Identification of cancer-stem cell antigens and development of CTL-mediated cancer immunotherapy.

Sho Miyamoto, Takayuki Kanaseki, Yoshihiko Hirohashi, Tomohide Tsukahara, Yasuhiro Kikuchi, Noriyuki Sato, Toshihiko Torigoe
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引用次数: 2

Abstract

Cancer-stem cells (or cancer-stem like cells, CSC) play an indispensable role in tumor initiation or tumor development in vivo. However, CSCs are resistant to conventional therapies including chemo/radiotherapy and a certain molecularly-targeted therapy, thereby are responsible for tumor relapse or metastasis in clinical settings. In this review, we focus on cytotoxic T-cell mediated immune responses against CSCs and discuss a challenge of targeting CSCs as well as the development of CSC-based cancer immunotherapy, which is an emerging and promising strategy toward a complete cure of quite a few types of cancers.

肿瘤干细胞抗原的鉴定及ctl介导的肿瘤免疫治疗进展。
肿瘤干细胞(或癌干细胞样细胞,CSC)在体内肿瘤的发生或发展中起着不可或缺的作用。然而,CSCs对包括化疗/放疗和某些分子靶向治疗在内的常规治疗具有耐药性,因此在临床环境中是肿瘤复发或转移的原因。在这篇综述中,我们将重点关注细胞毒性t细胞介导的针对CSCs的免疫反应,并讨论靶向CSCs的挑战以及基于CSCs的癌症免疫治疗的发展,这是一种新兴的、有希望完全治愈许多类型癌症的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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