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Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine最新文献

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Ni3S2-induced leiomyosarcomas in rabbit skeletal muscle: analysis of the tumoral myosin and its significance in the retrodifferentiation concept. ni3s2诱导兔骨骼肌平滑肌肉瘤:肿瘤肌球蛋白分析及其在后向分化概念中的意义。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
H F Hildebrand, D Tetaert
{"title":"Ni3S2-induced leiomyosarcomas in rabbit skeletal muscle: analysis of the tumoral myosin and its significance in the retrodifferentiation concept.","authors":"H F Hildebrand,&nbsp;D Tetaert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Leimyosarcomas were induced in rabbit skeletal muscle by Ni3S2 implantation. Tumor myosin was isolated and compared with normal adult muscle myosin and cow uterine smooth muscle myosin. This study has shown that this leiomyosarcoma myosin precipitates as long fusiform filaments and possesses two light-chain of 25000 and 18000 daltons as does the once-fetal type. The biochemical findings demonstrate that tumoral stem myoblasts originate from retrodifferentiated muscle cells.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 1-2","pages":"101-8"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18314621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CEA positivity in tissue and sera of patients with benign breast lesions. 乳腺良性病变患者组织及血清CEA阳性。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
C Wittekind, S Von Kleist, W Sandritter
{"title":"CEA positivity in tissue and sera of patients with benign breast lesions.","authors":"C Wittekind,&nbsp;S Von Kleist,&nbsp;W Sandritter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The presence of CEA was studied in paraffin sections of 100 benign breast lesions using an immunoperoxidase technique. In fibroadenomas, CEA was found in 25% of cases as opposed to 64% with cystic disease with or without epitheliosis. Our results demonstrate a tendency for an increased frequency of CEA tissue positivity in association with a more prominent form of epithelial hyperplasia with cystic disease. The observed higher positivity of tissue CEA may reflect a higher 'cellular activity' in the latter lesions compared with fibroadenomas.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 6","pages":"381-90"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18358746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demonstration of gamma-glutamyl transferase, alkaline phosphatase, CEA and HCG in human lung cancer. γ -谷氨酰转移酶、碱性磷酸酶、CEA和HCG在人肺癌中的作用。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
K Dempo, K A Elliott, W Desmond, W H Fishman
{"title":"Demonstration of gamma-glutamyl transferase, alkaline phosphatase, CEA and HCG in human lung cancer.","authors":"K Dempo,&nbsp;K A Elliott,&nbsp;W Desmond,&nbsp;W H Fishman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In contrast to its absence in normal and hyperplastic bronchial mucosa, gamma glutamyl transferase (GGT) has been demonstrated on the luminal surface of adenocarcinoma cells of bronchogenic cancer in three cases studied. On the other hand, little or no GGT was demonstrable in four epidermoid carcinomas and one oat cell cancer. Metaplastic alveolar cells appearing as cuboidal epithelial cells were uniformly positive for GGT and L-homoarginine-sensitive alkaline phosphatase. Whereas interest in GGT has centered in the past on experimental hepatocarcinogenesis, the current results demonstrate an ectopic expression of GGT in metaplastic alveolar cells and in adenocarcinoma of the lung. These findings merit further exploration to document the extent of the expression of GGT in bronchogenic cancer and to attempt to explain its presence in alveolar cell metaplasia.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 1-2","pages":"21-37"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17184648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpha-fetoprotein production by the synchronized regenerating murine liver. Its independence on the phases of the mitotic cycle. 同步再生小鼠肝脏产生甲胎蛋白。它在有丝分裂周期阶段的独立性。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
M N Lazareva
{"title":"Alpha-fetoprotein production by the synchronized regenerating murine liver. Its independence on the phases of the mitotic cycle.","authors":"M N Lazareva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>DNA synthesis in the regenerating liver of mice poisoned with carbon tetrachloride (CCl4) was inhibited by infusion of hydroxyurea (HU). The infusion was started prior to the beginning of DNA synthesis and continued up to 60-72 h after CCl4 administration. The AFP-containing cells in liver were demonstrated by the immunoperoxidase technique. Phases of the cell cycle were estimated by autoradiography following the administration of [3H] thymidine. Despite the arrest of all proliferating hepatocytes at the G1-S interphase, the pattern of AFP production in the HU-infused mice was the same as in normal regeneration. Serum AFP levels rose from the 2nd up to the 3rd to 4th day after administration of CCl4 and AFP was demonstrated in a small number of hepatocytes, bordering the necrotic areas of the liver. After release from the HU block, hepatocytes synchronously entered S phase. The degree of synchronization was of the same order as the size of the hepatocyte proliferative pool in regenerating liver. AFP was found in all the phases of the mitotic cycle - from G1 to postmitotic cells indicating that there is no direct correlation between AFP production and the phases of the mitotic cycle of hepatocytes in the murine regenerating liver.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 1-2","pages":"89-99"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17236630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Similarity of hydrophobic properties of alpha-fetoprotein and albumin. 甲胎蛋白和白蛋白疏水特性的相似性。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
V Zizkovský, P Strop, S Lukesová, J Korcáková, P Dvorák
{"title":"Similarity of hydrophobic properties of alpha-fetoprotein and albumin.","authors":"V Zizkovský,&nbsp;P Strop,&nbsp;S Lukesová,&nbsp;J Korcáková,&nbsp;P Dvorák","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human alpha-fetoprotein (AFP) and serum albumin (HSA) were studied by hydrophobic interaction chromatography. A close resemblance was observed both in the native state and after various perturbations (pH, salt and alcohol) indicating a significant similarity in their molecular structures. Both proteins displayed similar hydrophobic properties which apparently were different from those of other globular proteins. In agreement with the domain structure proposed by Brown (1976), our results indicated that surface nonpolar side chains of both the native HSA and AFP produced large hydrophobic areas located solely in crevices.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 5","pages":"323-30"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17238907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered dynamics of alpha-fetoprotein production following pyridoxine and adenosine 5'-triphosphate administration to cirrhotic patients with or without primary hepatomas and to liver-injured and hepatoma-bearing rats. 合并或不合并原发性肝癌的肝硬化患者以及肝损伤和肝癌大鼠给予吡哆醇和5'-三磷酸腺苷后甲胎蛋白生成动力学的改变
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
A Watanabe, H Nagashima
{"title":"Altered dynamics of alpha-fetoprotein production following pyridoxine and adenosine 5'-triphosphate administration to cirrhotic patients with or without primary hepatomas and to liver-injured and hepatoma-bearing rats.","authors":"A Watanabe,&nbsp;H Nagashima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 12 cirrhotic patients who developed primary hepatocellular carcinomas during long-term follow-up, surveillance by frequent serum alpha-fetoprotein (AFP) measurements was not useful for their earlier detection. Difficulty was encountered in deciding whether or not hepatomas had already developed in cirrhotic patients with serum AFP levels over 200 ng/ml. Simultaneous injections of pyridoxine and adenosine 5'-triphosphate (ATP) resulted insignificant decreases of elevated serum AFP levels in carbon tetrachloride (CCl4)-injured rats but in 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB)-induced hepatoma-bearing rats. On clinical application of this procedure, it was found that cirrhotic patients without hepatomas could be differentiated from those with primary hepatomas since in the former a clear reduction of AFP levels following the administration of pyridoxine and ATP took place. This may be a new approach to the earlier diagnosis of primary hepatomas in cirrhotic patients with elevated serum AFP levels.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 5","pages":"313-21"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17238906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initiation and characterization of cultures of human colonic carcinoma with different biological characteristics utilizing feeder layers of confluent fibroblasts. 利用融合成纤维细胞饲养层培养具有不同生物学特性的人结肠癌细胞。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
M G Brattain, D E Brattain, W D Fine, F M Khaled, M E Marks, P M Kimball, L A Arcolano, B H Danbury
{"title":"Initiation and characterization of cultures of human colonic carcinoma with different biological characteristics utilizing feeder layers of confluent fibroblasts.","authors":"M G Brattain,&nbsp;D E Brattain,&nbsp;W D Fine,&nbsp;F M Khaled,&nbsp;M E Marks,&nbsp;P M Kimball,&nbsp;L A Arcolano,&nbsp;B H Danbury","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The tissue culture of human colonic carcinoma with and without feeder layers of confluent C3H 10T1/2 mouse fibroblast was compared. In a series of 27 different tumor specimens, 21 long-term cultures (6 mos. or more) were obtained by utilizing feeder layers. Only 3 long-term cultures were obtained from the same set of specimens when feeder layers were not employed. Several of the long-term cultures were established as cell lines weaned from fibroblast feeder layers. These lines could be classified into 3 groups based upon their expression of several biological properties including tumorigenicity in nude mice, degree of differentiation of the tumors growing in nude mice, growth in semisolid medium, morphology in vitro and production of carcinoembryonic antigen in vitro.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 5","pages":"355-66"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18343110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concanavalin A binding of pregnancy-specific beta-1-glycoprotein in normal pregnancy and trophoblastic disease. 豆豆蛋白:正常妊娠和滋养层疾病中妊娠特异性β -1糖蛋白的结合物。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
R Koistinen, M Heikinheimo, E M Rutanen, U H Stenman, J N Lee, M Seppälä
{"title":"Concanavalin A binding of pregnancy-specific beta-1-glycoprotein in normal pregnancy and trophoblastic disease.","authors":"R Koistinen,&nbsp;M Heikinheimo,&nbsp;E M Rutanen,&nbsp;U H Stenman,&nbsp;J N Lee,&nbsp;M Seppälä","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The binding of pregnancy-specific beta-1-glycoprotein (SP1) to Concanavalin A (Con A) has been studied in serum samples from 34 pregnant women and 13 patients with trophoblastic diseases. In normal pregnancy and in hydatidiform moles, the fraction that did not bind to Con A accounted for 0.5--4.3% of the total SP1 concentration whereas, in 5 out of 6 patients with choriocarcinoma, the fraction was 4.8--30%. The secretion of Con A non-binding SP1 appears to be an inherent characteristic of some malignant trophoblast tissues and may result from its altered glycosylation.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 3","pages":"179-82"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17334137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor and placental histaminase, I. affinity chromatography purification and characterization of the placental enzyme. 肿瘤与胎盘组胺酶，1 .胎盘组胺酶的亲和层析纯化与表征。
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
C W Lin, S D Kirley, M St Pierre
{"title":"Tumor and placental histaminase, I. affinity chromatography purification and characterization of the placental enzyme.","authors":"C W Lin,&nbsp;S D Kirley,&nbsp;M St Pierre","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Histaminase (diamine oxidase) is an enzyme produced at very high levels by the decidua of the placenta and is found to be associated with a number of human cancers. A procedure for the affinity chromatography purification of this enzyme is described. In this procedure, cadaverine-AH-sepharose was used to bind the enzyme in the placental extract. After extensive washing of the column with 2.5% Triton X-100 in 1 M NaCl, the enzyme was released from the column by 0.1 N chromotropic acid. This purification, essentially a one step procedure, provided 1800-fold purification, and yielded mg quantities of histaminase, homogeneous by SDS-gel electrophoresis and immunodiffusion tests. The procedure usually recovered more than 40% of the enzyme applied and the specific activity of the final enzyme preparation was around 5000 units/mg protein. SDS-gel electrophoresis of the enzyme in different concentrations of acrylamide indicated that the subunit molecular weight of histaminase was about 90,000. Isoelectric focusing of the enzyme in polyacrylamide gel revealed 5 major enzyme components. Results of amino acid analyses indicated that the enzyme had a low content of sulfur-containing amino acids and a relatively high content of dicarboxylic amino acids. The availability of this purification will be useful for the development of immunological methods for detections and quantitation of this enzyme in specimens from cancer patients.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 4","pages":"267-80"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17847072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of placental protein five (PP5) and pregnancy-specific glycoprotein (SP1) in benign and malignant breast disease. 胎盘蛋白5 (PP5)和妊娠特异性糖蛋白(SP1)在乳腺良恶性病变中的检测
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Pub Date : 1981-01-01
R D Bremner, A D Nisbet, R Herriot, C H Horne, C McArdle, D Crawford, H Bohn
{"title":"Detection of placental protein five (PP5) and pregnancy-specific glycoprotein (SP1) in benign and malignant breast disease.","authors":"R D Bremner,&nbsp;A D Nisbet,&nbsp;R Herriot,&nbsp;C H Horne,&nbsp;C McArdle,&nbsp;D Crawford,&nbsp;H Bohn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sensitive radioimmunoassays for the placental proteins PP5 and SP1 were used to investigate possible ectopic synthesis of these proteins by breast tumors. Elevated serum levels of the proteins were found in a small proportion of patients who had undergone mastectomy for malignant tumors, but little useful information on tumor spread could be gained from such measurements. In two patients with elevated pre-operative serum PP5, the levels fell to normal upon resection of the tumor, suggesting that PP5 may be a product of the tumor. PP5 and SP1 were found to be present in the majority of homogenates of malignant and benign breast lesions; the highest concentrations of SP1 were found in malignant tumors, whereas with PP5, especially high levels were found in cases of simple cystic disease.</p>","PeriodicalId":79244,"journal":{"name":"Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine","volume":"2 1-2","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18023435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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