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Spindle cell hemangioendotheliomas associated with multiple skeletal enchondromas: a variant of Maffucci's syndrome. 梭形细胞血管内皮瘤与多发性骨骼内生纤维瘤相关:马夫奇综合征的一种变体。
General & diagnostic pathology Pub Date : 1998-04-01
S Yáñez, J F Val-Bernal, C Mira, M A Echevarría, M C González-Vela, F Arce
{"title":"Spindle cell hemangioendotheliomas associated with multiple skeletal enchondromas: a variant of Maffucci's syndrome.","authors":"S Yáñez,&nbsp;J F Val-Bernal,&nbsp;C Mira,&nbsp;M A Echevarría,&nbsp;M C González-Vela,&nbsp;F Arce","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An unusual case of Maffucci's syndrome confined to an extremity with an additional superficial lymphangioma in the same limb is described. The patient, a 47-year-old woman, presented with several painful subcutaneous spindle cell hemangioendotheliomas (SCHs) and multiple lytic bone lesions, some calcified, in the left leg. She has been followed for two years and continues to do well. The combination of SCHs and multiple enchondromas (ENCHs) should be searched in any patient who presents with SCHs or multiple ENCHs, because there is a significant risk of malignant transformation.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 5-6","pages":"331-5"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20572474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcomatoid carcinoma (carcinosarcoma) of the gallbladder. 胆囊肉瘤样癌(癌肉瘤)。
General & diagnostic pathology Pub Date : 1998-04-01
J Ryś, A Kruczak, M Iliszko, M Babińska, A Wasilewska, J Limon, A Niezabitowski
{"title":"Sarcomatoid carcinoma (carcinosarcoma) of the gallbladder.","authors":"J Ryś,&nbsp;A Kruczak,&nbsp;M Iliszko,&nbsp;M Babińska,&nbsp;A Wasilewska,&nbsp;J Limon,&nbsp;A Niezabitowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report a case of carcinoma of the gallbladder in a 67-year-old woman. The description comprises the histological, immunohistochemical, ultrastructural and cytogenetical picture of the tumor. The ultrastructural features as well as chromosomal changes may denote the epithelial derivation of the tumor studied.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 5-6","pages":"321-5"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20572472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic assessment of histologic parameters in breast carcinomas: a prospective study. 乳腺癌组织学参数的预后评估:一项前瞻性研究。
General & diagnostic pathology Pub Date : 1998-04-01
A Niezabitowski, J Skołyszewski, J Ryś, A Gruchała, A Sokołowski, A Stelmach, B Lackowska, W Sklarski, A Wasilewska, A Kruczak, I Swiatkiewicz
{"title":"Prognostic assessment of histologic parameters in breast carcinomas: a prospective study.","authors":"A Niezabitowski,&nbsp;J Skołyszewski,&nbsp;J Ryś,&nbsp;A Gruchała,&nbsp;A Sokołowski,&nbsp;A Stelmach,&nbsp;B Lackowska,&nbsp;W Sklarski,&nbsp;A Wasilewska,&nbsp;A Kruczak,&nbsp;I Swiatkiewicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A group of 350 unselected breast cancer patients, treated at the Center of Oncology in Cracow, Poland, between January 1992 and December 1994, was analyzed. The following reciprocally interrelated histologic characteristics were evaluated: 1) histologic tumor type (considered in 3 categories of aggressivity), 2) tumor grade (according to Scarf-Bloom-Richardson), 3) constituent of in-situ carcinoma in invasive cancers and characterization of breast lobuli, 4) tumor growth pattern (microfocal, macrofocal or mixed), 5) invasion of nerves, 6) vascular invasion by cancer cells in tumor surroundings, 7) extensiveness of tumor necrosis, 8) involvement of the breast distant from the tumor mass by cancer cells, 9) status of axillary lymph nodes, 10) invasion of metastatic lymph node surroundings. Metastases in axillary lymph nodes were independently influenced by vascular invasion in tumor surroundings and tumor diameter. The disease-free survival was independently influenced by tumor diameter, necrosis and stage of the disease (pTNM), whereas total survival related to tumor diameter, nodal status, microfocal pattern of tumor growth, vascular invasion and involvement of breast by cancer distant from the tumor mass was independently influenced only by tumor stage (pTNM).</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 5-6","pages":"279-85"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20571879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stereological estimation of mean nuclear volume and staining pattern of Ki-67 antigen in keratoacanthomas and squamous cell carcinomas. 角棘瘤和鳞状细胞癌中Ki-67抗原染色模式和平均核体积的体视学评价。
General & diagnostic pathology Pub Date : 1998-04-01
O Sağol, B Kurtoğlu, E Ozer, U Pabuççuoğlu
{"title":"Stereological estimation of mean nuclear volume and staining pattern of Ki-67 antigen in keratoacanthomas and squamous cell carcinomas.","authors":"O Sağol,&nbsp;B Kurtoğlu,&nbsp;E Ozer,&nbsp;U Pabuççuoğlu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Keratoacanthomas and squamous cell carcinomas of the skin share many histopathologic features, making differential diagnosis difficult. The aim of this study is to investigate the staining pattern of proliferating cells in keratoacanthomas and squamous cell carcinomas of the skin and to evaluate the value of nuclear morphometric criteria in differential diagnosis. Mean nuclear volume was assessed in 21 keratoacanthomas and 21 squamous cell carcinomas in tissue sections by a stereologic method. Immunohistochemical expression of Ki-67 monoclonal antibody was assessed and the distribution pattern (random or peripheral) of proliferating cells evaluated. Mean nuclear volume (MNV +/- SD) was 590 +/- 293.0 for squamous cell carcinomas and 615 + 305.9 for keratoacanthomas. Statistical analysis showed no significant differences between both groups (p = 0.78) in terms of mean nuclear volume values. Proliferating cells in keratoacanthomas showed a peripheral distribution, whereas there was a random distribution of proliferating cells in squamous cell carcinomas. Our results indicate that quantitative nuclear features are not helpful in making a differentiation between keratoacanthomas and squamous cell carcinomas, while immunohistochemistry with Ki-67 antibody may give useful additional information in differential diagnosis.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 5-6","pages":"305-9"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20572469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathologic aspects of 8 Kaposi's sarcomas among 1009 renal transplant patients. 1009例肾移植患者8例卡波西肉瘤的临床病理分析。
General & diagnostic pathology Pub Date : 1997-12-01
B Szende, A Tóth, F Perner, K Nagy, K Takács
{"title":"Clinicopathologic aspects of 8 Kaposi's sarcomas among 1009 renal transplant patients.","authors":"B Szende,&nbsp;A Tóth,&nbsp;F Perner,&nbsp;K Nagy,&nbsp;K Takács","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 8 of 1009 patients receiving renal grafts and consecutive immunosuppressive therapy during the last 20 years in Budapest, Hungary, Kaposi's sarcoma developed 6.5 months (average) after transplantation. Of 8 cutaneous cases of this disease, 5 also presented visceral manifestations. Seven patients died. Those with visceral tumors died because of the tumor itself. One patient affected by cutaneous tumor has survived for 5 years post-treatment. The relatively high incidence of Kaposi's sarcoma may be explained by a high infection rate with Herpes virus 8, which was shown to be positive in all three cases investigated.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 4","pages":"209-13"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20414640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The application of image analysis in the measurement of the myocardial infarct area in an experimental model. 图像分析在实验模型心肌梗死面积测量中的应用。
General & diagnostic pathology Pub Date : 1997-12-01
E Agapitos, J Nanas, N Kavantzas, S Nanas, D Yova, A Trikoupis, P Davaris
{"title":"The application of image analysis in the measurement of the myocardial infarct area in an experimental model.","authors":"E Agapitos,&nbsp;J Nanas,&nbsp;N Kavantzas,&nbsp;S Nanas,&nbsp;D Yova,&nbsp;A Trikoupis,&nbsp;P Davaris","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Thrombolytic therapy improves left ventricular ejection fraction and survival. Using the image analysis method, the study was undertaken to evaluate the effects of intraaortic balloon pump used in conjunction with reperfusion in reducing infarct size by measuring the infarct area. Also, the usefulness of image analysis as an objective method for the measurement of myocardial infarct area is evaluated.</p><p><strong>Methods: </strong>22 dogs were subjected to proximal left anterior descending coronary artery occlusion. The dogs were classified into 3 groups. In group I (n = 7), occlusion lasted for 6 hours. In group II (n = 6), 2 hours of occlusion were followed by reperfusion. In group III, (n = 9) after 2 hours of occlusion, the dogs were assisted with the intraaortic balloon pump throughout the 4 hours of reperfusion. The measurement of the infarcted area components (fragmentation, edema, hemorrhage and polymorphonuclear infiltrations) was followed by a semiautomatic method including in connection a microscope photographic camera, a scanner and a computer with the appropriate software. The results were analyzed statistically using the t-test.</p><p><strong>Result: </strong>In group I, the mean value of fragmentation was 28.2%, in group II, 10.1% (p < 0.01 versus group I) and in group III, 3.9% (p < 0.01 versus I and p < 0.05 versus group II).</p><p><strong>Conclusion: </strong>Reperfusion and intraaortic balloon pump increased the salvage of the ischemic myocardium over that achieved by reperfusion alone in a canine occlusion - reperfusion model. Image analysis could be considered as an accurate and objective method for the measurement of the myocardial infarct area in the experimental model of our study and it could be used in any other experimental study in which the accurate measurement of myocardial infarct area is needed.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 4","pages":"215-8"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20414641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of DNA cytometry in transitional cell carcinoma of the urinary bladder. DNA细胞术在膀胱移行细胞癌诊断中的价值。
General & diagnostic pathology Pub Date : 1997-12-01
H Nenning, J Rassler, D H Minh, J U Stolzenburg
{"title":"The value of DNA cytometry in transitional cell carcinoma of the urinary bladder.","authors":"H Nenning,&nbsp;J Rassler,&nbsp;D H Minh,&nbsp;J U Stolzenburg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Transitional cell carcinomas are tumors with a high tendency of local recurrence. The extent of the primary tumor and histopathologic grade incompletely predict the individual outcome. In several studies, measurement of nuclear DNA content has been found to be of prognostic value in bladder cancer. We performed static DNA cytometry on transitional cell carcinomas of 130 patients. DNA parameters were correlated with stage and grade. There was a good correlation between local tumor extent (T category), grading, and DNA parameters. Ta and T1 tumors had significantly lower levels of 5c exceeding rate and DNA grade of malignancy than muscle invasive carcinoma. Well-differentiated carcinoma (G1) also had lower levels than G2 and G3 tumors. As a result of earlier studies, a DNA-based risk-adapted concept for treatment has been developed for superficial tumors. First preliminary results of a clinical study are given in the present paper.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 4","pages":"231-6"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20415197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of perineurioma. 脑膜周围瘤1例。
General & diagnostic pathology Pub Date : 1997-12-01
M Zámecník, P Gomolcák
{"title":"A case of perineurioma.","authors":"M Zámecník,&nbsp;P Gomolcák","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 4","pages":"261"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20415203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrauterine rhabdomyoma of the heart. A case report. 子宫内心脏横纹肌瘤。一份病例报告。
General & diagnostic pathology Pub Date : 1997-12-01
M Guschmann, M Entezami, R Becker, M Vogel
{"title":"Intrauterine rhabdomyoma of the heart. A case report.","authors":"M Guschmann,&nbsp;M Entezami,&nbsp;R Becker,&nbsp;M Vogel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary cardiac tumors are rare findings in adults and children. A case is presented in which ultrasound examination revealed an incredibly large tumor in the heart of a fetus at 24 weeks. Tumor filled the whole left ventricle. Histology and immunohistochemistry were indicative of rhabdomyoma, i.e., a hamartoma that is often associated with tuberous sclerosis.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 4","pages":"255-9"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20415202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical expression and distribution of alpha2beta1, alpha6beta1, alpha5beta1 integrins and their extracellular ligands, type IV collagen, laminin and fibronectin in palmar fibromatosis. alpha2beta1、alpha6beta1、alpha5beta1整合素及其细胞外配体、IV型胶原、层粘连蛋白和纤维连接蛋白在掌纤维瘤病中的免疫组织化学表达和分布
General & diagnostic pathology Pub Date : 1997-12-01
G Magro, F Fraggetta, S Travali, S Lanzafame
{"title":"Immunohistochemical expression and distribution of alpha2beta1, alpha6beta1, alpha5beta1 integrins and their extracellular ligands, type IV collagen, laminin and fibronectin in palmar fibromatosis.","authors":"G Magro,&nbsp;F Fraggetta,&nbsp;S Travali,&nbsp;S Lanzafame","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Palmar fibromatosis is characterized by changes in the expression of extracellular matrix (ECM) proteins and re-organization of the interactions between cellular and extracellular compartments. We compared the expression and distribution of alpha2beta1, alpha6beta1, alpha5beta1 integrins and their corresponding extracellular ligands, type IV collagen, laminin and fibronectin in palmar fibromatosis nodules from 24 patients. Depending on the degree of cellularity and fibrosis, three different histologic phases were identified: proliferative, involutional, and residual. Immunohistochemistry revealed that only stromal cells of the highly cellular areas of both proliferative and involutional phases were myofibroblasts, as demonstrated by their cytoplasmic positivity for alpha-smooth-muscle actin. The ECM, surrounding these cells, was strongly and diffusely positive to type IV collagen, laminin and fibronectin, whereas no immunoreactivity was found in the ECM of the fibrotic and hypocellular areas of both involutional and residual phases. Immunostaining for alpha2beta1, alpha6beta1 and alpha5beta1 integrins revealed that alpha5beta1 integrin was expressed and restricted to the myofibroblast-rich cellular areas, whereas no expression was detected for alpha2beta1 and alpha6beta1 integrins. By examining serial sections, a co-localization of alpha5beta1 integrin and fibronectin was observed in the myofibroblast-rich cellular areas, indicating that, in palmar fibromatosis, a co-ordinate expression between cellular and extracellular ligand is detected only for the alpha5beta1 integrin/fibronectin complex. These findings suggest that the alpha5beta1 integrin/fibronectin complex may be involved in regulating the interactions between myofibroblasts and ECM in palmar fibromatosis.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 4","pages":"203-8"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20414639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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