Clinical and experimental hypertension. Part B, Hypertension in pregnancy最新文献_第3页

Pre-eclampsia in a second pregnancy. 第二次怀孕的先兆子痫。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309006088

D M Campbell, R Carr-Hill, A E Orisaseyi

引用次数: 96

A clinical follow-up study of 260 women with hypertension in pregnancy. 260例妊娠期高血压妇女临床随访研究

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023462

A Svensson, B Andersch, L Hansson

引用次数: 5

Plasma catecholamines in normal pregnancy and in pregnancies complicated by mild chronic hypertension. 正常妊娠和合并轻度慢性高血压妊娠的血浆儿茶酚胺。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023464

R W O'Shaughnessy, G D Scott, J D Iams, F P Zuspan

引用次数: 6

Maternal-fetal immunity: presence of specific cellular hyporesponsiveness and humoral suppressor activity in normal pregnancy and their absence in preeclampsia. 母胎免疫:正常妊娠中存在特异性细胞低反应性和体液抑制活性，而子痫前期不存在。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023465

P A Taufield, M Suthanthiran, K Ales, M Druzin, L M Resnick, J H Laragh, K H Stenzel, A L Rubin

{"title":"Maternal-fetal immunity: presence of specific cellular hyporesponsiveness and humoral suppressor activity in normal pregnancy and their absence in preeclampsia.","authors":"P A Taufield, M Suthanthiran, K Ales, M Druzin, L M Resnick, J H Laragh, K H Stenzel, A L Rubin","doi":"10.3109/10641958309023465","DOIUrl":"https://doi.org/10.3109/10641958309023465","url":null,"abstract":"The hypothesis that aberrant maternal-fetal immunity might lead to the development of preeclampsia was examined using mixed lymphocyte culture reactions (MLC) as an in vitro analogue of maternal-fetal immunity. Maternal lymphocytes and serum from five normal pregnant women differed significantly from lymphocytes and serum from five preeclamptics. Maternal cells from normal pregnancy responded appropriately to unrelated control cells, but demonstrated selective hyporesponsiveness to fetal cells in the MLC. Serum from normal pregnancy suppressed MLCs when maternal cells were responder cells (RC) and maternal cells or fetal cells were stimulator cells (SC), and did not inhibit MLCs where maternal cells were RC and control cells were SC. Maternal lymphocytes and serum from preeclamptics did not demonstrate cellular hyporesponsiveness or humoral suppressor activity. Our findings support the notion that specific cellular hyporesponsiveness and humoral suppressor activity is responsible for normal pregnancy; absence of such adaptive immunity might lead to the development of preeclampsia.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"2 1","pages":"123-31"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958309023465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17287501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Beta blocker therapy in 125 cases of hypertension during pregnancy. -受体阻滞剂治疗妊娠期高血压125例。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023458

D Dubois, J Petitcolas, B Temperville, A Klepper, P Catherine

引用次数: 12

Effects on the renin-angiotensin system of the administration of prostaglandin E1 and E2 in second trimester human pregnancy. 前列腺素E1和E2对人妊娠中期肾素-血管紧张素系统的影响。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309006083

F Broughton Pipkin, J C Hunter, P M O'Brien, L J Sant-Cassia, S R Turner

{"title":"Effects on the renin-angiotensin system of the administration of prostaglandin E1 and E2 in second trimester human pregnancy.","authors":"F Broughton Pipkin, J C Hunter, P M O'Brien, L J Sant-Cassia, S R Turner","doi":"10.3109/10641958309006083","DOIUrl":"https://doi.org/10.3109/10641958309006083","url":null,"abstract":"We have measured evoked changes in plasma renin concentration (PRC), plasma renin substrate (PRS) amd plasma aldosterone concentration (ALD) during the infusion of angiotensin II (AII) with and without the simultaneous administration of prostaglandin E2, 5 micrograms min-1 i.v. (PGE2) or prostaglandin E1, 15 ng kg-1 min-1 (PGE1). Experiments have been carried out using PGE2 in 20 patients, and in 5 patients to date with PGE1. AII alone (16 ng kg-1 min-1 i.v.) significantly reduced PRC in both groups of patients without altering PRS, while ALD concentrations more than doubled. The infusion of PGE2 stimulated basal PRC; PGE1 at the dose used did not alter PRC. Neither prostaglandin altered basal RS or ALD concentrations. When AII was infused simultaneously, PRC was again suppressed, in the presence of PGE2. However, only minimal feedback suppression occurred when PGE1 was being used. Furthermore, AII was still associated with a more than two-fold rise in ALD concentration when given together with PGE2, but the rise was considerably smaller and not significant in the presence of PGE1. PGE2 is a known stimulus to renin secretion, apparently acting directly at the juxtaglomerular apparatus. These preliminary results suggest that while a similar mechanism exists in second trimester human pregnancy, PGE1 may have a different effect. The apparent blockade of the normal feedback suppression of PRC in the presence of increased PGE1 concentrations by raised concentrations of AII is especially interesting.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"2 2","pages":"233-45"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958309006083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17408243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipoxygenase activity in human uterine and intrauterine tissues: new prospects for control of prostacyclin production in pre-eclampsia. 人子宫和宫内组织脂氧合酶活性:控制子痫前期前列环素产生的新前景。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023463

S A Saeed, M D Mitchell

{"title":"Lipoxygenase activity in human uterine and intrauterine tissues: new prospects for control of prostacyclin production in pre-eclampsia.","authors":"S A Saeed, M D Mitchell","doi":"10.3109/10641958309023463","DOIUrl":"https://doi.org/10.3109/10641958309023463","url":null,"abstract":"The formation of lipoxygenase metabolites by human uterine and intrauterine tissues was evaluated using [1-14C]arachidonic acid (AA) as substrate. The major lipoxygenase product synthesized by human amnion, decidua vera and placenta was identified as 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE); smaller amounts of 5-HETE and 5-HETE (lactone form) were also formed. In chorion laeve only a trace amount of 12-HETE was detected. Human myometrium and cervical tissue converted [1-14C]AA to 5-HETE and 12-HETE in almost equal amounts. The formation of lipoxygenase products in all tissues was markedly inhibited by nordihydroguaiaretic acid (NDGA) an inhibitor of lipoxygenase activity and slightly stimulated or inhibited by indomethacin, an inhibitor of cyclooxygenase activity. These results are indicative that uterine and intrauterine tissues are probably potential sources of lipoxygenase products during pregnancy and parturition. Since 12-hydroperoxy-eicosatetraenoic acid (12-HPETE), the labile precursor of 12-HETE potently inhibits prostacyclin biosynthesis, our findings are suggestive of the possibility that aberrant lipoxygenase activities may contribute to the complications of pre-eclampsia.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"2 1","pages":"103-11"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958309023463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17469153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Evans Blue disappearance rate in normal and pre-eclamptic pregnancy. 正常妊娠和子痫前期的埃文斯蓝消失率。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023468

D M Campbell, A J Campbell

引用次数: 33

Prostaglandins, angiotensin and blood pressure in pregnant rabbits. 孕兔前列腺素、血管紧张素与血压的关系。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309006089

T J Sheehan, F Broughton Pipkin, P M O'Brien

引用次数: 3

The value of the mean arterial blood pressure in the second trimester (MAP-2 value) as a predictor of pregnancy-induced hypertension and preeclampsia. A preliminary report. 妊娠中期平均动脉血压(MAP-2值)作为妊娠高血压和先兆子痫的预测因子。初步报告。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309006081

T Oney, H Kaulhausen

{"title":"The value of the mean arterial blood pressure in the second trimester (MAP-2 value) as a predictor of pregnancy-induced hypertension and preeclampsia. A preliminary report.","authors":"T Oney, H Kaulhausen","doi":"10.3109/10641958309006081","DOIUrl":"https://doi.org/10.3109/10641958309006081","url":null,"abstract":"In 200 healthy nulliparous women the mean arterial blood pressure in the second trimester (MAP-2 value) was calculated. 85 women (42 %) had a MAP-2 value of greater than or equal to 90 mmHg (positive test result), but only 27 women (32 %) developed a hypertensive complication. Conversely, 113 of the 115 (98 %) women with a negative test result (MAP-2 value less than 90 mmHg) remained normotensive. Only two women of this group (2 %) later showed a mild pregnancy-induced hypertension. Thus, the MAP-2 value has a high sensitivity (93 %) and a high predictive value of negative test results (98 %). On the other hand, there is a high rate of false-positive results (68 %) and thus a low predictive value of positive test results (32 %). It is concluded that the MAP-2 value is a simple method for selecting pregnant women who should be examined with other more specific predictive tests. Alternatively, weekly measurements of blood pressure are recommended for early diagnosis of hypertensive disorders of late pregnancy in all women with a MAP-2 value of 90 mmHg or more.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"2 2","pages":"211-6"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958309006081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17922079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33