Annals of Internal Medicine最新文献

{"title":"All about alpha-gal syndrome from early days to now.","authors":"Stacey Butterfield","doi":"10.7326/ANNALS-26-03644-IM","DOIUrl":"10.7326/ANNALS-26-03644-IM","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"IMN95-IMN98"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In adults with active cancer and suspected PE, the YEARS algorithm was noninferior to CTPA alone for ruling out VTE at 3 mo.","authors":"Ali Eshaghpour, Wendy Lim","doi":"10.7326/ANNALS-26-03605-JC","DOIUrl":"10.7326/ANNALS-26-03605-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Oncology: [Formula: see text] Hematology: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"JC117"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In CKD without diabetes, finerenone vs. placebo slowed kidney function decline over 32 mo.","authors":"Shubha Ananthakrishnan","doi":"10.7326/ANNALS-26-03577-JC","DOIUrl":"10.7326/ANNALS-26-03577-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>GIM/FP/GP: [Formula: see text] Nephrology: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"JC115"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Would You Screen This 26-Year-Old Woman for Cervical Cancer? Grand Rounds Discussion From Beth Israel Deaconess Medical Center.","authors":"C Christopher Smith, David Chelmow, Karen M Freund, Risa B Burns","doi":"10.7326/ANNALS-26-02904","DOIUrl":"10.7326/ANNALS-26-02904","url":null,"abstract":"<p><p>Cervical cancer is the third most common gynecologic cancer, with more than 13 000 new cases diagnosed in 2025. The incidence of and mortality from cervical cancer vary across racial and ethnic groups and in persons living in medically underserved or geographically isolated areas, with half of all cervical cancers occurring in women who are underscreened or have never been screened. Persistent infection with high-risk types of human papillomavirus (HPV) is the most important risk factor for cervical cancer and is associated with nearly all cases. Although genital tract HPV infection is common, most HPV infections are transient, and cervical cancer occurs in only a small portion of patients with HPV. For decades, cervical cancer screening relied on annual cytologic assessment. A growing understanding of the role of HPV infection in the natural progression of cervical cancer has led to updated screening recommendations from the American Cancer Society and the Women's Preventive Services Initiative, as well as a draft update from the U.S. Preventive Services Task Force. These recommendations include primary HPV testing as a preferred screening strategy and include an option for self-collected specimens for HPV testing. Here, 2 experts in this field, a primary care physician and an obstetrics and gynecology physician, debate how to apply these guidelines when screening a patient for cervical cancer. They discuss a range of screening options and consider the challenges of applying these guidelines across different age groups and in patients at increased risk.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"1473-1481"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Doctor in the Waiting Room.","authors":"Stephanie Chang","doi":"10.7326/ANNALS-26-03016","DOIUrl":"https://doi.org/10.7326/ANNALS-26-03016","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"179 10","pages":"1509-1510"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary for Patients: An Updated Systematic Review on Efficacy and Safety of Glucagon-like Peptide-1 Receptor Agonists and Co-agonists for Weight Loss Among Adults Without Diabetes.","authors":"","doi":"10.7326/ANNALS-25-05519-PS","DOIUrl":"10.7326/ANNALS-25-05519-PS","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"I15"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzodiazepine Prescriptions to Older Adults in the United States, 2015 to 2024.","authors":"Mark Olfson, Fangzhou Xie, Greta Bushnell, Naomi Cruz, Jialiang Hua, Jennifer Miles, Stephen Crystal","doi":"10.7326/ANNALS-25-05594","DOIUrl":"10.7326/ANNALS-25-05594","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"1514-1519"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Blood Hemoglobin Concentration and Mortality by Age and Sex : A Prospective Cohort Study.","authors":"Malek Ahmad, John G F Cleland, Pasquale Maffia, Rona J Strawbridge, Naveed Sattar, Jill P Pell, Qiaoling Liu, Jocelyn M Friday, Ahmad Alsaeed, Moustafa I Morsy, Htet Htet Ei Khin, Paul Welsh, Pierpaolo Pellicori","doi":"10.7326/ANNALS-26-00057","DOIUrl":"10.7326/ANNALS-26-00057","url":null,"abstract":"<p><strong>Background: </strong>The 1959 World Health Organization (WHO) definition of anemia is widely used, but its relationship with mortality in the general adult population is uncertain.</p><p><strong>Objective: </strong>To evaluate associations between baseline hemoglobin concentration and long-term mortality by age and sex.</p><p><strong>Design: </strong>Prospective cohort study.</p><p><strong>Setting: </strong>Population-based cohort in the United Kingdom.</p><p><strong>Participants: </strong>502 188 adults (median age, 58 years; 54.4% women) recruited from 2006 to 2010; hemoglobin concentration was measured in 477 876 (95.2%). Analyses were stratified by sex and age (<60 vs. ≥60 years). Median follow-up was 13.6 years.</p><p><strong>Measurements: </strong>Hemoglobin concentration categorized relative to WHO sex-specific thresholds (men, <13.0 g/dL; women, <12.0 g/dL). Outcomes were all-cause, cardiovascular, and cancer mortality.</p><p><strong>Results: </strong>All-cause mortality showed a U-shaped association with hemoglobin concentration, with lowest risk 1 to 3 g/dL above the WHO threshold. In the primary adjusted model, the 10-year standardized cumulative incidence (SCI) was 4.5% in the reference group versus 12.5% among participants more than 2 g/dL below the threshold (absolute risk difference [ARD], +8.1 percentage points; 95% CI, 6.7 to 9.4 percentage points); over the entire follow-up, the adjusted hazard ratio (HR) was 2.87 (CI, 2.54 to 3.25). Among those 0 to 1 g/dL above the threshold, the 10-year SCI was 5.3% (ARD, +0.8 percentage points; CI, 0.7 to 1.0 percentage points) and the adjusted HR was 1.18 (CI, 1.15 to 1.21). Associations were less consistent in women younger than 60 years. Patterns for cardiovascular and cancer mortality were similar at low and borderline concentrations but attenuated at higher concentrations.</p><p><strong>Limitation: </strong>Single baseline hemoglobin concentration measurement; predominantly White population.</p><p><strong>Conclusion: </strong>Mortality was lowest at hemoglobin concentrations 1 to 3 g/dL above current WHO thresholds, with higher mortality below and above this range. These hypothesis-generating findings should not define new thresholds but may inform clinical interpretation and evaluation of borderline hemoglobin concentration values.</p><p><strong>Primary funding source: </strong>None.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"1398-1411"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to I.M. Matters News: Wrestling with recurrent UTIs.","authors":"","doi":"10.7326/ANNALS-26-03790-IM","DOIUrl":"10.7326/ANNALS-26-03790-IM","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"IMN108"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Both Paternal and Maternal Nutrition Status Matter: An Exemplar From Folate and Vitamin B₁₂ in Association With Risks for Birth Defects.","authors":"Cuilin Zhang, Jing Zhu","doi":"10.7326/ANNALS-26-03045","DOIUrl":"10.7326/ANNALS-26-03045","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"1502-1503"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}