General & diagnostic pathology最新文献_第3页

The consequences for renal function of the glomerular deposition of PAS positive material in proliferative glomerulopathies. A quantitative study. 增生性肾小球病变中PAS阳性物质肾小球沉积对肾功能的影响。定量研究。

General & diagnostic pathology Pub Date : 1997-12-01

M Danilewicz, M Wagrowska-Danilewicz

{"title":"The consequences for renal function of the glomerular deposition of PAS positive material in proliferative glomerulopathies. A quantitative study.","authors":"M Danilewicz, M Wagrowska-Danilewicz","doi":"","DOIUrl":"","url":null,"abstract":"15 renal biopsy specimens from patients with mesangial proliferative glomerulopathy (MPGN), 15 from patients with IgA nephropathy (IgAN), and 15 from patients with mesangiocapillary glomerulopathy type I (MCGN-I), for whom both light and electron microscopy as well as immunofluorescence microscopy and full clinical data were available, were examined and compared with 15 normal controls. Morphometric investigations were performed by means of a computer image analysis system to evaluate quantitatively the glomerular deposition of PAS positive material in these glomerulopathies, as well as to assay whether this parameter could correlate with the renal function. The morphometric study demonstrated that the mean values of glomerular deposition of PAS positive material (% of total glomerular area) were similar in MPGN, IgAN, and MCGN-I. Although correlations between glomerular deposition of PAS positive material and serum creatinine tended to be positive in MPGN, IgAN and MCGN-I, they were weak and not significant. Thus, the present study could not confirm earlier suggestions concerning a significant correlation between these parameters.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 4","pages":"225-30"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20415196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudoangiomatous hyperplasia of mammary stroma in an HIV patient. HIV患者乳腺间质假性血管瘤增生。

General & diagnostic pathology Pub Date : 1997-12-01

N de Saint Aubain Somerhausen, D Larsimont, N Cluydts, O Heymans, A Verhest

引用次数: 0

Histiocytosis of regional lymph nodes associated with hip replacement. 与髋关节置换术相关的局部淋巴结组织细胞增生。

General & diagnostic pathology Pub Date : 1997-12-01

D Dudorkinová, C Povýsil, R Tomanová

引用次数: 0

Mammary hamartoma with brown adipose tissue. 乳腺错构瘤伴棕色脂肪组织。

General & diagnostic pathology Pub Date : 1997-12-01

M F Garijo, B Torío, J F Val-Bernal

引用次数: 0

Tumor proliferative fraction in infiltrating duct carcinoma. 浸润性导管癌的肿瘤增殖分数。

General & diagnostic pathology Pub Date : 1997-12-01

A L Kesari, V G Chellam, P P Nair, J Madhavan, P Nair, M K Nair, M R Pillai

{"title":"Tumor proliferative fraction in infiltrating duct carcinoma.","authors":"A L Kesari, V G Chellam, P P Nair, J Madhavan, P Nair, M K Nair, M R Pillai","doi":"","DOIUrl":"","url":null,"abstract":"Deregulated cell proliferation is a key factor in malignancy and therefore may be of prognostic significance. Both Proliferating Cell Nuclear Antigen (PCNA) and silver binding Argyrophilic Nucleolar Organizer Regions (AgNORs) have been established as a valuable reflection of the tissue proliferative compartment and hence could be of value in studying the biologic behavior of malignant cells. In the present study, we evaluated the proliferative activity of 120 infiltrating duct carcinomas by analysing for PCNA and AgNOR expression in relation to pathologic variables. The AgNOR scores were significantly greater in the malignant tissue than in benign lesions. Expression of PCNA was also found to be increased in malignant breast tumors, when compared to controls. A strong positive correlation between PCNA immunoreactivity and AgNORs was evident. There was also a positive correlation between histologic grading and AgNOR score in breast cancer (r = 0.92, p = 0.000). Tumor with elevated AgNOR counts were often poorly differentiated. It is therefore apparent that evaluation of AgNORs and PCNA may help in the elaboration of histopathologic grading of infiltrating duct carcinoma and may be of prognostic significance.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 4","pages":"219-24"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20414642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bellini duct carcinoma of the kidney--a case report. 肾贝利尼管癌1例报告。

General & diagnostic pathology Pub Date : 1997-12-01

H U Kasper, P Buhtz, G Krüger, D Samland, A Roessner

引用次数: 0

Angiomyomatous hamartoma of the lymph node: case report with adipose tissue component. 淋巴结血管肌瘤错构瘤:含脂肪组织成分1例报告。

General & diagnostic pathology Pub Date : 1997-12-01

G Magro, S Grasso

引用次数: 0

Villous cytotrophoblast proliferating potential in complete and partial hydatidiform mole: diagnostic value of silver-stained nucleolar organizer region (AgNOR)-associated proteins. 完全和部分葡萄胎绒毛细胞滋养细胞增殖潜能:银染色核仁组织区(AgNOR)相关蛋白的诊断价值。

General & diagnostic pathology Pub Date : 1997-11-01

H Neudeck, M Unger, P Hufnagl, B Eiben, K Peters, J Kalla, R Graf, M Vogel

{"title":"Villous cytotrophoblast proliferating potential in complete and partial hydatidiform mole: diagnostic value of silver-stained nucleolar organizer region (AgNOR)-associated proteins.","authors":"H Neudeck, M Unger, P Hufnagl, B Eiben, K Peters, J Kalla, R Graf, M Vogel","doi":"","DOIUrl":"","url":null,"abstract":"Aside from their typical morphologic features, complete (CHM) and partial hydatidiform mole (PHM) are characterized by variable trophoblastic proliferation and/or atypia. CHM and PHM usually present little diagnostic difficulty. However, some may be extremely difficult to distinguish by morphologic features alone. Therefore, we investigated the diagnostic value of silver-stained nucleolar organizer region (AgNOR)-associated proteins in cytotrophblasts as compared to cytogenetic features of nine CHM, nine PHM and six non-molar spontaneous embryonic abortions (controls), as well as of two suspected CHM and two histologically suspected PHM. Tissue sections were submitted to autoclave pretreatment and to silver colloid solution. The proliferating potential of cytotrophoblasts was determined by the analysis of mean number and mean area of AgNORs per nucleus using a PC-based image analysis system. Mean values of AgNOR parameters were significantly different from each other (p < 0.001). Each of the four cases of tentative diagnosis could be assigned to the corresponding group of examined trophoblastic lesions. The evaluation of AgNORs in cytotrophoblasts contributes to a reliable discrimination of CHM and PHM; this fairly simple and economical method could serve as an useful addition to conventional methods of diagnosis in gestational trophoblastic disease.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 2-3","pages":"179-84"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20371420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-erbB-2 amplification and expression in gestational trophoblastic disease correlates with DNA content and karyotype. C-erbB-2在妊娠滋养细胞疾病中的扩增和表达与DNA含量和核型相关。

General & diagnostic pathology Pub Date : 1997-11-01

M Bauer, L C Horn, J Kowalzik, W Mair, K Czerwenka

引用次数: 0

Postpartal gestational choriocarcinoma fatally misdiagnosed as squamous cell cancer of the uterine cervix. 妊娠期后绒毛膜癌被误诊为宫颈鳞状细胞癌。

General & diagnostic pathology Pub Date : 1997-11-01

L C Horn, K Bilek, H Nenning

{"title":"Postpartal gestational choriocarcinoma fatally misdiagnosed as squamous cell cancer of the uterine cervix.","authors":"L C Horn, K Bilek, H Nenning","doi":"","DOIUrl":"","url":null,"abstract":"Gestational choriocarcinoma (CCA) is a well-defined tumor, but there may be a surprising variation in its morphologic appearance. A 33-year-old woman with term-pregnancy six months before presented with dysfunctional bleedings that lasted about five weeks. Cervical punch biopsy and currettage revealed a polymorphic tumor which was initially diagnosed as poorly differentiated squamous cell cancer of the cervix. Methotrexat monochemotherapy was performed after histology definitely revealed CCA on the radical abdominal hysterectomy-specimen (Wertheim-Meigs). Immediately after HE, the patient developed diffuse pulmonary metastases and died of respiratory insufficiency after two courses of MTX-therapy. The autopsy confirmed metastatic CCA. The second patient, a 48-year-old women with pregnancy 24 years before, was initially treated with radical HE after misdiagnosis of cervical currettage as squamous cell cancer of the uterine cervix. The patient showed complete remission after two courses of medium risk-protocol and seven courses of high risk-protocol (CHAMOCA). All cervical curettage specimens which did not show typical squamous cell cancer. even in older women, were suspicious of CCA. CCA often shows degenerative changes or predominantly intermediate or cytotrophoblastic cellular elements. To detect the cells of most diagnostic value in CCA, the syncytiotrophoblastic elements, HCG-immunohistochemistry may be helpful.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 2-3","pages":"191-6"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20371422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0