非特异性相互作用对蛋白质关联的影响:体内生物化学的意义。

IF 12.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Annual review of biochemistry Pub Date : 2022-02-14 DOI:10.1146/annurev-biochem-040320-104151

G. Rivas, A. Minton

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引用次数: 17

摘要

细胞内部由不同的局部成分和依赖于成分的分子间相互作用所定义的各种微环境组成。我们回顾了蛋白质之间以及蛋白质与其他大分子和超分子结构之间的各种非特异性相互作用，这些相互作用会影响特定微环境中特定时间点存在的特定蛋白质的结合状态和功能特性。总结了目前的研究现状，并对今后的研究方向提出了建议。预计《生物化学年度评论》91卷的最终在线出版日期为2022年6月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

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Influence of Nonspecific Interactions on Protein Associations: Implications for Biochemistry In Vivo.

The cellular interior is composed of a variety of microenvironments defined by distinct local compositions and composition-dependent intermolecular interactions. We review the various types of nonspecific interactions between proteins and between proteins and other macromolecules and supramolecular structures that influence the state of association and functional properties of a given protein existing within a particular microenvironment at a particular point in time. The present state of knowledge is summarized, and suggestions for fruitful directions of research are offered. Expected final online publication date for the Annual Review of Biochemistry, Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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来源期刊

Annual review of biochemistry 生物-生化与分子生物学

CiteScore

33.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.