The Journal of maternal-fetal medicine最新文献

{"title":"Preterm premature rupture of membranes is not an independent risk factor for neonatal morbidity.","authors":"B. Furman, I. Shoham-Vardi, A. Bashiri, O. Erez, M. Mazor","doi":"10.1080/714904311","DOIUrl":"https://doi.org/10.1080/714904311","url":null,"abstract":"Objective : To evaluate the risk factors for development of neonatal morbidity in cases of preterm premature rupture of membranes (PPROM). Methods : The study population consisted of 2326 singleton preterm births occurring between 1994 and 1997 at Soroka University Medical Center. The neonatal morbidity included respiratory distress syndrome, intraventricular hemorrhage (grade III-IV), necrotizing enterocolitis, periventricular leukomalacia, bronchopulmonary dysplasia, neonatal pneumonia and sepsis. A cross-sectional study was designed to compare neonatal morbidity between two groups: the study group consisted of patients with PPROM ( n = 376) and the comparison group of patients without PPROM ( n = 1950). Results : The prevalence of the neonatal morbidity associated with PPROM was 13.0% (49/376). There was no statistically significant difference in neonatal morbidity rates between the PPROM group and the group with intact membranes in any of the birth-weight groups (Mantel-Haenszel weighted odds ratio 1....","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"31 1","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78719691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes in women with systemic lupus erythematosus.","authors":"S. Yasmeen, E. Wilkins, N. Field, R. A. Sheikh, W. Gilbert","doi":"10.1080/714904302","DOIUrl":"https://doi.org/10.1080/714904302","url":null,"abstract":"Objective : The purpose of this study was to examine pregnancy outcomes in women with systemic lupus erythematosus (SLE). Study design : Data from the California Health Information for Policy Project, which links records from birth certificates and hospital discharge records of mothers and newborns who delivered in all civilian hospitals in the state of California between 1 January 1993 and 31 December 1994, were retrospectively reviewed. Patients with a singleton gestation were stratified into the study group if they had a diagnosis of SLE, based on the International Classification of Disease, 9th Revision, or into the control group if they did not have SLE and delivered during the interval from 1 January 1994 to 31 December 1994. Specific maternal outcomes including pregnancy complications and fetal and neonatal outcomes were assessed and compared between the two groups. Results : During the 2-year study period, 555 women had a diagnosis of SLE, and approximately 600 000 women were included in the contr...","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"30 1","pages":"91-96"},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73116048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of epidural analgesia on rates of episiotomy use and episiotomy extension in an inner-city hospital.","authors":"M. Newman, M. Lindsay, W. Graves","doi":"10.1080/714052725","DOIUrl":"https://doi.org/10.1080/714052725","url":null,"abstract":"Objective : To determine the relationship between epidural analgesia and episiotomy usage and episiotomy extension in parturients delivering vaginally. Methods : A database of 20 888 women experiencing spontaneous vaginal delivery at Grady Memorial Hospital from 1990 to 1995 was examined to identify those receiving epidural analgesia. Patients who underwent epidural catheter placement and had adequate perineal anesthesia at delivery comprised the epidural group, and all others comprised the control group. Demographic characteristics and obstetric outcomes were compared. Univariate and multivariate analyses were used to test the association between epidural analgesia, rates of episiotomy and episiotomy extension. Results : Of the 20 888 women experiencing spontaneous vaginal deliveries 6785 (32.5%) received epidural analgesia. Women receiving epidural analgesia were more likely than those not receiving epidural analgesia to be African-American and nulliparous, and to have an occiput posterior presentation....","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"21 1","pages":"97-101"},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81745796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artifactual fetal electrocardiographic detection using internal monitoring following intrapartum fetal demise during VBAC trial","authors":"Patrick S. Ramsey,&nbsp;Bruce W. Johnston,&nbsp;Vincent E. Welter,&nbsp;Paul L. Ogburn Jr.","doi":"10.1002/1520-6661(200011/12)9:6<360::AID-MFM1008>3.0.CO;2-Y","DOIUrl":"10.1002/1520-6661(200011/12)9:6<360::AID-MFM1008>3.0.CO;2-Y","url":null,"abstract":"<p>Absent or erratic fetal electrocardiographic signal can result in artifactual electronic fetal heart rate recording. We report a case where detection of maternal heart rate through internal fetal scalp monitor may have masked intrauterine fetal demise secondary to acute uterine rupture during a VBAC trial. J. Matern.-Fetal Med. 2000;9:360–361. © 2000 Wiley-Liss, Inc.</p>","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"9 6","pages":"360-361"},"PeriodicalIF":0.0,"publicationDate":"2001-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1520-6661(200011/12)9:6<360::AID-MFM1008>3.0.CO;2-Y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76998666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Will cervicovaginal interleukin-6 combined with fetal fibronectin testing improve the prediction of preterm delivery?","authors":"Nanette LaShay,&nbsp;George Gilson,&nbsp;Gary Joffe,&nbsp;Clifford Qualls,&nbsp;Luis Curet","doi":"10.1002/1520-6661(200011/12)9:6<336::AID-MFM1003>3.0.CO;2-F","DOIUrl":"https://doi.org/10.1002/1520-6661(200011/12)9:6<336::AID-MFM1003>3.0.CO;2-F","url":null,"abstract":"<div>\u0000 \u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We sought to investigate if determination of cervicovaginal interleukin-6 (IL-6) levels would enhance the positive predictive value of fetal fibronectin (fFN) for preterm birth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective cohort study was undertaken of 135 women between 24 and 34 weeks gestation with symptoms of suspected preterm labor. Cervicovaginal secretions were collected for both IL-6 and fFN and measured by immunoassay and ELISA, respectively. Outcome variables included preterm delivery in less than 48 h, within 7 days, and prior to 37 weeks. Statistical analysis was performed with Fisher's exact test, regression for logarithmic transform levels, and multivariate logistic regression. ROC curves were created for IL-6 levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>IL-6 and fFN levels were both elevated in cervicovaginal secretions of women with symptoms of preterm labor. IL-6 values &gt;100 pg/ml resulted in a odds ratio for delivery at &lt;37 weeks of 1.57 (95%CI=0.89–2.75, <i>P</i>=.11), whereas fFN values &gt;50 ng/ml resulted in a preterm delivery risk of 4.58 (95%CI=1.54–13.35, <i>P</i>=.003). Combining IL-6 and fFN results did not improve upon the predictive value of fFN alone for preterm birth [odds ratio 4.00 (95%CI=1.31–12.17, <i>P</i>=.015)].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cervicovaginal IL-6 levels did not provide any additional, independent effect on the prediction of preterm birth beyond that of fFN testing alone. J. Matern.-Fetal Med. 2000;9:336–341. © 2000 Wiley-Liss, Inc.</p>\u0000 </section>\u0000 </div>","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"9 6","pages":"336-341"},"PeriodicalIF":0.0,"publicationDate":"2001-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1520-6661(200011/12)9:6<336::AID-MFM1003>3.0.CO;2-F","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134806117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short cervix: A cause of preterm delivery in young adolescents?†","authors":"Catherine Stevens-Simon,&nbsp;Joan Barrett,&nbsp;James A. McGregor,&nbsp;Janice French,&nbsp;Wayne Persutte","doi":"10.1002/1520-6661(200011/12)9:6<342::AID-MFM1004>3.0.CO;2-D","DOIUrl":"https://doi.org/10.1002/1520-6661(200011/12)9:6<342::AID-MFM1004>3.0.CO;2-D","url":null,"abstract":"<div>\u0000 \u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To test the hypothesis that at midgestation younger adolescents (&lt;16 years of age at conception) have shorter cervices than older adolescents (16–19 years of age at conception).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>At midgestation (22.9 ± 2.4 weeks) we measured cervical length by transvaginal ultrasound in a group of 46 13–19-year-old participants in an intensive, adolescent-oriented, antenatal program. Subjects were also comprehensively screened and treated for other recognized physiologic, microbiologic, obstetric, behavioral, and psychosocial factors associated with preterm delivery. Univariate, bivariate, and logistic regression analyses were used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 18 younger adolescents had significantly shorter cervices than the 28 older adolescents (30 ± 11 mm vs. 39 ± 8 mm; <i>P</i> = 0.002). The younger adolescents' cervices were also more likely to be ≤25 mm long (33% and 4%, respectively; <i>P</i> = 0.02) and to exhibit funneling (39% vs. 4%; <i>P</i> = 0.01). Teenagers with cervices ≤25 mm long were younger, thinner, more apt to report vaginal bleeding and substance abuse, and to be treated for preterm labor (71% vs. 21%; <i>P</i> = 0.005). Logistic regression analyses revealed that age &lt;16 years at conception (odds ratio = 13.7; 95% CI: 1.3–151.4) and substance abuse (odds ratio = 8.5; 95% CI: 1.2–62.8) were associated with cervical length ≤25 mm. Cervical length ≤25 mm was the only significant predictor of preterm delivery (odds ratio = 26.2; 95% CI: 2.1–333.6; <i>P</i> = 0.01) in this population of adolescents who were routinely treated for other recognized causes of preterm delivery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Cervical length ≤25 mm and cervical funneling may be complications of conception prior to 16 years of age. Randomized trials are needed to determine if younger adolescents benefit preferentially from ultrasound screening for short cervix at midgestation. J. Matern.-Fetal Med. 2000;9:342–347. © 2000 Wiley-Liss, Inc.</p>\u0000 </section>\u0000 </div>","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"9 6","pages":"342-347"},"PeriodicalIF":0.0,"publicationDate":"2001-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1520-6661(200011/12)9:6<342::AID-MFM1004>3.0.CO;2-D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134806118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Color flow mapping for myometrial invasion in women with a prior cesarean delivery","authors":"Diane M. Twickler,&nbsp;Michael J. Lucas,&nbsp;Amy Brown Balis,&nbsp;Rigoberto Santos-Ramos,&nbsp;Lisa Martin,&nbsp;Shirley Malone,&nbsp;Beverly Rogers","doi":"10.1002/1520-6661(200011/12)9:6<330::AID-MFM1002>3.0.CO;2-O","DOIUrl":"10.1002/1520-6661(200011/12)9:6<330::AID-MFM1002>3.0.CO;2-O","url":null,"abstract":"<div>\u0000 \u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Objectives:</p>\u0000 \u0000 <p>Our aim was to evaluate the utility of color flow mapping in the prediction of placental myometrial invasion in women with Cesarean delivery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ultrasound color flow mapping was performed on placental implantations in potential proximity to the hysterotomy scar. The smallest myometrial thickness was measured under the placenta to evaluate the degree of myometrial attenuation in this area and note was made of unusual vascular lakes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two hundred fifteen women with placentas in proximity to the prior hysterotomy scar underwent color Doppler mapping. Of 20 women with placenta previa and Cesarean delivery, 15 had Cesarean hysterectomy for bleeding complications and nine had the pathological diagnosis of placental invasion. The measurement of &lt;1 mm for the smallest myometrial thickness or presence of large intraplacental lakes was predictive of myometrial invasion (sensitivity 100%, specificity 72%, PPPV 72%, and NPV 100%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Color flow mapping predicted myometrial invasion when the smallest myometrial thickness was &lt;1 mm and large intraplacental lakes were demonstrated. J. Matern.-Fetal Med. 2000;9:330–335. © 2000 Wiley-Liss, Inc.</p>\u0000 </section>\u0000 </div>","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"9 6","pages":"330-335"},"PeriodicalIF":0.0,"publicationDate":"2001-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1520-6661(200011/12)9:6<330::AID-MFM1002>3.0.CO;2-O","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85280047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent fetal cystic hygroma with normal chromosomes: Case report and review of the literature†","authors":"Katherine E. Teague,&nbsp;Maurice K. Eggleston,&nbsp;Patrick E. Muffley,&nbsp;Robert B. Gherman","doi":"10.1002/1520-6661(200011/12)9:6<366::AID-MFM1010>3.0.CO;2-E","DOIUrl":"10.1002/1520-6661(200011/12)9:6<366::AID-MFM1010>3.0.CO;2-E","url":null,"abstract":"<p>Recurrence of fetal cystic hygroma in subsequent pregnancies is extremely rare. A review of the literature to date revealed only two other reports of recurrence with normal fetal karyotypes documented in at least two of the affected pregnancies. At 11 weeks' gestation, the fetus of a 19-year-old gravida 3 para 0 was discovered to have a large cystic hygroma. Subsequent evaluation during the second trimester revealed increasing size of the septated nuchal mass and ascites. A 46,XX fetal karyotype was noted in her two prior pregnancies, both of which had also been complicated by the development of cystic hygroma and nonimmune hydrops. Cystic hygroma, associated with a normal karyotype, can be inherited as an autosomal recessive trait. J. Matern.-Fetal Med. 2000;9:366–369. © 2000 Wiley-Liss, Inc.</p>","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"9 6","pages":"366-369"},"PeriodicalIF":0.0,"publicationDate":"2001-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1520-6661(200011/12)9:6<366::AID-MFM1010>3.0.CO;2-E","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72410515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbilical vein white blood cell count as a marker of acidemia in term neonates","authors":"Kathleen M. Hanlon-Lundberg,&nbsp;Russell S. Kirby","doi":"10.1002/1520-6661(200011/12)9:6<327::AID-MFM1001>3.0.CO;2-N","DOIUrl":"10.1002/1520-6661(200011/12)9:6<327::AID-MFM1001>3.0.CO;2-N","url":null,"abstract":"<div>\u0000 \u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>White blood cells are mobilized under both hypoxic and infectious conditions. Intrauterine hypoxia is linked to increased risk of cerebral palsy and is potentiated by the presence of infection. We hypothesized that umbilical vein white blood cell elevation in term neonates is associated with intrauterine acidemia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We prospectively evaluated all liveborn neonates delivered at our institution for a 6-month period. Umbilical arterial blood was analyzed for pH and blood gas and venous blood for hematologic indices. Medical records of cases greater than or equal to 37 weeks' gestation were reviewed for correlative data. Student's <i>t</i>-test was used to determine difference of means and Chi-square test for goodness of fit. Pearson coefficients of correlation were applied where appropriate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1,948 liveborn, term neonates were delivered during the study period; 1,561 cases had white blood cell analysis and arterial blood gas data available. Acidemic cases had higher white blood cell (15.0 vs. 12.4 cells × 10³/mm³, <i>P</i> &lt; 0.001), lymphocyte (4.43 vs. 3.59 cells × 10³/mm³, <i>P</i> &lt; 0.0001), and neutrophil counts (9.08 vs. 7.71 cells × 10³/mm³, <i>P</i> &lt; 0.01). As umbilical artery pH decreased, white blood cells became more prevalent. Likewise, as base deficit deepened, white blood cell counts increased.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrates an association between deepening acidemia and increasing white blood cell, lymphocyte, and neutrophil counts. Although statistically different, mean white blood cell counts for acidemic and nonacidemic cases are fairly close, limiting the clinical applicability in determining whether pathology is present in an individual case. J. Matern.-Fetal Med. 2000;9:327–329. © 2000 Wiley-Liss, Inc.</p>\u0000 </section>\u0000 </div>","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"9 6","pages":"327-329"},"PeriodicalIF":0.0,"publicationDate":"2001-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1520-6661(200011/12)9:6<327::AID-MFM1001>3.0.CO;2-N","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74668649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of lipopolysaccharide on interleukin-6 production in perfused human placental cotyledons†","authors":"Richard K. Wagner,&nbsp;Roger M. Hinson,&nbsp;Christina C. Apodaca,&nbsp;Nathan Hoeldtke,&nbsp;Trey Buchanan,&nbsp;Roderick F. Hume Jr.,&nbsp;Byron C. Calhoun","doi":"10.1002/1520-6661(200011/12)9:6<351::AID-MFM1006>3.0.CO;2-5","DOIUrl":"10.1002/1520-6661(200011/12)9:6<351::AID-MFM1006>3.0.CO;2-5","url":null,"abstract":"<div>\u0000 \u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To determine if lipopolysaccharide (LPS) alters production of interleukin-6 (IL-6) or vascular tone in perfused placental cotyledons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Control and study cotyledons from nine placentas were perfused for 3 h. Study cotyledons received LPS in concentrations of 0.01 mcg/ml (n = 3), 0.1 mcg/ml (n = 3), or 1.0 mcg/ml (n = 3). Effluents were collected at 30, 60, 120, and 180 min following infusion with LPS. IL-6 concentrations were measured by enzyme-linked immunosorbant assay. Perfusion pressures were recorded at 10-min intervals. Data were analyzed using ANOVA for repeated measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>IL-6 production significantly increased over time in both the study and control cotyledons (<i>P</i> = 0.002). LPS treatment did not affect IL-6 production (<i>P</i> = 0.85) and there were no observable dose effects (<i>P</i> = 0.13). Perfusion pressures did not differ (<i>P</i> = 0.16).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The isolated perfused placental cotyledon produces IL-6 and concentrations increase over time. LPS does not alter production of IL-6 or fetoplacental vascular tone. J. Matern.-Fetal Med. 2000;9:351–355. © 2000 Wiley-Liss, Inc.</p>\u0000 </section>\u0000 </div>","PeriodicalId":79464,"journal":{"name":"The Journal of maternal-fetal medicine","volume":"9 6","pages":"351-355"},"PeriodicalIF":0.0,"publicationDate":"2001-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1520-6661(200011/12)9:6<351::AID-MFM1006>3.0.CO;2-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81806772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}