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Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine最新文献

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Production of monoclonal antibodies against the non-specific cross-reacting antigen (NCA). 产生抗非特异性交叉反应抗原(NCA)的单克隆抗体。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
G Chavanel, N Frenoy, M J Escribano, P Burtin
{"title":"Production of monoclonal antibodies against the non-specific cross-reacting antigen (NCA).","authors":"G Chavanel,&nbsp;N Frenoy,&nbsp;M J Escribano,&nbsp;P Burtin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hybridomas were prepared by fusion of mouse spleen cells immunized with purified NCA (non-specific cross-reacting antigen) with cells of myeloma SP2/0. After cloning, several clones were obtained which produced antibodies specific for NCA, i.e., not reacting with CEA. All antibodies were IgG1 Kappa. Their affinity constants were higher at 4 degrees C than at 37 degrees C. They revealed the existence of at least two epitopes on the specific moiety of NCA.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 3","pages":"209-17"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17462057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-seminomatous germ cell tumors of the testis. Analysis of AFP and HCG production by primary tumors and retroperitoneal lymph node metastases after PVB combination chemotherapy. 睾丸非半瘤性生殖细胞瘤。PVB联合化疗后原发肿瘤及腹膜后淋巴结转移患者AFP及HCG生成分析。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
A J Suurmeijer, J W Oosterhuis, J Marrink, H W De Bruin, H Schraffordt Koops, D T Sleijfer, G J Fleuren
{"title":"Non-seminomatous germ cell tumors of the testis. Analysis of AFP and HCG production by primary tumors and retroperitoneal lymph node metastases after PVB combination chemotherapy.","authors":"A J Suurmeijer,&nbsp;J W Oosterhuis,&nbsp;J Marrink,&nbsp;H W De Bruin,&nbsp;H Schraffordt Koops,&nbsp;D T Sleijfer,&nbsp;G J Fleuren","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum AFP and HCG values were correlated with AFP and HCG tissue staining in 27 non-seminomatous germ cell tumors (NSGCT) of the testis and their retroperitoneal lymph node metastases after PVB chemotherapy. We found a poor correlation between tissue and serum AFP positivity and a moderately good correlation between tissue and serum HCG positivity in the testicular tumor. The therapy-related differentiated teratomatous elements did occasionally produce AFP or HCG, but AFP or HCG were not detectable in the patients' sera. These serum markers have no value for the detection of mature residual tumor following chemotherapy.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 4","pages":"289-308"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17252848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical demonstration of hemoglobin F (HbF) in testicular germ cell tumors. 睾丸生殖细胞肿瘤中血红蛋白F (HbF)的免疫组化表达。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
G K Jacobsen, M Jacobsen
{"title":"Immunohistochemical demonstration of hemoglobin F (HbF) in testicular germ cell tumors.","authors":"G K Jacobsen,&nbsp;M Jacobsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Increased serum levels of fetal hemoglobin (HbF) in patients with testicular malignancy have been suggested to be due to reactivation of HbF synthesis in the bone marrow. Since HbF is known to be present in the normal yolk sac, a series of 12 testicular germ cell tumors containing yolk sac tumor (YST) components and/or embryonal carcinoma (EC) were examined by the indirect immunoperoxidase technique for the presence of HbF in the tumor tissue. In nine tumors, the YST components, i.e., cells of the microcystic and reticular patterns as well as of endodermal appearance, were positively stained. In addition, groups of positively stained cells were found in the mesenchymal stroma of the tumors. In seven tumors, varied numbers of EC tumor cells were also HbF-positive. In the vessels positively stained, blood cells occurred to a variable extent. The appearance and distribution of HbF-positive cells in the YST components are in accordance with the various types of blood-forming cells hitherto accepted to be present in the normal conceptus during development. In addition, the staining results indicate that YST imitates not only the yolk sac proper, but also other fetal structures. Furthermore, the results support the suggestion, that the HbF in the peripheral blood of patients with testicular tumors may originate in the tumor tissue, and not necessarily in the bone marrow. Evaluation of HbF as a serologic tumor marker in such patients is, therefore, recommended.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 6","pages":"C45-51"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17261770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence for the presence of a precursor form to gamma-glutamyl transpeptidase in cultured yolk sac tumor cells. 在培养的卵黄囊肿瘤细胞中存在γ -谷氨酰转肽酶前体形式的证据。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
N Yokosawa, N Taniguchi, Y Tsukada, A Makita
{"title":"Evidence for the presence of a precursor form to gamma-glutamyl transpeptidase in cultured yolk sac tumor cells.","authors":"N Yokosawa,&nbsp;N Taniguchi,&nbsp;Y Tsukada,&nbsp;A Makita","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The biosynthesis of gamma-glutamyl transpeptidase was studied in a yolk sac tumor cell line. Cell suspensions were labeled with [14C]leucine; immunoprecipitates were obtained with anti-gamma-glutamyl transpeptidase antibody and analyzed on SDS-polyacrylamide gel electrophoresis++. A radioactive 80 000 dalton peak and peaks identical to heavy and light subunits were detected in the immunoprecipitates from the extract which was labeled for 15 min. After 45 min labeling, the 80 000 dalton species disappeared, although the two subunits were still observed. Tunicamycin-pretreated cells were labeled with [3H]glucosamine and [14C]leucine for 3.5 h. The 80 000 dalton species was glycosylated, and accumulated to a great degree compared to non-treated cells.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 6","pages":"C71-8"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17205397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human aldolase B subunit-specific radioimmunoassay. 人醛缩酶B亚基特异性放射免疫测定。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
M Asaka, E Alpert
{"title":"Human aldolase B subunit-specific radioimmunoassay.","authors":"M Asaka,&nbsp;E Alpert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A radioimmunoassay was developed for the direct quantification of aldolase B in human serum and tissues. The method is a double antibody radioimmunoassay technique using radioiodinated aldolase B homopolymer as ligand, chicken antibodies to aldolase B and rabbit antibodies to chicken IgG. This radioimmunoassay was shown to be specific for the aldolase B subunit, with no cross-reactivity with either human aldolase A subunit or homopolymeric human aldolase C (C4). The lowest measurable amount by this method was 2 ng/ml. Aldolase B is predominantly found in normal liver tissue, with relatively high aldolase B levels also observed in kidney. Aldolase B levels in the serum obtained from 11 normal subjects ranged from 23 to 38 ng/ml, with a mean of 28.5 +/- 9.2 (S.D.) ng/ml. Almost all of patients with hepatitis had serum aldolase B levels greater than 30 ng/ml. In cancer patients, serum aldolase B was slightly elevated in patients with metastatic liver cancer and primary lever cell carcinoma, whereas no elevation of serum aldolase B was shown in patients without liver metastasis.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 3","pages":"187-95"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17879431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). 两种新的胎盘组织可溶性蛋白(PP13和PP17)的纯化和鉴定。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
H Bohn, W Kraus, W Winckler
{"title":"Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17).","authors":"H Bohn,&nbsp;W Kraus,&nbsp;W Winckler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two new soluble placental tissue proteins (PP13 and PP17) have been isolated and characterized. PP13 has an electrophoretic mobility the same as that of albumin, an isoelectric point in the range 4.7-4.8 and a sedimentation coefficient of 3.1 S. Its molecular weight was found to be 30 000. PP13 appears to be composed of two identical subunits which are held together by disulfide bonds. PP17 has an electrophoretic mobility in between the beta 1- and alpha 2-globulins, an isoelectric point in the range 5.2-5.3 and a sedimentation coefficient of 2.7 S. Its molecular weight was determined to be 30 300 by ultracentrifugation and 38 000 by SDS-polyacrylamide gel electrophoresis. PP17 apparently consists of a single peptide chain. The amino acid and carbohydrate compositions of these proteins also have been determined. Immunochemical methods were used to detect and quantitate the new proteins in extracts of placental and other human tissues as well as in body fluids. From one human term placenta an average of 3.7 mg PP13 and 2.5 mg PP17 could be extracted. In concentrated extracts of other human tissues and in body fluids, these proteins could not be detected, at least not in concentrations higher than 1 mg/dl. The immunohistochemical localization of these proteins as well as measurement of their concentrations in body fluids by sensitive radioimmunoassays are presently under investigation.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 5","pages":"343-50"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17905704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Localizing properties of antibody to alphafetoprotein (AFP) to AFP-producing tumor cells. 甲胎蛋白抗体对产甲胎蛋白肿瘤细胞的定位特性。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
K Kono, K Nakata, T Muro, R Furukawa, T Ogino, Y Kusumoto, N Ishii, T Munehisa, T Koji, S Nagataki
{"title":"Localizing properties of antibody to alphafetoprotein (AFP) to AFP-producing tumor cells.","authors":"K Kono,&nbsp;K Nakata,&nbsp;T Muro,&nbsp;R Furukawa,&nbsp;T Ogino,&nbsp;Y Kusumoto,&nbsp;N Ishii,&nbsp;T Munehisa,&nbsp;T Koji,&nbsp;S Nagataki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies have been undertaken to clarify the localizing properties of radioactively labeled antibody to AFP using ascitic hepatoma cells which produce AFP. In the in vitro studies, radioantibodies to AFP were incorporated into the AFP-producing cells, even though excess antigen existed in the medium and the antibodies remained on the cell surface for a long time. In the in vivo studies, the radioantibodies to AFP bound to the AFP-producing cells, especially those producing high levels of AFP (AH66). Tumor localization by scintigraphy was clearer with the AH66 hepatoma than with the AH41C hepatoma, which produces less AFP. The presence of large amounts of AFP in the circulation did not prevent the tumor radioimmunodetection. It is suggested that radioantibodies to AFP bind to the AFP-producing cells despite the presence of large amounts of AFP in the circulation or in ascitic fluid.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 6","pages":"C87-94"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17261772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of placental protein 5 (PP5) by non-malignant human fibroblasts in culture. Comparison with 'pregnancy-specific' glycoprotein (SP1). 培养的非恶性人成纤维细胞产生胎盘蛋白5 (PP5)。与“妊娠特异性”糖蛋白(SP1)比较。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
A D Nisbet, S W Rosen, N Ellmore, R D Bremner, C H Horne
{"title":"Production of placental protein 5 (PP5) by non-malignant human fibroblasts in culture. Comparison with 'pregnancy-specific' glycoprotein (SP1).","authors":"A D Nisbet,&nbsp;S W Rosen,&nbsp;N Ellmore,&nbsp;R D Bremner,&nbsp;C H Horne","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Placental protein 5 (PP5) was detected by radioimmunoassay in the culture media from 11/19 (58%) of cell lines derived from non-malignant human fibroblasts. One line was studied in detail. Its rate of PP5 secretion was polyphasic, with maxima of 3.1 pmol/10(6) cells per 24 h on day 1, 1.7 on day 8 and 2.0 on day 14, and minima of 0.9 on day 4, 1.0 on day 10 and 0.7 on day 15 of culture. A discordance with the secretion of pregnancy-specific glycoprotein (SP1) was demonstrated; the SP1 concentration was constant initially at 2.9 pmol/10(6) cells per 24 h, followed by a steady decrease to 0.5 on day 15. A small amount of PP5 was retained in the cells, but usually less than 5% of that secreted. When the culture medium was changed daily, more PP5 and SP1 were produced than when the cells were grown in conditioned media. A cell line derived from a human fibrosarcoma produced SP1 at rates exceeding that of the normal fibroblasts, but PP5 production was not detected in the fibrosarcoma.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 4","pages":"281-8"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17657179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are there factors preventing cancer development during embryonic life? 在胚胎期是否有预防癌症发展的因素?
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
L Einhorn
{"title":"Are there factors preventing cancer development during embryonic life?","authors":"L Einhorn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>On the basis of the following literature observations, a hypothesis is advanced that the development of cancer is actively inhibited during embryonic life. Although the processes of cell differentiation and proliferation are--without comparison--most pronounced during embryonic life, cancer is rarely found in the newborn and is seldom a cause of neonatal death or spontaneous abortion. Attempts to induce cancer in early-stage animal embryos by irradiation or by transplacental chemical carcinogenesis have been unsuccessful, even when exposed animals have been observed throughout their life-time. After the period of major organogenesis, however, the embryos become susceptible to carcinogenesis. In humans, the most common embryonic tumors arise in tissues which have an unusually late ongoing development and are still partly immature at or shortly before birth. For many human embryonic tumors the survival rates are higher, and spontaneous regression more frequent, in younger children, i.e. prognosis is age-dependent. Thus, although cancer generally appears in tissues capable of proliferation and differentiation, induction of malignancy in the developmentally most active tissues seems to be beset with difficulty. One possible explanation for this paradox could be that cancer is controlled by the regulators influencing development, regulators that are most active during embryonic life.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 3","pages":"219-29"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17360613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of cyclic adenosine 3',5'-monophosphate in differentiation of fetal liver cells in vitro. 环腺苷3′，5′-单磷酸在体外胎儿肝细胞分化中的作用。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1983-01-01
J Y Chou
{"title":"Role of cyclic adenosine 3',5'-monophosphate in differentiation of fetal liver cells in vitro.","authors":"J Y Chou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Regulation of the synthesis of alpha-fetoprotein (AFP), albumin, and transferrin was studied in temperature-sensitive (ts), simian virus 40 (SV40) tsA mutant-transformed rat fetal liver RLA209-15 cells. The intracellular cyclic AMP (cAMP) levels in RLA209-15 cells grown at the nonpermissive temperature (40 degrees C, the temperature at which the cells exhibit the differentiated phenotype) were higher than the levels in these cells grown at the permissive temperature (33 degrees C, the temperature at which these cells exhibit the transformed phenotype). We have shown previously that differentiation of RLA209-15 cells at 40 degrees C was accompanied by increases in AFP, albumin and transferrin. In the present study, we found that 8 bromo-cAMP (8 BrcAMP), cholera toxin and methylisobutylxanthine (MIX), agents that increase intracellular cAMP levels, greatly stimulated the production of AFP, albumin and transferrin. The phosphodiesterase inhibitor MIX was the most effective inducer of AFP and albumin. The kinetics of AFP induction in the presence of 8BrcAMP, cholera toxin and MIX were similar to the kinetics of albumin induction. The positive correlation of cAMP levels and the differentiated state of these cells indicate that cAMP may be one of the factors that maintains differentiation of fetal liver cells in vitro.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"4 3","pages":"177-85"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17251449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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