Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology最新文献_第10页

WS5-4 全身性エリテマトーデスと免疫不全 WS5-4系统性红斑狼疮和免疫缺陷

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/JSCI.40.271B

哲治沢田, 太原恒一郎

引用次数: 0

MS1-1 関節リウマチ治療のトピックス MS1-1类风湿关节炎治疗专题

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/JSCI.40.290A

敏宏南木

引用次数: 0

P1-37 Tacrolimusで初めて治療し得た心筋障害合併例を含むTAFRO症候群の2症例 2例TAFRO综合征病例，包括P1-37 Tacrolimus首次治疗的合并心肌梗死病例

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/jsci.40.307a

白井太一朗, 大輔脇, 荘千藤, 健吾明石, 輝大西, 淳三枝, 暁雄森信

引用次数: 0

[From property of IL-1β to imaging of inflammation]. [从IL-1β的性质到炎症的影像学]。

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/jsci.40.329

Takao Iwawaki

引用次数: 3

Susceptibility genes for nontuberculous mycobacterial disease. 非结核分枝杆菌病的易感基因。

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/jsci.40.60

Ho Namkoong, Naoki Hasegawa, Tomoko Betsuyaku

{"title":"Susceptibility genes for nontuberculous mycobacterial disease.","authors":"Ho Namkoong, Naoki Hasegawa, Tomoko Betsuyaku","doi":"10.2177/jsci.40.60","DOIUrl":"https://doi.org/10.2177/jsci.40.60","url":null,"abstract":"The number of patients with nontuberculous mycobacterial (NTM) disease is reportedly increasing both in Japan and worldwide. NTM diseases are classified into disseminated and pulmonary diseases based on their clinical characteristics. These two types of NTM diseases are thought to be controlled by different mechanisms. Disseminated NTM disease is caused by a defect in signal transduction of Th1 cellular immune responses, including the IFN-γ/IL-12 axis. The precise molecular mechanisms of disseminated NTM disease are understood in detail. Pulmonary NTM disease progression is associated with both bacterial factors as well as host factors. Furthermore, it is suggested that some susceptibility genes for NTM diseases may also exist. A previous study on the susceptibility genes for pulmonary NTM disease was performed using Single Nucleotide Polymorphism (SNP) analysis and microsatellite marker analysis. However, a number of challenges remain in terms of the reproducibility. The emergence of next generation sequencing enables genome-wide analysis, and further studies on the susceptibility genes for pulmonary NTM disease are expected in the future.","PeriodicalId":79359,"journal":{"name":"Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology","volume":"40 1","pages":"60-67"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2177/jsci.40.60","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35024082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Identification of cancer-stem cell antigens and development of CTL-mediated cancer immunotherapy. 肿瘤干细胞抗原的鉴定及ctl介导的肿瘤免疫治疗进展。

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/jsci.40.40

Sho Miyamoto, Takayuki Kanaseki, Yoshihiko Hirohashi, Tomohide Tsukahara, Yasuhiro Kikuchi, Noriyuki Sato, Toshihiko Torigoe

引用次数: 2

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/jsci.40.261b

引用次数: 0

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/jsci.40.263b

引用次数: 0

[Imaging of bone and joint destruction]. [骨骼和关节破坏的成像]。

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/jsci.40.344

Junichi Kikuta, Masaru Ishii

{"title":"[Imaging of bone and joint destruction].","authors":"Junichi Kikuta, Masaru Ishii","doi":"10.2177/jsci.40.344","DOIUrl":"https://doi.org/10.2177/jsci.40.344","url":null,"abstract":" Osteoclasts are bone-resorbing giant polykaryons that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursors. We have originally established an advanced imaging system for visualizing in vivo behavior of osteoclasts and their precursors with intravital two-photon microscopy. By means of the system, we found that sphingosine-1-phosphate, a lipid mediator enriched in blood, controlled the migratory behavior of osteoclast precursors. We also developed pH-sensing chemical fluorescent probes to detect localized acidification by bone-resorbing osteoclasts on the bone surface in vivo, and identified two distinct functional states of differentiated osteoclasts, 'bone-resorptive' and 'non-resorptive'. In this review, we summarize our recent studies on the dynamics and functions of osteoclasts. Our intravital imaging techniques would be beneficial for studying the cellular dynamics in arthritic inflammation and bone destruction in vivo and would thus be useful for evaluating novel therapies targeting aspects of osteoclast dynamics in patients with bone-destructive diseases.","PeriodicalId":79359,"journal":{"name":"Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology","volume":"40 5","pages":"344-351"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2177/jsci.40.344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35654130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prolonged optic disc swelling in Kawasaki disease - A case report and literature review]. 川崎病视盘肿胀延长1例并文献复习。

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Pub Date : 2017-01-01 DOI: 10.2177/jsci.40.377

Yusuke Tsumura, Hiroshi Masuda, Sachiko Nishina, Tohru Kobayashi, Hiroshi Ono, Hitoshi Kato, Jun Abe, Akira Ishiguro

{"title":"[Prolonged optic disc swelling in Kawasaki disease - A case report and literature review].","authors":"Yusuke Tsumura, Hiroshi Masuda, Sachiko Nishina, Tohru Kobayashi, Hiroshi Ono, Hitoshi Kato, Jun Abe, Akira Ishiguro","doi":"10.2177/jsci.40.377","DOIUrl":"https://doi.org/10.2177/jsci.40.377","url":null,"abstract":" Kawasaki disease (KD), an acute childhood panvasculitis, presents a variety of ocular complications as well as conjunctival injection among the principal symptoms. However, most pediatricians are unfamiliar with the ophthalmological complications of KD. A 2-year-old girl was referred to us from the ophthalmology department due to injected bulbar conjunctivae and optic disc swelling. She had familial exudative vitreoretinopathy as an underlying disease and the ocular findings had been made by chance while the patient was receiving an eye examination. Although she was afebrile at the time of her first medical interview, KD was diagnosed based on the presence of four of the principal symptoms including fever and dilatation of the coronary arteries. Intravenous immunoglobulin (IVIG) therapy was administered on Day 15 from the onset of fever. After IVIG administration, her laboratory test results showed rapid improvement but her optic disc swelling continued for six months. Eye complications in KD generally occur in the anterior segment, and recovery occurs within two months. Past reports have shown that in three of seven KD cases with optic disc involvement, optic disc swelling lasted over two months. This is the second case in which the condition lasted six months.","PeriodicalId":79359,"journal":{"name":"Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology","volume":"40 5","pages":"377-381"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2177/jsci.40.377","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35654134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1