DEAD-Box-ATP酶在基因表达中的作用及对RNA蛋白凝结物的调控。

IF 12.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Annual review of biochemistry Pub Date : 2022-02-18 DOI:10.1146/annurev-biochem-032620-105429

K. Weis, Maria Hondele

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引用次数: 13

摘要

DEAD-box ATP酶是一个存在于所有细胞中的非常大的蛋白质家族，通常丰度很高。从细菌到人类，它们在RNA代谢的许多方面发挥着关键作用，由于它们在RNA生物学中的广泛重要性，它们在结构和生化水平上都得到了详细的表征。DEAD盒蛋白作为RNA依赖性ATP酶发挥作用，可以解开RNA的短双链体，重塑核糖核蛋白（RNP）复合物，或充当促进RNP组装的夹子。然而，个体DEAD盒蛋白是如何在特定的RNA加工步骤中发挥作用的，这通常仍然是个谜。在此，我们综述了DEAD-box ATP酶在基因表达调控中的作用，并提出这些酶的一个共同功能是调节RNP缩合物的液-液相分离。《生物化学年度评论》第91卷预计最终在线出版日期为2022年6月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

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The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA-Protein Condensates.

DEAD-box ATPases constitute a very large protein family present in all cells, often in great abundance. From bacteria to humans, they play critical roles in many aspects of RNA metabolism, and due to their widespread importance in RNA biology, they have been characterized in great detail at both the structural and biochemical levels. DEAD-box proteins function as RNA-dependent ATPases that can unwind short duplexes of RNA, remodel ribonucleoprotein (RNP) complexes, or act as clamps to promote RNP assembly. Yet, it often remains enigmatic how individual DEAD-box proteins mechanistically contribute to specific RNA-processing steps. Here, we review the role of DEAD-box ATPases in the regulation of gene expression and propose that one common function of these enzymes is in the regulation of liquid-liquid phase separation of RNP condensates. Expected final online publication date for the Annual Review of Biochemistry, Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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来源期刊

Annual review of biochemistry 生物-生化与分子生物学

CiteScore

33.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.