多肽和焦虑:五胃泌素在健康志愿者中的剂量反应评估

Anxiety Pub Date : 1994-01-01 DOI:10.1002/anxi.3070010603
Una D. McCann, Shiyoko O. Slate, Marilla Geraci, Thomas W. Uhde
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引用次数: 18

摘要

大量数据表明,大脑胆囊收缩素(CCK)系统参与焦虑的调节,大量研究表明,CCK-4,一种CCKB激动剂,可靠地诱导惊恐障碍患者的惊恐发作。最近,市售的CCKB激动剂pentagastrin也被报道具有类似的焦虑特性。为了进一步探索pentagastrin作为激发剂的效用,并确定其作用是否与剂量相关,在10名健康志愿者中进行了一项剂量-反应研究。在4个单独的挑战日中,以双盲方式在1分钟内注射Pentagastrin (0.2 μg/kg, 0.6 μg/kg和1.0 μg/kg)和非活性安慰剂。受试者在参与一个结构化的社会互动任务时接受了五甲斯特林。在基线和输注后反复测量焦虑、血压、脉搏、ACTH和皮质醇。Pentagastrin给药导致焦虑、脉搏、ACTH、皮质醇和恐慌的身体症状以剂量相关的方式增加。参与社会互动任务会导致焦虑程度增加,脉搏和血压也会增加。0.2 μg/kg剂量的pentagastrin与安慰剂、0.6 μg/kg剂量的pentagastrin与1.0 μg/kg剂量的pentagastrin之间差异不大。这些发现支持了CCK系统参与焦虑调节的观点,并建议0.6 μg/kg剂量可能是增加焦虑症状的最佳剂量,同时最大限度地减少令人不快的副作用。社会互动任务的强大焦虑效应强调了情境变量在挑战研究中的重要性。焦虑:258 - 267(1994/1995)。©1995 Wiley-Liss, Inc
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peptides and anxiety: A dose-response evaluation of pentagastrin in healthy volunteers

A large body of data suggest that brain cholecystokinin (CCK) systems are involved in the regulation of anxiety, and numerous studies have demonstrated that CCK-4, a CCKB agonist, reliably induces panic attacks in patients with panic disorder. Recently, pentagastrin, a commercially available CCKB agonist, has been reported to have similar anxiogenic properties. To further explore the utility of pentagastrin as a challenge agent and to determine whether its effects are dose-related, a dose-response study was conducted in ten healthy volunteers. Pentagastrin (0.2 μg kg, 0.6 μg/kg and 1.0 μg/kg) and inactive placebo were infused over one minute on four separate challenge days in a double-blind fashion. Subjects received pentagastrin while participating in a structured social interaction task. Repeated measures of anxiety, blood pressure, pulse, ACTH, and cortisol were taken at baseline and postinfusion. Pentagastrin administration led to increases in anxiety, pulse, ACTH, cortisol and physical symptoms of panic, in a dose-related manner. Participation in the social interaction task led to increases in measures of anxiety as well as increases in pulse and blood pressure. Few differences were found between the 0.2 μg/kg dose of pentagastrin and placebo, or between the 0.6 μg/kg and the 1.0 μg/kg doses of pentagastrin. These findings support the notion that CCK systems are involved in the regulation of anxiety, and suggest that the 0.6 μg/kg dose may be optimal for increasing symptoms of anxiety while minimizing unpleasant side effects. The powerful anxiogenic effects of the social interaction task underscore the importance of contextual variables in challenge studies. Anxiety 1:258–267 (1994/1995). © 1995 Wiley-Liss, Inc.

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