Annals of Internal Medicine最新文献

{"title":"Coadministration of RSV + influenza or COVID-19 vaccines was noninferior to separate administration for immune responses in adults aged ≥50 y.","authors":"Clifford C Dacso","doi":"10.7326/ANNALS-25-00904-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-25-00904-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>GIM/FP/GP: [Formula: see text] Infectious Disease: [Formula: see text] Pulmonology: [Formula: see text] Public Health: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In adults treated with OACs after a first VTE, NSAID use was linked to increased risk for bleeding.","authors":"Geoffrey D Barnes","doi":"10.7326/ANNALS-25-00368-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-25-00368-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>GIM/FP/GP: [Formula: see text] Hematology: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In menopause-related moderate-to-severe vasomotor symptoms not suitable for hormone therapy, fezolinetant safely improved symptoms.","authors":"Angela M Cheung","doi":"10.7326/ANNALS-25-00829-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-25-00829-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>GIM/FP/GP: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Navigation to Improve Colonoscopy Completion After an Abnormal Stool Test Result : A Randomized Controlled Trial.","authors":"Gloria D Coronado, Amanda F Petrik, Jamie H Thompson, Michael C Leo, Matthew Slaughter, Priyanka Gautom, Syed A Hussain, Leslie Mosso, Jeffrey Gibbs, Neha Yadav, Rajasekhara R Mummadi, Eric S Johnson, Ricardo Jimenez","doi":"10.7326/ANNALS-24-01885","DOIUrl":"https://doi.org/10.7326/ANNALS-24-01885","url":null,"abstract":"<p><strong>Background: </strong>Patient navigation is a recommended practice of the Guide to Community Preventive Services; little is known about whether it improves colonoscopy completion for adults who have received an abnormal stool test result.</p><p><strong>Objective: </strong>To determine whether patient navigation delivered to persons with an abnormal stool test result increased follow-up colonoscopy completion (primary) at 1 year.</p><p><strong>Design: </strong>Randomized controlled trial. (ClinicalTrials.gov: NCT03925883).</p><p><strong>Setting: </strong>A federally qualified health center (<i>n</i> = 32 clinics) in Washington state.</p><p><strong>Patients: </strong>Persons aged 50 to 75 years with an abnormal fecal test result in the prior month.</p><p><strong>Intervention: </strong>A 6-topic, telephone-based patient navigation program delivered by bilingual (English and Spanish) clinical staff.</p><p><strong>Measurements: </strong>Receipt of follow-up colonoscopy at 1 year (primary); time to colonoscopy receipt (secondary); and program effectiveness by patient characteristics, including patients' probability of obtaining a colonoscopy without navigation, derived using health record data (secondary).</p><p><strong>Results: </strong>Of 985 participants enrolled (mean age, 61 years [SD, 6.8]; 170 [18%] had a Spanish-language preference listed in the medical record), 967 were included in the primary intention-to-treat analysis (479 in patient navigation, 488 in usual care). Receipt of follow-up colonoscopy was higher in the patient navigation group than in the usual care group (55.1% vs. 42.1%; risk difference, 13.0 percentage points [95% CI, 6.5 to 19.4 percentage points]). The intervention effect was not moderated by patients' probability of obtaining a colonoscopy without navigation.</p><p><strong>Limitation: </strong>The study was primarily done during the height of the COVID-19 pandemic, which created additional barriers to colonoscopy at the health system and patient levels.</p><p><strong>Conclusion: </strong>These findings support the effectiveness of patient navigation for follow-up colonoscopy completion.</p><p><strong>Primary funding source: </strong>National Cancer Institute.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annals On Call - Is Adherence to SEP-1 Linked to Mortality Reduction for Patients With Sepsis?","authors":"Robert M Centor, James S Ford, Gabriel Wardi","doi":"10.7326/ANNALS-25-01406-OC","DOIUrl":"https://doi.org/10.7326/ANNALS-25-01406-OC","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"e2501406OC"},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In acute respiratory failure, HFNO was noninferior to NIV for endotracheal intubation or death at 7 d in 4 of 5 patient subgroups.","authors":"KoKo Aung, Thwe Htay","doi":"10.7326/ANNALS-25-00593-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-25-00593-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Critical Care: [Formula: see text] Pulmonology: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephrology: What You May Have Missed in 2024.","authors":"Abdulla Alfadhel, Razan Alfarsi, Hussa Alkhajah, Jhonna Collins, Ashwini R Sehgal","doi":"10.7326/ANNALS-25-00796","DOIUrl":"https://doi.org/10.7326/ANNALS-25-00796","url":null,"abstract":"<p><p>This article highlights some important nephrology studies published in 2024 that may be relevant for nonnephrologist physicians. Four studies examined progression of chronic kidney disease (CKD), cardiovascular events, and nephrolithiasis with respect to use of semaglutide or sodium-glucose cotransporter-2 inhibitors. Three studies examined treatments to improve specific aspects of CKD management, including mineralocorticoid receptor agonists to address heart failure, avenciguat to address albuminuria, and oral phosphate binders to address fracture risk. One study demonstrated that inorganic nitrate reduced the risk for contrast-induced nephropathy. Finally, a trial of cefepime-taniborbactam showed benefit for treating complicated urinary tract infection.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In HF with mildly reduced or preserved ejection fraction, finerenone reduced CV death and worsening HF, regardless of baseline LVEF.","authors":"Yang Wang, Gregory Y H Lip","doi":"10.7326/ANNALS-25-00713-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-25-00713-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hospitalizations Among a National Sample of U.S. Adults With Substance Use Disorders.","authors":"Eden Y Bernstein, Susan L Calcaterra, Vineet Chopra, E Jennifer Edelman, Gina R Kruse","doi":"10.7326/ANNALS-24-03385","DOIUrl":"https://doi.org/10.7326/ANNALS-24-03385","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonology: What You May Have Missed in 2024.","authors":"Namarik Alenezy, Yusing Gu, Rana Saleh, Laura Sheriff, Michael Unger","doi":"10.7326/ANNALS-25-00797","DOIUrl":"https://doi.org/10.7326/ANNALS-25-00797","url":null,"abstract":"<p><p>The past year saw many important publications in the specialty of pulmonology. We screened more than 750 articles published in 2024 and carefully selected 10 that feature important advancements in the management of several respiratory conditions. We highlight 4 articles that describe management options for patients with chronic obstructive pulmonary disease (COPD) beyond pharmacotherapy, including breathing techniques, duration of long-term oxygen therapy, high-intensity compared with low-intensity noninvasive ventilation for exacerbations, and the potential harmful effect of gabapentinoids. Two articles delved into the evidence for various biologic therapies and inhaled relievers used in asthma. We include a randomized trial examining treatment of acute eosinophilic COPD and asthma exacerbations with benralizumab. One article explores dual glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonists as a novel treatment option for obstructive sleep apnea. Another discusses the efficacy of inhaled antibiotics in bronchiectasis. Finally, a meta-analysis examines the evidence for postexposure prophylaxis antiviral agents to reduce transmission and severity of influenza infections.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}