DNA-蛋白质交联及其解析。

IF 12.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Annual review of biochemistry Pub Date : 2022-02-18 DOI:10.1146/annurev-biochem-032620-105820

P. Weickert, Julian Stingele

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引用次数: 23

摘要

共价DNA蛋白质交联（DPCs）是一种普遍存在的DNA损伤，干扰转录或复制等基本染色质过程。这篇综述致力于提供细胞DPC形成的来源和原理的概述。DPCs是由内源性反应性代谢产物和各种化疗药物引起的。然而，在某些条件下，DPC也在细胞中产生。我们讨论了解决这些威胁基因组完整性的细胞机制。DPCs的检测和修复不仅需要典型DNA修复途径的作用，还需要专门的蛋白水解酶（包括SPRTN/Wss1家族的蛋白酶）的活性来降解交联蛋白。DPC修复能力的丧失具有显著的后果，从酵母和蠕虫的基因组不稳定到小鼠和人类的癌症易感性和过早衰老。《生物化学年度评论》第91卷预计最终在线出版日期为2022年6月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

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DNA-Protein Crosslinks and Their Resolution.

Covalent DNA-protein crosslinks (DPCs) are pervasive DNA lesions that interfere with essential chromatin processes such as transcription or replication. This review strives to provide an overview of the sources and principles of cellular DPC formation. DPCs are caused by endogenous reactive metabolites and various chemotherapeutic agents. However, in certain conditions DPCs also arise physiologically in cells. We discuss the cellular mechanisms resolving these threats to genomic integrity. Detection and repair of DPCs require not only the action of canonical DNA repair pathways but also the activity of specialized proteolytic enzymes-including proteases of the SPRTN/Wss1 family-to degrade the crosslinked protein. Loss of DPC repair capacity has dramatic consequences, ranging from genome instability in yeast and worms to cancer predisposition and premature aging in mice and humans. Expected final online publication date for the Annual Review of Biochemistry, Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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来源期刊

Annual review of biochemistry 生物-生化与分子生物学

CiteScore

33.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.