General & diagnostic pathology最新文献

Quantitative analysis of HLA DR expression and lymphocytic infiltrate in laryngeal cancer including clinical and morphological correlations. 喉癌患者HLA - DR表达与淋巴细胞浸润的定量分析及临床形态学相关性。

General & diagnostic pathology Pub Date : 1998-04-01

B Sikorska, M Danilewicz, M Wagrowska-Danilewicz

{"title":"Quantitative analysis of HLA DR expression and lymphocytic infiltrate in laryngeal cancer including clinical and morphological correlations.","authors":"B Sikorska, M Danilewicz, M Wagrowska-Danilewicz","doi":"","DOIUrl":"","url":null,"abstract":"HLA DR antigen expression in tumor cells and lymphocytic infiltrates at the tumour periphery were investigated in 68 laryngeal carcinomas. The tissue sections were studied by a quantitative method using computer image analysis system. The highest number of CD45RO+ cells was observed in the groups of the lowest clinical stage. There were statistically significant differences between the groups in the number of T cells, whereas no differences were found in HLA DR+ cancer cell number, B cell number or mitosis count. Statistical analysis revealed a significant correlation between T-cell number at the periphery of the tumour and the number of cancer cells showing HLA DR expression. The results of the analysis, using Cox proportional hazard model with selected factors, showed that only HLA DR expression in cancer cells had a significant effect on survival, whereas the number of CD45RO+ and CD20+ cells, histological grade and mitosis count did not contribute further to prognostic information. To our knowledge, this is the first time that HLA DR expression and its correlation with lymphocytic infiltration have been shown by a quantitative method in laryngeal cancer.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 5-6","pages":"297-303"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20572468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atherosclerotic lesions, myocardial damage and lipidograms: a multiarterial study applying an atherometric system and canonical correlation. 动脉粥样硬化病变，心肌损伤和脂质图:应用动脉粥样硬化系统和典型相关的多动脉研究。

General & diagnostic pathology Pub Date : 1998-04-01

J E Fernández-Britto, R Wong, R Campos, L Falcon, K Affeld, H Guski

引用次数: 0

Proliferative activity, p53 accumulation and neoangiogenesis in pulmonary carcinosarcomas and pulmonary blastomas. 肺癌肉瘤和肺母细胞瘤的增殖活性、p53积累和新生血管生成。

General & diagnostic pathology Pub Date : 1998-04-01

D Theegarten, M Zorn, S Philippou

{"title":"Proliferative activity, p53 accumulation and neoangiogenesis in pulmonary carcinosarcomas and pulmonary blastomas.","authors":"D Theegarten, M Zorn, S Philippou","doi":"","DOIUrl":"","url":null,"abstract":"Carcinosarcoma and pulmonary blastomas are rare biphasic tumors. Lung cancer pathogenesis is a multistep process. Proliferative activity, p53 accumulation and angiogenesis are of well-known relevance and ought to be evaluated in the epithelial and mesenchymal components of these tumors. Using antibodies against Ki-67 epitope MIB1 and proliferating cell nuclear antigen (PC 10) in 10 carcinosarcomas, tumors revealed a significantly higher proliferative activity in the epithelial component compared with the mesenchymal component in the MIB1 reaction (p = 0.013). In three pulmonary blastomas of the biphasic subtype, proliferative activity was similar in both parts. In five of 10 carcinosarcomas and in one of three pulmonary blastomas, accumulation of the p53 epitopes Pab 1801 and/or DO-1 was found. At the tumor front, a significantly higher vessel density was found compared with the central parts (p < or = 0.015) using a monoclonal antibody against human endothelium (CD 31). No differences were found between carcinosarcomas and pulmoblastomas. Higher proliferative activity in carcinosarcomas revealed a better prognosis regarding metastasis behavior (p = 0.05) and tumor-associated death in the follow-up (p < or = 0.017). p53 accumulation and microvessel density were of no prognostic value. This is in contrast to results in non-small cell lung cancer, pointing to a different biologic behavior.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 5-6","pages":"265-70"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20571877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human vaginal mucosal immune system: characterization and function. 人阴道粘膜免疫系统:特征和功能。

General & diagnostic pathology Pub Date : 1998-04-01

Y Elitsur, S Jackman, C Neace, S Keerthy, X Liu, J Dosescu, J A Moshier

{"title":"Human vaginal mucosal immune system: characterization and function.","authors":"Y Elitsur, S Jackman, C Neace, S Keerthy, X Liu, J Dosescu, J A Moshier","doi":"","DOIUrl":"","url":null,"abstract":"Objective: The mucosal immune system has been recognized as the first line of defense against foreign antigens. The limited information available on the mucosal immunity of the lower reproductive organs have restricted our ability to fight infections, especially, the sexually transmitted disease. The aim of this study was to characterize in-vitro the human vaginal lamina propria lymphocytes (VLPL), their cell surface phenotypes, and cellular function.Methods: VLPL were isolated from human vaginal mucosa by enzymatic techniques. Cell surface characteristics were investigated by immunohistochemistry and flow cytometric analysis. Cellular immune function was evaluated by 3H-thymidine incorporation studies and ornithine decarboxylase (ODC) activity.Results: Immunohistochemistry and flow cytometric analysis showed that the CD4/CD8 ratio of the human vaginal mucosa is reversed compared to the gut lamina propria lymphocytes (0.55 +/- 0.17). PHA and ConA mitogens enhanced VLPL thymidine incorporation, while PWM did not have any significant effect. Very high level of ODC activity was observed in VLPL after PHA stimulation.Conclusions: The human VLPL can be isolated, characterized, and respond to a mitogenic stimulus. We postulate that further analysis of the vaginal immune system will enhance our understanding of local defence mechanisms which will help in the development of new therapeutic modalities against vaginal infections.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 5-6","pages":"271-7"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20571878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency of endocervical cells in cervical smears and hysterectomy rate of the patients. 宫颈涂片中宫颈内膜细胞频率与患者子宫切除术率的关系。

General & diagnostic pathology Pub Date : 1998-04-01

U Schenck, W Planding

{"title":"Frequency of endocervical cells in cervical smears and hysterectomy rate of the patients.","authors":"U Schenck, W Planding","doi":"","DOIUrl":"","url":null,"abstract":"In gynecologic cytology, different reporting schemes suggest mentioning the presence of endocervical cells or asking for a statement on adequacy. We were interested in the question whether our data could provide a possible basis for discussing a sampling technique with smear takers. At the time of writing, in all cases, both the presence of endocervical cells and hysterectomy are recorded in our laboratory information system. Most smears are taken with cotton swabs, but the sampling technique is often modified according to the clinical situation. In a series of 20,471 cervical/vaginal smears, 2,152 (10.5%) were taken from hysterectomy patients. Among the non-hysterectomy patients, endocervical cells were found in 65% of the cases. Typically, there was a lower frequency of endocervical cells in smears stemming from older women. The frequency decreased from a maximum of 75% in the age group of 40-44 years to 45% in the age group of 65-69 years. With regard to the smear takers, some differences were evident, with age distribution and frequency of hysterectomy being different among the smear takers. In a setting where many smears of hysterectomized patients are examined by cytology, good data quality is required to evaluate the sampling techniques of different smear takers. The age dependence of endocervical cell yield is confirmed. Different age distribution of the patients from different smear takers suggests that the percentage of smears showing endocervical cells cannot be considered an optimal estimator.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 5-6","pages":"291-6"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20572467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic nonspecific endometritis. 慢性非特异性子宫内膜炎。

General & diagnostic pathology Pub Date : 1998-04-01

K Yörükoğlu, F Kuyucouğlu

{"title":"Chronic nonspecific endometritis.","authors":"K Yörükoğlu, F Kuyucouğlu","doi":"","DOIUrl":"","url":null,"abstract":"To assess the proliferative activity of glands and stroma in nonspecific chronic endometritis (NCE), we evaluated the plasma and morphologic features. We examined 25 endometrial sections that were coded as inactive for the morphologic features of NCE other than plasma cells and 25 proliferative endometria (PE) as controls. Furthermore, the sections were stained with methyl green pyronin (MGP) to demonstrate plasma cells and proliferative cell nuclear antigen (PCNA) for proliferative activity. The number of plasma cells and the grade of proliferative activity were determined by a semiquantitative scale. The results were compared by using the Mann-Whitney-U-test. Of the 25 inactive endometria cases, 11 were NCE and 14 were either early proliferative endometria (seven cases), lower uterine segments (five cases), or under hormone effect (two cases). The number of plasma cells in NCE was significantly higher than in PE. However, there were cases of NCE without plasma cells and cases of PE containing plasma cells. Proliferative activity was significantly lower in NCE cases than in the PE group (p < 0.05). The diagnosis of NCE should rely more on morphologic abnormalities than on plasma cell criteria. Identification of plasma cells may be useful for diagnosis.","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 5-6","pages":"287-90"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20571880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary malignant lymphoma of the kidney: case report and literature review. 原发性肾恶性淋巴瘤:病例报告及文献复习。

General & diagnostic pathology Pub Date : 1998-04-01

M J Fernandez-Aceñero, M Galindo, O Bengoechea, P Borrega, J J Reina, R Carapeto

引用次数: 0

Concurrence of localized Castleman's disease and peripheral small B-Lymphocytic lymphoma within the same lymph node. 局部Castleman病和周围小b淋巴细胞淋巴瘤在同一淋巴结内同时发生。

General & diagnostic pathology Pub Date : 1998-04-01

G F Orcioni, V Mambelli, S Ascani, E Sabattini, M Piccioli, F Pieri, B Falini, S A Pileri

引用次数: 0

Solitary neurofibroma of the gallbladder. A case report and review of the literature. 胆囊孤立性神经纤维瘤。病例报告及文献回顾。

General & diagnostic pathology Pub Date : 1998-04-01

E Acebo, F A Fernández, J F Val-Bernal