicalIF":16.6,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40150641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory. 驱动E3连接酶底物特异性靶向蛋白降解:从自然界和实验室的经验教训。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 Epub Date: 2022-03-23 DOI: 10.1146/annurev-biochem-032620-104421

Angus D Cowan, Alessio Ciulli

{"title":"Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory.","authors":"Angus D Cowan, Alessio Ciulli","doi":"10.1146/annurev-biochem-032620-104421","DOIUrl":"https://doi.org/10.1146/annurev-biochem-032620-104421","url":null,"abstract":"Methods to direct the degradation of protein targets with proximity-inducing molecules that coopt the cellular degradation machinery are advancing in leaps and bounds, and diverse modalities are emerging. The most used and well-studied approach is to hijack E3 ligases of the ubiquitin-proteasome system. E3 ligases use specific molecular recognition to determine which proteins in the cell are ubiquitinated and degraded. This review focuses on the structural determinants of E3 ligase recruitment of natural substrates and neo-substrates obtained through monovalent molecular glues and bivalent proteolysis-targeting chimeras. We use structures to illustrate the different types of substrate recognition and assess the basis for neo-protein-protein interactions in ternary complex structures. The emerging structural and mechanistic complexity is reflective of the diverse physiological roles of protein ubiquitination. This molecular insight is also guiding the application of structure-based design approaches to the development of new and existing degraders as chemical tools and therapeutics.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":" ","pages":"295-319"},"PeriodicalIF":16.6,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40316865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Sensory TRP Channels in Three Dimensions. 三维感官 TRP 通道

IF 12.1 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 Epub Date: 2022-03-14 DOI: 10.1146/annurev-biochem-032620-105738

Melinda M Diver, John V Lin King, David Julius, Yifan Cheng

{"title":"Sensory TRP Channels in Three Dimensions.","authors":"Melinda M Diver, John V Lin King, David Julius, Yifan Cheng","doi":"10.1146/annurev-biochem-032620-105738","DOIUrl":"10.1146/annurev-biochem-032620-105738","url":null,"abstract":"Transient receptor potential (TRP) ion channels are sophisticated signaling machines that detect a wide variety of environmental and physiological signals. Every cell in the body expresses one or more members of the extended TRP channel family, which consists of over 30 subtypes, each likely possessing distinct pharmacological, biophysical, and/or structural attributes. While the function of some TRP subtypes remains enigmatic, those involved in sensory signaling are perhaps best characterized and have served as models for understanding how these excitatory ion channels serve as polymodal signal integrators. With the recent resolution revolution in cryo-electron microscopy, these and other TRP channel subtypes are now yielding their secrets to detailed atomic analysis, which is beginning to reveal structural underpinnings of stimulus detection and gating, ion permeation, and allosteric mechanisms governing signal integration. These insights are providing a framework for designing and evaluating modality-specific pharmacological agents for treating sensory and other TRP channel-associated disorders.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":"91 ","pages":"629-649"},"PeriodicalIF":12.1,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233036/pdf/nihms-1809634.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9702300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Purinosome: A Case Study for a Mammalian Metabolon. 嘌呤酶:哺乳动物代谢物的案例研究。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 DOI: 10.1146/annurev-biochem-032620-105728

Anthony M Pedley, Vidhi Pareek, Stephen J Benkovic

引用次数: 15

Better, Faster, Cheaper: Recent Advances in Cryo-Electron Microscopy. 更好，更快，更便宜:冷冻电子显微镜的最新进展。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 DOI: 10.1146/annurev-biochem-032620-110705

Eugene Y D Chua, Joshua H Mendez, Micah Rapp, Serban L Ilca, Yong Zi Tan, Kashyap Maruthi, Huihui Kuang, Christina M Zimanyi, Anchi Cheng, Edward T Eng, Alex J Noble, Clinton S Potter, Bridget Carragher

引用次数: 19

Evolutionary Dynamics and Molecular Mechanisms of HORMA Domain Protein Signaling. HORMA结构域蛋白信号的进化动力学和分子机制。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 Epub Date: 2022-01-18 DOI: 10.1146/annurev-biochem-090920-103246

Yajie Gu, Arshad Desai, Kevin D Corbett

引用次数: 15

Encapsulins. 密封剂。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 DOI: 10.1146/annurev-biochem-040320-102858

Tobias W Giessen

{"title":"Encapsulins.","authors":"Tobias W Giessen","doi":"10.1146/annurev-biochem-040320-102858","DOIUrl":"https://doi.org/10.1146/annurev-biochem-040320-102858","url":null,"abstract":"Subcellular compartmentalization is a defining feature of all cells. In prokaryotes, compartmentalization is generally achieved via protein-based strategies. The two main classes of microbial protein compartments are bacterial microcompartments and encapsulin nanocompartments. Encapsulins self-assemble into proteinaceous shells with diameters between 24 and 42 nm and are defined by the viral HK97-fold of their shell protein. Encapsulins have the ability to encapsulate dedicated cargo proteins, including ferritin-like proteins, peroxidases, and desulfurases. Encapsulation is mediated by targeting sequences present in all cargo proteins. Encapsulins are found in many bacterial and archaeal phyla and have been suggested to play roles in iron storage, stress resistance, sulfur metabolism, and natural product biosynthesis. Phylogenetic analyses indicate that they share a common ancestor with viral capsid proteins. Many pathogens encode encapsulins, and recent evidence suggests that they may contribute toward pathogenicity. The existing information on encapsulin structure, biochemistry, biological function, and biomedical relevance is reviewed here.","PeriodicalId":7980,"journal":{"name":"Annual review of biochemistry","volume":"91 ","pages":"353-380"},"PeriodicalIF":16.6,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944552/pdf/nihms-1869567.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10750512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The Structural Dynamics of Translation. 翻译的结构动力学。

IF 16.6 1区生物学

Annual review of biochemistry Pub Date : 2022-06-21 DOI: 10.1146/annurev-biochem-071921-122857

Andrei A Korostelev

引用次数: 13