Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine最新文献

Effects of estrogen on the growth of mouse teratocarcinoma OTT6050 in vivo. 雌激素对小鼠畸胎瘤ot6050体内生长的影响。

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

K Kubota, R Kubota, T Matsuzawa

{"title":"Effects of estrogen on the growth of mouse teratocarcinoma OTT6050 in vivo.","authors":"K Kubota, R Kubota, T Matsuzawa","doi":"","DOIUrl":"","url":null,"abstract":"The effects of estrogen, antiestrogen and ovariectomy on the growth of a mouse teratocarcinoma, OTT6050, were studied in vivo. Subcutaneous tumors transplanted in syngeneic 129/Sv male and female mice were measured, and tumor-growth curves were constructed using the products of three principal tumor diameters, designated tumor volume. There was a linear correlation between the measured tumor volume and the actual excised tumor volume. The tumor growth rate in estrogen-treated groups was significantly greater than that in the control group, and the difference in tumor volume between treated groups and controls increased with time. However, dose responsiveness was not observed. In antiestrogen-treated or ovariectomized mice, tumor growth was partially inhibited only at the early stages. The mean survival time of estrogen-treated and ovariectomized groups was shorter than that of controls, while that of the antiestrogen-treated group was identical to that of controls. Histologically, no specifically different types of differentiated tissues were observed in any group. Our experiments show that estrogen is one important factor which stimulates the growth of one form of teratocarcinoma.","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 5","pages":"309-17"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17907792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiocrossed immunoelectrophoretical heterogeneity of beta 2-microglobulin in blood from patients with germ cell tumors and with colorectal cancer. 生殖细胞肿瘤和结直肠癌患者血液中β 2微球蛋白的放射交叉免疫电泳异质性

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

J Hangaard, B Norgaard-Pedersen

引用次数: 0

Maternal plasma HbF levels in pregnancy. 妊娠期孕妇血浆HbF水平。

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

R F James, R Szumski, P G Gillett, J Shuster, P Gold

引用次数: 0

Relationship of neoantigens induced by 3-methyl-cholanthrene treatment of Syrian hamster embryo cells to antigens expressed on fetal and 3-methyl-cholanthrene-transformed neoplastic cells. 3-甲基胆蒽处理叙利亚仓鼠胚胎细胞诱导的新抗原与胚胎和3-甲基胆蒽转化的肿瘤细胞上表达的抗原的关系

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

R P McCabe, C H Evans, J A Dipaolo

{"title":"Relationship of neoantigens induced by 3-methyl-cholanthrene treatment of Syrian hamster embryo cells to antigens expressed on fetal and 3-methyl-cholanthrene-transformed neoplastic cells.","authors":"R P McCabe, C H Evans, J A Dipaolo","doi":"","DOIUrl":"","url":null,"abstract":"Neoantigen(s) induced on Syrian hamster cells during chemical carcinogenesis are also found on fetal and neoplastic hamster cells. 46 neoplastic cell lines independently isolated from colonies of 3-methylcholanthrene (3-MCA) in vitro-transformed hamster cells growing in semi-solid agar medium were assayed for expression of neoantigens recognized by hamster antisera to primary cultured late-term (15 days) hamster embryo cells treated for 18 h with 10 micrograms 3-MCA/ml. Ratios of the binding of this sera compared to solvent control sera ranged from 0.7 to 2.1 in terms of cpm bound. Only four of the 46 neoplastic cell lines exhibited significant (P less than 0.05) neoantigen expression. No correlation existed between the concentration of 3-MCA used to establish the neoplastic cell line and expression of the neoantigen(s). Absorption of the sera with these four highly reactive neoplastic cell lines and mid-term (10 days) embryo cells indicated that the neoantigen(s) recognized were common to the four reactive neoplastic cell lines and the mid-gestation fetal cells. The occurrence of early persistent immunogenic cell-surface alterations during in vitro carcinogenesis provides an approach to isolation of preneoplastic populations and provides potential target structures for the inhibition of carcinogenesis.","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 6","pages":"383-93"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17701445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The occurrence of chicken foetal antigen after infection with Marek's disease virus in three strains of chicken. 三株鸡感染马立克氏病病毒后鸡胎儿抗原的发生。

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

P C Powell, K J Hartley, B M Mustill, M Rennie

{"title":"The occurrence of chicken foetal antigen after infection with Marek's disease virus in three strains of chicken.","authors":"P C Powell, K J Hartley, B M Mustill, M Rennie","doi":"","DOIUrl":"","url":null,"abstract":"An indirect immunofluorescence procedure employing specific antiserum was used to demonstrate chicken foetal antigen (CFA), a membrane antigen typically present on embryonic cells. The expression of CFA by lymphocytes from the peripheral blood, spleen, thymus and bursa was found to decline rapidly after hatching; the bursa, however, contained about 30% CFA-positive cells until at least 120 days of age. After infection of a genetically susceptible strain of chickens (HPRS Rhode Island Red) with Marek's disease virus, the expression of CFA by lymphocytes in the blood and lymphoid organs was found to increase steadily. Lymphomas which developed contained, on average, 25.7% CFA-expressing cells. In contrast, a second susceptible strain (line 7) showed no increase in CFA expression (compared with uninfected controls), and lymphomas from these birds contained only 4.8% positive cells. A genetically resistant strain (line 6) also did not differ from uninfected controls. It was concluded that in Marek's disease, CFA expression is associated with malignant transformation, although transformation may occur without the appearance of CFA, and that CFA is a marker for a stage of dedifferentiation of transformed cells rather than a marker for transformation. The degree of dedifferentiation seems to vary from strain to strain.","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 4","pages":"261-71"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17886586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production of Kasahara isoenzyme by OKK cell line established from a human maxillary carcinoma. 上颌癌OKK细胞系产生Kasahara同工酶。

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

M Tanaka, S Kudo, K Higashino, S Kishimoto

引用次数: 0

Tumor markers in testicular germ cell tumors related to the stage of the disease at the time of diagnosis. 睾丸生殖细胞肿瘤的肿瘤标志物与诊断时疾病的分期有关。

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

G K Jacobsen

{"title":"Tumor markers in testicular germ cell tumors related to the stage of the disease at the time of diagnosis.","authors":"G K Jacobsen","doi":"","DOIUrl":"","url":null,"abstract":"A series of 170 consecutive patients with testicular germ cell tumors (88 seminomas and 82 non-seminomas) had preoperative serum samples and primary tumor tissue examined for the presence of the tumor markers, alphafetoprotein (AFP) and human chorionic gonadotropin (HCG) by immunologic techniques. Staging was performed, using a clinico- radiological system, i.e., stage I, tumor confined to testis; stage II, metastases to abdominal lymph nodes only: stage III, metastases to supradiaphragmatic lymph nodes and/or extranodal disease. Seminoma:all 36% had stage II+III disease. 55% of the patients with AFP had localized disease, and 45% had stage II+III. The frequency of patients with stage I non-seminoma with raised serum HCG was 63% compared to 37% in stage II+III. Within the group of HCG-positive non-seminomas, 60% were in stage I and 40% in stage II. Since a high frequency of patients with metastatic disease did not occur among the patients with AFP or HCG in preoperative serum samples or in primary tumor tissue, we conclude that neither AFP nor HCG are especially associated with metastatic properties. The higher frequency of patients with raised serum values among all patients with metastatic disease compared to localized disease may only reflect a greater tumor burden.","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 6","pages":"C39-44"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17261173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lectin-binding heterogeneity of alphafetoprotein (AFP). An observation in nude mouse xenografts of endodermal sinus tumors and in pediatric surgical patients. 甲胎蛋白(AFP)凝集素结合异质性。裸鼠内胚层窦肿瘤异种移植及小儿外科患者的观察。

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

Y Tsuchida, S Saito, M Kaneko, R Yoshida, Y Endo

{"title":"Lectin-binding heterogeneity of alphafetoprotein (AFP). An observation in nude mouse xenografts of endodermal sinus tumors and in pediatric surgical patients.","authors":"Y Tsuchida, S Saito, M Kaneko, R Yoshida, Y Endo","doi":"","DOIUrl":"","url":null,"abstract":"We determined by affinity chromatography on concanavalin A-Sepharose the carbohydrate variant patterns of alphafetoprotein in the sera of 15 infants and children with endodermal sinus tumors (five cases), a neonatal mature teratoma (one case), hepatoblastomas (two cases), pancreatic carcinoma (one case), biliary atresia (four cases), neonatal hepatitis (one case) and neonatal hyperbilirubinemia (one case), in the sera from four normal neonates, and in the sera from two kinds of nude mice bearing human endodermal sinus tumors. Sera from patients with endodermal sinus tumors and pancreatic carcinoma were found to contain a relatively high proportion (48.4 +/- 4.5 and 52.6%) of alphafetoprotein which did not bind to concanavalin A. Sera from nude mice with human endodermal sinus tumors contained AFP, 96.2% of which did not bind to concanavalin A. Sera from patients with other lesions (nine cases) and from normal neonates, whose AFPs are all presumed to be of hepatic origin, contained much less (5.9 +/- 3.6%) of the concanavalin A non-binding AFP variant. These results indicate that human AFP has three distinct patterns of reactivity with concanavalin A and that studies in xenograft models may give important information relating to the glycosylation and secretion process of AFP.","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 6","pages":"C53-61"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17261771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yolk sac-derived malignant tumors develop in the absence of germ cells. 卵黄囊衍生的恶性肿瘤是在没有生殖细胞的情况下发生的。

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

H Sobis, M Vandeputte

引用次数: 0

Monoclonal antibodies against pregnancy-specific beta 1-glycoprotein (SP1) in immunohistochemistry and radioimmunoassay. 妊娠特异性β 1-糖蛋白(SP1)单克隆抗体免疫组化和放射免疫分析。

Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01

T Wahlström, M Heikinheimo

引用次数: 0