Anxiety最新文献

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Decline in serum lactate levels over time 血清乳酸水平随时间下降
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010109
Dr. Terry M. Brown, George N. M. Gurguis
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引用次数: 0
Safety signals and human anxiety: A fear-potentiated startle study 安全信号和人类焦虑:一项恐惧增强的惊吓研究
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010105
Christian Grillon M.D., Williams A. Falls M.D., Rezvan Ameli, Michael Davis
{"title":"Safety signals and human anxiety: A fear-potentiated startle study","authors":"Christian Grillon M.D.,&nbsp;Williams A. Falls M.D.,&nbsp;Rezvan Ameli,&nbsp;Michael Davis","doi":"10.1002/anxi.3070010105","DOIUrl":"10.1002/anxi.3070010105","url":null,"abstract":"<p>The effect of a safety signal on the magnitude of anticipatory anxiety was investigated using the fear-potentiated startle reflex paradigm in humans. The amplitude of the acoustic startle reflex was measured during the anticipation of unpleasant electric chocks (“threat”) and during “safe” conditions. Threat and safe conditions were signaled by three different colored lights. Two lights signaled safe conditions (safe 1, safe 2) and the other light signaled the threat condition (threat). In phase I, the lights alternated, each presentation consisting of one colored light. In phase II, the lights were presented alone or in the two combinations of safe 1 (or safe 2) + threat and safe 1 + safe 2. In both phases, the contingency between the lights and the shock was explained to the subjects. It was emphasized that no shock could be administered when the safe 1 and threat light were simultaneously presented in phase II. Subjects' belief and understanding of the instructions were verified. In Phase I, startle was increased in the threat-alone compared to the safe-alone condition, reflecting increased anticipatory anxiety in the threat-alone condition. In phase II, startle in the safe + threat condition was smaller than in the threat-alone condition, but was larger than in the safe + threat. These results were interpreted as suggesting that the threat signal was still able to elicit anticipatory anxiety despite the fact that it was no longer associated with a threat. Anxiety 1:13–21 (1994). © 1994 Wiley-Liss, Inc.</p>","PeriodicalId":79474,"journal":{"name":"Anxiety","volume":"1 1","pages":"13-21"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/anxi.3070010105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20108038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Peptides and anxiety: A dose-response evaluation of pentagastrin in healthy volunteers 多肽和焦虑:五胃泌素在健康志愿者中的剂量反应评估
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010603
Una D. McCann, Shiyoko O. Slate, Marilla Geraci, Thomas W. Uhde
{"title":"Peptides and anxiety: A dose-response evaluation of pentagastrin in healthy volunteers","authors":"Una D. McCann,&nbsp;Shiyoko O. Slate,&nbsp;Marilla Geraci,&nbsp;Thomas W. Uhde","doi":"10.1002/anxi.3070010603","DOIUrl":"10.1002/anxi.3070010603","url":null,"abstract":"<p>A large body of data suggest that brain cholecystokinin (CCK) systems are involved in the regulation of anxiety, and numerous studies have demonstrated that CCK-4, a CCK<sub>B</sub> agonist, reliably induces panic attacks in patients with panic disorder. Recently, pentagastrin, a commercially available CCK<sub>B</sub> agonist, has been reported to have similar anxiogenic properties. To further explore the utility of pentagastrin as a challenge agent and to determine whether its effects are dose-related, a dose-response study was conducted in ten healthy volunteers. Pentagastrin (0.2 μg kg, 0.6 μg/kg and 1.0 μg/kg) and inactive placebo were infused over one minute on four separate challenge days in a double-blind fashion. Subjects received pentagastrin while participating in a structured social interaction task. Repeated measures of anxiety, blood pressure, pulse, ACTH, and cortisol were taken at baseline and postinfusion. Pentagastrin administration led to increases in anxiety, pulse, ACTH, cortisol and physical symptoms of panic, in a dose-related manner. Participation in the social interaction task led to increases in measures of anxiety as well as increases in pulse and blood pressure. Few differences were found between the 0.2 μg/kg dose of pentagastrin and placebo, or between the 0.6 μg/kg and the 1.0 μg/kg doses of pentagastrin. These findings support the notion that CCK systems are involved in the regulation of anxiety, and suggest that the 0.6 μg/kg dose may be optimal for increasing symptoms of anxiety while minimizing unpleasant side effects. The powerful anxiogenic effects of the social interaction task underscore the importance of contextual variables in challenge studies. Anxiety 1:258–267 (1994/1995). © 1995 Wiley-Liss, Inc.</p>","PeriodicalId":79474,"journal":{"name":"Anxiety","volume":"1 6","pages":"258-267"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/anxi.3070010603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20107013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Dot-probe evaluation of cognitive processing biases in patients with panic disorder: A failure to replicate and extend 惊恐障碍患者认知加工偏差的点探针评估:复制和扩展的失败
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010304
Gordon J. G. Asmundson Ph.D., Murray B. Stein
{"title":"Dot-probe evaluation of cognitive processing biases in patients with panic disorder: A failure to replicate and extend","authors":"Gordon J. G. Asmundson Ph.D.,&nbsp;Murray B. Stein","doi":"10.1002/anxi.3070010304","DOIUrl":"10.1002/anxi.3070010304","url":null,"abstract":"<p>A number of cognitive psychology paradigms have been used to demonstrate that panic disorder patients selectively process stimuli that are related to themes of physical threat and catastrophe. The present investigation was an attempt to replicate and extend initial findings obtained with the dot-probe paradigm, a visual attention paradigm which allows for the assessment of allocation of visual attention to stimuli of varied emotional valence via the measurement of detection latencies for visual probes that follow their presentation. Twenty-two panic disorder patients and 20 healthy control subjects were tested using neutral, social threat, and panic symptom/fear cues. No between-group differences were observed in detection latencies for visual probes that followed neutral, social threat, or panic symptom/fear cues. These results represent a failure to replicate previous reports of selective processing in panic disorder and suggest that panic disorder patients may not selectively process cues related to bodily sensation and panic-related fears. Implications of this finding are discussed. Anxiety 1:123–128 (1994/1995). © 1995 Wiley-Liss, Inc.</p>","PeriodicalId":79474,"journal":{"name":"Anxiety","volume":"1 3","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/anxi.3070010304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20107284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Sleep disorders medicine: Basic science, technical considerations, and clinical aspects. S. Chokroverty. Butterworth-Heineman, Boston, 1994, 504 pp, $125.00 睡眠障碍医学:基础科学、技术考虑和临床方面。美国Chokroverty。巴特沃斯-海涅曼,波士顿,1994,504页,125美元
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010216
Terry M. Brown
{"title":"Sleep disorders medicine: Basic science, technical considerations, and clinical aspects. S. Chokroverty. Butterworth-Heineman, Boston, 1994, 504 pp, $125.00","authors":"Terry M. Brown","doi":"10.1002/anxi.3070010216","DOIUrl":"10.1002/anxi.3070010216","url":null,"abstract":"","PeriodicalId":79474,"journal":{"name":"Anxiety","volume":"1 2","pages":"107-108"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/anxi.3070010216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50821464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to critique of suffocation alarm theory 对窒息警报理论批判的回应
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010310
Donald F. Klein M.D.
{"title":"Response to critique of suffocation alarm theory","authors":"Donald F. Klein M.D.","doi":"10.1002/anxi.3070010310","DOIUrl":"10.1002/anxi.3070010310","url":null,"abstract":"","PeriodicalId":79474,"journal":{"name":"Anxiety","volume":"1 3","pages":"145-148"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/anxi.3070010310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50821492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Neurocognitive function in panic disorder and social phobia patients 惊恐障碍和社交恐惧症患者的神经认知功能
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010503
Gordon J. G. Asmundson Ph.D., Murray B. Stein, Derrick K. Larsen, John R. Walker
{"title":"Neurocognitive function in panic disorder and social phobia patients","authors":"Gordon J. G. Asmundson Ph.D.,&nbsp;Murray B. Stein,&nbsp;Derrick K. Larsen,&nbsp;John R. Walker","doi":"10.1002/anxi.3070010503","DOIUrl":"10.1002/anxi.3070010503","url":null,"abstract":"<p>A neuropsychological test battery designed to assess verbal learning and memory, visual memory, psychomotor speed, cognitive flexibility and concentration was administered to patients with panic disorder (N = 18) and social phobia (N = 18) and a group of healthy control subjects (N = 16). Overall, the neurocognitive performance of the panic disorder and social phobia patients was lower than that of control subjects. Analyses of the verbal test variables indicated reduced performance in panic disorder and social phobia patients, relative to control subjects, on measures of verbal learning and memory. In addition, panic disorder patients exhibited deficits on short-delay free recall. No group differences were observed on tests of visual memory, psychomotor speed, cognitive flexibility, and concentration. These results, while indicative of diminished neuropsychological test performance in patients with panic disorder and social phobia, do not suggest the presence of syndrome-specific or localized neurocognitive deficits. Anxiety 1:201–207 (1994/1995). © 1995 WIey-Liss, Inc.</p>","PeriodicalId":79474,"journal":{"name":"Anxiety","volume":"1 5","pages":"201-207"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/anxi.3070010503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50821507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 100
Sertraline in the treatment of patients with social phobia 舍曲林在治疗社交恐惧症患者中的作用
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010609
Eduina A. Martins M.D., Teresa A. Pigott, Suzanne E. Bernstein, Brian B. Doyle, Brent Sunderland, Virginia M. Smolka, Billinda Dubbert
{"title":"Sertraline in the treatment of patients with social phobia","authors":"Eduina A. Martins M.D.,&nbsp;Teresa A. Pigott,&nbsp;Suzanne E. Bernstein,&nbsp;Brian B. Doyle,&nbsp;Brent Sunderland,&nbsp;Virginia M. Smolka,&nbsp;Billinda Dubbert","doi":"10.1002/anxi.3070010609","DOIUrl":"10.1002/anxi.3070010609","url":null,"abstract":"","PeriodicalId":79474,"journal":{"name":"Anxiety","volume":"1 6","pages":"291-297"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/anxi.3070010609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20107018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Single ion gas chromatographic/mass spectroscopic quantitative analysis of environmental CO2 in agoraphobic environments 恐旷环境中二氧化碳的单离子气相色谱/质谱定量分析
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010605
Stephen Cox M.D., Jeff Lawrence, David Sheehan
{"title":"Single ion gas chromatographic/mass spectroscopic quantitative analysis of environmental CO2 in agoraphobic environments","authors":"Stephen Cox M.D.,&nbsp;Jeff Lawrence,&nbsp;David Sheehan","doi":"10.1002/anxi.3070010605","DOIUrl":"10.1002/anxi.3070010605","url":null,"abstract":"","PeriodicalId":79474,"journal":{"name":"Anxiety","volume":"1 6","pages":"275-277"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/anxi.3070010605","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20107019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Panic disorder in subjects with pure mania and depressive mania 单纯躁狂症和抑郁性躁狂症患者的惊恐障碍
Anxiety Pub Date : 1994-01-01 DOI: 10.1002/anxi.3070010611
Dr. Arif M. Shoaib, Steven C. Dilsaver
{"title":"Panic disorder in subjects with pure mania and depressive mania","authors":"Dr. Arif M. Shoaib,&nbsp;Steven C. Dilsaver","doi":"10.1002/anxi.3070010611","DOIUrl":"10.1002/anxi.3070010611","url":null,"abstract":"","PeriodicalId":79474,"journal":{"name":"Anxiety","volume":"1 6","pages":"302-304"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/anxi.3070010611","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20107021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
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