General & diagnostic pathology最新文献_第4页

What's new in gestational trophoblastic disease? 妊娠滋养细胞疾病有什么新进展?

General & diagnostic pathology Pub Date : 1997-11-01

K Benirschke

引用次数: 0

Histologic classification and staging of gestational trophoblastic disease. 妊娠滋养细胞疾病的组织学分类和分期。

General & diagnostic pathology Pub Date : 1997-11-01

L C Horn, K Bilek

{"title":"Histologic classification and staging of gestational trophoblastic disease.","authors":"L C Horn, K Bilek","doi":"","DOIUrl":"","url":null,"abstract":"Gestational trophoblastic disease (GTD) forms a heterogeneous group of interrelated lesions which are characterized by an abnormal proliferation of the different types of trophoblastic epithelium. Complete hydatidiform moles represent a noninvasive placental disease that is characterized by hydropic swelling of the chorionic villi with marked trophoblastic proliferation. The partial mole contains two populations of villi: one of normal size, the other hydropic with less marked trophoblastic hyperplasia. The risk of developing persistent GTD is very low. Choriocarcinomas represent an avillous invasive proliferation of trophoblastic cells surrounded by necroses and hemorrhages displaying a dimorphic pattern with early vascular invasion and hematogeneous metastatic spread. Placental site trophoblastic tumor (PSTT) resembles the rarest form of GTD. In its cellular composition, PSTT preferentially contains intermediate trophoblastic cells with typically positive hPL-immunostaining. Mostly, PSTT's are benign tumors, but malignant cases are well known. Miscelleanous forms of GTD include the exaggerated placental site and the placental site nodule or plaque. Both lesions are proliferations of the intermediate trophoblast. Staging of GTD should only be applied in cases of persistent disease. All different staging systems, including the revised FIGO system, the classification of the National Institute of Health (NIH), the WHO scoring system and the currently adopted TNM-system are able to define high risk patients.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 2-3","pages":"87-101"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20371481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential diagnosis of hydatidiform moles. 葡萄胎的鉴别诊断。

General & diagnostic pathology Pub Date : 1997-11-01

H Fox

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Clinicopathologic analysis of gestational trophoblastic disease--report of 158 cases. 妊娠滋养细胞病158例临床病理分析

General & diagnostic pathology Pub Date : 1997-11-01

L C Horn, K Bilek

{"title":"Clinicopathologic analysis of gestational trophoblastic disease--report of 158 cases.","authors":"L C Horn, K Bilek","doi":"","DOIUrl":"","url":null,"abstract":"Gestational trophoblastic disease (GTD) forms a heterogeneous pool of clinically and histopathologically defined entities with different malignant potential. The clinicopathologic characteristics of 158 cases, including 110 complete hydatidiform moles (CHM), 13 invasive moles, 32 choriocarcinomas, two placental site nodules and one placental site trophoblastic tumor are reported. Of all cases, 63.9% showed spontaneous regression after D&C. 36.1% resulted in a persistent or metastatic (11.4%) disease, including 12 CHM. Lung is found to be the most common site of metastasis (61%). The median time between antecedent pregnancy and GTD was 4.4 months. 44% had an antecedent CHM, 16% a term pregnancy. The median complete remission rate was 91.2% with 5.3% recurrent disease. Three women died. Eight patients received adjuvant surgical therapy for chemoresistant foci. In general, management of GTD is interdisciplinary with an emphasis placed on individualized treatment. In most cases, exact histopathologic diagnosis of the trophoblastic lesion remains the gold standard for guiding clinical therapy. Currently, there are no reliable genetic or molecular biologic markers predicting an aggressive behavior of CHM. Thus, all lesions should be followed by serial measurements of serum-HCG. All cases of persistent GTD should be treated in specialized centers.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 2-3","pages":"173-8"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20371419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The epidemiology of gestational trophoblastic disease. 妊娠滋养细胞疾病的流行病学。

General & diagnostic pathology Pub Date : 1997-11-01

E Di Cintio, F Parazzini, C Rosa, L Chatenoud, G Benzi

引用次数: 0

Trophoblastic lesions of the placental site. 胎盘部位的滋养层损伤。

General & diagnostic pathology Pub Date : 1997-11-01

R N Baergen, J L Rutgers

{"title":"Trophoblastic lesions of the placental site.","authors":"R N Baergen, J L Rutgers","doi":"","DOIUrl":"","url":null,"abstract":"The trophoblast of the chorionic villi as well as the hydatidiform mole and choriocarcinoma have been recognized and studied for many years. However, the trophoblast comprising the implantation site, chorionic plate, chorion laeve, cell islands and septa have only in recent years received attention in the literature. These \"extravillous\" trophoblastic cells were originally referred to as \"X\" cells due to doubt regarding their derivation from either maternal or fetal tissue (70). Subsequent studies determined that they were trophoblastic in origin (42), but the term X-cell is still in use today by some researchers (30, 4). Due to continued uncertainty regarding their nature and origin, many other terms have been used including syncytial wandering cells (21), placental site trophoblast, placental site giant cells (42), extravillous trophoblast (25), extravillous cytotrophoblast, nonvillous trophoblast, and intermediate trophoblast (49). Light microscopic and immunohistochemical studies have led to elucidation of specific morphologic and biochemical features of the extravillous trophoblast (48-50) which is commonly designated as the \"intermediate trophoblast\". Lesions of the \"intermediate\" or extravillous trophoblast of the placental site include the exaggerated placental site, the placental site trophoblast tumor and the recently described placental site nodule. This article will review the clinical and pathologic features of these lesions, their differential diagnosis, treatment, and prognostic factors after discussion of the origin, nature and definition of the \"intermediate\" trophoblast.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 2-3","pages":"143-58"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20371486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic aspects of gestational trophoblastic diseases: a general overview with emphasis on new approaches in determining genetic composition. 妊娠滋养细胞疾病的遗传方面:一般概述，重点是确定遗传组成的新方法。

General & diagnostic pathology Pub Date : 1997-11-01

J M Lage, S S Sheikh

引用次数: 0

Gestational choriocarcinoma. 妊娠期绒毛膜癌。

General & diagnostic pathology Pub Date : 1997-11-01

R N Baergen

{"title":"Gestational choriocarcinoma.","authors":"R N Baergen","doi":"","DOIUrl":"","url":null,"abstract":"The malignant transformation of trophoblast is interesting to contemplate, as trophoblast normally behaves in a manner that is interpreted as indicative of malignancy. First of all, trophoblasts show \"controlled invasion\" at the placental site as part of the normal process of implantation. Secondly, it is estimated that 100,000 syncytiotrophoblastic cells are deported to the maternal circulation daily and these are commonly identified in the pulmonary circulation of pregnant women (38). These trophoblastic cells do not ordinarily produce disease and presumably are rejected by the mother, unlike true metastases. When trophoblastic malignancy does develop, however, the trophoblast continues to invade and grow without limit, eventually metastasizing and ultimately leading to death. Choriocarcinoma is, therefore, unique in that it represents a malignant transformation of a tissue that inherently has \"invasive\" and \"metastatic\" properties. It is also the only tumor which contains DNA foreign to the host, as it is derived from a conception which contains paternal genetic material. Thus, choriocarcinoma is a complex neoplasm, and to study it, one must study and understand graft rejection, immunologic mechanisms and a multitude of genetic concepts in addition to the mechanisms of invasion and metastasis.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 2-3","pages":"127-41"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20371485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of gestational trophoblastic disease. 妊娠滋养细胞疾病的治疗。

General & diagnostic pathology Pub Date : 1997-11-01

M J Seckl, E S Newlands

引用次数: 0

Stereologic estimates of volume-weighted mean nuclear volume in colorectal adenocarcinoma: correlation with histologic grading, Dukes' staging, cell proliferation activity and p53 protein expression. 结直肠癌体积加权平均核体积的体视学评估:与组织学分级、Dukes分期、细胞增殖活性和p53蛋白表达的相关性

General & diagnostic pathology Pub Date : 1997-07-01

R Martín, S Nieto, L Santamaría

{"title":"Stereologic estimates of volume-weighted mean nuclear volume in colorectal adenocarcinoma: correlation with histologic grading, Dukes' staging, cell proliferation activity and p53 protein expression.","authors":"R Martín, S Nieto, L Santamaría","doi":"","DOIUrl":"","url":null,"abstract":"Colorectal cancer has been studied from the point of view of the relationships between several variables, including proliferative activity and p53 protein expression. However, stereologic evaluation of nuclear size has not been thoroughly described. In the present study, measurements of the volume-weighted mean nuclear volume (nuclear Vv), have been performed in well, moderately and poorly differentiated colorectal adenocarcinomas and correlated with the Dukes' stage and other factors such as proliferative activity and p53 protein immunoreactivity. Although the mean values of nuclear Vv were higher in poorly differentiated cancers or Dukes' C&D stage than in well and moderately differentiated tumors or Dukes' A&B stage, these differences were not significant. However, the variability of nuclear size in colorectal cancers was more relevant than the mean values of nuclear Vv with respect to their invasive classification. The carcinomas which extended beyond the serosa (Dukes' stage C&D) had higher biologic variation than those grouped as Dukes' stage A&B. The results of the present study also indicate that nuclear size in colorectal cancers has a positive correlation with both proliferative activity and p53 protein expression. The relationship between nuclear Vv and proliferative activity emphasizes the possible prognostic relevance of this stereologic estimate of nuclear size in colorectal adenocarcinoma.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20211963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0