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Renal perineurioma in childhood. 儿童肾周围瘤。
General & diagnostic pathology Pub Date : 1997-07-01
J F Val-Bernal, M Hernando, M F Garijo, P Villa
{"title":"Renal perineurioma in childhood.","authors":"J F Val-Bernal,&nbsp;M Hernando,&nbsp;M F Garijo,&nbsp;P Villa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Perineurioma of the kidney in a 7-year-old girl is described. The tumor in the upper pole was discovered during the evaluation of a urinary tract infection. The neoplasm measured 2.6 cm and radiographically it mimicked a nephroblastoma. The diagnosis of perineurioma was confirmed with histologic, immunohistochemical, and ultrastructural studies. These revealed findings typical of perineurioma of other locations. Histopathologically, differential diagnosis may include nephroblastoma, mesoblastic nephroma, neurofibroma, schwannoma, malignant peripheral nerve sheath tumor with perineural cell differentiation, and other benign and malignant mesenchymal tumors with spindle cell pattern. To the best of our knowledge, we report a unique renal perineurioma in a child.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"75-81"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20211969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Findings of computerized nuclear morphometry of papillary thyroid carcinoma in correlation with the age of the patients. 甲状腺乳头状癌计算机核形态测定与患者年龄的关系。
General & diagnostic pathology Pub Date : 1997-07-01
S Tseleni, N Kavantzas, D Yova, E Alexandratou, M loannou-Lambrouli, H Paraskevakou, P Davaris
{"title":"Findings of computerized nuclear morphometry of papillary thyroid carcinoma in correlation with the age of the patients.","authors":"S Tseleni,&nbsp;N Kavantzas,&nbsp;D Yova,&nbsp;E Alexandratou,&nbsp;M loannou-Lambrouli,&nbsp;H Paraskevakou,&nbsp;P Davaris","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this study was to evaluate the usefulness of nuclear morphometry in the pathology of papillary thyroid carcinoma by computer-aided image analysis and the statistical comparison of nuclear morphometric parameters with the age of patients. Seventy cases of papillary thyroid carcinoma diagnosed by fine needle aspiration (FNA) biopsies were classified into two groups according to the patients' age (group I: <45 years and group II: >45 years). The following six nuclear morphometric parameters were measured in a large number of randomly selected nuclei of each case: area, perimeter, major axis length, elongation, roundness, and compactness. The statistical analysis was performed by using special algorithms, and the results of the two groups were compared for each of the parameters measured using the t-test. Area, perimeter, and major axis length of papillary thyroid carcinoma nuclei demonstrate a statistically significant correlation with the age of patients, whereas elongation, roundness, and compactness did not show any correlation. Nuclear morphometry in association with the follow-up of patients could be suggested as an important prognostic index for papillary thyroid carcinoma.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"23-7"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20212654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metanephric adenoma of the kidney: histologic, immunohistochemical and DNA content analysis study. A case report. 肾后肾腺瘤:组织学、免疫组化及DNA含量分析研究。一份病例报告。
General & diagnostic pathology Pub Date : 1997-07-01
F Fraggetta, A Galia, M Lopes, A Cosentino, E Vasquez
{"title":"Metanephric adenoma of the kidney: histologic, immunohistochemical and DNA content analysis study. A case report.","authors":"F Fraggetta,&nbsp;A Galia,&nbsp;M Lopes,&nbsp;A Cosentino,&nbsp;E Vasquez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Metanephric adenoma is an uncommon and distinct clinicopathologic entity, recently described among benign epithelial kidney tumors. The authors report a case of a metanephric adenoma in a 70-year-old man. Because of its benign clinical course, it is important to distinguish metanephric adenoma from renal cell carcinomas and adult Wilms' tumor for which it is usually mistaken. Clinical, pathologic features and diagnostic problems of the case are discussed.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20211966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mixed type in Laurén's classification of gastric carcinoma. Histologic description and biologic behavior. 劳氏胃癌分型中的混合型。组织学描述和生物学行为。
General & diagnostic pathology Pub Date : 1997-07-01
S Stelzner, P Emmrich
{"title":"The mixed type in Laurén's classification of gastric carcinoma. Histologic description and biologic behavior.","authors":"S Stelzner,&nbsp;P Emmrich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Of 198 gastric carcinomas, resected at the Surgical Department, Leipzig University between 1986 and 1995, 28 cases were classified as mixed type according to Laurén's classification. These cases were examined in respect to morphologic features associated with biologic behavior. Contrary to the intestinal and diffuse type carcinomas, the mixed type carcinomas showed a deeper infiltration of the gastric wall (pT, P < 0.001), a higher metastatic rate to regional lymph nodes (pN, P < 0.05), and the need of higher staging at the UICC-classification system (P < 0.05). Histologically, it is possible to establish four distinct groups; the first group shows a combination of intestinal and diffuse features, the second shows more diffuse structures with a nodular growth pattern, the third group shows both a glandular pattern and signet ring cells. In the fourth group, the tumors reveal an excessive production of mucin. The authors conclude that this subclassification of the mixed type of gastric carcinomas is useful for a better understanding and interpretation of these tumors.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20211964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokeratins and the evaluation of tumor differentiation in squamous lesions of the uterine cervix. 细胞角蛋白与宫颈鳞状病变肿瘤分化的评价。
General & diagnostic pathology Pub Date : 1997-07-01
S A Nair, M B Nair, P G Jayaprakash, T N Rajalekshmy, M K Nair, M R Pillai
{"title":"Cytokeratins and the evaluation of tumor differentiation in squamous lesions of the uterine cervix.","authors":"S A Nair,&nbsp;M B Nair,&nbsp;P G Jayaprakash,&nbsp;T N Rajalekshmy,&nbsp;M K Nair,&nbsp;M R Pillai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The differential expression of cytokeratins in epithelial or squamous cells has been demonstrated to be altered during the process of carcinogenesis. This altered expression of cytokeratins (CKs) may be closely related with epithelial differentiation and may remain stable in malignant tumors. In the present study an analysis using two monoclonal antibodies, CK 8.12 antibody specific for CK type 13 and 16 and CK 8.60 antibody specific for CK type 1, 10 and 11 was done in different grades of lesions in the uterine cervix. Changes from the normal expression pattern were seen in high grade Squamous intraepithelial lesions (SIL) (CIN-2/3) and invasive squamous cell carcinoma (SCC). No conspicuous difference in the staining expression between normal/benign cervical tissue and low grade SIL (CIN-I) was evident. Statistical analysis also revealed a significant correlation between the expression of these CK types to the differentiation status of the cervical lesions analyzed. Alterations in the expression of these CKs can be correlated to the differentiation pathway which may be deregulated during cervical carcinogenesis. The findings of the present study suggest that the expression of CK types 13 and 16 and 1, 10 and 11 using CK 8.12 and CK 8.60 antibodies respectively may serve as markers of differentiation in cervical squamous neoplasms.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20212653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular abnormalities of the uterus, concerning a case of diffuse cavernous angiomatosis of the uterus. 子宫血管异常:一例弥漫性海绵状血管瘤。
General & diagnostic pathology Pub Date : 1997-07-01
S Gantchev
{"title":"Vascular abnormalities of the uterus, concerning a case of diffuse cavernous angiomatosis of the uterus.","authors":"S Gantchev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of diffuse cavernous angiomatosis of the uterus after delivery is reported. Owing to suspicion of abruptio placentae, cesarean section was performed. In the course of this section, several hematomas were noted in the myometrium, making total hysterectomy necessary. In view of this case, etiopathogenesis, causes and dynamics of clinical manifestation, possible complications, differential diagnosis and opportunities for the clinical diagnosis of uterine vascular abnormalities are discussed.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"71-4"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20211968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. A histopathologic study on diabetic mastopathy and report of ten cases. 长期胰岛素依赖型糖尿病患者的淋巴细胞性乳房炎和乳房纤维化。糖尿病性乳腺病变的组织病理学研究并附10例报告。
General & diagnostic pathology Pub Date : 1997-07-01
K P Hunfeld, R Bässler
{"title":"Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. A histopathologic study on diabetic mastopathy and report of ten cases.","authors":"K P Hunfeld,&nbsp;R Bässler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diabetic mastopathy represents less than 1% of benign breast diseases, but is more frequent (13%) in insulin-dependent diabetics. We report on 10 cases (eight females and two males) of this rare lesion of the breast in patients with additional diabetes mellitus type I. All cases showed a marked B-lymphocytic mastitis in combination with a homogenous fibrosis of the breast and with presence of epithelioid fibroblasts. In the male patients, diabetic mastopathy simulated gynecomastia. A comparative examination of 12 cases of lymphocytic mastitis without long-standing type-I-diabetes mellitus revealed a more heterogeneous pattern with lower degrees of inflammation and fibrosis. From the pathophysiologic point of view, lymphocytic mastitis in diabetic mastopathy is thought to be a diabetes-induced reaction probably of autoimmune origin. Moreover, lymphocytic mastitis with or without diabetes mellitus may represent a lymphoepithelial lesion of the MALT-type which, under certain circumstances, is considered to bear a prelymphomatous potential.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"49-58"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20211965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcomatoid chromophobe cell renal carcinoma: immunohistochemical and lectin study in one case. 肉瘤样嫌色细胞肾癌:1例免疫组化及凝集素研究。
General & diagnostic pathology Pub Date : 1997-07-01
J J Gómez-Román, M Mayorga-Fernández, F Fernández-Fernández, J F Val-Bernal
{"title":"Sarcomatoid chromophobe cell renal carcinoma: immunohistochemical and lectin study in one case.","authors":"J J Gómez-Román,&nbsp;M Mayorga-Fernández,&nbsp;F Fernández-Fernández,&nbsp;J F Val-Bernal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present one case of sarcomatoid chromophobe cell renal carcinoma with an indolent clinical course and assume that the carcinomatous component may affect the biologic behavior. The patient was a 61-year-old man who underwent right radical nephrectomy for a 11.2 cm tumor in the lower pole. The immunohistochemical findings demonstrate that EMA and cytokeratins 8 and 18 are useful markers for the sarcomatoid fraction, and the lectin study shows a loss of surface blood antigen. Chromophobe cell carcinoma may convert into sarcomatoid carcinoma. The existence of sarcomatoid renal cell carcinoma as a distinct entity should be re-considered.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"63-9"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20211967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations of p53 gene in soft tissue and bone tumors. p53基因在软组织和骨肿瘤中的改变。
General & diagnostic pathology Pub Date : 1997-07-01
A Roessner, R Schneider-Stock, K Radig, W Neumann, U Mittler
{"title":"Alterations of p53 gene in soft tissue and bone tumors.","authors":"A Roessner,&nbsp;R Schneider-Stock,&nbsp;K Radig,&nbsp;W Neumann,&nbsp;U Mittler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"143 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20212652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical expression of p53 and c-erbB-2 in breast carcinoma: relation with epidemiologic factors, histologic features and prognosis. 乳腺癌中p53和c-erbB-2的免疫组化表达:与流行病学因素、组织学特征及预后的关系
General & diagnostic pathology Pub Date : 1997-06-01
M J Fernández Aceñero, J Farina González, P Arangoncillo Ballesteros
{"title":"Immunohistochemical expression of p53 and c-erbB-2 in breast carcinoma: relation with epidemiologic factors, histologic features and prognosis.","authors":"M J Fernández Aceñero,&nbsp;J Farina González,&nbsp;P Arangoncillo Ballesteros","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have performed immunohistochemical staining for p53 and c-erbB-2 on formaldehyde-fixed, paraffin-embedded primary invasive ductal carcinomas from 112 patients, with a minimal follow-up time of 60 months. All of them had received postoperative chemoradiation therapy. We have analyzed the association of these factors with epidemiologic risk factors, histopathologic features and hormonal receptor status and the influence on prognosis. Our results indicate that the expression of c-erbB-2 protein defines a group of node-negative patients with poor prognosis. The overexpression of c-erbB-2 has shown a significant association with estrogen receptor status (those tumors expressing c-erbB-2 are usually estrogen receptor negative), presence of fibrosis and lymphoplasmacytoid infiltrates. P53 expression has shown no relation either with prognosis or with any other histopathologic or clinical feature. The only factors with prognostic influence in our series have been tumor size, the presence of node metastases, TNM stage and the prognostic morphometric index (Baak's index), apart from c-erbB-2 in node-negative patients. However, only the TNM stage showed an independent association with prognosis after a multivariate analysis. In summary, in our experience the expression of p53 protein has no prognostic influence on breast carcinoma, and TNM stage remains to be as the most powerful prognostic factor in these patients.</p>","PeriodicalId":79430,"journal":{"name":"General & diagnostic pathology","volume":"142 5-6","pages":"289-96"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20171601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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