Annals of Internal Medicine最新文献

{"title":"A next-generation mt-sDNA test had 94% sensitivity for colorectal cancer and 91% specificity for advanced neoplasia.","authors":"Sander Veldhuyzen van Zanten, Ernst J Kuipers","doi":"10.7326/ANNALS-24-01660-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-24-01660-JC","url":null,"abstract":"<p><strong>Source citation: </strong>Imperiale TF, Porter K, Zella J, et al; BLUE-C Study Investigators. <b>Next-generation multitarget stool DNA test for colorectal cancer screening.</b> N Engl J Med. 2024;390:984-993. 38477986.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In acute ischemic stroke with a large core infarct, endovascular thrombectomy reduced disability at 90 d.","authors":"Nishanth Kodumuri, Mithilesh Siddu, Dinesh Jillella","doi":"10.7326/ANNALS-24-01578-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-24-01578-JC","url":null,"abstract":"<p><strong>Source citation: </strong>Costalat V, Jovin TG, Albucher JF, et al; LASTE Trial Investigators. <b>Trial of thrombectomy for stroke with a large infarct of unrestricted size.</b> N Engl J Med. 2024;390:1677-1689. 38718358.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Cardiovascular Risk Classification of U.S. Adults According to Pooled Cohort Equations and PREVENT Equations: Cross-Sectional Analysis of the National Health and Nutrition Examination Survey.","authors":"Abdul Mannan Khan Minhas, Salim S Virani, Erin D Michos, Vijay Nambi, Roger S Blumenthal, Alexander C Razavi, Layla Abushamat, Christie M Ballantyne, Dmitry Abramov","doi":"10.7326/ANNALS-24-00074","DOIUrl":"https://doi.org/10.7326/ANNALS-24-00074","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining Women's Willingness to Screen for Breast Cancer: Does False-Positive Recall Matter?","authors":"Neha Pathak, Michelle Beth Nadler","doi":"10.7326/M24-0893","DOIUrl":"https://doi.org/10.7326/M24-0893","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In T2DM with CKD, semaglutide reduced major kidney disease events at 3 y.","authors":"David Collister, Neesh Pannu","doi":"10.7326/ANNALS-24-01579-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-24-01579-JC","url":null,"abstract":"<p><strong>Source citation: </strong>Perkovic V, Tuttle KR, Rossing P, et al; FLOW Trial Committees and Investigators. <b>Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes.</b> N Engl J Med. 2024;391:109-121. 38785209.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In factor Xa inhibitor-related acute ICH, andexanet vs. usual care improved hemostatic efficacy but increased thrombotic events.","authors":"Benton R Hunter, Jonathan M Kirschner","doi":"10.7326/ANNALS-24-01365-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-24-01365-JC","url":null,"abstract":"<p><strong>Source citation: </strong>Connolly SJ, Sharma M, Cohen AT, et al; ANNEXA-I Investigators. <b>Andexanet for factor Xa inhibitor-associated acute intracerebral hemorrhage.</b> N Engl J Med. 2024;390:1745-1755. 38749032.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"After ACS, telemedicine-based care with remote patient monitoring vs. usual care reduced hospital readmissions at 6 mo.","authors":"Ayman R Fath, Islam Y Elgendy","doi":"10.7326/ANNALS-24-01775-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-24-01775-JC","url":null,"abstract":"<p><strong>Source citation: </strong>Alshahrani NS, Hartley A, Howard J, et al. <b>Randomized trial of remote assessment of patients after an acute coronary syndrome.</b> J Am Coll Cardiol. 2024;83:2250-2259. 38588928.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Effects of Individualized Acupuncture for Chronic Neck Pain : A Randomized Controlled Trial.","authors":"Ling Zhao, Mingsheng Sun, Zihan Yin, Jin Cui, Ruihui Wang, Laixi Ji, Guoyan Geng, Jiao Chen, Dingjun Cai, Qi Liu, Hui Zheng, Fanrong Liang","doi":"10.7326/M23-2425","DOIUrl":"https://doi.org/10.7326/M23-2425","url":null,"abstract":"<p><strong>Background: </strong>Long-term effects of individualized acupuncture in persons with chronic neck pain (CNP) remain unknown.</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of pressure pain, sensory-based individualized acupuncture for relieving CNP.</p><p><strong>Design: </strong>A 24-week multicenter randomized controlled clinical trial. (ChiCTR1800016371).</p><p><strong>Setting: </strong>Outpatient settings at 4 clinical centers in China from May 2018 to March 2020.</p><p><strong>Participants: </strong>716 participants with CNP.</p><p><strong>Intervention: </strong>Participants were randomly assigned to a waiting list (WL) group or to 1 of 3 interventions, which consisted of 10 sessions over 4 weeks: higher sensitive acupoints (HSA), lower sensitive acupoints (LSA), and sham acupoints (SA) acupuncture groups.</p><p><strong>Measurements: </strong>The primary outcome was the change in the visual analogue scale (VAS) score for neck pain (range, 0 to 100) from baseline to 4 weeks, with a difference of 10 points considered the minimum clinically important threshold. The VAS was also assessed every 4 weeks through 24 weeks.</p><p><strong>Results: </strong>The modified intention-to-treat population included 683 participants. The mean baseline VAS was 50.36, 50.10, 49.24, and 49.16 for HSA, LSA, SA, and WL, respectively. Compared with a mean baseline to week 4 change of -12.16 in the HSA group, the mean changes were -10.19 in the LSA group (net difference [ND], -1.97 [95% CI, -5.03 to 1.09]), -6.11 in the SA group (ND, -6.05 [CI, -9.10 to -3.00]), and -2.24 in the WL group (ND, -9.93 [CI, -12.95 to -6.90]). The intervention effects persisted at 24-week follow-up.</p><p><strong>Limitation: </strong>Lack of complete blinding and limited generalizability.</p><p><strong>Conclusion: </strong>Individualized acupuncture interventions using high- or low-sensitivity acupuncture points were more effective in reducing CNP than SA and WL control groups sustained through 24 weeks, but the magnitude of relative improvement did not reach a minimal clinically important difference.</p><p><strong>Primary funding source: </strong>National Natural Science Foundation of China.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In early Parkinson disease, daily subcutaneous lixisenatide reduced motor disability progression at 12 mo.","authors":"Joseph H Friedman","doi":"10.7326/ANNALS-24-01662-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-24-01662-JC","url":null,"abstract":"<p><strong>Source citation: </strong>Meissner WG, Remy P, Giordana C, et al; LIXIPARK Study Group. <b>Trial of lixisenatide in early Parkinson's disease.</b> N Engl J Med. 2024;390:1176-1185. 38598572.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In sepsis, continuous and intermittent infusion of β-lactam antibiotics did not differ for mortality at 90 d.","authors":"Morgan K Walker, Jeffrey R Strich","doi":"10.7326/ANNALS-24-01752-JC","DOIUrl":"https://doi.org/10.7326/ANNALS-24-01752-JC","url":null,"abstract":"<p><strong>Source citation: </strong>Dulhunty JM, Brett SJ, De Waele JJ, et al; BLING III Study Investigators. <b>Continuous vs intermittent β-lactam antibiotic infusions in critically ill patients with sepsis: the BLING III randomized clinical trial.</b> JAMA. 12 June 2024. [Epub ahead of print.] 38864155.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":null,"pages":null},"PeriodicalIF":19.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}