Metalloproteomics for Biomedical Research: Methodology and Applications.

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ying Zhou, Hongyan Li, Hongzhe Sun
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引用次数: 13

Abstract

Metals are essential components in life processes and participate in many important biological processes. Dysregulation of metal homeostasis is correlated with many diseases. Metals are also frequently incorporated into diagnosis and therapeutics. Understanding of metal homeostasis under (patho)physiological conditions and the molecular mechanisms of action of metallodrugs in biological systems has positive impacts on human health. As an emerging interdisciplinary area of research, metalloproteomics involves investigating metal-protein interactions in biological systems at a proteome-wide scale, has received growing attention, and has been implemented into metal-related research. In this review, we summarize the recent advances in metalloproteomics methodologies and applications. We also highlight emerging single-cell metalloproteomics, including time-resolved inductively coupled plasma mass spectrometry, mass cytometry, and secondary ion mass spectrometry. Finally, we discuss future perspectives in metalloproteomics, aiming to attract more original research to develop more advanced methodologies, which could be utilized rapidly by biochemists or biologists to expand our knowledge of how metal functions in biology and medicine. Expected final online publication date for the Annual Review of Biochemistry, Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
生物医学研究的金属代谢组学:方法论和应用。
金属是生命过程中的重要组成部分,并参与许多重要的生物过程。金属稳态失调与许多疾病有关。金属也经常被用于诊断和治疗。了解(病理)生理条件下的金属稳态以及金属药物在生物系统中的分子作用机制对人类健康有积极影响。作为一个新兴的跨学科研究领域,金属蛋白质组学涉及在蛋白质组学范围内研究生物系统中的金属-蛋白质相互作用,受到越来越多的关注,并已被应用于金属相关研究。本文综述了近年来金属蛋白质组学的研究进展及其应用。我们还重点介绍了新兴的单细胞金属蛋白质组学,包括时间分辨电感耦合等离子体质谱法、质谱仪和二次离子质谱法。最后,我们讨论了金属蛋白质组学的未来前景,旨在吸引更多原创研究来开发更先进的方法,生物化学家或生物学家可以迅速利用这些方法来扩展我们对金属在生物学和医学中如何发挥作用的知识。《生物化学年度评论》第91卷预计最终在线出版日期为2022年6月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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